Article
Plant Sciences
Pengyan Zhou, Zesen Wang, Yingang Li, Qi Zhou
Summary: MADS-box transcription factors play important roles in various organisms, including the development of flower organ structures and seed development in plants. This study identified and analyzed MADS-box genes in two genome versions of Ginkgo biloba, revealing the presence of specific gene subfamilies and variations in gene structure. The expression analysis demonstrated the involvement of these genes in the development of Ginkgo reproductive organs, suggesting a potential genetic role in sexual differentiation.
Article
Plant Sciences
Xin Han, Hao Rong, Yining Feng, Yue Xin, Xiaoyue Luan, Qi Zhou, Meng Xu, Li-an Xu
Summary: In this study, a highly efficient isolation and transient expression system for ginkgo protoplasts was established. A large number of intact and homogeneous ginkgo mesophyll protoplasts were successfully isolated using 2% cellulase and 0.25% pectinase in 0.4 M mannitol. The transformation efficiency of the protoplasts reached 40% when the concentration of the polyethylene glycol 4000 solution was 30%-40% (w/v). This system provides a technical platform for the identification and analysis of ginkgo gene functions, partially compensating for the limitations associated with the lack of a genetic transformation system.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Xiaoming Yang, Tingting Zhou, Mengke Wang, Tingting Li, Guibin Wang, Fang-Fang Fu, Fuliang Cao
Summary: In this study, 69 GbR2R3-MYB genes were identified and classified into 33 groups based on their amino acid sequence and gene structure characteristics. Expression profiling in different tissues and developmental stages revealed temporal and spatial expression patterns, with specific genes showing responses to abiotic stresses and hormonal exposures. The investigation of GbR2R3-MYB19 indicated its nuclear localization and transcriptional activity, suggesting potential roles in the regulation of biological processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Yating Tian, Xin Han, Yanshu Qu, Yifan Zhang, Hao Rong, Kai Wu, Li'an Xu
Summary: This study systematically investigated the LBD gene family in ginkgo, including gene structure, phylogenetic analysis, and expression profiling. The results revealed two distinct classes of LBD genes, with the class II genes showing enriched expression in different tissues and developmental stages and playing a key role in abiotic stress treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Wanwen Yu, Huimin Liu, Jiaqin Luo, Shuqing Zhang, Peng Xiang, Wei Wang, Jinfeng Cai, Zhiguo Lu, Zhidong Zhou, Jingjing Hu, Yan Lu
Summary: The study revealed that partial root-zone drying led to greater flavonoid accumulation compared to full root-zone drying in ginkgo leaves. Metabolites, structural genes, and transcription factors played crucial roles in regulating flavonoid concentrations in response to drought stress. This highlights the efficiency of partial root-zone drying in harvesting ginkgo leaves with high flavonoid concentrations.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2022)
Article
Plant Sciences
Hailin Liu, Xiaobo Wang, Guibin Wang, Peng Cui, Shigang Wu, Cheng Ai, Nan Hu, Alun Li, Bing He, Xiujuan Shao, Zhichao Wu, Hu Feng, Yuxiao Chang, Desheng Mu, Jing Hou, Xiaogang Dai, Tongming Yin, Jue Ruan, Fuliang Cao
Summary: Analysis of a nearly complete genome of Ginkgo biloba has revealed the reasons behind genome expansion and identified candidate genes associated with the formation of spermatophore flagellum, advancing our understanding of gymnosperm evolution. The genome provides new insights into the expansion and evolution of gymnosperms, along with a detailed annotation of protein-coding genes.
Article
Biochemistry & Molecular Biology
Qingjie Wang, Shiyuan Xu, Lei Zhong, Xiya Zhao, Li Wang
Summary: This study investigates the effects of different concentrations of ZnO-NPs on the growth and accumulation of flavonoids in Ginkgo biloba. The results show that 25 mg/L of ZnO-NPs enhances plant growth and flavonoid content, while higher concentrations have an inhibitory effect. The promotion of flavonoid accumulation is mainly attributed to the upregulation of flavonol structural genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Y. Li, H. Han, M. Fu, X. Zhou, J. Ye, F. Xu, W. Zhang, Y. Liao, X. Yang
Summary: This study analyzed the characteristics and expression patterns of the NAC transcription factor family in Ginkgo biloba using bioinformatics and quantitative reverse transcription PCR. The results showed that NAC transcription factors play important roles in plant growth and development, as well as in response to abiotic stresses and flavonoid biosynthesis in Ginkgo biloba.
