Article
Endocrinology & Metabolism
Nihar Ranjan Dash, Mohammad Tahseen Al Bataineh
Summary: The study found that Gut microbiome of T2DM patients are enriched in metabolic pathways associated with vitamin K2 biosynthesis, which may be related to insulin resistance. T2DM patients with high glycosylated hemoglobin levels have different gene abundances in metabolic pathways, which could be significant for the development of new biomarkers and better management strategies for T2DM in the future.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Microbiology
Wei Mi, Zhiyong Hu, Lanlan Xu, Xiangyu Bian, Wu Lian, Shuying Yin, Shuying Zhao, Weina Gao, Changjiang Guo, Tala Shi
Summary: Quercetin increases the abundance of butyrate-producing bacteria, which leads to increased butyrate production and accelerated carbohydrate and energy metabolism, while reducing cell motility and endotoxemia. This results in the enhancement of gut barrier function.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Keli Yang, Junkun Niu, Tao Zuo, Yang Sun, Zhilu Xu, Whitney Tang, Qin Liu, Jingwan Zhang, Enders K. W. Ng, Simon K. H. Wong, Yun Kit Yeoh, Paul K. S. Chan, Francis K. L. Chan, Yinglei Miao, Siew C. Ng
Summary: This study reveals that obese individuals, especially those with T2DM, have decreased gut viral richness and diversity compared to lean controls. There are altered viral taxonomic composition and weakened viral-bacterial correlations in obesity, and the gut virome may play a role in the development of obesity and T2DM.
Article
Environmental Sciences
Juliette O'Keeffe, Joseph Akunna
Summary: This study provides a simple and cost-effective method for assessing the risks of organic pollutants in waste materials. The results showed little variability in dissolved organic carbon levels in primary sludges from different wastewater treatment plants, but significant differences in secondary sludges. Treated biosolids leached less dissolved organic carbon but had higher proportions of persistent or poorly biodegradable dissolved organic carbon.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Microbiology
Federico Fontana, Giulia Longhi, Giulia Alessandri, Gabriele Andrea Lugli, Leonardo Mancabelli, Chiara Tarracchini, Alice Viappiani, Rosaria Anzalone, Marco Ventura, Francesca Turroni, Christian Milani
Summary: The PDO designation ensures the traceability and restricted geographical area of food production. However, the sensory qualities of dairy products with the same PDO differ between manufacturers. This study analyzed the microbiome of raw milk cheeses in Italy and found that the microbial communities and use of site-specific Natural Whey Cultures (NWCs) had a significant impact on the organoleptic features and bioactive compounds of the cheeses. These findings suggest the need to revise the PDO designation to consider the site-specific microbial metabolism and guarantee the desired qualities of the final product.
Article
Microbiology
Shan Sun, Huijun Wang, Annie Green Howard, Jiguo Zhang, Chang Su, Zhihong Wang, Shufa Du, Anthony A. Fodor, Penny Gordon-Larsen, Bing Zhang
Summary: Recent rapid urbanization has had a profound impact on human lifestyles and is associated with increased disease risks. This study discovered significant changes in the community structure and functional capacity of the human gut microbiota with urbanization, indicating potential loss and suppression of novel symbionts. The findings highlight the importance of studying microbial diversity in rural populations.
