Article
Multidisciplinary Sciences
Maarten Vanloon, Vincent Raymaekers, Sacha Meeuws, Mark Plazier
Summary: Dorsal root ganglion stimulation (DRG-S) is a promising therapy for chronic neuropathic pain, but its complications are not well understood. This case report presents the first-of-a-kind occurrence of Twiddler's syndrome, a rare complication characterized by lead displacement and coiling of wires, after 8 months of DRG-S. It highlights the importance of considering Twiddler's syndrome as a potential complication in patients undergoing DRG-S, especially those with significant weight loss history.
Article
Orthopedics
D. Chao, H. Tran, Q. H. Hogan, B. Pan
Summary: GFS produces analgesia in MIA-OA rats at least in part by producing blockade of afferent inputs, possibly also by blocking efferent activity from the dorsal horn.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Otorhinolaryngology
Nikhil Bellamkonda, Travis Shiba, Abie H. Mendelsohn
Summary: The use of hypoglossal nerve stimulator has greatly improved surgical treatment for multilevel airway collapse in OSA patients. However, technical difficulties and complications still exist during the perioperative period, emphasizing the need for clear communication with patients during the surgical consent process.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Clinical Neurology
Yingda Li, Michael Y. Wang
Summary: This study demonstrated the feasibility of direct intraoperative neuromonitoring within Kambin's triangle in transforaminal endoscopic surgery for the first time. The incidence of new onset symptoms increased with lower stimulation thresholds, and 8 milliampere seems to be a reasonable compromise between sensitivity and specificity for this monitoring technique.
Article
Anesthesiology
Cormac F. Mullins, Gaetano Joseph Palumbo, Stephany Harris, Omar Al-Kaisy, Sam Wesley, Thomas Yearwood, Adnan Al-Kaisy
Summary: This retrospective case series analyzed the outcomes of combined DRGS and SCS treatment in patients with neuropathic pain. The results showed that the combined treatment was effective in reducing pain intensity and had sustained analgesic effects.
Article
Medicine, Research & Experimental
Kenneth B. Chapman, Tariq A. Yousef, Kris C. Vissers, Noud van Helmond, Michael D. Stanton-Hicks
Summary: This study found that very low-frequency dorsal root ganglion neurostimulation (DRG-S) is effective in treating chronic pain, maintaining over 75% pain relief while reducing charge-per-second by nearly two-thirds. It also suggests that the mechanism of action may involve preferential recruitment of low-threshold mechanoreceptor fibers via the endogenous opioid system.
Article
Clinical Neurology
Tariq Parker, Ashley Raghu, Yongzhi Huang, Martin J. Gillies, James J. FitzGerald, Tipu Aziz, Alexander L. Green
Summary: The study findings suggest that the combination of single-session tDCS with DRGS is safe and significantly reduces pain acutely in neuropathic pain patients.
Review
Medicine, Research & Experimental
Jonathan M. Hagedorn, Ian McArdle, Ryan S. D'Souza, Abhishek Yadav, Alyson M. Engle, Timothy R. Deer
Summary: This single-center retrospective study found that patients prescribed chronic opioids at the time of DRG stimulator implantation had a higher likelihood of less than 50% pain relief and 80% pain relief at one month, three months, and 12 months follow-up visits. This suggests that chronic opioid use may be associated with poor long-term outcomes of DRG stimulation.
Article
Cell Biology
Bin Pan, Di Guo, Li Jing, Ke Li, Xin Li, Gen Li, Xiao Gao, Zhi-Wen Li, Wei Zhao, Hu Feng, Meng-Han Cao
Summary: This study reveals the role of lncRNA Pvt1 in the repair of peripheral nerve injury and highlights it as a potential treatment target. The findings show that Pvt1 increases c-Jun expression through sponging miRNA-214, enhancing the proliferation and migration of Schwann cells, and improving the regeneration of injured sciatic nerves and locomotor function in mice.
NEURAL REGENERATION RESEARCH
(2023)
Article
Engineering, Biomedical
Ashley N. Dalrymple, Jordyn E. Ting, Rohit Bose, James K. Trevathan, Stephan Nieuwoudt, Scott F. Lempka, Manfred Franke, Kip A. Ludwig, Andrew J. Shoffstall, Lee E. Fisher, Douglas J. Weber
Summary: The study found that the Injectrode can effectively activate primary afferents within the clinical DRG stimulation parameters, with activation thresholds increasing with wider pulse widths. Activation rates decrease with wider pulse widths, and the Injectrode maintains consistent ECAP thresholds over several hours of stimulation.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Clinical Neurology
G. S. Piedade, S. Gillner, P. S. McPhillips, J. Vesper, P. J. Slotty
Summary: This study aimed to investigate the influence of stimulation frequency on pain reduction and quality of life in dorsal root ganglion stimulation (DRG-S). The results showed that lower stimulation frequencies were most effective in reducing neuropathic pain, significantly decreasing pain intensity and improving quality of life. Therefore, specific frequencies should be preferred based on the condition treated.