Article
Biochemistry & Molecular Biology
Ying Guo, Tongli Wang, Fang-Fang Fu, Yousry A. El-Kassaby, Guibin Wang
Summary: The study revealed variations in photosynthetic capacity and related compounds in developing ginkgo leaves. A co-expression network was constructed to demonstrate the regulatory role of transcription factors in the photosynthetic light reaction pathway. This analysis identified candidate genes that could potentially improve photosynthetic capacity and yield in ginkgo trees.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Xinyue Yang, Depeng Li, Meihong Zhang, Yuqing Feng, Xiaolu Jin, Dan Liu, Yuming Guo, Yongfei Hu
Summary: Ginkgo biloba extract (GBE) can alleviate fatty liver hemorrhagic syndrome (FLHS) in laying hens by reshaping the composition of gut microbiota and improving antioxidant activity. It also promotes the production of short-chain fatty acids (SCFAs) that affect overall lipid metabolism. These findings lay the foundation for the use of GBE as an additive to prevent and control FLHS in the laying hen industry.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gongping Nie, Xiaomeng Liu, Xian Zhou, Qiling Song, Mingyue Fu, Feng Xu, Xuefeng Wang
Summary: Cryptochrome (CRY) is a blue light receptor that regulates gene expression and plays a crucial role in growth and development. The study identified a cryptochrome gene, GbCRY1, in Ginkgo biloba, which is related to circadian clock, photomorphogenesis, and stoma opening processes. GbCRY1 expression is influenced by light, circadian cycle, and space, with blue light reducing its expression during photomorphogenesis and stoma opening.
PLANT SIGNALING & BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Qingqing Wang, Zihou Liu, Rui Wang, Run Li, Xiaoru Lian, Yanquan Yang, Jiao Yan, Zhiqi Yin, Guangji Wang, Jianguo Sun, Ying Peng
Summary: This study investigated the additional benefits of Ginkgo biloba extract (GBE) in combination with statins for the treatment of dyslipidaemia. The results showed that the combination therapy significantly improved blood lipid parameters, reduced liver fat content, and had additional liver protection. GBE also regulated abnormal lipid metabolism and increased the exposure of statins in plasma, providing important implications for disease progression and statin resistance.
Article
Plant Sciences
Bing Wang, Peng-Wei Wei, Shan Wan, Yang Yao, Chao-Rong Song, Ping-Ping Song, Guo-Bo Xu, Zu-Quan Hu, Zhu Zeng, Cong Wang, Hong-Mei Liu
Summary: Ginkgo biloba L. exocarp extract (GBEE) has excellent antibacterial effects against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) and inhibits their biofilm-forming ability by altering related gene expression.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Sian Liu, Xiaoyin Gu, Yanbing Jiang, Lu Wang, Nan Xiao, Yadi Chen, Biao Jin, Li Wang, Weixing Li
Summary: Ginkgo biloba leaves have a higher level of flavonoids at high altitudes, and UV-B radiation plays a key role in this increase. The transcription factor GbHY5 promotes flavonoid accumulation by interacting with GbMYB1 protein. This study provides insights into the molecular mechanisms of UV-B-induced flavonoid biosynthesis and the enhancement of flavonoid content in ginkgo leaves.
HORTICULTURE RESEARCH
(2023)
Article
Forestry
Ke Yang, Zhongbing Liu, Xueyin Chen, Xian Zhou, Jiabao Ye, Feng Xu, Weiwei Zhang, Yongling Liao, Xiaoyan Yang, Qijian Wang
Summary: As the most significant transformation stage of plants, the flowering process has been a focus of research. This study identified 26 MADS-box genes from Ginkgo biloba and analyzed their gene structures, protein features, and expression patterns. The findings suggest that these genes may play an important role in the development and differentiation of G. biloba flowers.
