Article
Medicine, Research & Experimental
Maha Ismail Mohammed Ali, Samar Imbaby, Horeya Erfan Korayem Arafat, Shymaa Ahmed Maher, Eman Kolieb, Shrouk Mohamed Ali
Summary: The aim of this study was to demonstrate the potential defensive function of venlafaxine (VLF) in cardiotoxicity and nephrotoxicity caused by cisplatin (CP) through modulation of ERK1/2 and NOX4 pathways. The results showed that VLF treatment reduced oxidative stress, inflammation, and apoptosis, thereby alleviating cardiac and renal damage caused by CP.
Article
Plant Sciences
Bo Chen, Jing-Pu Zhang
Summary: BBR can alleviate DOX-induced cardiotoxicity by balancing cardiomyocyte autophagy and apoptosis. It exhibits biphasic dose-response effects in response to DOX, and the protective effects are mediated by Bcl-xL.
Article
Cardiac & Cardiovascular Systems
Azza A. K. El-Sheikh, Zenat Khired
Summary: The study found that morphine may exacerbate CP-induced cardiotoxicity during cancer chemotherapy through oxidant, pro-inflammatory and apoptotic mechanisms, while also reducing the chemotherapeutic efficacy of CP.
CARDIOVASCULAR TOXICOLOGY
(2021)
Article
Multidisciplinary Sciences
Mahitab M. Nageeb, Sara F. Saadawy, Seba Hassan Attia
Summary: This study investigated the role of Breast Milk mesenchymal stem cells (Br-MSCs) in cisplatin-induced cardiotoxicity. The results showed that Br-MSCs treatment restored heart function and structure damaged by cisplatin injection, and exhibited antioxidant, anti-inflammatory, and anti-apoptotic effects. These effects were enhanced when combined with metformin.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Yasser A. Khadrawy, Eman N. Hosny, Mayada M. El-Gizawy, Hussein G. Sawie, Heba S. Aboul Ezz
Summary: Curcumin nanoparticles can alleviate the cardiotoxic effects induced by cisplatin, reduce oxidative stress and inflammation in cardiac tissue of rats.
CARDIOVASCULAR TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Chunmei Geng, Changmeng Cui, Changshui Wang, Shuxin Lu, Maokun Zhang, Dan Chen, Pei Jiang
Summary: This study systematically evaluated the toxicity of DOX in various tissues using gas chromatography-mass spectrometry. The results showed disturbed metabolites and pathways related to amino acid metabolism, energy metabolism, and lipid metabolism in serum, heart, liver, brain, and kidney. This information may help to elucidate the metabolic changes and underlying mechanisms of DOX-induced toxicity.
Article
Environmental Sciences
Reham M. Abd-Elsalam, Shymaa A. El Badawy, Hanan A. Ogaly, Faten M. Ibrahim, Ola M. Farag, Kawkab A. Ahmed
Summary: Eruca sativa seed extract (ESS) has a protective effect on acrylamide-induced hypogonadism in male rats, improving sperm quality, restoring testosterone level, and reducing testicular degeneration and cell death.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Fares E. M. Ali, Emad H. M. Hassanein, Omnia A. M. Abd El-Ghafar, Eman K. Rashwan, Fayez M. Saleh, Ahmed M. Atwa
Summary: This study demonstrates that canagliflozin has cardioprotective effects against cisplatin-induced heart toxicity by modulating multiple signaling pathways including iNOS/NF-kappa B, Nrf2, PI3K/AKT, and Bax/cytochrome C/Bcl-2.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Integrative & Complementary Medicine
Shih-Hao Wang, Kun-Ling Tsai, Wan-Ching Chou, Hui-Ching Cheng, Yu-Ting Huang, Hsiu-Chung Ou, Yun-Ching Chang
Summary: This study demonstrates that quercetin can protect against cisplatin-induced cardiotoxicity by reducing ROS-mediated mitochondrial damage and inflammation through the Nrf2/HO-1 and p38MAPK/NF-kappa Bp65/IL-8 signaling pathways. These findings provide a theoretical and experimental basis for the clinical application of quercetin as a new effective strategy to alleviate chemotherapy-induced cardiotoxicity.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Chemistry, Medicinal
Jing-Jing Xing, Xiao-Jie Mi, Jin-Gang Hou, En-Bo Cai, Si-Wen Zheng, Shi-Han Wang, Zi Wang, Chen Chen, Wei Li
Summary: Our current research aims to evaluate the efficiency of a flavor enhancer, maltol, in protecting against cisplatin-induced cardiotoxicity. In both animal and cell models, maltol was found to effectively suppress cardiac damage caused by cisplatin by inhibiting the activation of the PI3K/Akt signaling pathways, reducing oxidative stress, and alleviating apoptosis.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ilter Ilhan, Halil Asci, Nursel Hasseyid, Hatice Kubra Dogan, Serife Agirca, Melike Altintas, Muhammet Yusuf Tepebasi
Summary: This study aimed to evaluate the renoprotective effects of Irbesartan on cisplatin-induced acute kidney injury. The results showed that Irbesartan exerted anti-inflammatory and antioxidant activity by inhibiting mitochondrial stress, leading to significant regression of kidney damage.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Jiazhan Mei, Guiju Liu, Ruijun Li, Peng Xiao, Dan Yang, Hua Bai, Yibin Hao
Summary: The study revealed that lncRNA SNHG6 has inhibitory effects on DDP resistance and progression of GC by sponging miR-1297 and regulating BCL-2 expression.
