Article
Endocrinology & Metabolism
Xiaopan Chen, Linjie Chen, Yang Wang, Chongyi Shu, Yier Zhou, Ruifang Wu, Bihui Jin, Leixiang Yang, Junhui Sun, Ming Qi, Jing Shu
Summary: In this study, two novel FSHR variants were identified as potential genetic causes for POI with ROS. The p.Ala462Pro variant resulted in complete loss of FSHR function, while the p.Ala621Val variant led to partial loss of receptor activation. This study expands the current phenotypic and genotypic spectrum of POI.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cell Biology
Seung Joo Chon, Zobia Umair, Mee-Sup Yoon
Summary: Premature ovarian insufficiency (POI) is a condition characterized by the loss of normal ovarian function before the age of 40, affecting a small percentage of women under 40. The condition is biochemically defined by amenorrhea, low estrogen levels, and high gonadotropin levels, potentially leading to infertility. POI has a heterogeneous etiology, including both genetic and non-genetic factors, and current research focuses on genetic basis, non-coding RNA, and animal models to uncover pathogenesis and potential treatment targets. Despite recent advances, understanding gene regulatory networks and exploring therapies remain critical for future research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Minyi Yang, Yu Jiang, Xinyu Shao
Summary: This case report describes a 32-year-old Chinese woman with Trichohepatoenteric syndrome (THES) who presented with intractable diarrhea, low weight at birth, allergic reactions to milk, amenorrhea, and osteoporosis. Genetic testing revealed a novel mutation in the SKIV2L gene, expanding the understanding of this disease.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Shan Li, Weiwei Xu, Bingying Xu, Shuchang Gao, Qian Zhang, Yingying Qin, Ting Guo
Summary: This study identified novel homozygous variations in the HSF2BP gene through WES and found that these variations impaired the function of HSF2BP, playing an essential role in the pathogenesis of sporadic POI.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Zhongkang Li, Mingle Zhang, Yanpeng Tian, Qian Li, Xianghua Huang
Summary: Premature ovarian insufficiency (POI) is a complex endocrine disease that severely affects females' physiological and reproductive functions. Conventional treatment methods for POI have side effects and do not effectively restore ovarian functions. Mesenchymal stem cell transplantation is a promising approach for POI treatment, with potential to modulate various functions of ovarian cells and improve POI outcomes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Oren Kashi, Dror Meirow
Summary: This manuscript reviews the impact of chemotherapy on ovarian reserve and the preventive measures. Chemotherapy can deplete dormant follicles and potentially lead to ovarian insufficiency. Ideal drugs for fertility preservation can be found by intervening in ovarian toxic mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Xiaodi Pu, Leisheng Zhang, Peiyu Zhang, Yaqiong Xu, Jun Wang, Xiaomei Zhao, Zhihua Dai, Hua Zhou, Shuyun Zhao, Anran Fan
Summary: Premature ovarian insufficiency (POI) induced by chemotherapy is a difficult-to-treat disorder that affects female fertility. The use of human umbilical cord mesenchymal stem cells (hUCMSCs) and exosomes derived from them shows potential in improving ovarian function and protecting fertility in POI patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
M. Moyses-Oliveira, A. M. C. Scaff, L. N. G. Adami, H. Hachul, M. L. Andersen, S. Tufik
Summary: Premature ovarian insufficiency (POI) is a condition where women below the age of 40 experience a loss of regular hormone production and egg release, leading to infertility, vaginal dryness, and dysfunctional sleep. A study found overlapping genes between POI and insomnia, particularly in pathways related to DNA replication, homologous recombination, and Fanconi anemia. The overlap may be due to oxidative stress and dysregulated DNA repair mechanisms, which could be potential targets for treatment. This study provides a new understanding of the relationship between insomnia and POI.
Article
Oncology
Lianli He, Xiaojuan Wang, Daigang Cheng, Zhengai Xiong, Xiaoyun Liu
Summary: The study demonstrated that ginsenoside Rg1 had significant effects on D-gal-induced POI mouse models by increasing uterine and ovarian weight, improving uterine morphology, reducing the expression of senescence factors, and enhancing anti-oxidant and anti-inflammatory abilities.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Qingling Yang, Sezcan Mumusoglu, Yingying Qin, Yingpu Sun, Aaron J. Hsueh
Summary: Ovarian infertility and subfertility are major challenges in developed countries due to the trend of delayed childbirth. Through genetic studies, genes related to premature ovarian insufficiency and ovarian senescence have been identified, especially those crucial for DNA repair, meiosis, and mitochondrial functions.
