Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 283, Issue -, Pages 24-33Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2018.11.009
Keywords
Magnetic resonance imaging (MRI); Voxel-based morphometry (VBM); Amplitude of low-frequency fluctuation (ALFF); Functional connectivity strength (FCS)
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Funding
- National Key R&D Program of China [2016YFC1307100, 2016YFC1306900]
- National Natural Science Foundation of China [81571310, 81630033, 81771447, 81471363]
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Schizophrenia (SZ) is a mental disorder that involves cerebral and cerebellar abnormalities. The cerebellum plays an indispensable role in the pathophysiology of SZ. However, individual studies pertaining to the structural and resting-state functional cerebellar abnormalities in patients with SZ have been inconsistent. To make a relatively robust conclusion with little interference, such as different disease episode times and antipsychotic treatment, we conducted this meta-analysis as a first attempt to comprehensively analyze and combine studies of voxel-based morphometry (VBM), amplitude of low-frequency fluctuation (ALFF), and functional connectivity strength (FCS) in first-episode and drug-naive SZ patients, employing the Seed-based d Mapping (SDM) method. Thirteen VBM studies, eight ALFF studies, and three FCS studies involving 783 patients and 704 matched healthy controls were included. Our results showed the presence of structural and functional abnormalities within the cerebellar regions, including most superior/anterior cerebellum (lobule III-V or VI) and posterior/inferior cerebellum (lobule VIII) related to motor function, and posterior cerebellum (lobule VIIa, Crus I, and II) associated with cognition and emotion, and such anomalies might be related to illness duration and clinical symptom severity.
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