Article
Medicine, General & Internal
Solmaz Abdolrahimzadeh, Mariachiara Di Pippo, Edoardo Sordi, Sandrine Anne Zweifel
Summary: The study found a significant reduction in inner retinal layer thickness in the central macula and in the superior parafovea in patients with SDD or CD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Yuhua Zhang, SriniVas R. Sadda, David Sarraf, Thomas A. Swain, Mark E. Clark, Kenneth R. Sloan, William E. Warriner, Cynthia Owsley, Christine A. Curcio
Summary: The study suggests that SDD-associated decrements in rod-mediated vision can be detected close to the foveola, and these deficits are proportionately worse than functional loss in the rod-rich perifovea. Larger prospective studies are required to confirm these observations.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Dongwan Kang, Young Joo Lee, Ki Tae Nam, Mihyun Choi, Cheolmin Yun
Summary: The distribution of hyperreflective foci (HRF) in eyes with dry age-related macular degeneration (AMD) was investigated. Optical coherence tomography (OCT) images of 58 dry AMD eyes were retrospectively reviewed, and the distribution of HRF was analyzed according to the presence of subretinal drusenoid deposits (SDDs) in the early treatment diabetic retinopathy study area. The results showed that HRF distributions varied according to the presence of SDDs, indicating potential differences in degenerative features between dry AMD eyes with and without SDDs.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Solmaz Abolrahimzadeh, Sandrine Anne Zweifel, Mariachiara Di Pippo, Anahita Bajka, Gianluca Scuderi, Andrew John Lotery
Summary: This study aimed to evaluate the impact of subretinal drusenoid deposits (SDD) on the central macular choriocapillaris (CC) and retinal microvasculature in patients with early age-related macular degeneration (AMD) phenotypes. The results showed a significant reduction in the flow area of the CC in the SDD group. Although not statistically significant, there was a trend of reduction in vessel density of the superficial and deep capillary plexus in the SDD and conventional drusen (CD) groups.
Article
Ophthalmology
Ling Chen, Jeffrey D. Messinger, Deepayan Kar, Jacque L. Duncan, Christine A. Curcio
Summary: The study revealed that the volume of BLinD may be associated with the progression risk of AMD, with BLinD potentially acting as a precursor to type 1 macular neovascularization. Pre-BLinD is more prevalent in control eyes, while BLinD/soft drusen is more common in AMD eyes.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Review
Ophthalmology
Zhichao Wu, Erica L. Fletcher, Himeesh Kumar, Ursula Greferath, Robyn H. Guymer
Summary: Reticular pseudodrusen are distinct lesions in the subretinal space that have been increasingly recognized in association with age-related macular degeneration. Understanding their pathogenesis is crucial for understanding the processes driving vision loss in AMD.
PROGRESS IN RETINAL AND EYE RESEARCH
(2022)
Article
Ophthalmology
R. O. B. E. R. T. J. THOMSON, J. O. S. H. U. A. CHAZARO, O. S. C. A. R. OTERO-MARQUEZ, G. E. R. A. R. D. O. LEDESMA-GIL, Y. U. E. H. O. N. G. TONG, A. R. I. E. L. L. E. C. COUGHLIN, Z. A. C. H. A. R. Y. R. TEIBEL, S. H. A. R. M. I. N. A. ALAUDDIN, K. A. T. Y. TAI, H. A. R. R. I. E. T. LLOYD, M. A. R. I. A. SCOLARO, A. R. U. N. GOVINDAIAH, A. L. A. U. D. D. I. N. BHUIYAN, M. A. N. D. I. P. S. DHAMOON, A. V. N. I. S. H. DEOBHAKTA, J. A. G. A. T. NARULA, R. I. C. H. A. R. D. B. ROSEN, L. A. W. R. E. N. C. E. A. YANNUZZI, K. B. A. I. L. E. Y. FREUND, R. T. H. E. O. D. O. R. E. SMITH
Summary: Soft drusen and subretinal drusenoid deposits (SDDs) represent two different pathways to advanced age-related macular degeneration (AMD), with distinct genetic, serum, and systemic disease associations. SDDs are associated with lower high-density lipoprotein, cardiovascular disease and stroke, and ARMS2 risk allele; while non-SDDs are associated with higher high-density lipoprotein, CFH risk allele, and two lipid risk genes.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Daniel Rudolf Muth, Mario Damiano Toro, Anahita Bajka, Kamil Jonak, Roman Rieder, Myrtha Magdalena Kohler, Jeanne Martine Gunzinger, Eric H. Souied, Michael Engelbert, K. Bailey Freund, Sandrine Anne Zweifel
Summary: This study investigated the associations and predictive factors between different types of macular neovascularization (MNV) lesion variants and drusen types in patients with treatment-naive neovascular age-related macular degeneration (AMD). The findings suggest that subretinal drusenoid deposits (SDDs) are a common characteristic in AMD eyes with treatment-naive MNV, and the predominant drusen type may help predict the type of MNV that will develop.
