Pharmacological interventions for non-alcoholic fatty liver disease: a systematic review and network meta-analysis

Nonalcoholic Fatty Liver Disease and Risk of Incident Type 2 Diabetes: A Meta-analysis

(2018) Alessandro Mantovani et al.   DIABETES CARE

Short article

(2017) Xiao-Long Deng et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

Effects of Probiotics on Nonalcoholic Fatty Liver Disease in Obese Children and Adolescents

(2017) Fatemeh Famouri et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

NASPGHAN Clinical Practice Guideline for the Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease in Children

(2017) Miriam B. Vos et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

A randomised controlled trial of losartan as an anti-fibrotic agent in non-alcoholic steatohepatitis

(2017) Stuart McPherson et al.   PLoS One

Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial

(2017) Tisha R Joy et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Randomized trial comparing the effects of gliclazide, liraglutide, and metformin on diabetes with non-alcoholic fatty liver disease

(2017) Wenhuan Feng et al.   Journal of Diabetes

Prevalence of non-alcoholic fatty liver disease and risk factors for advanced fibrosis and mortality in the United States

(2017) Michael H. Le et al.   PLoS One

Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus

(2016) Kenneth Cusi et al.   ANNALS OF INTERNAL MEDICINE

Omega-3 polyunsaturated fatty acids in treating non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled trial

(2016) Monize Aydar Nogueira et al.   CLINICAL NUTRITION

Epidemiology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in the United States and the Rest of the World

(2016) Mehmet Sayiner et al.   Clinics in Liver Disease

Conjugated linoleic acid improves glycemic response, lipid profile, and oxidative stress in obese patients with non-alcoholic fatty liver disease: a randomized controlled clinical trial

(2016) Mehrangiz Ebrahimi-Mameghani et al.   CROATIAN MEDICAL JOURNAL

Global Epidemiology of Nonalcoholic Fatty Liver Disease and Perspectives on US Minority Populations

(2016) Zaki A. Sherif et al.   DIGESTIVE DISEASES AND SCIENCES

Perspectives on Treatment for Nonalcoholic Steatohepatitis

(2016) Guillaume Lassailly et al.   GASTROENTEROLOGY

Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

(2016) Vlad Ratziu et al.   GASTROENTEROLOGY

EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

(2016)   JOURNAL OF HEPATOLOGY

Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial

(2016) Jeffrey Cui et al.   JOURNAL OF HEPATOLOGY

Do symbiotic and Vitamin E supplementation have favorite effects in nonalcoholic fatty liver disease? A randomized, double-blind, placebo-controlled trial

(2016) Farzad Shidfar et al.   Journal of Research in Medical Sciences

Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study

(2016) Matthew James Armstrong et al.   LANCET

Placebo-controlled, randomised clinical trial: high-dose resveratrol treatment for non-alcoholic fatty liver disease

(2016) Sara Heebøll et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Effects of Omega-3 Fatty Acid in Nonalcoholic Fatty Liver Disease: A Meta-Analysis

(2016) Wenxia Lu et al.   Gastroenterology Research and Practice

An open-label randomized control study to compare the efficacy of vitamin e versus ursodeoxycholic acid in nondiabetic and noncirrhotic Indian NAFLD patients

(2016) Pathik Parikh et al.   Saudi Journal of Gastroenterology

Effect of telmisartan on histological activity and fibrosis of non-alcoholic steatohepatitis: A 1-year randomized control trial

(2016) Shahinul Alam et al.   Saudi Journal of Gastroenterology

Effectiveness of Omega-3 Polyunsaturated Fatty Acids in Non-Alcoholic Fatty Liver Disease: A Meta-Analysis of Randomized Controlled Trials

(2016) Xi-Xi He et al.   PLoS One

Docosahexanoic Acid Plus Vitamin D Treatment Improves Features of NAFLD in Children with Serum Vitamin D Deficiency: Results from a Single Centre Trial

(2016) Claudia Della Corte et al.   PLoS One

The PRISMA Extension Statement for Reporting of Systematic Reviews Incorporating Network Meta-analyses of Health Care Interventions: Checklist and Explanations

(2015) Brian Hutton et al.   ANNALS OF INTERNAL MEDICINE

Ranking treatments in frequentist network meta-analysis works without resampling methods

(2015) Gerta Rücker et al.   BMC Medical Research Methodology

Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: A randomized controlled trial

(2015) Shihui Chen et al.   DIGESTIVE AND LIVER DISEASE

Effects of Pentoxifylline on Non-Alcoholic Steatohepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial in Iran

(2015) Nadieh Baniasadi et al.   Hepatitis Monthly

Comparative effectiveness of pharmacological interventions for nonalcoholic steatohepatitis: A systematic review and network meta-analysis

(2015) Siddharth Singh et al.   HEPATOLOGY

Ezetimibe for the treatment of nonalcoholic steatohepatitis: Assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial)

