Article
Environmental Sciences
Ahmed A. A. Aioub, Ahmed S. S. Hashem, Ahmed H. H. El-Sappah, Amged El-Harairy, Amira A. A. Abdel-Hady, Laila A. A. Al-Shuraym, Samy Sayed, Qiulan Huang, Sarah I. Z. Abdel-Wahab
Summary: This study identified and characterized GST genes in the fall armyworm S. frugiperda and evaluated the toxicity of emamectin benzoate (EBZ) and chlorantraniliprole (CHP) on the larvae. A total of 31 GST genes were identified, and SfGSTe10 and SfGSTe13 showed the highest expression after EBZ and CHP treatments. Molecular docking analysis revealed high binding affinity between EBZ and CHP with SfGSTe10 and SfGSTe13. These findings provide important insights into the detoxification processes of S. frugiperda regarding EBZ and CHP.
Article
Agriculture, Multidisciplinary
Zhang Dan-dan, Xiao Yu-tao, Xu Peng-jun, Yang Xian-ming, Wu Qiu-lin, Wu Kong-ming
Summary: This study tested the susceptibility of fall armyworm populations from five regions in China to various insecticides, revealing high resistance ratios to certain chemicals. The results have implications for chemical control, resistance monitoring, and management of the pest in China.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2021)
Article
Entomology
Sheng-Lan Lv, Yang Shi, Jia-Cheng Zhang, Pei Liang, Lei Zhang, Xi-Wu Gao
Summary: The study investigated resistance levels to chlorantraniliprole and tetrachloropyramid in 13 populations of Spodoptera frugiperda in China. Results showed low resistance levels to diamide insecticides in China, and differences in relative resistance among populations were not caused by mutations in RyR or its expression.
Article
Entomology
Jia-Ying Zhu, Lu Li, Kai-Ran Xiao, Shu-Qi He, Fu-Rong Gui
Summary: The study identified 206 cuticular proteins (CPs) from the fall armyworm genome and found that 51 CP genes significantly changed after exposure to 17 insecticides, with 8 CP genes responding to 4 insecticides confirmed through RT-PCR analysis. These findings suggest a potential role of CPs in insecticide stress response in fall armyworms.
Article
Multidisciplinary Sciences
Atif Idrees, Ziyad Abdul Qadir, Ayesha Afzal, Qiu Ranran, Jun Li
Summary: This study assessed the toxicity of seven synthetic insecticides on the fall armyworm larvae and found that broflanilide and abamectin were the most toxic. The results provide a basis for the development of novel insecticides for controlling fall armyworm populations.
Article
Multidisciplinary Sciences
Lei Yang, Binglin Xing, Fen Li, Li Kui Wang, Linlin Yuan, Amosi Leonard Mbuji, Zhengqiang Peng, Farag Malhat, Shaoying Wu
Summary: This study used PacBio single-molecule real-time (SMRT) sequencing to uncover the full-length transcriptome profiling of fall armyworm larval brain, identifying a large number of detoxification genes and providing crucial data support for understanding the insecticide resistance mechanisms in fall armyworm.
Article
Chemistry, Multidisciplinary
Youwu Hao, Di Liu, Yonghui Song, Xinming Yin, Jia Liu, Risong Na, Qing X. Li
Summary: The translocation and delivery of pesticides to their target molecules is often a limiting factor in their efficacy. Nanomaterials have provided a new approach to increase pesticide efficacy and reduce risks. In this study, a mitochondria-targeted pesticide nanocarrier was successfully synthesized, which enhanced the toxicity and efficacy of the pesticide chlorfenapyr by inducing mitochondrial damage.
ENVIRONMENTAL SCIENCE-NANO
(2022)
Article
Multidisciplinary Sciences
Sudeeptha Yainna, Wee Tek Tay, Karine Durand, Estelle Fiteni, Frederique Hilliou, Fabrice Legeai, Anne-Laure Clamens, Sylvie Gimenez, R. Asokan, C. M. Kalleshwaraswamy, Sharanabasappa S. Deshmukh, Robert L. Meagher, Carlos A. Blanco, Pierre Silvie, Thierry Brevault, Anicet Dassou, Gael J. Kergoat, Thomas Walsh, Karl Gordon, Nicolas Negre, Emmanuelle D'Alencon, Kiwoong Nam
Summary: The fall armyworm, a major agricultural pest insect, has spread globally and poses a threat to corn production. Genetic analysis reveals that invasive populations of the fall armyworm originated from the corn strain and exhibit adaptive evolution in detoxification, chemosensory, and digestion genes.