Article
Ophthalmology
Matthias M. Mauschitz, Benedikt J. Hochbein, Hannah Klinkhammer, Marlene Sassmannshausen, Jan H. Terheyden, Peter Krawitz, Robert P. Finger
Summary: This study investigated the prevalence and determinants of subretinal drusenoid deposits (SDD) in first-degree relatives of patients. The results suggest an association between SDD and age, and a potential hereditary aspect.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Manjot Kaur Grewal, Shruti Chandra, Sarega Gurudas, Rajna Rasheed, Piyali Sen, Deepthy Menon, Alan Bird, Glen Jeffery, Sobha Sivaprasad
Summary: In this study, functional and structural correlations in AMD patients, particularly focusing on subretinal drusenoid deposits (SDD), were evaluated. Patients with SDD showed impaired visual acuity and scotopic function, along with delayed rod-intercept time (RIT) compared to controls and AMD patients without SDD. Functional parameters were closely associated with retinal structure, suggesting the importance of evaluating potential prophylactic agents and different therapeutic interventions in AMD patients with SDD.
Article
Ophthalmology
Dongwan Kang, Eun Gyu Yoon, Ki Tae Nam, Cheolmin Yun
Summary: This study investigated the chorioretinal thickness and RPE degenerative features in eyes with early AMD and SDDs, and their association with MNV in fellow eyes. The neovascular AMD group had greater retinal, GCIPL, and choroidal thickness values compared to the non-neovascular AMD group. RPE degeneration was more prevalent in the neovascular AMD group. Greater GCIPL and choroidal thickness values and the presence of RPE degeneration were associated with type 3 MNV in fellow eyes.
Review
Ophthalmology
Yoichi Sakurada, Koji Tanaka, Serena Fragiotta
Summary: Drusen, as precursor lesions to advanced age-related macular degeneration (AMD), have different lifecycles and risks depending on their types and sizes. Various imaging modalities can show specific characteristics of drusen types, aiding in assessing the risk of advanced AMD.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shruti Chandra, Manjot K. Grewal, Sarega Gurudas, Rajan Sondh, Alan Bird, Glen Jeffery, Victor Chong, Sobha Sivaprasad
Summary: The qAF8 levels in patients with non-neovascular AMD were found to be significantly lower compared to age-matched controls, indicating a early and sustained loss of function of the retinal pigment epithelium in AMD.
Article
Ophthalmology
Sebastian Weber, Rowena Simon, Linda-Sophia Schwanengel, Christine A. Curcio, Regine Augsten, Daniel Meller, Martin Hammer
Summary: Fundus autofluorescence lifetimes and peak emission wavelengths of subretinal drusenoid deposits in age-related macular degeneration were measured using fluorescence lifetime imaging ophthalmoscopy. The study found that the lifetimes of these deposits were longer and the peak emission wavelengths were shorter than their surrounding environment. It also suggested that a high lifetime contrast in short-wavelength channels could predict disease progression to late-stage AMD.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Seung Wan Nam, Hoon Noh, Je Moon Yoon, Mingui Kong, Don-Il Ham
Summary: Eyes with pachydrusen in the Korean population exhibit characteristic AMD lesions at low frequencies, suggesting that pachydrusen may have diagnostic and prognostic values distinct from other drusen or drusenoid deposits.
