Article
Plant Sciences
Thi-Kim-Dung Le, Ade Danova, Thammarat Aree, Thuc-Huy Duong, Mamoru Koketsu, Masayuki Ninomiya, Yoshiharu Sawada, Pharit Kamsri, Pornpun Pungpo, Warinthorn Chavasiri
Summary: Six new compounds, globunones A-F (1-6), and two new flavonoids (7 and 8), along with nine known compounds (9-17), were isolated from the stems of Knema globularia. These compounds exhibited potent inhibition towards yeast alpha-glucosidase.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Applied
Yasser El Halmouch, Hassan A. H. Ibrahim, Nourhan M. Dofdaa, Mona E. M. Mabrouk, Mohammad Magdy El-Metwally, Tatsuo Nehira, Khalid Ferji, Yasuhiro Ishihara, Koichi Matsuo, Mohammed I. A. Ibrahim
Summary: This study aimed to produce marine bacterial exopolysaccharides (EPS) as biodegradable and nontoxic biopolymers that can compete with synthetic derivatives. The most potent isolate, Bacillus para-licheniformis ND2, was identified through genetic analysis. The optimization conditions for EPS production were determined using Plackett-Burman design, resulting in a 1.26-fold increase in EPS yield compared to the basal conditions. Two purified EPSs, NRF1 and NRF2, were obtained and characterized. The EPSs showed antibacterial activity and induced proinflammatory cytokine expression.
CARBOHYDRATE POLYMERS
(2023)
Article
Biotechnology & Applied Microbiology
Ticiana Monteiro Abreu, Fernanda Pires Corpe, Felipe Barros Teles, Renata Line da Conceicao Rivanor, Caren Nadia Soares de Sousa, Ingridy da Silva Medeiros, Ismael Nilo Lino de Queiroz, Janaina Figueira-Mansur, Erika Freitas Mota, Ronaldo Mohana-Borges, Danielle S. Macedo, Silvania Maria Mendes de Vasconcelos, Jose Eduardo Ribeiro Honorio Junior, Norma Maria Barros Benevides
Summary: This study aimed to test the effects of algae lectin on LPS-induced depressive-like behavior and elucidate its antioxidant mechanism. The results showed that the algae lectin could prevent and reverse the behavioral and neurochemical changes induced by LPS.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2022)
Article
Chemistry, Medicinal
Dmitry A. Makarov, Sergey D. Negrya, Maxim V. Jasko, Inna L. Karpenko, Pavel N. Solyev, Vladimir O. Chekhov, Dmitry N. Kaluzhny, Olga V. Efremenkova, Byazilya F. Vasilyeva, Alexander O. Chizhov, Darya A. Avdanina, Alexander A. Zhgun, Sergey N. Kochetkov, Liudmila A. Alexandrova
Summary: The emergence of drug-resistant strains of pathogenic microorganisms necessitates the creation of new drugs. In this study, a series of uridine derivatives with extended substituents at the C-5 position were obtained and their antimicrobial properties and solubility were explored. It was found that these new ribonucleoside derivatives have significantly higher solubility in water than their 2'-deoxy analogues and effectively inhibit the growth of several drug-resistant Gram-positive bacteria.
Article
Chemistry, Applied
Jian-Ni Yang, Xiu-Qiao Zhou, Xu-Hua Nong, Jian Cao, Yang Hui, Mian Wen, Wen-Hao Chen
Summary: Chemical investigations of the flowers of Praxelis clematidea led to the isolation of 12 known compounds, with the structures determined by extensive spectroscopic studies. Among them, compounds 1, 4, and 11 were isolated from the Praxelis genus for the first time, while compounds 1-6, 8-12 were isolated from P. clematidea for the first time. Additionally, the antibacterial activity of compounds 1, 2, 7, and 9 was evaluated.
NATURAL PRODUCT RESEARCH
(2021)
Article
Environmental Sciences
M. V. K. Reddy, K. Y. Rao, G. Anusha, G. M. Kumar, A. G. Damu, Kakarla Raghava Reddy, Nagaraj P. Shetti, Tejraj M. Aminabhavi, Peddiahgari Vasu Govardhana Reddy
Summary: By exploring the inhibitory activities and antioxidant properties of various derivatives against AChE and BuChE enzymes, some compounds were found to exhibit selective AChE inhibition and strong affinity to bind with the AChE enzyme under physiological conditions, providing potential drug targets for treating Alzheimer's disease.
