Article
Biochemistry & Molecular Biology
Mareena Daus, Suttiwan Wunnoo, Supayang P. Voravuthikunchai, Saowanit Saithong, Preeyaporn Poldorn, Siriporn Jungsuttiwong, Natharika Chomlamay, Kanyaluck Yangok, Ramida Watanapokasin, Suda Chakthong
Summary: Fourteen undescribed phloroglucinol-meroterpenoids were isolated from Eucalyptus camaldulensis leaves, along with twelve known phloroglucinols, three known flavonoids, and four known phenolic compounds. The structures of the undescribed compounds were analyzed using NMR spectroscopy and mass spectrometry, and their cytotoxic, antibacterial, and antifungal activities were evaluated.
Article
Plant Sciences
Nadjat Righi, Sabah Boumerfeg, Amirouche Deghima, Pedro A. R. Fernandes, Elisabete Coelho, Faiza Baali, Susana M. Cardoso, Manuel A. Coimbra, Abderrahmane Baghiani
Summary: The hydromethanolic extract of Salvia verbenaca showed strong antioxidant and anti-inflammatory activities both in vitro and in vivo, with no acute/subacute toxicity effects on mice. This indicates its potential as a safe and effective option for wound healing and anti-ulcer treatments.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Organic
Wei-Hua Jiao, Jia-Xin Li, Hong-Yan Liu, Xiang-Chao Luo, Tian-Yong Hu, Guo-Hua Shi, Dong-Dong Xie, Hai-Feng Chen, Bao-Hui Cheng, Hou-Wen Lin
Summary: An unusual secomeroterpenoid, dysambiol (1), was isolated from a Dysidea sp. marine sponge collected from the South China Sea. Dysambiol features an unprecedented secomeroterpene scaffold with a rare lactone bridge. Dysambiol displayed potent anti-inflammatory activity in LPS-induced Raw 264.7 macrophages by regulating the NF-κB/MPAK signaling pathway.
Review
Chemistry, Medicinal
Do Thi Lan Huong, Dau Xuan Duc, Ninh The Son
Summary: Baeckea frutescens L. is a traditional herbal medicine in Southeast Asia with numerous metabolites of medicinal value. This review highlights the pharmacological properties of B frutescens plant extracts and compounds isolated from them, including cytotoxic, antimicrobial, anti-inflammatory, antioxidant, skin protective, and mosquito larvicidal activities. However, further experimental studies are needed to understand the mechanisms of action.
NATURAL PRODUCT COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Engy A. Mahrous, Ahmed M. Al-Abd, Maha M. Salama, Magda M. Fathy, Fathy M. Soliman, Fatema R. Saber
Summary: The Myrteacae family is a rich source of phloroglucinols, with two new phloroglucinol derivatives showing selective antiproliferative action against colorectal cancer cells. The compounds may induce cytotoxicity through both necrosis and apoptosis pathways, suggesting potential as selective chemotherapeutic agents.
Article
Biochemistry & Molecular Biology
Min Zhao, Xiao-Cong Chen, Wen-Cong Pan, Xia Liu, Shao-Li Tan, Hui Cui, Zhong-Xiang Zhao
Summary: Seven undescribed meroterpenoids, named peniscmeroterpenoids A-G, were isolated from a marine-derived fungus. Peniscmeroterpenoid A possesses a unique pentacyclic system with a tetrahydrofuro [2,3-b]furan-2(3H)-one motif. Peniscmeroterpenoids B-E have rare fused rings and peniscmeroterpenoid E represents a new berkeleyone analogue devoid of a methyl ester fragment. Peniscmeroterpenoids A and D exhibit inhibitory effects on nitric oxide production and inflammatory mediators in bioassays.
Article
Biochemistry & Molecular Biology
Xin Deng, Jing Xia, Bo Hu, Xing-cun Hou, Xiang-dong Pu, Lin Wu
Summary: Four new trimethylated compounds, along with hyjapone A featuring a unique hybrid structure, were isolated from Hypericum japonicum Thunb. These compounds showed anti-inflammatory effects, with hyjapone A demonstrating pronounced activity possibly by inhibiting the activation of nuclear factor-kappa B.
