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Multidisciplinary Sciences
Farhana Yesmin, Keiko Furukawa, Mariko Kambe, Yuhsuke Ohmi, Robiul Hasan Bhuiyan, Mohammad Abul Hasnat, Momoka Mizutani, Orie Tajima, Noboru Hashimoto, Akiko Tsuchida, Kei Kaneko, Koichi Furukawa
Summary: Exosomes, small extracellular vesicles, play significant roles in cell-to-cell communication and have been extensively studied for their contents, generation mechanisms, and functions. However, the presence and roles of glycans, especially glycosphingolipids, in exosomes have been rarely reported. This study investigated the expression and function of the cancer-associated ganglioside GD2 in malignant melanomas. The results showed that GD2-expressing melanoma-derived exosomes enhanced the malignant phenotypes of GD2-negative melanomas and induced increased phosphorylation of signaling molecules.
SCIENTIFIC REPORTS
(2023)
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Cell Biology
Joanna P. Wroblewska, Dora Dias-Santagata, Adam Ustaszewski, Cheng-Lin Wu, Masakazu Fujimoto, M. Angelica Selim, Wojciech Biernat, Janusz Rys, Andrzej Marszalek, Mai P. Hoang
Summary: The NRAS mutation is an independent predictor of worse survival in mucosal melanomas, while the significance of other related mutations remains unclear.
Review
Biochemistry & Molecular Biology
Yijia Xu, Jianfang Sun, Liying Yang, Shangfeng Zhao, Xin Liu, Yang Su, Jinghai Zhang, Mingyi Zhao
Summary: Gangliosides are crucial components of neuronal cell membranes, playing a vital role in neuronal and brain development. They are involved in neurotransmission and considered as the structural foundation of learning and memory. Gangliosides also participate in various physiological processes, including cell differentiation, cell signaling, neuroprotection, nerve regeneration, and cell apoptosis. The regulation of ion concentration by gangliosides is important in neurological diseases, highlighting their role in neuronal excitability and synaptic transmission. Therefore, understanding the role of gangliosides in maintaining ion concentration homeostasis is essential for their potential use as drugs for treating nervous system diseases.
NEUROCHEMICAL RESEARCH
(2022)
Article
Veterinary Sciences
Sara Saellstrom, Arian Sadeghi, Emma Eriksson, Thomas Segall, Maria Dimopoulou, Olle Korsgren, Angelica SI. Loskog, Thomas H. Totterman, Akseli Hemminki, Henrik Ronnberg
Summary: Local AdCD40L therapy in dogs with melanoma showed infiltration of T and B lymphocytes in tumor tissue post treatment, suggesting immune stimulation. The best overall response included 7 complete responses, 5 partial responses, 5 stable, and 2 progressive disease statuses based on immunotherapy results.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Zhenwang Zhang, Mengxi Li, Tian Sun, Zhengrong Zhang, Chao Liu
Summary: Forkhead box (FOX) proteins, including FOXM1, play significant roles in metabolism, aging, immune regulation, development, and diseases in mammals. These proteins regulate gene expression and interact with various co-regulators. Recent studies aim to translate these findings into clinical applications for improving quality of life, targeting conditions such as diabetes, inflammation, and pulmonary fibrosis. Further research is needed to fully understand the role of FOXM1 in human diseases and its involvement in multiple signaling pathways.
Review
Cell Biology
Hiroyuki Suzuki, Mika K. Kaneko, Yukinari Kato
Summary: Podoplanin plays a critical role in tumor development and normal development of various organs. It is overexpressed in tumors and influences platelet aggregation and signal transductions, thereby contributing to the malignant progression of tumors. Additionally, in the tumor microenvironment, Podoplanin expression is upregulated in the tumor stroma and immune cells, implicating its involvement in tumor development and immune evasion.
Review
Cell Biology
Ying-Chen Cheng, Yu-An Chang, Yi-Jen Chen, Hsu-Min Sung, Ivan Bogeski, Hong-Lin Su, Ya-Ling Hsu, Hui-Min David Wang
Summary: Different types of cells release extracellular vesicles (EVs) in the tumor microenvironment, affecting tumor growth, progression, and immune response. Recent studies have explored the potential application of EVs in cancer treatment. This review summarizes the mechanisms by which EVs regulate melanoma development and progression, and their potential use in therapy.
