Review
Health Care Sciences & Services
Marika Musielak, Wiktoria M. Suchorska, Magdalena Fundowicz, Piotr Milecki, Julian Malicki
Summary: Proton therapy offers a more favorable dose distribution for breast cancer patients, potentially reducing toxicity. However, challenges and prospects for preventing cardiotoxicity remain unclear and require further research.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Oncology
Zhenkun Fu, Zhoujun Lin, Mao Yang, Chenggang Li
Summary: Breast cancer is a common type of cancer, with surgery being the preferred treatment method. Various adjuvant therapies such as radiotherapy, chemotherapy, endocrine therapy, and targeted drug therapy can also be used.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Eva Kimpe, Amber Werbrouck, Mark De Ridder, Koen Putman
Summary: Radiation-induced cardiotoxicity can cause additional costs and disutility in breast cancer survivors, but these effects are relatively minor. The past investments in achieving current mean heart dose (MHD) seem justified considering the reduction in costs and disutility resulting from radiation-induced cardiovascular events.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biology
Camila Salata, Carlos E. deAlmeida, Samara C. Ferreira-Machado, Regina C. Barroso, Liebert P. Nogueira, Andrea Mantuano, Arissa Pickler, Carla L. Mota, Cherley B. V. de Andrade
Summary: Advancements in breast cancer treatment have significantly improved survival but can lead to potential side effects, especially cardiac toxicity. Side effects may also affect other organs besides the heart.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Review
Health Care Sciences & Services
Vasiliki Nikovia, Evangelos Chinis, Areti Gkantaifi, Maria Marketou, Michalis Mazonakis, Nikolaos Charalampakis, Dimitrios Mavroudis, Kornilia Vasiliki Orfanidou, Antonios Varveris, Chrysostomos Antoniadis, Maria Tolia
Summary: Breast cancer is the most common malignancy in females. Radiotherapy plays an important role in its treatment, but traditional methods can cause cardiotoxicity and cardiovascular diseases. Recent radiotherapeutic techniques have shown potential in reducing post-radiotherapy cardiovascular diseases. This review discusses the role of current cardioprotective strategies in preventing cardiotoxic effects in breast cancer radiotherapy.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
N. Fourati, S. Charfeddine, I. Chaffai, F. Dhouib, L. Farhat, M. Boukhris, L. Abid, S. Kammoun, W. Mnejja, J. Daoud
Summary: This prospective study revealed that breast cancer radiotherapy can lead to cardiotoxicity, and using echocardiographic parameters can detect LV dysfunction. In radiotherapy planning, factors such as radiation dose, age, and obesity should be considered.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Michal Laufer-Perl, Orly Arias, Svetlana Sirota Dorfman, Guy Baruch, Ehud Rothschild, Gil Beer, Shira Peleg Hasson, Yaron Arbel, Zach Rozenbaum, Yan Topilsky, Livia Kapusta
Summary: This study aimed to evaluate changes in left atrial strain (LAS) during Anthracycline (ANT) therapy in female breast cancer patients and to assess the correlation between LAS and routine echocardiographic diastolic parameters. The results showed significant reductions in LASr and LASc are frequent during ANT therapy, with significant correlation to routine echocardiographic diastolic parameters, indicating a potential role in early detection of cardiotoxicity.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Health Care Sciences & Services
Jibran Mirza, Sunitha Shyam Sunder, Badri Karthikeyan, Sharma Kattel, Saraswati Pokharel, Brian Quigley, Umesh C. Sharma
Summary: In this study, the utility of echocardiography and cardiac MRI in examining the effects of ICI-induced myocarditis and cardiomyopathy was investigated. The results showed that both imaging modalities can effectively detect the cardiac changes associated with ICI-induced cardiomyopathy.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Jiaqiang Zhang, Shao-Yin Sum, Jeng-Guan Hsu, Ming-Feng Chiang, Tian-Shyug Lee, Szu-Yuan Wu
Summary: The study found that adjuvant whole breast radiotherapy was significantly associated with decreased all-cause death, locoregional recurrence, and distant metastasis in women with left-sided breast invasive ductal carcinoma and heart failure with reduced ejection fraction compared to non-adjuvant WBRT.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Oncology
Grzegorz Slawinski, Maja Hawryszko, Aleksandra Lizewska-Springer, Izabela Nabialek-Trojanowska, Ewa Lewicka
Summary: The assessment of global longitudinal strain (GLS) plays a crucial role in the early diagnosis of anticancer treatment-related cardiotoxicity in cardio-oncology. Baseline left ventricular (LV) GLS and right ventricular (RV) GLS assessments can identify patients at risk for systolic dysfunction and heart failure. Serial echocardiography with GLS assessment should be performed during anticancer therapy to promptly initiate and adjust cardioprotection for subclinical myocardial contractile dysfunction.