Article
Environmental Sciences
Hannah C. Lepper, Meghan R. Perry, Bryan A. Wee, David Wills, Hanne Nielsen, Saria Otani, Moray Simon, Frank M. Aarestrup, Mark E. J. Woolhouse, Bram A. D. van Bunnik
Summary: This study compares the resistome and microbiome of hospital, community, and mixed municipal wastewater and finds that the resistome in hospital wastewater is different from that in other locations.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Immunology
Yajuan Fan, Yuan Gao, Qingyan Ma, Zai Yang, Binbin Zhao, Xiaoyan He, Jian Yang, Bin Yan, Fengjie Gao, Li Qian, Wei Wang, Feng Zhu, Xiancang Ma
Summary: Schizophrenia is associated with immune dysfunctions and disturbed intestinal microbiota. This study found that abnormal gut metabolism-immune network exists in schizophrenia, and gut microbiota may influence immune responses by regulating host metabolic processes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Hyungmin Choi, Jinsu Kim, Changsoo Lee
Summary: This study found that co-digestion of TMAH wastewater with EL wastewater significantly enhances methane production rate and yield, showing a synergistic effect, which could provide a cost-effective option for wastewater treatment in the semiconductor and TFT-LCD industries.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Article
Medicine, General & Internal
Carlos Rocha-de-Lossada, Cosimo Mazzotta, Federico Gabrielli, Filomena Tiziana Papa, Carmen Gomez-Huertas, Celia Garcia-Lopez, Facundo Urbinati, Rahul Rachwani-Anil, Maria Garcia-Lorente, Jose-Maria Sanchez-Gonzalez, Miguel Rechichi, Giovanni Rubegni, Davide Borroni
Summary: This study utilized the mNGS 16S rRNA sequencing method to investigate the ocular microbiota of keratoconus patients who had not undergone any surgical treatment. The findings suggest that alterations in the microbiota may play a role in the development of keratoconus.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Environmental Sciences
Jin Du, Qidong Yin, Mengqi Gu, Guangxue Wu
Summary: This study investigated the effects of intermediates acetate, propionate, and ethanol on methanogenesis. Ethanol was found to be the easiest intermediate to be biodegraded, enhancing methane production rate. Different microbial communities and syntrophic patterns were observed in four reactors, with different bacteria playing important roles in different reactors.
ENVIRONMENTAL RESEARCH
(2021)
Article
Microbiology
Wen Zhang, Na Han, Tingting Zhang, Yujun Qiang, Xianhui Peng, Xiuwen Li, Biao Kan
Summary: This study aimed to understand the gut microbial composition of a healthy Chinese population and its variability across different regions and time points. The results showed that Chinese individuals share some common gut bacteria, but also have differences. Compared to samples from the United States, the gut microbiota of the Chinese population in this study exhibited higher richness, diversity, and evenness. This study provides important insights into the gut microbiota of the healthy Chinese population.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Marius Bredon, Elisabeth Depuydt, Lucas Brisson, Laurent Moulin, Ciriac Charles, Sophie Haenn, Bouziane Moumen, Didier Bouchon
Summary: This study manipulated the digestive microbiota of detritivore Armadillidium vulgare and found that the microbiota in the hepatopancreas were stable while those in the hindgut were diverse and unstable over time. Dysbiosis and selective diets could affect host fitness by altering microbiota structure and predicted functions, influencing not only the holobiont but also the eco-holobiont conceptualization of macroorganisms.
Article
Engineering, Environmental
Xiaoyun Dai, Chengyuan Su, Ruxin Nong, Xinjie Huang, Yaqi Xie, Bocai Liang, Shu Gao, Menglin Chen
Summary: Coke was used as adsorbent in an adsorption-biological coupling reactor for treating sulfonamide antibiotics wastewater. The optimal influent frequency was found to be once every two days with aeration rate of 10.00 mL/min. The treatment efficiency resulted in high removal rates of COD, TP, NH3-N, sulfadiazine (SD) and sulfamethoxazole (SMX) as well as the presence of specific functional bacteria and intermediate metabolites. The use of adsorption-biological coupling technology in wastewater treatment has promising application prospects.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Biotechnology & Applied Microbiology
Min Yap, David Gleeson, Paul W. O'Toole, Orla O'Sullivan, Paul D. Cotter
Summary: This study investigated the factors influencing the raw milk microbiota, with results showing that season and location have a greater impact on the milk microbiota than the cleaning agents used. The microbiota compositions of raw milk from farms that used chlorine-based and chlorine-free cleaning methods were similar, supporting the further use of chlorine-free cleaning agents in dairy production.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Andrea Mesa-Restrepo, Ana Civantos, Jean Paul Allain, Edwin Patino, Juan Fernando Alzate, Norman Balcazar, Robinson Montes, Juan Jose Pavon, Jose Antonio Rodriguez-Ortiz, Yadir Torres
Summary: The combined effect of recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) and nanopatterned Ti6Al4V fabricated with Directed irradiation synthesis (DIS) improves the biological properties of titanium implants, particularly in enhancing alkaline phosphatase activity and calcium deposit formation.