Review
Oncology
Shusen Zhang, Zhigang Cai, Hui Li
Summary: The AHNAK family, consisting of AHNAK and AHNAK2, plays a crucial role in regulating various biological functions, including calcium channel modulation and membrane repair. Recent studies have shown that AHNAK family members have important regulatory roles in tumor progression and prognosis in multiple types of cancers. They activate signaling pathways and promote epithelial-mesenchymal transition to regulate tumor progression.
FRONTIERS IN ONCOLOGY
(2023)
Review
Medicine, Research & Experimental
Guohuan Sun, Quan Gu, Junke Zheng, Hui Cheng, Tao Cheng
Summary: Hematopoietic stem cells rely on a regulated microenvironment for normal blood production, but leukemia cells disrupt this environment to promote their own survival, leading to impaired hematopoiesis. Understanding the functions of extracellular vesicles and their potential clinical applications in hematologic malignancies is crucial.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Medicine, Research & Experimental
Guohuan Sun, Quan Gu, Junke Zheng, Hui Cheng, Tao Cheng
Summary: Leukemia cells disrupt normal hematopoiesis by remodeling the microenvironment, while extracellular vesicles (EVs) play a crucial role in intercellular communication and can serve as potential therapeutic targets. The focus of research lies in the biological molecules contained in EVs and the behavioral alterations they induce in recipient cells.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cell Biology
Fernanda S. O. Campos, Felipe M. Pina-Rodrigues, Alice Reis, Georgia C. Atella, Claudia S. Mermelstein, Silvana Allodi, Leny A. Cavalcante
Summary: OEC migration is sensitive to ganglioside blockage through specific antibodies, indicating the involvement of gangliosides in cell migration. The lipid rafts of OECs are enriched in cholesterol, sphingolipids, specific proteins, and gangliosides, suggesting a role for membrane lipid rafts in OEC migration and providing new insights into the molecular composition of OEC membrane microdomains.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jiange Qiu, Qianqian Li, Junqi Li, Fengmei Zhou, Peng Sang, Zhongkun Xia, Wei Wang, Lin Wang, Ying Yu, Jianxiong Jiang
Summary: The expression of EP2 and EP4 receptors is upregulated in human gliomas, and they are highly correlated with tumor-promoting cytokines, chemokines, and growth factors. These receptors are heterogeneously expressed in human GBM cells and play a role in promoting colony formation, cell invasion, and migration through PGE(2)-mediated cAMP signaling. Inhibition of EP2 and EP4 receptors may have compensatory effects in GBM development and growth.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Liam J. Peck, Ryan Patel, Paula Diaz, Yolanda M. Wintle, Anthony H. Dickenson, Andrew J. Todd, Margarita Calvo, David L. H. Bennett
Summary: The study looked at the expression of Kv1.6 in sensory neurons and its role in pain sensitivity, comparing two mouse models of constitutive Kv1.6 knock-out achieved by different methods. The results showed unexpected reductions in sensitivity to noxious heat stimuli in both mouse lines, with a more significant hyposensitivity in the gene trap model.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
Milica Jovisic, Nurbek Mambetsariev, Benjamin D. Singer, Luisa Morales-Nebreda
Summary: Acute respiratory infections trigger an immune response that can lead to tissue damage and impaired pulmonary function. CD4+FOXP3+ regulatory T cells (Tregs) play a critical role in limiting inflammation and promoting lung tissue repair. This review explores the mechanisms by which Tregs promote resolution of inflammation and repair of acute lung injury, and discusses the potential use of Tregs as cellular therapy for severe acute respiratory infections.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Medicine, Research & Experimental