Article
Oncology
Ana de la Fuente, Marta Santisteban, Josep Lupon, Jose Manuel Aramendia, Agnes Diaz, Ana Santaballa, Amparo Hernandiz, Pilar Sepulveda, German Cediel, Begona Lopez, Jose Maria Lopez Picazo, Manuel M. Mazo, Gregorio Rabago, Juan Jose Gavira, Ignacio Garcia-Bolao, Javier Diez, Arantxa Gonzalez, Antoni Bayes-Genis, Susana Ravassa
Summary: Elevated levels of procollagen type I C-terminal propeptide (PICP), a biomarker of myocardial fibrosis, are associated with early subclinical left ventricular dysfunction (LVD) and predict later development of cardiotoxicity in patients treated with anthracycline-based cancer chemotherapy (ACC). PICP is also associated with LVD in ACC-induced heart failure patients. These findings provide valuable insights into the mechanisms of LVD after ACC and suggest PICP as a promising tool for monitoring cardiotoxicity.
Article
Cardiac & Cardiovascular Systems
Jussi Niemela, Kaisa Ylanen, Anu Suominen, Kuberan Pushparajah, Sujeev Mathur, Taisto Sarkola, Kirsi Jahnukainen, Anneli Eerola, Tuija Poutanen, Kim Vettenranta, Tiina Ojala
Summary: LV longitudinal strain is a more sensitive method than LV EF for the detection of cardiac dysfunction among CCSs. Therefore, LV longitudinal strain should be added to the screening panel, especially for those with modifiable cardiovascular risk factors.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Medicine, General & Internal
Michal Laufer-Perl, Dan Gilon, Livia Kapusta, Zaza Iakobishvili
Summary: This article reviews the role of two-dimensional speckle tracking echocardiography in diagnosing early subclinical cardiac injury in patients undergoing cancer therapies, emphasizing the prevention of interference with optimal cancer therapy and the development of irreversible cardiac dysfunction.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Daniela Di Lisi, Antonella Moreo, Grazia Casavecchia, Christian Cadeddu Dessalvi, Corinna Bergamini, Concetta Zito, Cristina Madaudo, Rosalinda Madonna, Matteo Cameli, Giuseppina Novo
Summary: This study aimed to assess the impact of anti-cancer drugs on atrial function in breast cancer women and found that PALS and LASi, which are associated with GLS, significantly changed during chemotherapy. Atrial strain is an additional parameter that could be measured together with GLS to detect cardiotoxicity early.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Aviram Hochstadt, Joshua Arnold, Roni Rosen, Chen Sherez, Jack Sherez, Liat Mor, Yonatan Moshkovits, Ilan Merdler, Yishay Szekely, Yaron Arbel, Zach Rozenbaum, Livia Kapusta, Yan Topilsky, Michal Laufer-Perl
Summary: This study evaluated the correlation of diastolic strain slope (Dss) with routine echocardiography diastolic parameters and found a significant association between Dss changes and the development of systolic dysfunction. Particularly, changes in mid segment Dss were identified to have independent early predictive value for systolic dysfunction development.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Article
Health Care Sciences & Services
Brona Nic Giolla Easpaig, Yvonne Tran, Teresa Winata, Klay Lamprell, Diana Fajardo Pulido, Gaston Arnolda, Geoff P. Delaney, Winston Liauw, Kylie Smith, Sandra Avery, Kim Rigg, Johanna Westbrook, Ian Olver, David Currow, Jonathan Karnon, Robyn L. Ward, Jeffrey Braithwaite
Summary: This study used ethnographic research in four public hospital outpatient clinics to understand the delivery of cancer services. Staff in these clinics see themselves as part of local and multidisciplinary care teams. Care processes were supported by relationships, social capital, and institutional expertise. Staff were aware of communication difficulties and employed strategies to minimize negative impacts on patients. Complexity, coordination, culture, and capacity were found to underpin the themes characterizing care provision in these clinics.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vikneswary Batumalai, Joseph Descallar, Karen Wong, Gabriel Gabriel, Geoff P. Delaney, Jesmin Shafiq, Shalini K. Vinod, Michael B. Barton
Summary: In New South Wales, 19% of rectal cancer patients received short-course radiation therapy in the neoadjuvant setting. Factors associated with receiving short-course RT included older age, comorbidities, and less advanced disease. There was wide variation in the utilization of short-course RT across different health districts in NSW, suggesting a need for further research to investigate the reasons for this variability.
