Metal cofactors trafficking and assembly in the cell: a molecular view

In-Cell NMR in Human Cells: Direct Protein Expression Allows Structural Studies of Protein Folding and Maturation

(2018) Enrico Luchinat et al.   ACCOUNTS OF CHEMICAL RESEARCH

Investigating the role of the human CIA2A-CIAO1 complex in the maturation of aconitase

(2018) Vincenzo Maione et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Protein networks in the maturation of human iron–sulfur proteins

(2018) Simone Ciofi-Baffoni et al.   Metallomics

The human iron-proteome

(2018) Claudia Andreini et al.   Metallomics

Anamorsin/Ndor1 Complex Reduces [2Fe–2S]-MitoNEET via a Transient Protein–Protein Interaction

(2017) Francesca Camponeschi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

[4Fe-4S] Cluster Assembly in Mitochondria and Its Impairment by Copper

(2017) Diego Brancaccio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NBP35 interacts with DRE2 in the maturation of cytosolic iron-sulphur proteins inArabidopsis thaliana

(2017) Emma L. Bastow et al.   PLANT JOURNAL

The CIA Targeting Complex Is Highly Regulated and Provides Two Distinct Binding Sites for Client Iron-Sulfur Proteins

(2017) Diana C. Odermatt et al.   Cell Reports

A molecular chaperone activity of CCS restores the maturation of SOD1 fALS mutants

(2017) Enrico Luchinat et al.   Scientific Reports

The conserved protein Dre2 uses essential [2Fe-2S] and [4Fe-4S] clusters for its function in cytosolic iron-sulfur protein assembly

(2016) D. J. A. Netz et al.   BIOCHEMICAL JOURNAL

EPR studies of wild type and mutant Dre2 identify essential [2Fe–-2S] and [4Fe–-4S] clusters and their cysteine ligands

(2016) Yan Zhang et al.   JOURNAL OF BIOCHEMISTRY

A Glutaredoxin·BolA Complex Serves as an Iron-Sulfur Cluster Chaperone for the Cytosolic Cluster Assembly Machinery

(2016) Avery G. Frey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploiting Bacterial Operons To Illuminate Human Iron–Sulfur Proteins

(2016) Claudia Andreini et al.   JOURNAL OF PROTEOME RESEARCH

Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility

(2016) Xander Nuttle et al.   NATURE

Characterization of proteins by in-cell NMR spectroscopy in cultured mammalian cells

(2016) Letizia Barbieri et al.   Nature Protocols

Mitochondrial Bol1 and Bol3 function as assembly factors for specific iron-sulfur proteins

(2016) Marta A Uzarska et al.   eLife

Role of Nfu1 and Bol3 in iron-sulfur cluster transfer to mitochondrial clients

(2016) Andrew Melber et al.   eLife

The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron sulfur cluster biogenesis

(2016) Jonathan G Van Vranken et al.   eLife

Frataxin Accelerates [2Fe-2S] Cluster Formation on the Human Fe–S Assembly Complex

(2015) Nicholas G. Fox et al.   BIOCHEMISTRY

Emerging critical roles of Fe–S clusters in DNA replication and repair

(2015) Jill O. Fuss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Biogenesis of cytosolic and nuclear iron–sulfur proteins and their role in genome stability

(2015) Viktoria Désirée Paul et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Iron –sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery

(2015) Nunziata Maio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Fe–S proteins that regulate gene expression

(2015) Erin L. Mettert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The BioPlex Network: A Systematic Exploration of the Human Interactome

(2015) Edward L. Huttlin et al.   CELL

The role of mitochondria and the CIA machinery in the maturation of cytosolic and nuclear iron–sulfur proteins

(2015) Roland Lill et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The Yeast Nbp35-Cfd1 Cytosolic Iron-Sulfur Cluster Scaffold Is an ATPase

(2015) Eric J. Camire et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping Key Residues of ISD11 Critical for NFS1-ISD11 Subcomplex Stability

(2015) Prasenjit Prasad Saha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elucidating the Molecular Function of Human BOLA2 in GRX3-Dependent Anamorsin Maturation Pathway

(2015) Lucia Banci et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-terminal domains mediate [2Fe-2S] cluster transfer from glutaredoxin-3 to anamorsin

