Journal
RUSSIAN CHEMICAL BULLETIN
Volume 67, Issue 11, Pages 2025-2034Publisher
SPRINGER
DOI: 10.1007/s11172-018-2324-z
Keywords
sulfimides; 2; 6-di-tert-butylphenol; antioxidant activity; lipid peroxidation; antiglycation activity; X-ray diffraction
Categories
Funding
- Russian Science Foundation [14-13-00483, 14-25-00139]
- Russian Foundation for Basic Research [17-03-01070, 18-03-00203]
- Council on Grants at the President of the Russian Federation [SP-595.2018.4]
- Russian Science Foundation [14-13-00483] Funding Source: Russian Science Foundation
Ask authors/readers for more resources
New diphenylsulfimide derivatives containing substituents with the 2,6-di-tert-butylphenol moiety at the nitrogen atom were synthesized. Their molecular structures were established by X-ray diffraction. Antioxidant activity was experimentally evaluated by spectrophotometry based on hydrogen transfer to the stable radicals, namely, 2,2-diphenyl-1-picrylhydrazyl and the 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS(+)), and using in vitro lipid peroxidation in rat brain and liver homogenates. The presence of phenol and diphenylsulfimide moieties in one molecule leads to a significant enhancement of antioxidant activity. The new compounds exhibit moderate inhibitory activity against enzymes involved in carbohydrate and lipid metabolism. The evaluation of antiglycation activity showed that the new sulfimides taken at a concentration of 100 mol L-1 have activity comparable with that of aminoguanidine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available