(2015) Rohit Loomba et al.   HEPATOLOGY

Comparative clinical study between the effect of fenofibrate alone and its combination with pentoxifylline on biochemical parameters and liver stiffness in patients with non-alcoholic fatty liver disease

(2015) Sahar Mohamed El-Haggar et al.   Hepatology International

Double-blind Randomized Placebo-controlled Clinical Trial of Omega 3 Fatty Acids for the Treatment of Diabetic Patients With Nonalcoholic Steatohepatitis

(2015) Srinivasan Dasarathy et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Effects of n-3 fish oil on metabolic and histological parameters in NASH: A double-blind, randomized, placebo-controlled trial

(2015) Curtis K. Argo et al.   JOURNAL OF HEPATOLOGY

Omega-3 Fatty Acids Therapy in Children with Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial

(2015) Wojciech Janczyk et al.   JOURNAL OF PEDIATRICS

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

A double-blind, placebo-controlled randomized trial to evaluate the efficacy of docosahexaenoic acid supplementation on hepatic fat and associated cardiovascular risk factors in overweight children with nonalcoholic fatty liver disease

(2015) L. Pacifico et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Efficacy of poly-unsaturated fatty acid therapy on patients with nonalcoholic steatohepatitis

(2015) Yun-Hua Li et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Long-Term Treatment with n-3 Polyunsaturated Fatty Acids as a Monotherapy in Children with Nonalcoholic Fatty Liver Disease

(2015) Mehmet Boyraz et al.   Journal of Clinical Research in Pediatric Endocrinology

Fish Oil Supplements Lower Serum Lipids and Glucose in Correlation with a Reduction in Plasma Fibroblast Growth Factor 21 and Prostaglandin E2 in Nonalcoholic Fatty Liver Disease Associated with Hyperlipidemia: A Randomized Clinical Trial

(2015) Yu Qin et al.   PLoS One

Randomised clinical trial: the beneficial effects of VSL#3 in obese children with non-alcoholic steatohepatitis

(2014) A. Alisi et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Synbiotic supplementation in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled pilot study

(2014) Tannaz Eslamparast et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Resveratrol Does Not Benefit Patients With Nonalcoholic Fatty Liver Disease

(2014) Veronique S. Chachay et al.   Clinical Gastroenterology and Hepatology

The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial

(2014) Yumie Takeshita et al.   DIABETOLOGIA

No Significant Effects of Ethyl-Eicosapentanoic Acid on Histologic Features of Nonalcoholic Steatohepatitis in a Phase 2 Trial

(2014) Arun J. Sanyal et al.   GASTROENTEROLOGY

Effects of purified eicosapentaenoic and docosahexaenoic acids in nonalcoholic fatty liver disease: Results from the WELCOME* study

(2014) Eleonora Scorletti et al.   HEPATOLOGY

Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease

(2014) Forouzan Faghihzadeh et al.   NUTRITION RESEARCH

Management of nonalcoholic fatty liver disease: An evidence-based clinical practice review

(2014) Juan P Arab   WORLD JOURNAL OF GASTROENTEROLOGY

Randomized, Vitamin E-Controlled Trial of Bicyclol Plus Metformin in Non-Alcoholic Fatty Liver Disease Patients with Impaired Fasting Glucose

(2013) Ying Han et al.   CLINICAL DRUG INVESTIGATION

Cholic acid for hepatic steatosis in patients with lipodystrophy: a randomized, controlled trial

(2013) Zahid Ahmad et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

(2013) Sunder Mudaliar et al.   GASTROENTEROLOGY

The Effect of Pioglitazone and Metformin on Liver Function Tests, Insulin Resistance, and Liver Fat Content in Nonalcoholic Fatty Liver Disease: A Randomized Double Blinded Clinical Trial

(2013) Mohsen Razavizade et al.   Hepatitis Monthly

Effect of Telmisartan or Losartan for Treatment of Nonalcoholic Fatty Liver Disease: Fatty Liver Protection Trial by Telmisartan or Losartan Study (FANTASY)

(2013) Takumi Hirata et al.   International Journal of Endocrinology

Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: A randomized controlled trial

(2012) Carmela Loguercio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of Metformin, Pioglitazone, and Silymarin Treatment on Non- Alcoholic Fatty Liver Disease: A Randomized Controlled Pilot Study

(2012) Ali Akbar Hajiaghamohammadi et al.   Hepatitis Monthly

Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: A randomized controlled trial

(2012) Thuy-Anh Le et al.   HEPATOLOGY

Impact of combined therapy with alpha-lipoic and ursodeoxycolic acid on nonalcoholic fatty liver disease: double-blind, randomized clinical trial of efficacy and safety

(2012) Vincenzo Gianturco et al.   Hepatology International

Indirect and mixed-treatment comparison, network, or multiple-treatments meta-analysis: many names, many benefits, many concerns for the next generation evidence synthesis tool

(2012) Georgia Salanti   Research Synthesis Methods

Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults

(2011) G. Vernon et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trial

(2011) V. Nobili et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Telmisartan, a dual ARB/partial PPAR-γ agonist, protects myocardium from ischaemic reperfusion injury in experimental diabetes