(2015) Lucia Banci et al.   Nature Chemical Biology

Loop recognition and copper-mediated disulfide reduction underpin metal site assembly of CuAin human cytochrome oxidase

(2015) Marcos N. Morgada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols

(2015) Aubérie Parent et al.   Nature Communications

The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion

(2015) Viktoria Désirée Paul et al.   eLife

Control of the Electronic Ground State on an Electron-Transfer Copper Site by Second-Sphere Perturbations

(2014) Marcos N. Morgada et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metal Preferences and Metallation

(2014) Andrew W. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of [4Fe-4S] Clusters in the Mitochondrial Iron–Sulfur Cluster Assembly Machinery

(2014) Diego Brancaccio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

[2Fe-2S] cluster transfer in iron-sulfur protein biogenesis

(2014) L. Banci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone

(2014) Joseph Amick et al.   PROTEIN SCIENCE

In-cell NMR reveals potential precursor of toxic species from SOD1 fALS mutants

(2014) Enrico Luchinat et al.   Nature Communications

Functional reconstitution of mitochondrial Fe/S cluster synthesis on Isu1 reveals the involvement of ferredoxin

(2014) Holger Webert et al.   Nature Communications

Mitochondrial Complex I

(2013) Judy Hirst   Annual Review of Biochemistry

Iron/sulfur proteins biogenesis in prokaryotes: Formation, regulation and diversity

(2013) Béatrice Roche et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Human CIA2A-FAM96A and CIA2B-FAM96B Integrate Iron Homeostasis and Maturation of Different Subsets of Cytosolic-Nuclear Iron-Sulfur Proteins

(2013) Oliver Stehling et al.   Cell Metabolism

Iron sensing and regulation in Saccharomyces cerevisiae: Ironing out the mechanistic details

(2013) Caryn E Outten et al.   CURRENT OPINION IN MICROBIOLOGY

Human Mitochondrial Chaperone (mtHSP70) and Cysteine Desulfurase (NFS1) Bind Preferentially to the Disordered Conformation, Whereas Co-chaperone (HSC20) Binds to the Structured Conformation of the Iron-Sulfur Cluster Scaffold Protein (ISCU)

(2013) Kai Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IOP1 Protein Is an External Component of the Human Cytosolic Iron-Sulfur Cluster Assembly (CIA) Machinery and Functions in the MMS19 Protein-dependent CIA Pathway

(2013) Mineaki Seki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction with Cfd1 Increases the Kinetic Lability of FeS on the Nbp35 Scaffold

(2013) Leif J. Pallesen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human anamorsin binds [2Fe–2S] clusters with unique electronic properties

(2013) Lucia Banci et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Atomic-resolution monitoring of protein maturation in live human cells by NMR

(2013) Lucia Banci et al.   Nature Chemical Biology

The function of ORAOV1/LTO1, a gene that is overexpressed frequently in cancer: essential roles in the function and biogenesis of the ribosome

(2013) C Zhai et al.   ONCOGENE

Molecular view of an electron transfer process essential for iron-sulfur protein biogenesis

(2013) L. Banci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the N-terminal methyltransferase-like domain of anamorsin

(2013) Gaojie Song et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Maturation of cytosolic and nuclear iron–sulfur proteins

(2013) Daili J.A. Netz et al.   TRENDS IN CELL BIOLOGY

(IscS-IscU)2Complex Structures Provide Insights into Fe2S2Biogenesis and Transfer

(2012) Elodie N. Marinoni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Monothiol CGFS Glutaredoxins and BolA-like Proteins: [2Fe-2S] Binding Partners in Iron Homeostasis

(2012) Haoran Li et al.   BIOCHEMISTRY

Identification and function of auxiliary iron–sulfur clusters in radical SAM enzymes

(2012) Nicholas D. Lanz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease

(2012) T. A. Rouault   Disease Models & Mechanisms

The human mitochondrial ISCA1, ISCA2, and IBA57 proteins are required for [4Fe-4S] protein maturation

(2012) Alex D. Sheftel et al.   MOLECULAR BIOLOGY OF THE CELL

Human superoxide dismutase 1 (hSOD1) maturation through interaction with human copper chaperone for SOD1 (hCCS)

(2012) L. Banci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MMS19 Assembles Iron-Sulfur Proteins Required for DNA Metabolism and Genomic Integrity