Article
Plant Sciences
Sarita Munoz-Gomez, Harold Suarez-Baron, Juan F. Alzate, Favio Gonzalez, Natalia Pabon-Mora
Summary: Flavonoids, carotenoids, betalains, and chlorophylls are plant pigments responsible for floral color, with anthocyanins largely responsible for red, purple, pink, and blue colors. The R2R3-MYB genes act as upstream regulatory factors of the anthocyanin biosynthetic pathway, with species-specific duplications in core eudicots and local duplications in Aristolochiaceae. The expression of these genes in different developmental stages and plant organs largely overlaps with red and purple pigments, indicating their role in anthocyanin and flavonoid synthesis.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Sebastian Martinez-Salazar, Favio Gonzalez, Juan F. Alzate, Natalia Pabon-Mora
Summary: Floral spurs are key innovations in angiosperms, shifting floral symmetry from radial to bilateral. This study on Tropaeolum longifolium identified candidate genes involved in adaxial-abaxial differential growth during spur formation. Evolutionary analysis revealed specific duplications and losses of critical genes in Brassicales, shedding light on genetic mechanisms behind spur formation and floral symmetry.
AMERICAN JOURNAL OF BOTANY
(2021)
Article
Microbiology
Karen L. F. Alvarez-Eraso, Laura M. Munoz-Martinez, Juan F. Alzate, Luis F. Barrera, Andres Baena
Summary: Mycobacterium tuberculosis (Mtb) is a pathogen causing tuberculosis (TB) in humans. Some circulating strains of Mtb are more virulent and transmissible than others. sRNAs, including Mcr11, play a crucial role in the adaptive response of Mtb to host immune responses. Knocking down of mcr11 leads to downregulation of genes involved in lipid synthesis, metabolism, respiratory and energy systems, membrane and cell wall components, intermediary metabolism, and virulence genes. The sRNA Mcr11 may regulate genes that control Mtb growth and osmoregulation, with OprA (encoded by the gene rv0516c) being one of the interesting genes involved.
CURRENT MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Victor A. Lopez-Agudelo, Andres Baena, Vianey Barrera, Felipe Cabarcas, Juan F. Alzate, Dany J. V. Beste, Rigoberto Rios-Estepa, Luis F. Barrera
Summary: Tuberculosis, caused by Mycobacterium tuberculosis, can lead to both pulmonary and extrapulmonary TB. Early dissemination of the bacteria to various organs is crucial in the disease progression. Research has shown that different clinical strains of Mtb can elicit distinct host responses when infecting human splenic macrophages, with strain type also influencing the metabolic responses of both host and pathogen.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Alicia Mas, Abel Martinez-Rodrigo, Javier Carrion, Jose Antonio Orden, Juan F. Alzate, Gustavo Dominguez-Bernal, Pilar Horcajo
Summary: This study investigates the molecular mechanisms involved in the interaction of different isolates of L. infantum with canine macrophages and finds differences between outbreak isolates and a reference strain, which may explain the reduced infection ability of the outbreak isolates in canine cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Evolutionary Biology
Carolina Rodriguez-Pelayo, Barbara A. Ambrose, Alejandra Vasco, Juan F. Alzate, Natalia Pabon-Mora
Summary: LFY genes may play a role in the development of gametophytes and sporophytes in bryophytes and ferns, and have functions related to floral meristem differentiation in gymnosperms and flowering plants.
Article
Plant Sciences
Carolina Rodriguez-Pelayo, Barbara A. Ambrose, Alejandra Vasco, Juan F. Alzate, Natalia Pabon-Mora
Summary: This study provides a phylogenetic framework for PEBP genes and investigates their expression patterns in selected lycophytes and ferns. The results indicate that PEBP genes are involved in reproductive transitions and spore production in these plants, suggesting their important roles in meristem maintenance and sporangium development.