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Roya Merie, Jesmin Shafiq, Patsy S. Soon, Geoff P. Delaney
Summary: This study analyzed surgical and radiotherapy patterns of breast cancer care in NSW and ACT in Australia between 2009 and 2014, identifying factors such as age, socio-economic status, distance to radiotherapy facility and place of birth that are associated with utilization rates of mastectomy and axillary lymph node dissection. The 5-year overall survival rate was 80.5%, with older patients, the socioeconomically disadvantaged and those with advanced tumors having worse survival outcomes.
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2022)
Article
Oncology
Vikneswary Batumalai, Joseph Descallar, Gabriel Gabriel, Geoff P. Delaney, Andrew Oar, Michael B. Barton, Shalini K. Vinod
Summary: This study aimed to evaluate the utilization of curative treatment for non-small cell lung cancer (NSCLC) at a population level in New South Wales, Australia. The results showed low utilization of curative treatment, but it has increased over time. There were significant variations in the use of curative treatment between different health districts.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2023)
Letter
Oncology
Vikneswary Batumalai, Joseph Descallar, Gabriel Gabriel, Geoff P. Delaney, Andrew Oar, Michael B. Barton, Shalini K. Vinod
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Computer Science, Interdisciplinary Applications
Matthew Field, David I. Thwaites, Martin Carolan, Geoff P. Delaney, Joerg Lehmann, Jonathan Sykes, Shalini Vinod, Lois Holloway
Summary: Emerging evidence suggests that data-driven support tools, including for cancer care, have been widely used in clinical decision-making. However, improving and expanding their application in different clinical scenarios require coordinated data sharing and large-scale analysis. Nonetheless, there are significant challenges due to privacy, administrative, and political barriers in utilizing routinely collected data in practice.
JOURNAL OF BIOMEDICAL INFORMATICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vikneswary Batumalai, Shivani Kumar, Puma Sundaresan
Summary: Despite progress in science and medicine, women continue to be underrepresented in academic publication. This study examined gender differences in authorship in the Journal of Medical Imaging and Radiation Oncology (JMIRO). The results showed that women accounted for a smaller proportion of first authors and senior authors. The proportion of women as first authors remained stable over the study period, while the proportion of women as senior authors showed a slight increase followed by a decrease.
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2023)
Article
Oncology
Ali Haidar, Matthew Field, Vikneswary Batumalai, Kirrily Cloak, Daniel Al Mouiee, Phillip Chlap, Xiaoshui Huang, Vicky Chin, Farhannah Aly, Martin Carolan, Jonathan Sykes, Shalini K. K. Vinod, Geoffrey P. P. Delaney, Lois Holloway
Summary: In this paper, a new method for automatically standardizing the names of radiotherapy structures using machine learning algorithms was proposed and evaluated. The results showed that machine learning techniques can effectively standardize the dosimetry plan structures. Standardized naming conventions are important for data pooling and analysis in healthcare systems.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Maddison Picton, David Crawford, Michael Jameson, Stacy Alvares, Louise Hogan, Conrad Loo, Zoe Moutrie, Urszula Jelen, Claire Pagulayan, Nicolle Dunkerley, Tania Twentyman, Jeremy de Leon, Vikneswary Batumalai
Summary: The introduction of MR-Linac systems has ushered in a new era in radiotherapy. This resource-intensive and logistically challenging technology is currently operated by teams comprising radiation therapists, radiation oncology medical physicists, and radiation oncologists. In order to simplify the treatment process and optimize patient care, a workflow led by radiation therapists at the treatment console is essential. This article discusses our department's experiences in developing and implementing an RT-led workflow on a 1.5 T MR-Linac.