ENVIRONMENTAL RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Francis Ackah Armah, Isaac Tabiri Henneh, John Alake, Wisdom Ahlidja, Benjamin Amoani, Eric Gyamerah Ofori, Baffour Asante-Kyei, Gbadamosi Ismail Temitayo, Christian Kweku Adokoh
Summary: The seed extract of Allanblackia floribunda showed significant gastroprotective effects against gastric ulceration in rats due to its antisecretory, antioxidant, and anti-inflammatory properties. Additionally, the plant promoted ulcer healing by modulating the expression of Ki67 antigens and was found to be safe at supratherapeutic doses.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Food Science & Technology
Gbemisola J. Fadimu, Harsharn Gill, Asgar Farahnaky, Tuyen Truong
Summary: The effects of high-power and low-frequency ultrasound pretreatment, as well as different durations and proteases, on lupin protein hydrolysates were examined in this study. The results showed changes in structural characteristics, antioxidant activities, and physicochemical properties of the hydrolysates. Ultrasound treatment had a noticeable impact on the protein structure and antioxidant activity of the hydrolysates.
FOOD AND BIOPROCESS TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maidul Beg, Anukul Maji, Mt Nasima Aktara, Somenath Kundu, Samaresh Paria, Basudev Shit, Asima Dhal, Md Maidul Islam, Maidul Hossain
Summary: In this study, a simple and environmentally friendly method for synthesizing antibacterial silver nanoparticles using Cassia fistula leaf extract was provided. The CF-SNPs were characterized using various spectroscopic techniques, and their antibacterial and anticancer activities were evaluated against Escherichia coli and skin melanoma cell lines. The binding properties between HSA and CF-SNPs were also investigated.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Monica Arostica, Roberto Rojas, Luis Felipe Aguilar, Patricio Carvajal-Rondanelli, Fernando Albericio, Fanny Guzman, Constanza Cardenas
Summary: Cell-penetrating peptides rich in arginine are potential antibacterial compounds due to their lower chance of resistance development. Model homopeptides were used to study the relationship between activity and secondary structure, which is crucial for the development of functional heteropeptides. Substitution of arginine with other amino acids significantly improved the antibacterial activity, with nine peptides showing higher activity than R11 against Staphylococcus aureus and Escherichia coli. The peptides demonstrated cell-penetrating characteristics without damaging the bacterial membranes. The secondary structure of the peptides remained unchanged in most media, but was best defined in E. coli membrane extract.
Article
Chemistry, Multidisciplinary
Prangtip Nonkuntod, Jaursup Boonmak, Thanaset Senawong, Chaiyaporn Soikum, Prapansak Chaveerach, Athis Watwiangkham, Suwit Suthirakun, Unchulee Chaveerach
Summary: A new copper(II) complex containing N-(methylpyridin-2-yl)-amidino-O-methylurea and gallic acid was synthesized and characterized. The complex showed strong binding ability to calf-thymus DNA and exhibited the best cytotoxicity against MCF-7 cells. Additionally, it displayed excellent antibacterial activity.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Eleonora Russo, Andrea Spallarossa, Antonio Comite, Marcello Pagliero, Patrizia Guida, Vittorio Belotti, Debora Caviglia, Anna Maria Schito
Summary: The production of olive oil generates a considerable amount of wastewater, but this study successfully purified the wastewater and concentrated valuable polyphenols in a smaller volume using suitable filtration and concentration techniques. The purified water showed significant antioxidant activity and the wastewater samples showed widespread antimicrobial activity.
