Article
Medicine, General & Internal
Lucia Giordano, Alessandro Perri, Eloisa Tiberi, Annamaria Sbordone, Maria Letizia Patti, Vito D'Andrea, Giovanni Vento
Summary: This study assessed the feasibility and reliability of a continuous glucose monitoring system (CGMS) in asphyxiated neonates during therapeutic hypothermia. The CGMS detected more episodes of disglycemia than standard care, but showed poor accuracy in this particular setting.
Review
Endocrinology & Metabolism
Carlos A. Diaz-Balzac, David Pillinger, Steven D. Wittlin
Summary: Continuous subcutaneous insulin infusions (CSIIs) and continuous glucose monitors (CGMs) have revolutionized the management of diabetes mellitus (DM). They provide an integrated system to maintain tight glycemic control and reduce episodes of hypoglycemia, while improving the quality of life for individuals with DM. Ongoing efforts to develop an artificial pancreas (AP) have created effective tools for managing DM, but cost and accessibility remain obstacles to wider application.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Ralph Ziegler, Nick Oliver, Delia Waldenmaier, Jochen Mende, Cornelia Haug, Guido Freckmann
Summary: The evaluation revealed significant differences between the tested tubeless pump models, with ACS being more accurate than A6 and A6 less accurate than OP. These differences were most evident in terms of delivery errors over short times and small volumes.
DIABETES TECHNOLOGY & THERAPEUTICS
(2021)
Review
Endocrinology & Metabolism
Pim Dekker, Henk-Jan Aanstoot, Theo Sas, Martine de Vries, Erwin Birnie, Dick Mul, Giesje Nefs
Summary: The introduction of continuous subcutaneous insulin infusion has improved glycemic and quality-of-life outcomes for diabetes patients, compared to multiple daily injections. However, some insulin pump users still switch back to injections. This review analyzes recent discontinuation rates and reasons for and factors associated with discontinuation, finding that wear-related issues, treatment non-compliance, age, gender, and side effects are common reasons. Despite advancements in pump technology, discontinuation rates and factors remain consistent with previous studies. Continuation of insulin pump treatment depends on a supportive healthcare team and meeting patients' needs.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Denise Montt-Blanchard, Raimundo Sanchez, Karen Dubois-Camacho, Jaime Leppe, Maria Teresa Onetto
Summary: This study compared the glycemic variability and exercise-related diabetic management strategies of adults with type 1 diabetes achieving higher and lower physical activity loads. The results showed that active individuals with diabetes were able to maintain glycemic control within recommended values regardless of activity loads, but had a higher prevalence of hypoglycemia during nighttime and used fewer post-activity management strategies.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Endocrinology & Metabolism
Valentina Mancioppi, Erica Pozzi, Sara Zanetta, Anna Missineo, Silvia Savastio, Fabrizio Barbetti, Simona Mellone, Mara Giordano, Ivana Rabbone
Summary: Neonatal diabetes mellitus (NDM) is a rare genetic disease characterized by severe hyperglycemia. The disease can be temporary or permanent, and is often caused by abnormalities in specific genetic regions or mutations in certain genes. Insulin therapy can be switched to hypoglycemic sulfonylureas after the acute phase, but the timing of this switch can affect long-term complications.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Aditi Aggarwal, Smit Pathak, Richa Goyal
Summary: CGMS in patients with diabetes has important clinical implications in reducing hypoglycemic events, glucose and HbA1c levels. It also has an impact on the direct and indirect costs of management.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Endocrinology & Metabolism
Jieling Chen, Ludi Fan, Xiaomei Peng, Liza Ilag, Trang Ly, Jennal Johnson
Summary: The study revealed that individuals with type 2 diabetes receiving treatment with U-500R insulin reported improvements in diabetes management, treatment burden, and psychological health, with greater improvements seen in the CSII group. Both the CSII and MDI methods were similarly acceptable in terms of delivery device and function.