Article
Agriculture, Multidisciplinary
Xin Zhou, Wenjun Xu, Yiran Li, Meihui Zhang, Pengfei Tang, Weijia Lu, Qiji Li, Hao Zhang, Jun Luo, Lingyi Kong
Summary: In this study, 26 methylated acylphloroglucinol meroterpenoids were identified from the flowers of Hypericum bellum, including 18 new compounds. The structures, absolute configurations, and diverse skeletons were elucidated through detailed spectroscopic data, calculated ECD, and XRD. The compounds showed significant anti-inflammatory, antioxidant, and anti-NASH activities, suggesting their potential in daily health care.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Plant Sciences
Hazwani Mat Saad, Syarifah Nur Syed Abdul Rahman, Suerialoasan Navanesan, Chun Hoe Tan, Sugumaran Manickam, Sri Nurestri Abd Malek, Kae Shin Sim
Summary: Plant extracts such as essential oils, specifically from Baeckea frutescens and Leptospermum javanicum, were found to exhibit appreciable antioxidant activity in various radical scavenging assays, with BF essential oil demonstrating higher overall antioxidant capacity than LJ. Compounds 1-5 in the essential oils were identified as potent antioxidants that significantly contributed to their antioxidant capacity.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Karen de Jesus Nicacio, Miller Santos Ferreira, Albert Katchborian-Neto, Milbya Lima Costa, Michael Murgu, Danielle Ferreira Dias, Marisi Gomes Soares, Daniela Aparecida Chagas-Paula
Summary: Hops were evaluated for their anti-inflammatory potential through an ex vivo assay, with Columbus, Chinook, and Hallertau Mittelfruh cultivars showing high inhibition rates of PGE2 release. Metabolites such as prenylated phloroglucinol and phenolic homologs were identified as potential anti-inflammatory markers, suggesting promising anti-inflammatory hop compounds.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Chemistry, Multidisciplinary
Mengting Liu, Xueke Zhang, Ling Shen, Shuang Lin, Ying Ye, Changxing Qi, Jianping Wang, Zhengxi Hu, Yonghui Zhang
Summary: Six new meroterpenoids were isolated from the fungus Bipolaris zeicola, with compounds 5-8 showing potent inhibitory activity against T lymphocyte proliferation. Compound 1 features a formaldehyde group at C-11, while compound 3 has a rare amino group at C-11.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Applied
Dongqin Liu, Ying Wang, Zhaoxin Lu, Fengxia Lv, Xiaomei Bie, Haizhen Zhao
Summary: The study focused on optimizing separation procedures, characterizing galactoglycerolipids, and exploring their anti-inflammatory activities. Two new compounds were identified from Perilla frutescens, and they showed good inhibitory activities against nitric oxide production, indicating potential anti-inflammatory properties.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Zhonghao Sun, Yongben Ma, Jiawen Zhang, Guoxu Ma, Haifeng Wu, Leiling Shi, Zhaocui Sun, Xudong Xu
Summary: Four new meroterpenoids with aminoglycoside moiety and a 10-membered carbocycle fused with an alpha, beta-epoxy-gamma-lactone were isolated from Clitocybe clavipes. Compound 1 and 2 showed significant suppression of cell viability in the Hela cell line.
Article
Chemistry, Applied
Rui Guo, Yan Liu, Juan Pan, Wei Guan, Bing-You Yang, Hai-Xue Kuang
Summary: A new sesquiterpenoid glycoside, along with two known megastigmane sesquiterpenoids, were isolated from the leaves of Datura metel L. These compounds showed potential cytotoxicity against cancer cells and anti-inflammatory activity, indicating potential medicinal applications.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Minghua Jiang, Heng Guo, Qilin Wu, Xin Lu, Yating Zou, Quanyou Fu, Shuihao Chen, Lan Liu, Bo Peng, Senhua Chen
Summary: A combination strategy of 13C NMR and bioinformatics was used to discover acetylenic meroterpenoids from a specific fungus. 17 compounds were identified, including 5 new ones. Extensive spectroscopy and analysis methods were employed to determine the structures and configurations of the compounds. Some of these compounds showed anti-inflammatory activity and further studies revealed important structural features for their activity. These findings can contribute to the development of new anti-inflammatory drugs.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