Liuyi Yang, Sen Yang, Congcong Ren, Shihua Liu, Xiaopei Zhang, Aixia Sui
Summary: MiR-16-5p plays a significant role in tumors, exhibiting anti-tumor functions, and may serve as a target for novel anticancer therapies and a biomarker for early tumor detection.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Yusuke Makino, Kazunori Hamamura, Yoshifumi Takei, Robiul Hasan Bhuiyan, Yuki Ohkawa, Yuhsuke Ohmi, Hideyuki Nakashima, Keiko Furukawa, Koichi Furukawa
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2016)
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Pharmacology & Pharmacy
Kenjiro Tanaka, Takao Hirai, Daisuke Kodama, Hisataka Kondo, Kazunori Hamamura, Akifumi Togari
BRITISH JOURNAL OF PHARMACOLOGY
(2016)
Article
Pharmacology & Pharmacy
Shinya Takigawa, Brian Frondorf, Shengzhi Liu, Yang Liu, Baiyan Li, Akihiro Sudo, Joseph M. Wallace, Hiroki Yokota, Kazunori Hamamura
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2016)
Article
Biochemistry & Molecular Biology
Daisuke Kodama, Takao Hirai, Hisataka Kondo, Kazunori Hamamura, Akifumi Togari
Article
Dentistry, Oral Surgery & Medicine
Hironori Mori, Kazunori Hamamura, Shoyoku Yo, Kosuke Hamajima, Kenji Ootani, Masaki Honda, Kyoko Ishizuka, Hisataka Kondo, Kenjiro Tanaka, Daisuke Kodama, Takao Hirai, Ken Miyazawa, Shigemi Goto, Akifumi Togari
JOURNAL OF ORAL SCIENCE
(2018)
Article
Multidisciplinary Sciences
Andy Chen, Luqi Wang, Bai-Yan Li, Jesse Sherman, Jong E. Ryu, Kazunori Hamamura, Yunlong Liu, Harikrishna Nakshatri, Hiroki Yokota
SCIENTIFIC REPORTS
(2017)
Review
Oncology
Koichi Furukawa, Yuhsuke Ohmi, Yuki Ohkawa, Robiul H. Bhuiyan, Pu Zhang, Orie Tajima, Noboru Hashimoto, Kazunori Hamamura, Keiko Furukawa
Article
Medicine, Research & Experimental
Kenjiro Tanaka, Hisataka Kondo, Kazunori Hamamura, Akifumi Togari
Article
Biochemistry & Molecular Biology
Shoyoku Yo, Kazunori Hamamura, Yoshitaka Mishima, Kosuke Hamajima, Hironori Mori, Koichi Furukawa, Hisataka Kondo, Kenjiro Tanaka, Takuma Sato, Ken Miyazawa, Shigemi Goto, Akifumi Togari
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Kazunori Hamamura, Kosuke Hamajima, Shoyoku Yo, Yoshitaka Mishima, Koichi Furukawa, Makoto Uchikawa, Yuji Kondo, Hironori Mori, Hisataka Kondo, Kenjiro Tanaka, Ken Miyazawa, Shigemi Goto, Akifumi Togari
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Farhana Yesmin, Robiul H. Bhuiyan, Yuhsuke Ohmi, Satoko Yamamoto, Kei Kaneko, Yuki Ohkawa, Pu Zhang, Kazunori Hamamura, Nai-Kong V. Cheung, Norihiro Kotani, Koichi Honke, Tetsuya Okajima, Mariko Kambe, Orie Tajima, Keiko Furukawa, Koichi Furukawa
Summary: GD2 and integrin beta 1 physically associate in the microdomain of the cell membrane, leading to enhanced malignant phenotypes of melanoma cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Kosuke Hamajima, Kazunori Hamamura, Andy Chen, Hiroki Yokota, Hironori Mori, Shoyoku Yo, Hisataka Kondo, Kenjiro Tanaka, Kyoko Ishizuka, Daisuke Kodama, Takao Hirai, Ken Miyazawa, Shigemi Goto, Akifumi Togari
BIOMEDICAL REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Shinya Takigawa, Andy Chen, Akinobu Nishimura, Shengzhi Liu, Bai-Yan Li, Akihiro Sudo, Hiroki Yokota, Kazunori Hamamura
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2016)
Article
Biochemistry & Molecular Biology
Shinya Takigawa, Andy Chen, Qiaoqiao Wan, Sungsoo Na, Akihiro Sudo, Hiroki Yokota, Kazunori Hamamura
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2016)