DIABETES OBESITY & METABOLISM
(2021)
Article
Public, Environmental & Occupational Health
Keyu Guo, Jiaqi Li, Liyin Zhang, Jianan Ye, Li Fan, Zhiyi Ding, Qin Zhou, Xia Li, Lin Yang, Zhiguang Zhou
Summary: This study compared the efficacy of continuous subcutaneous insulin infusion (CSII) therapy with multiple daily injection (MDI) therapy in Chinese patients with type 1 diabetes mellitus (T1DM). The results showed that CSII therapy was associated with lower HbA1c levels and better glycemic outcomes. However, it did not improve the risk of hypoglycemia.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Psychology, Clinical
Ella Dowling, David W. Maidment
Summary: This study finds that adults with type 1 diabetes using multiple daily injections (MDI) insulin delivery method have lower scores on measures of depressive symptoms and diabetes distress compared to those using continuous subcutaneous insulin infusion (CSII). MDI users may require more targeted support to improve their psychological well-being.
JOURNAL OF HEALTH PSYCHOLOGY
(2023)
Review
Chemistry, Medicinal
Hui Li, Aimin Yang, Shi Zhao, Elaine Yk Chow, Mohammad Javanbakht, Yinhui Li, Dandan Lin, Lijuan Xu, Deng Zang, Kai Wang, Li Ma
Summary: The clinical efficacy of continuous subcutaneous insulin infusion (CSII) therapy combined with six classes of oral glucose-lowering drugs (GLDs) in the treatment of type 2 diabetes was evaluated using a network meta-analysis. The results showed that CSII combined with metformin had the best clinical effect in controlling blood sugar and improving insulin resistance.
Article
Biochemistry & Molecular Biology
Laura Bragagna, Christina Polak, Lisa Schuetz, Lina Maqboul, Carmen Klammer, Roland Feldbauer, Agnes Draxler, Martin Clodi, Karl-Heinz Wagner
Summary: Glucose variability is associated with increased risk of coronary heart disease and can contribute to the development of metabolic syndrome and type 2 diabetes. A study on healthy men showed that bolus vs. continuous glucose administration did not have a significant acute effect on DNA damage and markers of oxidative stress. This suggests that short-term glucose fluctuations may not have immediate harmful effects in healthy individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Immacolata Blasi, Jessica Daolio, Valeria Pugni, Giuseppina Comitini, Marcello Morciano, Giorgio Grassi, Tullia Todros, Giancarlo Gargano, Lorenzo Aguzzoli
Summary: The study investigated the feasibility of using parameters of glycaemic variability to predict neonatal complications in women with gestational diabetes mellitus (GDM). Retrospective analysis was conducted on pregnant women who tested positive for oral glucose tolerance test (OGTT) during specific gestational weeks. Trends in parameters of glycaemic variability were observed to correlate with foetal outcomes in the third trimester. Further research is needed to determine if monitoring glycaemic variability trends can be more informative than standard glycaemic checks for managing GDM during delivery.
Article
Engineering, Biomedical
Fernanda Silva Tenorio, Luiz Eduardo Galvao Martins, Tatiana Sousa Cunha
Summary: This study evaluates the accuracy and precision of a low-cost insulin infusion pump prototype using two different methods, showing that the prototype can accurately infuse programmed fluid doses with good performance in repeatability tests. It is presented as a candidate for type 1 diabetic patients in Brazil and developing countries for public health purposes.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Medicine, General & Internal
Nursel Surmelioglu, Merve Nenni, Ahmet Firat, Kutay Demirkan, Dilek Ozcengiz
Summary: The study evaluated the adsorption rate of insulin to polypropylene (PP) bags and polyvinyl chloride (PVC) infusion sets, as well as the stability of insulin during infusion. Results showed that at 24 hours, the adsorption rate of insulin to PP bags was at most 5%, while it was 57% for PVC infusion sets.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Letter
Endocrinology & Metabolism
Maurizio Delvecchio, Alessio Galati, Claudio Maffeis, Stefano Passanisi, Riccardo Bonfanti, Roberto Franceschi, Gianluca Tornese, Elena Calzi, Angela Zanfardino, Giulia Patrizia Bracciolini, Elvira Piccinno, SPED Diabetes Study Grp
DIABETES OBESITY & METABOLISM
(2023)
Article
Virology
Giulia Pruccoli, Emanuele Castagno, Irene Raffaldi, Marco Denina, Elisa Barisone, Luca Baroero, Fabio Timeus, Ivana Rabbone, Alice Monzani, Gian Maria Terragni, Cristina Lovera, Adalberto Brach del Prever, Paolo Manzoni, Michelangelo Barbaglia, Luca Roasio, Simona De Franco, Carmelina Calitri, Maddalena Lupica, Enrico Felici, Cinzia Marciano, Savino Santovito, Gaia Militerno, Enrica Abrigo, Antonio Curtoni, Paola Quarello, Claudia Bondone, Silvia Garazzino
Summary: The study observed a significant reduction in respiratory pathogens, including RSV, during the COVID-19 pandemic, but there was a dramatic rebound afterward. The research conducted a retrospective observational study in 15 Pediatric Emergency Departments and compared RSV infection cases in children under 3 years old between September 1 and December 31 in 2019, 2020, and 2021. The findings revealed an increase in RSV cases in 2021, particularly among older children, without a difference in severity compared to previous years.