Editorial Material
Ophthalmology
Andreas Berlin, Ling Chen, Jeffrey Messinger, Daniela Ferrara, K. Bailey Freund, Christine A. Curcio
ACTA OPHTHALMOLOGICA
(2022)
Article
Ophthalmology
Timothy M. Boyce, S. Scott Whitmore, Katayoun Varzavand, Stephen R. Russell, Elliott H. Sohn, James C. Folk, Edwin M. Stone, Ian C. Han
Summary: Patients with ADNIV have a high lifetime risk of severe vision loss, with tractional retinal detachment being an important risk factor for poor vision.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Claudio Iovino, Adrian Au, Prithvi Ramtohul, Tommaso Bacci, Abdullah AlBahlal, Abdullah M. Khan, Abdulelah A. Al-Abdullah, Robert Wendel, Jay Chhablani, SriniVas Sadda, K. Bailey Freund, David Sarraf
Summary: This study analyzed the imaging characteristics and clinical course of patients with coincident lesions of PAMM and AMN in the same eye, and found that this phenomenon may be associated with retinal vein impairment and hypoperfusion in the deep retinal capillary plexus.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Xiaofei Wang, Stanley Chang, Jack Grinband, Lawrence A. Yannuzzi, K. Bailey Freund, Quan Hoang, Michael J. A. Girard
Summary: The axial length is longer in highly myopic eyes and the adjusted tortuosity of the optic nerve is lower, suggesting higher traction forces during eye movements. Optic nerve displacements differ significantly between adduction and abduction, with smaller displacements in highly myopic eyes. Additionally, posterior segment displacements are smaller in highly myopic eyes in both gaze directions, with larger displacements in the anterior-most segment during adduction.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Max Brinkmann, Tommaso Bacci, Deepayan Kar, Jeffrey D. Messinger, Kenneth R. Sloan, Ling Chen, Timothy Hamann, Maximilian Wiest, K. Bailey Freund, Sandrine Zweifel, Christine A. Curcio
Summary: This study evaluated the role of acquired vitelliform lesion (AVL) in age-related macular degeneration pathophysiology and analyzed the histological and clinical features of AVL. The results showed that AVL deposits have low levels of retinal pigment epithelium (RPE) organelles and outer segments. The growth rates of collapsing and non-collapsing AVLs were different, suggesting dysregulation of lipid transfer pathways specific to cone photoreceptors and supporting cells in the formation of AVL deposits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Ling Chen, Dongfeng Cao, Jeffrey D. Messinger, Thomas Ach, Daniela Ferrara, K. Bailey Freund, Christine A. Curcio
Summary: Melanotic cells with large spherical melanosomes, possibly originating from retinal pigment epithelium, were found in eyes with neovascular age-related macular degeneration. These cells exhibit molecular differences from RPE, suggesting a process of transdifferentiation. Studying detailed histology of eyes affected by nvAMD may lead to the development of new therapies for fibrosis.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Oncology
Kelly Mulfaul, Nathaniel K. Mullin, Joseph C. Giacalone, Andrew P. Voigt, Melette DeVore, Edwin M. Stone, Budd A. Tucker, Robert F. Mullins
Summary: Activation of the alternative complement pathway is a crucial event in the development of age-related macular degeneration (AMD). Uncontrolled complement activation leads to the formation of the membrane attack complex (MAC). This study demonstrates that reduced levels of complement factor H (FH) in the choroid can contribute to MAC deposition on choroidal endothelial cells (CECs), while overexpression of FH can protect against MAC deposition. These findings highlight the importance of local FH production in preventing MAC deposition in AMD.