Article
Multidisciplinary Sciences
Maria D'Accolti, Denise Bellotti, Emilia Dzien, Carlotta Leonetti, Silvia Leveraro, Valentina Albanese, Erika Marzola, Remo Guerrini, Elisabetta Caselli, Magdalena Rowinska-Zyrek, Maurizio Remelli
Summary: The main limitation of using antimicrobial peptides as drugs is their susceptibility to proteolytic enzyme degradation. This study focused on improving the plasma stability of a metal-chelating antimicrobial peptide called calcitermin through structural modifications. The study evaluated the peptide stability and characterized its metal complexes, finding that protecting the peptide termini increased its half-life and metal complex formation enhanced its resistance to degradation.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Inorganic & Nuclear
Hande Pekbelgin Karaoglu, Ozgul Saglam, Sadin Ozdemir, Serpil Gonca, Makbule Burkut Kocak
Summary: A new fluorinated phthalonitrile compound and phthalocyanine derivatives were synthesized and characterized. The compounds showed potential biological activities including antioxidant, DNA cleavage, antimicrobial, biofilm inhibition, and bacterial viability inhibition. The results indicated effective activities in different assays, highlighting the potential applications of these compounds in various fields.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Prangtip Nonkuntod, Atittaya Meenongwa, Thanaset Senawong, Chaiyaporn Soikum, Prapansak Chaveerach, Athis Watwiangkham, Suwit Suthirakun, Unchulee Chaveerach
Summary: Two mixed-Eigand complexes of copper(u) chloride containing guanidine derivatives and ciprofloxacin were synthesized and characterized. The complexes showed strong binding ability to DNA, higher anticancer activity against cancer cells, and antibacterial activity against food poisoning bacteria. Evaluation of their cytotoxicity revealed no toxicity against normal cells. The complexes may induce cell death in cancer cells through apoptosis pathways. The antibacterial activity of the complexes was the best against Salmonella.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Iliassou L. Mouafon, Gesquiere Laure M. Tiani, Bel Youssouf G. Mountessou, Mehreen Lateef, Muhammad S. Ali, Ivan R. Green, Bonaventure T. Ngadjui, Simeon F. Kouam
Summary: Chemical investigation of the whole plant of Indigofera spicata Forsk from Cameroon led to the isolation of a new benzofuran compound named spibenzofuran, along with ten known secondary metabolites. These compounds, including benzofuran, flavonoid, saponin, triterpenes, steroids, phthalate, and fatty acids, were isolated for the first time from this plant. The structures of the compounds were identified using spectroscopic analysis and comparison with reported data, and some of them showed antibacterial and urease inhibitory activities.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Placide M. Toklo, Eleonore Yayi Ladekan, Anthony Linden, Sylvie Hounzangbe-Adote, Simeon F. Kouam, Joachim D. Gbenou
Summary: A study on Combretum glutinosum leaves resulted in the isolation and identification of nine compounds, with three flavonoids showing promising anthelmintic activity against Haemonchus contortus. These flavonoids could potentially be used for the development of new derivatives to improve anthelmintic efficacy.
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY
(2021)
Article
Plant Sciences
Michel Pouofo Nguiam, Steven Collins Njonte Wouamba, Frida Longo, Raceline Gounoue Kamkumo, Larissa Donji Kenne Foweda, Paul Desire Dzeufiet Djomeni, Bruno Lenta Ndjakou, Norbert Sewald, Fabrice Fekam Boyom, Simeon Kouam Fogue, Theophile Dimo
Summary: The study evaluated the efficacy of Xylopia staudtii bark extract against Shigella flexneri infection in immunodepressed mice. The extract showed significant antibacterial activity against Shigella, reducing fecal pathology and mortality rate in mice. It also exhibited anti-inflammatory properties and protected intestinal tissue from damage caused by Shigella infection.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Applied
Iliassou Lah Mouafon, Bel Youssouf Gbetnkom Mountessou, Mehreen Lateef, Joseph Tchamgoue, Muhammad Shaiq Ali, Jean Claude Tchouankeu, Ivan Robert Green, Bonaventure Tchaleu Ngadjui, Simeon Fogue Kouam
Summary: Phytochemical investigation of a previously unstudied species of Indigofera led to the isolation of two new phenolic compounds, as well as the identification of nine known secondary metabolites. Antibacterial activity was observed for compounds 7 and 9, and compound 9 showed potent inhibition of the enzyme urease.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Nadine Tseme Wandji, G. Thierry Mbahbou Bitchagno, Joseph Tchamgoue, Hans-Georg Stammler, Marcel Frese, Bruno Ndjakou Lenta, Norbert Sewald, Simeon Fogue Kouam
Summary: Two furanocoumarin derivatives and nine known compounds were isolated from the twigs of Ficus chlamydocarpa. These compounds showed antibacterial activity against bacterial strains and cytotoxicity towards human cervical carcinoma cell line KB-3-1.