Article
Endocrinology & Metabolism
Xudong Zhang, Yimeng Lu, Shanshan Wu, Xinyang Zhao, Shuyu Li, Siwen Zhang, Jichun Tan
Summary: This study conducted a bibliometric analysis of primary ovarian insufficiency (POI) related literature, and found that significant progress has been made in POI research over the past 20 years, but unevenly developed globally. The United States may lead in POI research influence. Research hotspots mainly focus on pathogenesis and treatment, including genetic mutation, hormone therapy, fertility preservation, and stem cell transplantation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Qian Zhang, Chengqiu Tao, Shuchang Gao, Shan Li, Bingying Xu, Hanni Ke, Yiyang Wang, Feng Zhang, Yingying Qin, Ling Zhang, Ting Guo
Summary: A splicing site variant in KASH5 is responsible for POI due to defective meiotic homolog pairing and accelerated depletion of oocytes. Our study is the first to report the involvement of disorganized LINC complex in the pathogenesis of POI, potentially suggesting the essential roles of meiotic telomere attachment and dynein-driven proteins for chromosome movement in ovarian function maintenance.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Obstetrics & Gynecology
Ling Zhang, Jing Zhang, Jun Zhai, Xiaochun Liu, Weifen Deng, Hong Wang, Zhiguo Zhang, Wei Liu, Beili Chen, Chongbo Wu, Huidong Long, Boqun Xu, Xiaoyan Ying, Huijuan Zou, Jun He, Pei Li, Tiling Hu, Wenpei Xiang, Jing Li
Summary: The new IVA protocol shows increased follicular activation and development in both mouse and human ovarian tissues, leading to improved fertility outcomes in POI patients without significant side effects. Further clinical trials with larger patient cohorts are needed to validate the efficacy of this approach.
HUMAN REPRODUCTION
(2021)
Review
Cell Biology
Narjes Nouri, Olduz Shareghi-Oskoue, Leili Aghebati-Maleki, Shahla Danaii, Javad Ahmadian Heris, Mohammad Sadegh Soltani-Zangbar, Amin Kamrani, Mehdi Yousefi
Summary: Premature ovarian failure is a complex problem with diverse causes and clinical manifestations. Lack of ovarian sex hormones is believed to be a major factor in its occurrence. Despite limited scientific research progress, clinical medicine has made significant strides in optimizing the quality of life and long-term health of women with premature ovarian insufficiency through timely intervention. Recent investigations have focused on the regulating effects of small RNA molecules on various ovarian processes. This literature review discusses the mechanisms of miRNAs in regulating gene expression in the ovary after transcription.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kim van der Ham, Charissa Van Zwol-Janssens, Birgitta K. Velthuis, Maria P. H. Koster, Yvonne Louwers, Dustin Goei, Maurits S. H. Blomjous, Arie Franx, Bart C. J. M. Fauser, Eric Boersma, Joop S. E. Laven, Ricardo P. J. Budde
Summary: This study aimed to assess the prevalence of incidental findings (IFs) on coronary computed tomography (CCT) in middle-aged women with reproductive disorders such as polycystic ovary syndrome, premature ovarian insufficiency, or preeclampsia. The study found that 19.8% of women had one or more IFs, some of which required follow-up. The use of a small field of view (FOV) for scanning reduced the prevalence of IFs and the need for follow-up.
INSIGHTS INTO IMAGING
(2022)
Article
Obstetrics & Gynecology
Alice Newman-Sanders, Jackson C. Kirkman-Brown, Meurig T. Gallagher
Summary: This study revealed a significant lack of awareness among young adults in the UK regarding the potential impacts of gym lifestyles and supplementation on male infertility. Men were found to have a concerning lack of concern for their own fertility, with differences in awareness levels between men and women. It was also observed that men were more likely to consider making changes to their behavior if it had a long-term impact on their fertility compared to short-term effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Shachar Reuvenny, Michal Youngster, Almog Luz, Rohi Hourvitz, Ettie Maman, Micha Baum, Ariel Hourvitz
Summary: Using a machine-learning model to determine the optimal trigger days can improve the outcomes of antagonist protocol cycles in freeze-all or fresh transfer cycles, for all age groups. Implementing these models can more accurately predict the number of retrieved oocytes, optimizing physicians' decisions, balancing workloads, and creating more standardized yet patient-specific protocols.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang
Summary: This study investigates the proteomic and phosphoproteomic differences in the endometrium of women with recurrent pregnancy loss (RPL) compared to healthy control women during different phases of the menstrual cycle. The results identify differentially expressed proteins and phosphorylated proteins, and highlight the insulin/cyclic nucleotide signalling pathway and AMPK/mTOR signalling pathway as major contributors to the abnormality of RPL endometrium. The findings provide insights into potential proteins associated with the pathogenesis of RPL and contribute to the identification of potential targets for RPL treatment.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Jaime Guerrero, Juan Carlos Castillo, Jorge Ten, Jose Antonio Ortiz, Belen Lledo, Domingo Orozco, Francisco Quereda, Andrea Bernabeu, Rafael Bernabeu
Summary: The study found no significant differences in clinical outcomes between using oocytes obtained from random-start protocols and those from conventional ovarian stimulation in oocyte donation treatments. Luteal-phase stimulation required longer stimulation and higher FSH consumption.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)