INTERNATIONAL JOURNAL OF PLANT SCIENCES
(2022)
Article
Multidisciplinary Sciences
Johanna Uran-Velasquez, Juan F. Alzate, Ana E. Farfan-Garcia, Oscar G. Gomez-Duarte, Larry L. Martinez-Rosado, Diego D. Dominguez-Hernandez, Winston Rojas, Ana Luz Galvan-Diaz, Gisela M. Garcia-Montoya
Summary: This study analyzed the genetic diversity of Cryptosporidium hominis and Cryptosporidium parvum using MLST approach. Multiple Cryptosporidium species were identified, and there was polymorphic behavior in all markers evaluated. Phylogenetic analysis showed taxonomic agreement and two monophyletic clades for C. hominis and C. parvum. The study supports the use of MLST analysis in studying the genetic diversity of Cryptosporidium.
Article
Multidisciplinary Sciences
Jairo A. Mesa-Arango, Ana M. Olave-Velandia, Gisela M. Garcia-Montoya, Juan P. Isaza-Agudelo, Antonio Jimenez-Ruiz, Juan F. Alzate
Summary: In this study, we developed a method to diagnose human toxocariasis by expressing and purifying recombinant polypeptides of T. canis antigenic proteins. The chimeric antigens showed better specificity and the ability to discriminate false positive cases with other parasitic infections.
Article
Multidisciplinary Sciences
Andres F. Baena, Felipe F. Cabarcas, Juan Ocampo, Luis Barrera, Juan Alzate
Summary: This study conducts an evolutionary and comparative genomic analysis of 522 L4 Latin American Mtb genomes, revealing novel South American clades and identifying novel gene deletions specific to certain sublineages. These findings provide important insights into the transmission and pathogenic mechanisms of tuberculosis.
Article
Plant Sciences
Yesenia Madrigal, Juan F. Alzate, Natalia Pabon-Mora
Summary: In this study, the phylogenetic analysis of several gene lineages in the Orchidaceae family was performed to investigate the flowering genetic regulatory network (FGRN) in orchids. The results revealed an increase in COL4 and FUL gene lineages in orchids compared to other monocots, while local duplications in COL, FD, and SOC1 gene lineages were less frequent. Interestingly, non-canonical factors sensing temperature changes during reproductive transition were identified in orchids. These findings provide important insights into gene function and the evolution of FGRN in neotropical orchids compared to temperate grasses.
PLANT REPRODUCTION
(2023)
Article
Biochemistry & Molecular Biology
Oscar Coltell, Eva M. Asensio, Jose V. Sorli, Carolina Ortega-Azorin, Rebeca Fernandez-Carrion, Eva C. Pascual, Rocio Barragan, Jose I. Gonzalez, Ramon Estruch, Juan F. Alzate, Alejandro Perez-Fidalgo, Olga Portoles, Jose M. Ordovas, Dolores Corella
Summary: This study examines the association between adherence to the Mediterranean diet and telomere length, and finds that higher adherence to the diet is associated with longer telomeres, particularly in women. Specific dietary items such as fruits and fish exhibit strong associations with telomere length. Additionally, the study identifies genetic variants and gene-diet interactions that modulate telomere length.
Article
Developmental Biology
Jessica A. Ramirez-Ramirez, Yesenia Madrigal, Juan F. Alzate, Natalia Pabon-Mora
Summary: The study highlights the diverse roles of AGL24 and SVP in the flowering transition in angiosperms, with variations in different lineages. Independent duplication events in monocots have resulted in at least three clades of AGL24/SVP homologs, some specific to Orchidaceae. The analysis suggests higher evolutionary rates and potential pleiotropic roles of these genes in maintaining the vegetative phase and promoting flowering in different plant groups.
CELLS & DEVELOPMENT
(2021)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