JOURNAL OF MEDICAL RADIATION SCIENCES
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Louise Hogan, Michael Jameson, David Crawford, Stacy Alvares, Conrad Loo, Maddison Picton, Zoe Moutrie, Claire Pagulayan, Ursula Jelen, Nicolle Dunkerley, Tania Twentyman, Jeremy de Leon, Vikneswary Batumalai
Summary: The introduction of MR-Linacs into radiotherapy departments has increased recently, but most radiation oncology professionals are not familiar with MR technology. This article provides an overview of training and credentialing requirements for radiation oncology professionals to develop competency and efficiency in delivering treatment safely on an MR-Linac.
JOURNAL OF MEDICAL RADIATION SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vikneswary Batumalai, Madeline Carr, Michael Jameson, David Crawford, Urszula Jelen, Claire Pagulayan, Tania Twentyman, Angela Hong, Jeremy de Leon
Summary: This study presents the first reported case of using magnetic resonance linear accelerator (MR-Linac) guided adaptive stereotactic ablative body radiotherapy (SABR) to treat a 78-year-old woman with recurrent cardiac sarcoma adjacent to a bioprosthetic mitral valve. The treatment was successful with no acute toxicity reported and follow-up appointments showed stable disease and good symptomatic relief. The transthoracic echocardiogram after radiotherapy also indicated normal functionality of the mitral valve prosthesis. This study provides evidence that MR-Linac guided adaptive SABR is a safe and viable option for the treatment of recurrent cardiac sarcoma with mitral valve bioprosthesis.
JOURNAL OF MEDICAL RADIATION SCIENCES
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jeremy de Leon, Tania Twentyman, Madeline Carr, Michael Jameson, Vikneswary Batumalai
Summary: The magnetic resonance linear accelerator (MR-Linac) provides improved visualization of targets and allows for real-time adaptation of treatment plans. Online MR-guided adaptive treatment has reduced uncertainties but has also increased treatment time and resource requirements. We share our experience of integrating MR-Linac into a busy department and provide recommendations for improved clinical and resource efficiency. We also discuss potential technological innovations for optimizing clinical productivity.
JOURNAL OF MEDICAL RADIATION SCIENCES
(2023)
Meeting Abstract
Oncology
Jesmin Shafiq, Vikneswary Batumalai, Karen Wong, Nasreen Kaadan, Alexandra Powell, Geoff Delaney, Shalini Vinod
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
A. Haidar, M. Field, V. Batumalai, K. Cloak, D. Al Mouiee, P. Chlap, X. Huang, V. Chin, M. Carolan, J. Sykes, S. Vinod, G. Delaney, L. Holloway
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Health Care Sciences & Services
Afaf Girgis, Adeola Bamgboje-Ayodele, Orlando Rincones, Shalini K. Vinod, Sandra Avery, Joseph Descallar, Allan 'Ben' Smith, Belinda Arnold, Anthony Arnold, Victoria Bray, Ivana Durcinoska, Nicole M. Rankin, PROMPT-Care Implementation Authorship Group, Geoff P. Delaney
Summary: This study implemented an effective ePROM system (PRM system) for lung cancer patients in routine care, using the RE-AIM framework. The study showed that the implementation of the PRM system successfully improved the routine care of lung cancer patients by identifying patient concerns early and providing timely responses, resulting in fewer visits to the cancer assessment unit and increased confidence and engagement of healthcare providers.
JOURNAL OF PATIENT-REPORTED OUTCOMES
(2022)
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)