Realizing private and practical pharmacological collaboration

Secure genome-wide association analysis using multiparty computation

(2018) Hyunghoon Cho et al.   NATURE BIOTECHNOLOGY

A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information

(2017) Yunan Luo et al.   Nature Communications

A New Nanobody-Based Biosensor to Study Endogenous PARP1 In Vitro and in Live Human Cells

(2016) Andrea Buchfellner et al.   PLoS One

Enabling Privacy-Preserving GWASs in Heterogeneous Human Populations

(2016) Sean Simmons et al.   Cell Systems

Deep learning

(2015) Yann LeCun et al.   NATURE

STITCH 5: augmenting protein–chemical interaction networks with tissue and affinity data

(2015) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Ensembl 2016

(2015) Andrew Yates et al.   NUCLEIC ACIDS RESEARCH

The Pfam protein families database: towards a more sustainable future

(2015) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

Drug repositioning by integrating target information through a heterogeneous network model

(2014) Wenhui Wang et al.   BIOINFORMATICS

Novel PARP-1 inhibitors based on a 2-propanoyl-3H-quinazolin-4-one scaffold

(2013) Giuseppe Giannini et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Predicting Drug–Target Interactions Using Probabilistic Matrix Factorization

(2013) Murat Can Cobanoglu et al.   Journal of Chemical Information and Modeling

Drug–target interaction prediction by learning from local information and neighbors

(2012) Jian-Ping Mei et al.   BIOINFORMATICS

Drug discovery in pharmaceutical industry: productivity challenges and trends

(2012) Ish Khanna   DRUG DISCOVERY TODAY

An Mdm2 antagonist, Nutlin-3a, induces p53-dependent and proteasome-mediated poly(ADP-ribose) polymerase1 degradation in mouse fibroblasts

(2011) Shingo Matsushima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT

(2011) Frank Sielaff et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 inhibitors

(2011) Hongbo Zeng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The NumPy Array: A Structure for Efficient Numerical Computation

(2011) Stéfan van der Walt et al.   COMPUTING IN SCIENCE & ENGINEERING

Traditional drug-discovery model ripe for reform

(2011) Daniel Cressey   NATURE

Semi-supervised drug-protein interaction prediction from heterogeneous biological spaces

(2010) Zheng Xia et al.   BMC Systems Biology

Extended-Connectivity Fingerprints

(2010) David Rogers et al.   Journal of Chemical Information and Modeling

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY

DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs

(2010) C. Knox et al.   NUCLEIC ACIDS RESEARCH

Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-α: Hit to lead studies

(2009) Adam M. Gilbert et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS