Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain

ETV4 and AP1 Transcription Factors Form Multivalent Interactions with three Sites on the MED25 Activator-Interacting Domain

(2017) Simon L. Currie et al.   JOURNAL OF MOLECULAR BIOLOGY

Transcription factor Etv5 is essential for the maintenance of alveolar type II cells

(2017) Zhen Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pea3 Transcription Factors, Etv4 and Etv5, Are Required for Proper Hippocampal Dendrite Development and Plasticity

(2016) Paula Aldana Fontanet et al.   CEREBRAL CORTEX

β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1

(2015) Rowena Suriben et al.   CELL

Regulation of c-Maf and αA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling

(2015) Qing Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ets Factors Regulate Neural Stem Cell Depletion and Gliogenesis in Ras Pathway Glioma

(2015) Joshua J. Breunig et al.   Cell Reports

Phosphorylation of ETS1 by Src Family Kinases Prevents Its Recognition by the COP1 Tumor Suppressor

(2014) Gang Lu et al.   CANCER CELL

RAS/ERK Signaling Controls Proneural Genetic Programs in Cortical Development and Gliomagenesis

(2014) S. Li et al.   JOURNAL OF NEUROSCIENCE

A comparative encyclopedia of DNA elements in the mouse genome

(2014) Feng Yue et al.   NATURE

COP1 targets C/EBP  for degradation and induces acute myeloid leukemia via Trib1

(2013) A. Yoshida et al.   BLOOD

Traumatic scratch injury in astrocytes triggers calcium influx to activate the JNK/c-Jun/AP-1 pathway and switch on GFAP expression

(2013) Kai Gao et al.   GLIA

ERK Inhibition Rescues Defects in Fate Specification of Nf1-Deficient Neural Progenitors and Brain Abnormalities

(2012) Yuan Wang et al.   CELL

MEK Is a Key Regulator of Gliogenesis in the Developing Brain

(2012) Xiaoyan Li et al.   NEURON

Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation

(2012) A. Dey et al.   SCIENCE

The F-box protein Fbw7 is required for cerebellar development

(2011) Anett Jandke et al.   DEVELOPMENTAL BIOLOGY

Oncogenic ETS proteins mimic activated RAS/MAPK signaling in prostate cells

(2011) P. C. Hollenhorst et al.   GENES & DEVELOPMENT

Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice

(2011) Domenico Migliorini et al.   JOURNAL OF CLINICAL INVESTIGATION

COP1 is a tumour suppressor that causes degradation of ETS transcription factors

(2011) Alberto C. Vitari et al.   NATURE

Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding

(2010) K. Keeshan et al.   BLOOD

Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun

(2010) Joerg D Hoeck et al.   NATURE NEUROSCIENCE

Olig2 regulates Sox10 expression in oligodendrocyte precursors through an evolutionary conserved distal enhancer

(2010) M. Kuspert et al.   NUCLEIC ACIDS RESEARCH

Role of Fgf8 signalling in the specification of rostral Cajal-Retzius cells

(2009) Céline Zimmer et al.   DEVELOPMENT

FGF-Regulated Etv Genes Are Essential for Repressing Shh Expression in Mouse Limb Buds

(2009) Zhen Zhang et al.   DEVELOPMENTAL CELL

Autism genome-wide copy number variation reveals ubiquitin and neuronal genes

(2009) Joseph T. Glessner et al.   NATURE