Article
Hematology
Marie-Kristin Schwaegermann, Lukas Hobohm, Johanna Rausch, Michael Reuter, Thomas-Friedrich Griemert, Visvakanth Sivanathan, Tanja Falter, Martin F. Sprinzl, Karl J. Lackner, Peter R. Galle, Stavros Konstantinides, Matthias Theobald, Charis von Auer
Summary: Immune thrombotic thrombocytopenic purpura (iTTP) is a rare autoimmune disorder characterized by reduced activity of ADAMTS13 due to autoantibodies. This results in thrombotic microangiopathy, decreased platelet count, hemolysis, and tissue ischemia.
Letter
Gastroenterology & Hepatology
Christian Labenz, Frank Lammert, Peter R. Galle
JOURNAL OF HEPATOLOGY
(2023)
Article
Health Care Sciences & Services
Maurice Michel, Alisha Wahl, Malena Anders, Saleh A. Alqahtani, Wolfgang M. Kremer, Peter R. Galle, Christian Labenz, Daniel Grimm, Martin Sprinzl, Joern M. Schattenberg
Summary: Metabolic comorbidities, significant fibrosis, and a lower socioeconomic status may negatively affect the health-related quality of life in people living with human immunodeficiency virus (HIV).
QUALITY OF LIFE RESEARCH
(2023)
Article
Oncology
Chiun Hsu, Michel Ducreux, Andrew X. Zhu, Shukui Qin, Masafumi Ikeda, Tae-You Kim, Peter R. Galle, Richard S. Finn, Ethan Chen, Ning Ma, Youyou Hu, Lindong Li, Ann-Lii Cheng
Summary: The IMbrave150 trial showed that atezolizumab + bevacizumab is safe and effective in treating patients with hepatocellular carcinoma, including those with hepatitis B or hepatitis C infection.
Article
Biochemistry & Molecular Biology
Mayrel Palestino-Dominguez, Alejandro Escobedo-Calvario, Soraya Salas-Silva, Moises Vergara-Mendoza, Veronica Souza-Arroyo, Roberto Lazzarini, Roxana Miranda-Labra, Leticia Bucio-Ortiz, Maria Concepcion Gutierrez-Ruiz, Luis E. Gomez-Quiroz
Summary: Alcohol-induced damage to the pancreas is a major risk factor for the development of pancreatitis. This study focused on the protective effect of hepatocyte growth factor (HGF) on pancreatic cells treated with ethanol and acetaldehyde. HGF reduced reactive oxygen species and lipid peroxidation, improved cell viability, and restored insulin expression impaired by alcohol metabolites.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Gastroenterology & Hepatology
Sophia Heinrich, Thomas Austgen, Darko Castven, Moritz Hess, Christian Labenz, Martha Kirstein, Carolin Zimpel, Lena Stockhoff, Benjamin Maasoumy, Bernd Heinrich, Hans Heinrich Wedemeyer, Peter Robert Galle, Harald Binder, Marc Nguyen-Tat, Jens Uwe Marquardt
Summary: In this study, serum levels of M30 and M65 were found to be able to effectively distinguish responders from non-responders to terlipressin therapy in patients with hepatorenal syndrome (HRS), and predict dialysis- and liver transplantation (LTX)-free survival.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Oncology
Jens Mittler, Stefan Heinrich, Martina Koch, Maria Hoppe-Lotichius, Ali Hadian, Arndt Weinmann, Roman Kloeckner, Peter Robert. Galle, Hauke Lang
Summary: In a study of nearly 100 elderly patients undergoing LT for cirrhosis-associated hepatocellular carcinoma, it was found that patients aged 65 and older can benefit from LT, with outcomes comparable to younger patients.
Article
Oncology
Masatoshi Kudo, Richard S. S. Finn, Peter R. R. Galle, Andrew X. X. Zhu, Michel Ducreux, Ann-Lii Cheng, Masafumi Ikeda, Kaoru Tsuchiya, Ken-ichi Aoki, Jing Jia, Riccardo Lencioni
Summary: The study demonstrates the efficacy and safety of atezolizumab + bevacizumab treatment in patients with baseline BCLC Stage B hepatocellular carcinoma, consistent with the overall study population.