(2011) S. N. Goyal et al.   DIABETES OBESITY & METABOLISM

Bifidobacterium longum with Fructo-Oligosaccharides in Patients with Non Alcoholic Steatohepatitis

(2011) Michele Malaguarnera et al.   DIGESTIVE DISEASES AND SCIENCES

Pentoxifylline improves nonalcoholic steatohepatitis: A randomized placebo-controlled trial

(2011) Claudia O. Zein et al.   HEPATOLOGY

Rosiglitazone versus rosiglitazone and metformin versus rosiglitazone and losartan in the treatment of nonalcoholic steatohepatitis in humans: A 12-month randomized, prospective, open- label trial

(2011) Dawn M. Torres et al.   HEPATOLOGY

Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents

(2011) Joel E. Lavine   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effects of Lactobacillus rhamnosus Strain GG in Pediatric Obesity-related Liver Disease

(2011) Pietro Vajro et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Treatment with insulin sensitizer metformin improves arterial properties, metabolic parameters, and liver function in patients with nonalcoholic fatty liver disease: a randomized, placebo-controlled trial

(2011) Elena Sofer et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Atorvastatin and Antioxidants for the Treatment of Nonalcoholic Fatty Liver Disease: The St Francis Heart Study Randomized Clinical Trial

(2010) Temitope Foster et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

l-Carnitine Supplementation to Diet: A New Tool in Treatment of Nonalcoholic Steatohepatitis—A Randomized and Controlled Clinical Trial

(2010) Mariano Malaguarnera et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: a double-blind, randomized, placebo-controlled trial

(2010) Ulrich F. H. Leuschner et al.   HEPATOLOGY

Effects of a 1-year dietary intervention with n-3 polyunsaturated fatty acid-enriched olive oil on non-alcoholic fatty liver disease patients: a preliminary study

(2010) Francesco Sofi et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Metformin versus dietary treatment in nonalcoholic hepatic steatosis: a randomized study

(2010) G A Garinis et al.   INTERNATIONAL JOURNAL OF OBESITY

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy of insulin-sensitizing agents in nonalcoholic fatty liver disease

(2009) Ziya Omer et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Metformin plus pentoxifylline versus prescriptive diet in non-alcoholic steatohepatitis (NASH): A randomized controlled pilot trial

(2009) N. Sturm et al.   GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE

Betaine for nonalcoholic fatty liver disease: Results of a randomized placebo-controlled trial

(2009) Manal F. Abdelmalek et al.   HEPATOLOGY

A Pilot Study Using Simvastatin in the Treatment of Nonalcoholic Steatohepatitis

(2009) Austin Nelson et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Effects of ursodeoxycholic acid in combination with vitamin E on adipokines and apoptosis in patients with nonalcoholic steatohepatitis

(2009) Maria Luisa Balmer et al.   LIVER INTERNATIONAL

Metformin in patients with non-alcoholic fatty liver disease: A randomized, controlled trial

(2009) John Willy Haukeland et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

The effect of metformin and standard therapy versus standard therapy alone in nondiabetic patients with insulin resistance and nonalcoholic steatohepatitis (NASH): a pilot trial

(2009) William W. Shields et al.   Therapeutic Advances in Gastroenterology

The effect of metformin on leptin in obese patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease

(2008) A. Nar et al.   ACTA DIABETOLOGICA

Clinical trial: insulin-sensitizing agents may reduce consequences of insulin resistance in individuals with non-alcoholic steatohepatitis

(2008) R. IDILMAN et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Rosiglitazone for Nonalcoholic Steatohepatitis: One-Year Results of the Randomized Placebo-Controlled Fatty Liver Improvement With Rosiglitazone Therapy (FLIRT) Trial

(2008) Vlad Ratziu et al.   GASTROENTEROLOGY

Randomized, Placebo-Controlled Trial of Pioglitazone in Nondiabetic Subjects With Nonalcoholic Steatohepatitis

(2008) Guruprasad P. Aithal et al.   GASTROENTEROLOGY

Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: A randomized, controlled trial

(2008) Valerio Nobili et al.   HEPATOLOGY

Orlistat for overweight subjects with nonalcoholic steatohepatitis: A randomized, prospective trial

(2008) Stephen A. Harrison et al.   HEPATOLOGY

A randomized controlled pilot study of Pentoxifylline in patients with non-alcoholic steatohepatitis (NASH)

(2008) Yin-Mei Lee et al.   Hepatology International

Treatment of non-alcoholic fatty liver disease with metformin versus lifestyle intervention in insulin-resistant adolescents

(2008) Kristen J Nadeau et al.   PEDIATRIC DIABETES

Effects of n-3 polyunsaturated fatty acids from seal oils on nonalcoholic fatty liver disease associated with hyperlipidemia

(2008) Feng-Shang Zhu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Effects of n-3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease

(2007) L. Spadaro et al.   DIGESTIVE AND LIVER DISEASE