BIOSCIENCE REPORTS
(2021)
Article
Veterinary Sciences
Tarek Kamal Abouzed, Eman Abd Elrahman Sherif, Mohamed El Sayed Barakat, Kadry Mohamed Sadek, Adil Aldhahrani, Nasr Elsayed Nasr, Ehab Eldomany, Khaled Khailo, Doaa Abdallha Dorghamm
Summary: This experiment identified early signs of nephrotoxicity induced by gentamicin and cisplatin in rats, with cisplatin showing greater nephrotoxic effects compared to gentamicin. The study suggests the use of necrotic, apoptotic genes as early biomarkers in detecting kidney damage, and recommends caution when co-administering cisplatin with gentamicin.
BMC VETERINARY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Petra Gorombei, Fabien Guidez, Saravanan Ganesan, Mathieu Chiquet, Andrea Pellagatti, Laure Goursaud, Nilgun Tekin, Stephanie Beurlet, Satyananda Patel, Laura Guerenne, Carole Le Pogam, Niclas Setterblad, Pierre de la Grange, Christophe LeBoeuf, Anne Janin, Maria-Elena Noguera, Laure Sarda-Mantel, Pascale Merlet, Jacqueline Boultwood, Marina Konopleva, Michael Andreeff, Robert West, Marika Pla, Lionel Ades, Pierre Fenaux, Patricia Krief, Christine Chomienne, Nader Omidvar, Rose Ann Padua
Summary: The study demonstrates that the BCL-2 inhibitor ABT-737 significantly extends survival in the high-risk MDS mouse model and reduces bone marrow blasts and LSK cells, providing new insights into the treatment of MDS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Fisheries
Xiaochen Fang, Bidan Liang, Haiying Liang, Jinzhao Lu
Summary: This study aims to reduce immune response in pearl oysters for improved pearl production. Bcl-2 family genes were found to play a crucial role in the immune response process. The cloned genes PmBak and PmBcl-2 showed different expression patterns in various tissues and developmental stages, and they interacted with each other to influence the apoptotic pathway in cells. This research provides insight into the mechanism of the Bcl-2 family genes in the immune response of pearl oysters.
Letter
Dermatology
Gulhan Gurel, Cigdem Ozdemir, Irem Nur Durusu
DERMATOLOGIC THERAPY
(2022)
Article
Neurosciences
I. H. Sever, B. Ozkul, M. F. Bozkurt, O. Erbas
Summary: In this study, it was found that finasteride significantly improved autism-like symptoms, exhibited antioxidant effects, and regulated Nrf2 through its anti-androgen effect. This study provides new insights for the treatment of autism.
NEUROSCIENCE LETTERS
(2022)
Letter
Medicine, General & Internal
Merve Sahin, Gozde Kurtulus, Cigdem Ozdemir, Mustafa Karalar
CUKUROVA MEDICAL JOURNAL
(2022)
Article
Cell Biology
Bahar Kartal, Mehmet Fatih Bozkurt, Ebru Alimogullari, Uygar Sacik
Summary: This study found that treatment with erythropoietin can effectively improve the histopathological changes caused by ovarian torsion-detorsion injury and reduce cell apoptosis.
JOURNAL OF HISTOTECHNOLOGY
(2023)
Article
Developmental Biology
Mumin Alper Erdogan, Mehmet Fatih Bozkurt, Oytun Erbas
Summary: Prenatal testosterone exposure may lead to autistic behaviors by altering serotonin, dopamine, IGF-1, and oxytocin levels, as shown in this study.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Cigdem Ozdemir, Selcuk Kuzu, Yigit Senol, Tuba Yigit, Erol Guldun, Abdulkadir Bucak, Sahin Ulu, Cigdem Tokyol
Summary: This study aimed to evaluate the effects and relationships between mast cells, mast cell enzymes tryptase and chymase, epithelial proliferation, microvascular density, and bone destruction in cholesteatoma. The results showed that cholesteatoma had higher Ki-67 expression, CD117-positive mast cells, chymase-positive mast cells, tryptase-positive mast cells, and microvessel density compared to the control group. There was a positive correlation between CD117 and chymase, tryptase, and microvessel density, as well as between tryptase, chymase, and microvessel density, and chymase and microvessel density. CD117-positive mast cells and chymase-positive mast cells were found to stimulate angiogenesis and increase epithelial proliferation in the cholesteatoma matrix, leading to bone erosion.
