Journal
SENSORS
Volume 18, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/s18124461
Keywords
SPR; TNTHCDR3; SWCNTs; pi-stacking; TNT analogues
Funding
- Japan Science and Technology Agency [HQJJ268702]
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In this study, we developed a surface plasmon resonance (SPR) sensor chip based on 2,4,6-trinitrotoluene (TNT) recognition peptide-modified single-walled carbon nanotubes (SWCNTs). The carboxylic acid-functionalized SWCNTs were immobilized on a 3-aminopropyltriethoxysilane (APTES)-modified SPR Au chip surface. Through pi-stacking between the aromatic amino acids and SWCNTs, the TNT recognition peptide TNTHCDR3 was immobilized onto the surface of the SWCNTs. The peptide-SWCNTs-modified sensor surface was confirmed and evaluated by atomic force microscope (AFM) observation. The peptide-SWCNTs hybrid SPR sensor chip exhibited enhanced sensitivity with a limit of detection (LOD) of 772 ppb and highly selective detection compared with commercialized carboxymethylated dextran matrix sensor chips.
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