Journal
ACTA DERMATO-VENEREOLOGICA
Volume 96, Issue 4, Pages 525-529Publisher
ACTA DERMATO-VENEREOLOGICA
DOI: 10.2340/00015555-2295
Keywords
complication; sequelae; Sjogren's syndrome; SJS; Stevens-Johnson syndrome; TEN; toxic epidermal necrolysis
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Funding
- National Taiwan University Hospital Hsin-Chu Branch [HCH103-025, HCH104-050]
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Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions characterized by different extents of epidermal necrosis and mucosal breakdown. A limited number of studies have reported the long-term patterns of SJS and TEN complications in patient populations over long follow-up periods. The aim of this retrospective study was to collect data on long-term sequelae in patients admitted for SJS, SJS/TEN overlap, or TEN between 1998 and 2012. Among all 102 patients eligible for analysis, the 2 most common sequelae were cutaneous and ocular problems, both with incidences of 44.1%. Visceral organ involvement was observed in 2 patients with irreversible deterioration of chronic kidney disease and in one patient with interstitial lung disease. Autoimmune disease was present in 6 patients: Sjogren's syndrome or Sjogren-like syndrome in 5 patients and concomitant systemic lupus erythematosus and Hashimoto thyroiditis in 1 patient.
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