Article
Chemistry, Multidisciplinary
Mehmet Fatih Bozkurt, Guennur Pesmen
Summary: The effect of in ovo injection of sodium borate on hatching power, chick weight, and chick length in fertile broiler eggs was investigated. The study involved 256 incubated fertile broiler eggs. The results showed that in ovo injection of sodium borate (0.5 mg) significantly increased hatching power, while there was no significant difference between the groups in terms of chick weights. However, a significant difference in chick length was observed between group B and other experimental groups. In ovo sodium borate injection (0.5 mg) had a positive effect on villus length, crypt width, villus absorption surface, and the number of proliferating cell nuclear antigen positive crypt cells.
Correction
Biology
Ömer Hazman, Mehmet Fatih Bozkurt, Zehra Betül Kumral, Mehmet Savrik, Bobur Sindarov, Muhammad Nasir Bhaya, Ahmet Buyukben
Article
Biology
Omer Hazman, Mehmet Fatih Bozkurt, Zehra Betul Kumral, Mehmet Savrik, Bobur Sindarov, Muhammad Nasir Bhaya, Ahmet Buyukben
Summary: This study investigated the effects of beta-escin, a component of the horse chestnut plant, on oxidative stress, inflammation, and islet cells in type 2 diabetes. The results showed that beta-escin can improve beta cell function by inhibiting apoptosis and increasing insulin synthesis, as well as reduce inflammation.
Article
Medicine, General & Internal
Sinan Kazan, Onur Tunca, Elif Dizen Kazan, Cigdem Ozdemir, Sumeyra Koyuncu, Hulya Akgun
Summary: This study compares the clinicopathologic features of idiopathic IgA nephropathy in relation to serum gamma-glutamyl trans-ferase (GGT) levels. The results indicate that GGT levels are significantly associated with mesangial cellularity, segmental glomerulosclerosis, tubular atrophy, serum albumin, and 24-hour proteinuria in IgA nephropathy patients.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2022)
Article
Pharmacology & Pharmacy
Mehmet Fatih Bozkurt, Muhammad Nasir Bhayal, Ibrahim Halil Severe, Bahattin Ozku, Oytun Erbas
Summary: This study evaluated the protective effect of medroxyprogesterone acetate on propionic acid-induced autism in rats. The results showed significant improvements in biochemical analysis, histopathological examination, immunohistochemical examination, and magnetic resonance spectroscopy in the medroxyprogesterone-treated group.
BANGLADESH JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Ali Gurel, Hasan Aydin, Alper Yalcin, Erkan Yilmaz, Ahmet Turk, Tuba Ozcan Metin, Ebru Balli, Ibrahim Seyfettin Celik, Mehmet Fatih Bozkurt, Hikmet Keles
Summary: This study aimed to investigate the protective effects of antioxidant compounds of cinnamon spice on Doxorubicin (DOX)-induced nephropathy. The results showed that concurrent administration of cinnamon significantly reversed DOX-induced kidney damage.
ANALYTICAL AND QUANTITATIVE CYTOPATHOLOGY AND HISTOPATHOLOGY
(2022)
Article
Veterinary Sciences
Mehmet Fatih Bozkurt, Fatma Cansiz
Summary: Gastric tumors in dogs are highly malignant and are not common, but are more likely to occur in dogs aged 10 and older. Although the cause of the disease is not well known, there may be some predisposing factors. A mass in the stomach of a 10-year-old female golden retriever dog, presented with nonspecific gastrointestinal disease, was detected through endoscopic examination. Cytological and histopathological examinations confirmed the diagnosis of gastric signet-ring cell carcinoma, using a biopsy taken from the lesion during endoscopy.
ACTA VETERINARIA EURASIA
(2022)
Article
Medicine, General & Internal
Alptekin Kucuk, Hacer Demir, Cigdem Ozdemir, Ismail Beypinar, Meltem Baykare, Dagistan Tolga Arioz
Summary: This study aimed to evaluate the frequency of MSI in endometrial cancer and its relationship with prognostic parameters and inflammatory indexes. The results showed that the frequency of MSI in endometrial cancer patients was 28.3%. The study concluded that MSI status does not affect the prognosis of endometrial cancer, but it has important predictive implications.
ANNALS OF CLINICAL AND ANALYTICAL MEDICINE
(2022)
Article
Surgery
Mehmet Fatih Bozkurt, Muhammed Nasir Bhaya, Cengiz Dibekoglu, Ayberk Akat, Utku Ates, Oytun Erbas
Summary: This study evaluated the therapeutic effect of MSCs on acetic acid-induced colitis model, showing that MSCs have a significant ameliorative effect in rats via the Nrf2/HO-1 pathway.
ACTA CIRURGICA BRASILEIRA
(2022)