ACTA NEUROCHIRURGICA
(2022)
Article
Anesthesiology
Andre Marques Mansano, Thiago Nouer Frederico, Sergio Luiz de Mirando, Adonai Peixoto Cheim Junior
Summary: This study describes a treatment method for refractory trigeminal neuralgia by implanting a dorsal root ganglion (DRG) stimulation electrode. The patient experienced effective pain relief without electrode displacement during the follow-up period.
Review
Urology & Nephrology
Nikhil Gopal, Bronwyn Long, John Phillips, Majid Eshghi
Summary: The study characterized the rates of endovascular stapler complications during minimally invasive radical nephrectomy over the last 10 years. Among the three types of staplers, TA staplers had a lower incidence of complications and were not associated with deaths or reoperations. Manufacturer evaluation suggested that human errors were a common cause of stapling malfunctions, emphasizing the importance of proper training for operating room staff to prevent potential complications.
Article
Neurosciences
Yuying Huang, Shao-Rui Chen, Hong Chen, Jing-Jing Zhou, Daozhong Jin, Hui-Lin Pan
Summary: Research shows that theta-burst stimulation (TBS) has an impact on synaptic plasticity and pain in mice, inducing more long-term potentiation (LTP) in spinal cord neurons. Nerve injury increases the prevalence of TBS-induced LTP, and interventions targeting NMDARs or a243-1 can reduce TBS-induced pain hypersensitivity.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Anesthesiology
Dongman Chao, Christina M. Mecca, Guoliang Yu, Ian Segel, Michael S. Gold, Quinn H. Hogan, Bin Pan
Summary: Dorsal root ganglion field stimulation can relieve neuropathic pain by blocking spontaneous activity in injured neurons, leading to reduced pain behavior and ongoing pain. The effects are more significant in injured neurons, affecting both pain behavior and ongoing pain.
Article
Anesthesiology
Vasudha Goel, Varun Kumar, Amol M. Patwardhan, Mohab Ibrahim, Eellan Sivanesan, David Darrow, Hariharan Shankar
Summary: The study finds that the 30-day readmission rate after SCS implantation is approximately 7.7% in the United States. Infection and postoperative complications are still the top etiologies for readmissions. Compared to percutaneous SCS implantation procedures, open surgical SCS implantation is associated with more extended initial hospitalization and a higher rate of readmission.
ANESTHESIA AND ANALGESIA
(2022)
Editorial Material
Anesthesiology
Eric S. Schwenk, Rajnish K. Gupta, Mark C. Bicket
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Article
Anesthesiology
Mark C. Bicket, Vidhya Gunaseelan, Pooja Lagisetty, Anne C. Fernandez, Amy Bohnert, Elizabeth Assenmacher, Melwyn Sequeira, Michael J. Englesbe, Chad M. Brummett, Jennifer F. Waljee
Summary: This study aimed to determine the effect of prescription opioid use in the year before surgery on opioid consumption after surgery. The results showed that preoperative opioid use is associated with small increases in patient-reported opioid consumption after surgery for most patients, though greater differences exist for patients with chronic use. Existing guidelines may meet the postoperative needs of most patients with preoperative opioid exposure, but may need tailoring for patients with chronic use.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Article
Anesthesiology
Shay N. Nguyen, Afton L. Hassett, Hsou-Mei Hu, Chad M. Brummett, Mark C. Bicket, Noelle E. Carlozzi, Jennifer F. Waljee
Summary: Perioperative anxiety is associated with postoperative pain and opioid use. Anxiety is most severe on the day of surgery and declines over time. Patients with anxiety are more likely to use opioids and report greater surgical pain compared to those without anxiety.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Editorial Material
Anesthesiology
Jayson S. Marwaha, Brendin R. Beaulieu-Jones, Chris J. Kennedy, Mark C. Bicket, Gabriel A. Brat
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Article
Anesthesiology
Shelby Hinds, Jacquelyn Miller, Merissa Maccani, Sarah Patino, Shivani Kaushal, Heidi Rieck, Monica Walker, Chad M. Brummett, Mark C. Bicket, Jennifer F. Waljee
Summary: Providers in this study believed that coordinated, multidisciplinary approaches could aid in identifying high-risk patients with prior opioid exposure and improve surgical transitions of care. Most providers across specialties showed preference for a screening tool that is coupled with actionable recommendations, sufficient resources, and facilitated coordination between specialties.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Review
Anesthesiology
Siddartha Simha, Yusuf Ahmed, Chad M. Brummett, Jennifer F. Waljee, Michael J. Englesbe, Mark C. Bicket
Summary: The COVID-19 pandemic has exacerbated the opioid crisis in the USA and Canada. The analysis of service utilization, urine drug testing results, and naloxone dispensation showed significant increases in opioid-related emergency medicine utilization and positive drug test results. These findings highlight the need to enhance prevention, treatment, and harm reduction efforts for the opioid crisis as the pandemic continues.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Editorial Material
Anesthesiology
M. C. Bicket, C. M. Brummett, E. R. Mariano
Article
Surgery
Anne C. Fernandez, Jennifer F. Waljee, Vidhya Gunaseelan, Chad M. Brummett, Michael J. Englesbe, Mark C. Bicket
Summary: The prevalence of unhealthy substance use before elective surgery was assessed in this study. It was found that 40.2% of patients reported unhealthy substance use, with illicit drugs and alcohol being the most common substances. Younger age, male gender, higher pain and anxiety scores were associated with a higher likelihood of unhealthy substance use.