PHYTOCHEMISTRY LETTERS
(2022)
Review
Plant Sciences
Bel Youssouf G. Mountessou, Joseph Tchamgoue, Iliassou L. Mouafon, Ivan R. Green, Muhammad I. Choudhary, Simeon F. Kouam
Summary: The genus Allanblackia includes ten species of flowering plants that grow in the rainforests of West, Central, and East Africa. These evergreen, medium-sized trees have the largest fruits in the African rainforest, and their stem barks are reddish-brown with small scales. The plants are used in traditional medicine and their seed oils have commercial potential. Chemical analysis has shown that xanthones and biflavonoids are major secondary metabolites in this genus. Some species have exhibited antimicrobial, antileishmanial, anticholinesterase, and cytotoxic activities, making them valuable for new drug discovery.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Review
Biochemistry & Molecular Biology
Boris Yotta Kianfe, Joseph Tchamgoue, Abolfazl Narmani, Remy Bertrand Teponno, Andre-Ledoux Njouonkou, Marc Stadler, Simeon Fogue Kouam
Summary: Cytospora is a genus of fungi that can produce diverse secondary metabolites with a broad range of biological activities, making it a prolific source of specialized metabolites. Previous studies have identified and elucidated the structures of several bioactive compounds from this genus, including cytosporones, nonanolides, macrocyclic dilactones, and terpenoids. This review provides a comprehensive summary of the chemical diversity of bioactive secondary metabolites from the genus Cytospora and highlights its potential as an alternative source for pharmacological studies. It also serves as a foundation for future investigations into compounds from this genus.
Article
Chemistry, Organic
Bel Youssouf G. Mountessou, Elodie Gisele M. Anoumedem, Blondelle M. Kemkuignou, Yasmina Marin-Felix, Frank Surup, Marc Stadler, Simeon F. Kouam
Summary: A new species of Diaporthe cameroonensis was isolated from the fresh root of Trema guineensis (Ulmaceae). The strain was fermented and extracted, resulting in the isolation of a hemiketal polyketide and an acetylated alternariol, as well as fifteen known secondary metabolites.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Microbiology
Blondelle Matio Kemkuignou, Christopher Lambert, Marc Stadler, Simeon Kouam Fogue, Yasmina Marin-Felix
Summary: Four unprecedented polyketides were isolated from the newly described endophytic fungus Diaporthe africana. The fungus was taxonomically identified using a polyphasic approach. The structures of the compounds were determined by spectral analysis, and their antimicrobial and cytotoxic properties were evaluated.
Article
Biochemistry & Molecular Biology
Nadine Tseme Wandji, Gabin Thierry M. Bitchagno, Isabelle Mawabo Kamga, Joseph Tchamgoue, Celine Nguefeu Nkenfou, Bruno Ndjakou Lenta, Norbert Sewald, Simeon Fogue Kouam
Summary: Four polyoxygenated stigmastanes, along with known analogues and flavonoids, were isolated from the whole plant of Vernonia kotschyana. Their structures were determined through spectroscopic and spectrometric analysis. The antibacterial activity of the crude extract, fractions, and compounds was evaluated against prevalent bacterial strains, showing low to moderate activity.
Article
Integrative & Complementary Medicine
Cyrille Armel N. Njanpa, Steven Collins N. Wouamba, Lauve Rachel T. Yamthe, Darline Dize, Brice Mariscal T. Tchatat, Patrick Valere F. Tsouh, Michel Nguiam Pouofo, Jean Bosco Jouda, Bruno Lenta Ndjakou, Norbert Sewald, Simeon Fogue Kouam, Fabrice Fekam Boyom
Summary: The study aimed to discover new inhibitors of Leishmania spp. using extracts from Diospyros gracilescens. The hydroethanolic crude extract of D. gracilescens trunk showed the most potent antileishmanial activity, with the hexane fraction showing the most potent activity. Further studies on the isolated compounds could lead to potential drug discovery for visceral leishmaniasis.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