Article
Virology
Alice Monzani, Cinzia Borgogna, Daniela Ferrante, Benedetta Ciacchini, Enrico Felici, Marisa Gariglio, Ivana Rabbone
Summary: The choice of the best SARS-CoV-2 detection approach is crucial to predict the high-risk spreaders among children. This study found that children with nasopharyngeal symptoms have higher levels of viral load in saliva, indicating a greater likelihood of spreading the virus. In contrast, asymptomatic children have low viral load and are unlikely to transmit the virus.
Article
Endocrinology & Metabolism
Cristina Partenope, Quincy Pedranzini, Antonella Petri, Ivana Rabbone, Flavia Prodam, Simonetta Bellone
Summary: The report presents a case of a 16-year-old boy who developed polyuria, polydipsia, and weight loss after receiving the COVID-19 vaccine. Diagnosis revealed neuroinfundibulohypophysitis, a rare disorder characterized by inflammation of the pituitary gland and stalk. Further studies are needed to explore the possible causal link between the COVID-19 vaccine and AVP deficiency.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Valentina Mancioppi, Erica Pozzi, Sara Zanetta, Anna Missineo, Silvia Savastio, Fabrizio Barbetti, Simona Mellone, Mara Giordano, Ivana Rabbone
Summary: Neonatal diabetes mellitus (NDM) is a rare genetic disease characterized by severe hyperglycemia. The disease can be temporary or permanent, and is often caused by abnormalities in specific genetic regions or mutations in certain genes. Insulin therapy can be switched to hypoglycemic sulfonylureas after the acute phase, but the timing of this switch can affect long-term complications.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pediatrics
B. Ciacchini, G. Di Nardo, M. Marin, E. Borali, M. Caraccia, R. Mogni, F. Cairello, I. Rabbone, G. B. Ferrero, A. Pini Prato, E. Felici
Summary: This report describes a case of cardio-facio-cutaneous syndrome, a rare genetic disorder, characterized by craniofacial, dermatologic and cardiac defects. The patient experienced severe feeding difficulties, which led to growth arrest and malnutrition. Treatment including nasogastric tube placement and laparoscopic surgeries improved the patient's condition.