Article
Medicine, Research & Experimental
Hemant Kalia, Alaa Abd-Elsayed, Mark Malinowski, Adam Burkey, Rany T. Abdallah, Eellan Sivanesan, Tariq Malik, Reda Tolba, Yashar Eshraghi, Kris Ferguson, Maricela Schnur, Ahmed Raslan, Maged Guirguis, Marc Russo, Konstantin V. Slavin
Summary: A competency-based PNS training curriculum was developed by a multidisciplinary task force of the North American Neuromodulation Society (NANS). The curriculum aims to provide training and guidance for learning and mastering PNS treatment.
Article
Medicine, Research & Experimental
Eellan Sivanesan, Karla R. Sanchez, Chi Zhang, Shao-Qiu He, Bengt Linderoth, Kimberly E. Stephens, Srinivasa N. Raja, Yun Guan
Summary: We conducted a study on the effects of spinal cord stimulation (SCS) on chemoefficacy and chemotherapy-induced peripheral neuropathy (CIPN) pain in rats with xenograft human non-small cell lung cancer. Our findings suggest that preemptive SCS can enhance the antitumor efficacy of paclitaxel (PTX) and prevent PIPN pain by modulating macrophages, fractalkine (CX3CL1), and inflammatory cytokines.
Article
Anesthesiology
Jiyeon Song, Yi Li, Jennifer F. Waljee, Vidhya Gunaseelan, Chad M. Brummett, Michael J. Englesbe, Mark C. Bicket
Summary: To develop precise opioid prescribing guidelines after surgery, it is important to understand patterns of patient-reported opioid consumption. This study analyzed data from over 10,000 surgical patients and found that many did not use any opioids after surgery. The study highlights the need for further investigation to ensure tailored recommendations for postoperative pain management.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Article
Medicine, General & Internal
Emma E. McGinty, Kayla N. Tormohlen, Nicholas J. Seewald, Mark C. Bicket, Alexander D. McCourt, Lainie Rutkow, Sarah A. White, Elizabeth A. Stuart
Summary: This study found that state medical cannabis laws did not have significant effects on the receipt of opioid or nonopioid pain treatment among patients with chronic noncancer pain.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Anesthesiology
Jessica Billig, Mark C. Bicket, Maryam Yazdanfar, Vidhya Gunaseelan, Erika D. Sears, Chad M. Brummett, Jennifer F. Waljee
Summary: In this study, the addition of off-label gabapentin did not result in a reduction of opioid dosage in the majority of patients with chronic opioid use. The coprescription of these medications should be critically evaluated to ensure patient safety.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Article
Clinical Neurology
Adrianne Kehne, Steven J. Bernstein, Jennifer Thomas, Mark C. Bicket, Amy S. B. Bohnert, Erin Fanning Madden, Victoria Powell, Pooja Lagisetty
Summary: The purpose of this study was to generate recommendations on policy, intervention, and research to improve access to care for US patients on long-term opioid therapy. The panel proposed recommendations on reimbursement reform, provider education, and reducing racial inequities in care. Panelists emphasized the need for reimbursement to incentivize evidence-based pain care and the importance of addressing racial disparities in pain management.
JOURNAL OF PAIN RESEARCH
(2023)