Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice

Diabetes mellitus and Alzheimer’s disease: GSK-3β as a potential link

(2018) Ying Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Palmitate Increases β-site AβPP-Cleavage Enzyme 1 Activity and Amyloid-β Genesis by Evoking Endoplasmic Reticulum Stress and Subsequent C/EBP Homologous Protein Activation

(2017) Gurdeep Marwarha et al.   JOURNAL OF ALZHEIMERS DISEASE

AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity

(2017) Soraya Wilke Saliba et al.   Journal of Neuroinflammation

Hyperglycemia Increases the Production of Amyloid Beta-Peptide Leading to Decreased Endothelial Tight Junction

(2016) A-Ching Chao et al.   CNS Neuroscience & Therapeutics

Identifying GSK-3β kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays

(2016) Chih-Hsin Lin et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Deciphering the role of ferulic acid against streptozotocin-induced cellular stress in the cardiac tissue of diabetic rats

(2016) Sayantani Chowdhury et al.   FOOD AND CHEMICAL TOXICOLOGY

Fibrillar Amyloid-β Accumulation Triggers an Inflammatory Mechanism Leading to Hyperphosphorylation of the Carboxyl-Terminal End of Tau Polypeptide in the Hippocampal Formation of the 3×Tg-AD Transgenic Mouse

(2016) Miguel Ángel Ontiveros-Torres et al.   JOURNAL OF ALZHEIMERS DISEASE

Atorvastatin ameliorates cognitive impairment, Aβ1-42 production and Tau hyperphosphorylation in APP/PS1 transgenic mice

(2016) Dongsheng Zhou et al.   METABOLIC BRAIN DISEASE

GSK3β inhibition protects the immature brain from hypoxic-ischaemic insult via reduced STAT3 signalling

(2016) Barbara D'Angelo et al.   NEUROPHARMACOLOGY

Chronic hyperglycemia induced via the heterozygous knockout of Pdx1 worsens neuropathological lesion in an Alzheimer mouse model

(2016) Chuang Guo et al.   Scientific Reports

Leucettine L41, a DYRK1A-preferential DYRKs/CLKs inhibitor, prevents memory impairments and neurotoxicity induced by oligomeric Aβ25–35 peptide administration in mice

(2015) Gaëlle Naert et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Anandamide-induced endoplasmic reticulum stress and apoptosis are mediated by oxidative stress in non-melanoma skin cancer: Receptor-independent endocannabinoid signaling

(2015) Eman Soliman et al.   MOLECULAR CARCINOGENESIS

Insulin resistance-induced hyperglycemia decreased the activation of Akt/CREB in hippocampus neurons: Molecular evidence for mechanism of diabetes-induced cognitive dysfunction

(2015) Qiong Xiang et al.   NEUROPEPTIDES

Administration of NaHS Attenuates Footshock-Induced Pathologies and Emotional and Cognitive Dysfunction in Triple Transgenic Alzheimer’s Mice

(2015) Hei-Jen Huang et al.   Frontiers in Behavioral Neuroscience

Intracellular Accumulation of Amyloid-  (A ) Protein Plays a Major Role in A -Induced Alterations of Glutamatergic Synaptic Transmission and Plasticity

(2014) C. Ripoli et al.   JOURNAL OF NEUROSCIENCE

The GSK3 Signaling Pathway Is Activated by Cocaine and Is Critical for Cocaine Conditioned Reward in Mice

(2014) Jonathan S. Miller et al.   PLoS One

Impaired glycemia increases disease progression in mild cognitive impairment

(2013) Jill K. Morris et al.   NEUROBIOLOGY OF AGING

Exendin-4 Protected against Cognitive Dysfunction in Hyperglycemic Mice Receiving an Intrahippocampal Lipopolysaccharide Injection

(2012) Hei-Jen Huang et al.   PLoS One

Chronic Temporal Lobe Epilepsy Is Associated with Enhanced Alzheimer-Like Neuropathology in 3×Tg-AD Mice

(2012) Xiao-Xin Yan et al.   PLoS One

Endothelial Nitric Oxide Modulates Expression and Processing of Amyloid Precursor Protein

(2010) Susan A. Austin et al.   CIRCULATION RESEARCH

Genetic Targeting Aromatase in Male Amyloid Precursor Protein Transgenic Mice Down-Regulates  -Secretase (BACE1) and Prevents Alzheimer-Like Pathology and Cognitive Impairment

(2010) C. McAllister et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endogenous cannabinoid signaling is essential for stress adaptation

(2010) M. N. Hill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developmental consequences of perinatal cannabis exposure: behavioral and neuroendocrine effects in adult rodents

(2010) Patrizia Campolongo et al.   PSYCHOPHARMACOLOGY

Cannabinoids modulate hippocampal memory and plasticity

(2009) Hila Abush et al.   HIPPOCAMPUS

Neurobiology ofAlzheimer′s disease

(2009) E Mohandas et al.   Indian Journal of Psychiatry

Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM404 and cannabidiol in conditioned rats

(2008) Rafael M. Bitencourt et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats

(2008) Michelle Roche et al.   IMMUNOLOGY