Article
Oncology
Masatoshi Kudo, Richard S. Finn, Ann-Lii Cheng, Andrew X. Zhu, Michel Ducreux, Peter R. Galle, Naoya Sakamoto, Naoya Kato, Michitaka Nakano, Jing Jia, Arndt Vogel
Summary: This exploratory analysis examined the prognostic impact of baseline albumin-bilirubin (ALBI) score in patients with unresectable hepatocellular carcinoma (HCC) treated with atezolizumab + bevacizumab or sorafenib. The study found that atezolizumab + bevacizumab improved overall survival and progression-free survival compared to sorafenib in patients with ALBI score of 1, but not in patients with ALBI score of 2. ALBI grade appeared to be prognostic for outcomes in both treatment groups.
Review
Gastroenterology & Hepatology
Simon J. Gairing, Eva M. Schleicher, Peter R. Galle, Christian Labenz
Summary: Hepatic encephalopathy is a significant complication of liver cirrhosis with detrimental effects on patients' quality of life. Identifying high-risk patients and implementing early prevention is crucial. Cognitive tests, composite scores, and blood-based biomarkers have shown promise in predicting the first-time occurrence of hepatic encephalopathy. However, the evidence for primary prophylaxis is limited.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Omar Hahad, Donya A. Gilan, Julian Chalabi, Sadeer Al-Kindi, Alexander K. Schuster, Felix Wicke, Matthias Buettner, Oliver Tuescher, Karl J. Lackner, Peter R. Galle, Stavros Konstantinides, Andreas Daiber, Philipp S. Wild, Thomas Muenzel
Summary: This study aims to investigate the association between social disadvantage and cardiovascular burden and mortality. The findings suggest that low socioeconomic status is associated with increased risk of cardiovascular disease and mortality, with education and occupation being stronger predictors compared to household net income.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Oncology
Benjamin Perez-Aguilar, Jens U. Marquardt, Encarnacion Munoz-Delgado, Rosa Maria Lopez-Duran, Maria Concepcion Gutierrez-Ruiz, Luis E. Gomez-Quiroz, Jose Luis Gomez-Olivares
Summary: The cholinergic system, specifically acetylcholine receptors (AChR) and acetylcholine (ACh), has been found to play a role in cancer development. Acetylcholinesterase (AChE), which regulates AChR by hydrolyzing ACh, has been observed to have a relevant role in cancer. However, there is controversy regarding AChE's participation in cancer, as its enzymatic activity can either increase or decrease in different tumors. This review focuses on analyzing the involvement of AChE in cancer progression and proposes AChE as a central regulator in the initiation and progression of cancer via the cholinergic system. Modulating ACh levels with AChE can regulate AChRs differentially, leading to diverse cancer events.
Article
Biochemistry & Molecular Biology
Tiemo Sven Gerber, Hagen Roland Witzel, Arndt Weinmann, Fabian Bartsch, Mario Schindeldecker, Peter R. Galle, Hauke Lang, Wilfried Roth, Dirk Andreas Ridder, Beate Katharina Straub
Summary: This study investigated the levels of 4-hydroxy-nonenal (4-HNE) in liver carcinomas and analyzed their correlation with clinical data and survival outcomes. The results showed that lower levels of 4-HNE were associated with unfavorable survival outcomes and aggressive tumor behavior in hepatocellular carcinoma (HCC). However, in intrahepatic cholangiocarcinoma (iCCA), 4-HNE levels were not correlated with prognostic parameters or survival outcomes.
Article
Gastroenterology & Hepatology
Natascha Roehlen, Fabian Stoehr, Lukas Mueller, Hendrik Luxenburger, Simon J. Gairing, Marlene Reincke, Michael Schultheiss, Floriona Berisha, Arndt Weinmann, Friedrich Foerster, Jens U. Marquardt, Robert Thimme, Peter R. Galle, Dominik Bettinger, Roman Kloeckner
Summary: This study demonstrates that tumor size and absence of liver cirrhosis are predictors of severe postembolization syndrome (PES) in HCC patients after TACE and are associated with poor prognosis.
HEPATOLOGY COMMUNICATIONS
(2023)
Letter
Gastroenterology & Hepatology
Simon Johannes Gairing, Leonard Kaps, Eva Maria Schleicher, Peter Robert Galle, Christian Labenz
JOURNAL OF HEPATOLOGY
(2023)