JOURNAL OF PATHOLOGY
(2022)
Review
Ophthalmology
Meira Fogel-Levin, SriniVas R. Sadda, Philip J. Rosenfeld, Nadia Waheed, Giuseppe Querques, Bailey K. Freund, David Sarraf
Summary: Imaging is crucial in the evaluation and management of retinal disorders, and different imaging modalities have unique capabilities to show different aspects of the disease. Multimodal retinal imaging provides abundant and insightful information, but integrating the complex data can be overwhelming. This article discusses the applications, strengths, and limitations of various retinal imaging tools, including color fundus photography, widefield imaging, fundus autofluorescence, near infrared reflectance, optical coherence tomography angiography, and en face optical coherence tomography, as well as the advantages and disadvantages of a multimodal approach.
SURVEY OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Marc J. Sirks, Elon H. C. van Dijk, Noa Rosenberg, Carla E. M. Hollak, Stamatios Aslanis, Chui Ming Gemmy Cheung, Itay Chowers, Chiara M. Eandi, K. Bailey Freund, Frank G. Holz, Peter K. Kaiser, Andrew J. Lotery, Kyoko Ohno-Matsui, Giuseppe Querques, Yousif Subhi, Ramin Tadayoni, Charles C. Wykoff, Dinah Zur, Roselie M. H. Diederen, Camiel J. F. Boon, Reinier O. Schlingemann
Summary: Since July 2021, there has been a worldwide shortage of verteporfin (Visudyne (R)), which has had a significant impact on the care of ophthalmic patients worldwide and may result in serious and irreversible vision loss.
ACTA OPHTHALMOLOGICA
(2022)
Article
Ophthalmology
K. Bailey Freund, Giovanni Staurenghi, Jesse J. Jung, Sandrine A. Zweifel, Mariano Cozzi, Lauren Hill, Steven Blotner, Min Tsuboi, Shamika Gune
Summary: The study aimed to investigate the relationship between the Consensus on Neovascular Age-Related Macular Degeneration (CONAN) Study Group classifications of macular neovascularization (MNV) and visual responses to ranibizumab therapy in patients with neovascular age-related macular degeneration (nAMD). Results showed that the different lesion types had varying effects on best-corrected visual acuity (BCVA) outcomes, supporting the use of an anatomic classification system to evaluate and predict visual responses to anti-vascular endothelial growth factor therapy for nAMD.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Editorial Material
Ophthalmology
Prithvi Ramtohul, Diogo Cabral, K. Bailey Freund
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Letter
Ophthalmology
Prithvi Ramtohul, Maria Vittoria Cicinelli, K. Bailey Freund
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Ophthalmology
Riccardo Sacconi, David Sarraf, SriniVas R. Sadda, K. Bailey Freund, Andrea Servillo, Meira Miri Fogel Levin, Eliana Costanzo, Giulia Corradetti, Diogo Cabral, Dinah Zur, Omer Trivizki, Mariacristina Parravano, Francesco Bandello, Anat Loewenstein, Giuseppe Querques
Summary: This study investigated the association between nascent geographic atrophy (GA) and the development of exudative type 3 macular neovascularization (MNV) in patients with age-related macular degeneration (AMD). The results showed that 22.7% of the patients had nascent GA preceding exudative type 3 MNV. Therefore, the detection of nascent GA in AMD patients may require closer surveillance to identify early exudative type 3 MNV warranting treatment.
OPHTHALMOLOGY RETINA
(2023)
Article
Ophthalmology
Prithvi Ramtohul, Diogo Cabral, Daniel Oh, Daniel Galhoz, K. Bailey Freund
Summary: The purpose of this study was to investigate whether noninvasive en face ultrawidefield (UWF) OCT can demonstrate distinctive features of choroidal vasculature in eyes with central serous chorioretinopathy (CSC). Patients diagnosed with CSC underwent UWF indocyanine green angiography (ICGA) and widefield OCT imaging. The results showed that en face UWF OCT imaging can show distinctive features of choroidal venous insufficiency previously identified with UWF ICGA in eyes with CSC.
OPHTHALMOLOGY RETINA
(2023)
Letter
Ophthalmology
Yu Qiang Soh, Quan V. Hoang, K. Bailey Freund, Jesse J. Jung
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)