SCIENTIFIC REPORTS
(2022)
Article
Agronomy
Hui-Ming Wu, Hang-Li Feng, Guo-Di Wang, Li-Li Zhang, Lovemore Zulu, Ya-Hui Liu, Yong-Li Zheng, Qiong Rao
Summary: The sublethal effects of common insecticides on Spodoptera frugiperda were studied. The results showed that the insecticides led to decreased pupation rates, inhibited fecundity, and restricted the growth of offspring population. However, one insecticide had a promoting effect on oviposition, which may cause the resurgence of pests.
Article
Entomology
Fang Guan, Zheng Zhang, Yuhang Lin, Xiangjie Liu, Xingliang Wang, Yihua Yang, Yves Carriere, Yidong Wu
Summary: This study investigated the susceptibility and diagnostic concentration of the fall armyworm population in southeastern China to Bt toxins and insecticides. The results showed that these populations were generally susceptible to the tested toxins and insecticides, providing useful information for the control of the fall armyworm in China.
JOURNAL OF ECONOMIC ENTOMOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jayaraman Kumaravel, Kandhasamy Lalitha, Murugan Arunthirumeni, Murugan Subramanian Shivakumar
Summary: In this study, bimetallic nanoparticles synthesized using fungal metabolites showed significant insecticidal activity against Spodoptera frugiperda larvae, as well as pupicidal and antifeedant activities. Additionally, these nanoparticles were found to affect detoxification enzymes in insects.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Entomology
Rubens H. Kanno, Aline S. Guidolin, Fernando E. O. Padovez, Juliana G. Rodrigues, Celso Omoto
Summary: Insecticide resistance is often associated with fitness costs, which are influenced by environmental and ecological factors. This study investigated how host plants can affect the fitness costs of insecticide resistance in Spodoptera frugiperda. The results showed that the fitness costs of spinetoram resistance in S. frugiperda depend on the host plants that S. frugiperda larvae fed on.
JOURNAL OF PEST SCIENCE
(2023)
Article
Multidisciplinary Sciences
Atif Idrees, Ayesha Afzal, Talha Ali Chohan, Sikandar Hayat, Ziyad Abdul Qadir, Abdel-Rhman Z. Gaafar, Ali Tan Kee Zuan, Jun Li
Summary: This study evaluated the effects of 16 different chemicals on the maize pest Spodoptera frugiperda. Botanical insecticides such as osthole, azadirachtin, nicotine, and pyrethrin showed significant larval mortality, while synthetic insecticides like emamectin benzoate, indoxacarb, and imidacloprid also had high mortality rates. These findings suggest the potential use of these chemicals in the management of S. frugiperda.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Arati Agarwal, Lea Rako, Mark K. Schutze, Melissa L. Starkie, Wee Tek Tay, Brendan C. Rodoni, Mark J. Blacket
Summary: Fall armyworm (FAW) is an invasive plant pest that has expanded globally, requiring rapid diagnostic tests for management and control. A newly developed LAMP assay based on a specific gene enables accurate field diagnosis of FAW.
SCIENTIFIC REPORTS
(2022)
Article
Agronomy
Fernando Elias Oliveira Padovez, Rubens Hideo Kanno, Celso Omoto, Aline Sartori Guidolin
Summary: The study revealed that there was no fitness cost associated with chlorantraniliprole resistance in the Spodoptera frugiperda strain with the near-isogenic background. On the other hand, a significant fitness cost was detected in the strain with a different genetic background. This suggests that the genetic background of resistant strains plays a crucial role in determining fitness costs.
PEST MANAGEMENT SCIENCE
(2022)
Review
Microbiology
Maria Antonia Cruz-Hernandez, Alberto Mendoza-Herrera, Virgilio Bocanegra-Garcia, Gildardo Rivera
Summary: This review explores the potential application of Azospirillum sp. in environmental remediation, its properties as a plant growth promoter, and its genomics.
Article
Chemistry, Medicinal
Alfredo Juarez-Saldivar, Nuria E. Campillo, Eyra Ortiz-Perez, Alma D. Paz-Gonzalez, Emma Saavedra, Gildardo Rivera
Summary: In this study, three ontology-based approaches were used to compare the proteomes of five species of protozoa, leading to the identification of 12 potential drug targets for the development of new broad-spectrum antiprotozoal drugs.
MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Lenci K. Vazquez-Jimenez, Alfredo Juarez-Saldivar, Rogelio Gomez-Escobedo, Timoteo Delgado-Maldonado, Domingo Mendez-Alvarez, Isidro Palos, Debasish Bandyopadhyay, Carlos Gaona-Lopez, Eyra Ortiz-Perez, Benjamin Nogueda-Torres, Esther Ramirez-Moreno, Gildardo Rivera
Summary: In this study, a ligand-based virtual screening was performed to identify potential TcTIM inhibitors. Molecular docking and molecular dynamics simulation analysis showed a favorable docking score of the BP5 compound on TcTIM, and a lower docking score on human TIM compared to the control ligand. Both BP2 and BP5 compounds exhibited good physicochemical and pharmacokinetic properties as new anti-T. cruzi agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Juan Jose Oropeza-Valdez, Jose de la Cruz Moreira Hernandez, Elena Jaime-Sanchez, Ernesto Lopez-Ramos, Edgar E. Lara-Ramirez, Yamile Lopez Hernandez, Julio Enrique Castaneda-Delgado, Jose Antonio Enciso Moreno
Summary: This study evaluated the transcriptomic profiles of different groups of patients to identify biomarkers for diabetic nephropathy. The results identified several induced genes that could potentially be used as biomarkers for diagnosing diabetic nephropathy.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Genetics & Heredity
Karina Janett Juarez-Rendon, Manuel Alejandro Castro-Garcia, Diddier Giovanni Prada-Ortega, Gildardo Rivera, Luz Maria Ruiz-Godoy, Virginia Isabel Enriquez-Carcamo, Miguel Angel Reyes-Lopez
Summary: This study identified five unreported gene variants in the HOXC13 and HOXD13 genes and suggested that two of these variants may be a risk factor for the development of cervical cancer.
Article
Infectious Diseases
Jose Vazquez-Villanueva, Karina Vazquez, Ana Veronica Martinez-Vazquez, Alfredo Wong-Gonzalez, Jesus Hernandez-Escareno, Omar Cabrero-Martinez, Wendy Lizeth Cruz-Pulido, Abraham Guerrero, Gildardo Rivera, Virgilio Bocanegra-Garcia
Summary: This study analyzed 336 samples from a bovine slaughterhouse and found that 83.3% of the samples were positive for E. coli infection. The study revealed that these E. coli isolates exhibited resistance to multiple antibiotics and carried various virulence factors and resistance genes. Therefore, E. coli poses a threat to public health.
Review
Chemistry, Medicinal
Timoteo Delgado-Maldonado, Antonio Moreno-Herrera, Gerard Pujadas, Lenci K. Vazquez-Jimenez, Alonzo Gonzalez-Gonzalez, Gildardo Rivera
Summary: New antiviral therapeutics are essential in combating emerging and re-emerging viral diseases like dengue and Zika. Non-structural protein with methyltransferase activity is a promising target for drug development due to its critical role in virus replication. Various drug strategies have identified potential methyltransferase inhibitors that can bind to the active site. This review analyzes different types of inhibitors and discusses the potential for developing effective antiviral drugs against dengue and Zika.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Luca De Angelis, Graham C. Haug, Gildardo Rivera, Soumen Biswas, Ammar Al-Sayyed, Hadi Arman, Oleg Larionov, Michael P. Doyle
Summary: One important reaction of 1,2,3-triazines is the inverse electron demand Diels-Alder (IEDDA) cycloaddition with a dienophile, which proceeds through nucleophilic addition to the triazine followed by N-2 loss and cyclization. Previous studies have not provided a comprehensive understanding of the site of nucleophilic addition on the triazine. This study investigated the C-, N-, H-, O-, and S-nucleophilic additions on 1,2,3-triazine and 1,2,3-triazine-1-oxide frameworks and revealed the differentiation of addition at the 4- and 6-positions. Computational studies further examined the factors influencing the outcomes of these reactions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Organic
Soumen Biswas, Luca De Angelis, Gildardo Rivera, Hadi Arman, Michael P. Doyle
Summary: 1,2,3-Triazine 1-oxides are highly effective substrates for inverse electron demand Diels-Alder reactions. These stable heterocyclic compounds, formed from vinyldiazoacetates via reaction with tert-butyl nitrite, undergo clean nucleophilic addition reactions with amidines to form pyrimidines, with beta-ketocarbonyl compounds and related nitrile derivatives to form polysubstituted pyridines, and with 3/5-aminopyrazoles to form pyrazolo[1,5-a]pyrimidines, in high yields. These reactions, catalyzed by bases, are rapid at room temperature and allow for a range of structural modifications.
Article
Chemistry, Medicinal
Alonzo Gonzalez-Gonzalez, Citlali Vazquez, Rusely Encalada, Emma Saavedra, Lenci K. K. Vazquez-Jimenez, Eyra Ortiz-Perez, Maria Laura Bolognesi, Gildardo Rivera
Summary: Phenothiazine derivatives have the potential to inhibit trypanothione reductase, an important antioxidant enzyme. A virtual screening of these derivatives identified compounds with higher affinity to the enzyme than the natural ligand trypanothione disulfide. Two compounds, ZINC1033681 and ZINC10213096, showed significant inhibition of parasite growth and acted as mixed-type inhibitors of recombinant TR. This study provides further insights into the potential of phenothiazine derivatives as TR inhibitors.
MOLECULAR INFORMATICS
(2023)
Review
Environmental Sciences
Alejandra Aguilar-Salazar, Ana Veronica Martinez-Vazquez, Guadalupe Aguilera-Arreola, Erick de Jesus de Luna-Santillana, Maria Antonia Cruz-Hernandez, Cesar Marcial Escobedo-Bonilla, Edgar Lara-Ramirez, Mario Sanchez-Sanchez, Abraham Guerrero, Gildardo Rivera, Virgilio Bocanegra-Garcia
Summary: This review aims to provide a comprehensive overview of the current dissemination and characterization of ESKAPE bacteria in surface water and wastewater sources, which display widespread antimicrobial resistance and have significant clinical implications globally.
Review
Chemistry, Medicinal
Carlos Gaona-Lopez, Ana Veronica Martinez-Vazquez, Juan Carlos Villalobos-Rocha, Karina Janett Juarez-Rendon, Gildardo Rivera
Summary: This article mainly discusses the issue of diarrhea caused by Giardia lamblia and points out its harm to children and adults worldwide. Although giardiasis is considered a major disease in low-income and developing countries, current migratory flows have caused an increase in giardiasis cases in high-income countries. This article focuses on the nucleolus of G. lamblia, discusses possible therapeutic targets, and describes some drugs under research that could be effective against this parasite.
Article
Infectious Diseases
Jessica L. Ortega-Balleza, Abraham Guerrero, Graciela Castro-Escarpulli, Ana Veronica Martinez-Vazquez, Maria Antonia Cruz-Hernandez, Erick de Jesus de Luna-Santillana, Erika Acosta-Cruz, Iram Pablo Rodriguez-Sanchez, Gildardo Rivera, Virgilio Bocanegra-Garcia
Summary: The global spread of antimicrobial resistance genes (ARGs) is a significant public health concern, driven primarily by the transfer of mobile genetic elements (MGEs). This study evaluated the whole genome of multidrug-resistant E. coli strains isolated from various sources, and identified numerous ARGs, plasmid replicons, and intact prophages. The findings highlight the high pathogenic potential of these E. coli strains and emphasize the need for monitoring.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Shaila A. Shetu, Nneoma James, Gildardo Rivera, Debasish Bandyopadhyay
Summary: Pancreatic enzymes and hormones like insulin and glucagon are crucial for digestion and blood sugar regulation. However, pancreatic cancer, which often has no early detection method, is highly lethal due to the malfunctioning of the pancreas. The article explores various small molecule inhibitors that can effectively target and inhibit the proteins responsible for pancreatic cancer, shedding light on potential treatments for this dreadful disease.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Chemistry, Medicinal
Ana Karen Estrada, Domingo Mendez-Alvarez, Alfredo Juarez-Saldivar, Edgar E. Lara-Ramirez, Ana Veronica Martinez-Vazquez, Juan Carlos Villalobos-Rocha, Isidro Palos, Eyra Ortiz-Perez, Gildardo Rivera
Summary: In this study, a ligand-based virtual screening method was used to identify 15 potential SGLT2 inhibitors from various databases. Molecular dynamics simulation analysis showed that spiroketal derivatives exhibited good stability.
MEDICINAL CHEMISTRY
(2023)