FRONTIERS IN PEDIATRICS
(2023)
Article
Health Care Sciences & Services
Maria Brentari, Roberto Franceschi, Jessica Longhini, Evelina Maines, Enza Mozzillo, Marco Marigliano, Cinzia Vivori
Summary: The lack of sufficient school nurses in Italy prevents the inclusion of students with type 1 diabetes in schools. The National Recovery and Resilience Plan aims to address this issue by creating community healthcare facilities and hiring family and community nurses to promote integration of healthcare professionals and services.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Health Care Sciences & Services
Marco Marigliano, Enza Mozzillo, Valentina Mancioppi, Francesca Di Candia, Francesco Maria Rosanio, Annalisa Antonelli, Ilaria Nichelatti, Claudio Maffeis, Stefano Tumini, Roberto Franceschi
Summary: Automated Insulin Delivery (AID) systems adjust insulin delivery based on glucose data, comprising of an insulin pump, a continuous glucose sensor, and an algorithm. However, all existing AID systems require users to announce carbohydrate intake, deliver meal boluses, and respond to alarms. Psychological factors can influence the initial and long-term usage of AID devices. Therefore, evaluating the psychological implications and tailoring education approach to address patient concerns is important for sustained use of AID systems.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Letter
Endocrinology & Metabolism
Giulia Pezzino, Rosario Ruta, Novella Rapini, Danilo Castellano Chiodo, Mafalda Mucciolo, Letizia Tomaselli, Stefano Cianfarani, Fabrizio Barbetti
Review
Endocrinology & Metabolism
Valentina Mancioppi, Tommaso Daffara, Martina Romanisio, Giovanni Ceccarini, Caterina Pelosini, Ferruccio Santini, Simonetta Bellone, Simona Mellone, Alessio Baricich, Ivana Rabbone, Gianluca Aimaretti, Baris Akinci, Mara Giordano, Flavia Prodam
Summary: This article describes a rare lipodystrophy syndrome called congenital generalized lipodystrophy type 4 (CGL4), which is caused by mutations in the PTRF gene. Two early childhood patients presented with features such as reduced subcutaneous fat, muscular hypertrophy, distinctive facial features, myopathy, and atlantoaxial instability. Blood tests showed elevated CK and triglyceride levels, and undetectable leptin and adiponectin concentrations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Antonietta Robino, Gianluca Tornese, Davide Tinti, Klemen Dovc, Valeria Castorani, Andrea Conti, Roberto Franceschi, Ivana Rabbone, Riccardo Bonfanti, Tadej Battelino, Eulalia Catamo
Summary: This study investigated the association between HNF1A gene SNPs and type 1 diabetes (T1D) susceptibility. The study found that one of the SNPs was associated with insulin dose-adjusted glycated hemoglobin A1c (IDAA1c) and glycated hemoglobin (HbA1c) values. These findings suggest that HNF1A variants may be a risk factor for beta cell function and glycaemic control in individuals with T1D.
Letter
Pediatrics
Alice Monzani, Giulia Minelli, Ivana Rabbone
Summary: Rates of antibiotic-resistant bacteria have increased globally, but the Italian Institute of Health found a disruption to this trend in 2021 compared to 2020. A retrospective study in Northern Italy examined the antibiotic prescription rate in a pediatric primary care clinic during the initial phase of the COVID-19 pandemic. Although there was only a slight reduction in the antibiotic prescription rate, there was a significant decrease in the total number of antibiotic prescriptions, particularly for respiratory tract infections.
ITALIAN JOURNAL OF PEDIATRICS
(2023)
Correction
Endocrinology & Metabolism
Carlo Bruno Giorda, Roberto Gnavi, Barbara Tartaglino, Roberta Manti, Alessandro Migliardi, Lucia Favella, Silvia Ferro, Ivana Rabbone
ACTA DIABETOLOGICA
(2023)
Article
Pediatrics
Francesca Di Candia, Valentina Di Iorio, Nadia Tinto, Riccardo Bonfanti, Claudio Iovino, Francesco Maria Rosanio, Ludovica Fedi, Fernanda Iafusco, Francesca Arrigoni, Rita Malesci, Francesca Simonelli, Andrea Rigamonti, Adriana Franzese, Enza Mozzillo
Summary: Early institution of high-dose thiamine supplementation seems to prevent the development of retinal changes and optic atrophy in TRMA patients. The spectrum of clinical manifestations is broad, and it is important to describe known Cases to gain a better understanding of this rare disease.
ITALIAN JOURNAL OF PEDIATRICS
(2023)
Article
Endocrinology & Metabolism
Valeria Castorani, Valeria Favalli, Andrea Rigamonti, Giulio Frontino, Raffaella Di Tonno, Elisa Morotti, Federica Sandullo, Francesco Scialabba, Francesca Arrigoni, Benedetta Dionisi, Riccardo Foglino, Camilla Morosini, Gabriele Olivieri, Graziano Barera, Franco Meschi, Riccardo Bonfanti
Summary: Early initiation of diabetes technologies can lead to better long-term glycemic control in young children with T1D, reducing the risk of complications.
ACTA DIABETOLOGICA
(2023)