(2012) O. Stehling et al.   SCIENCE

MMS19 Links Cytoplasmic Iron-Sulfur Cluster Assembly to DNA Metabolism

(2012) K. Gari et al.   SCIENCE

Mutations in Iron-Sulfur Cluster Scaffold Genes NFU1 and BOLA3 Cause a Fatal Deficiency of Multiple Respiratory Chain and 2-Oxoacid Dehydrogenase Enzymes

(2011) Jessie M. Cameron et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Fatal Mitochondrial Disease Is Associated with Defective NFU1 Function in the Maturation of a Subset of Mitochondrial Fe-S Proteins

(2011) Aleix Navarro-Sastre et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Anamorsin Is a [2Fe-2S] Cluster-Containing Substrate of the Mia40-Dependent Mitochondrial Protein Trapping Machinery

(2011) Lucia Banci et al.   CHEMISTRY & BIOLOGY

Copper: An essential metal in biology

(2011) Richard A. Festa et al.   CURRENT BIOLOGY

Functional Role of Two Interhelical Disulfide Bonds in Human Cox17 Protein from a Structural Perspective

(2011) Lucia Banci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyanobacterial metallochaperone inhibits deleterious side reactions of copper

(2011) S. Tottey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Copper Metallochaperones

(2010) Nigel J. Robinson et al.   Annual Review of Biochemistry

Characterization of the human monothiol glutaredoxin 3 (PICOT) as iron–sulfur protein

(2010) Petra Haunhorst et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Human Frataxin Is an Allosteric Switch That Activates the Fe−S Cluster Biosynthetic Complex

(2010) Chi-Lin Tsai et al.   BIOCHEMISTRY

Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron–sulfur cluster biogenesis

(2010) Helge Uhrigshardt et al.   HUMAN MOLECULAR GENETICS

Cytosolic Iron-Sulfur Cluster Assembly (CIA) System: Factors, Mechanism, and Relevance to Cellular Iron Regulation

(2010) Anil K. Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sco proteins are involved in electron transfer processes

(2010) Lucia Banci et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Molecular recognition in copper trafficking

(2010) Lucia Banci et al.   NATURAL PRODUCT REPORTS

Affinity gradients drive copper to cellular destinations

(2010) Lucia Banci et al.   NATURE

Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis

(2010) Daili J A Netz et al.   Nature Chemical Biology

Copper(I)-mediated protein–protein interactions result from suboptimal interaction surfaces

(2009) Lucia Banci et al.   BIOCHEMICAL JOURNAL

Human ISD11 is essential for both iron-sulfur cluster assembly and maintenance of normal cellular iron homeostasis

(2009) Y. Shi et al.   HUMAN MOLECULAR GENETICS

Copper Transport in Mammalian Cells: Special Care for a Metal with Special Needs

(2009) Jack H. Kaplan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NMR structural analysis of the soluble domain of ZiaA-ATPase and the basis of selective interactions with copper metallochaperone Atx1

(2009) Lucia Banci et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Human Ind1, an Iron-Sulfur Cluster Assembly Factor for Respiratory Complex I

(2009) A. D. Sheftel et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural and dynamic aspects related to oligomerization of apo SOD1 and its mutants

(2009) L. Banci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

“Pulling the plug” on cellular copper: The role of mitochondria in copper export

(2008) Scot C. Leary et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The functional duality of iron regulatory protein 1

(2008) Karl Volz   CURRENT OPINION IN STRUCTURAL BIOLOGY

The iron–sulphur protein Ind1 is required for effective complex I assembly

(2008) Katrine Bych et al.   EMBO JOURNAL

Human Nbp35 Is Essential for both Cytosolic Iron-Sulfur Protein Assembly and Iron Homeostasis

(2008) O. Stehling et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanisms for copper acquisition, distribution and regulation

(2008) Byung-Eun Kim et al.   Nature Chemical Biology

SOD1 and Amyotrophic Lateral Sclerosis: Mutations and Oligomerization

(2008) Lucia Banci et al.   PLoS One

Mitochondrial copper(I) transfer from Cox17 to Sco1 is coupled to electron transfer

(2008) L. Banci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Occurrence of Copper Proteins through the Three Domains of Life: A Bioinformatic Approach

(2007) Claudia Andreini et al.   JOURNAL OF PROTEOME RESEARCH