4.7 Article

Norditerpenoid alkaloids from Delphinium pseudoaemulans C. Y. Yang et B. Wang

Journal

PHYTOCHEMISTRY
Volume 156, Issue -, Pages 234-240

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2018.09.010

Keywords

Delphinium pseudoaemulans C. Y. Yang et B. Wang; Ranunculaceae; Diterpenoid alkaloids; Pseudophnine; Pseudorenine; Pseudonidine; Cytotoxicity

Funding

  1. National Key R&D Program of China [2016YFE0120700]
  2. International Science &Technology Cooperation of the Xinjiang Uygur Autonomous Region [20166014]
  3. West Light Foundation of Chinese Academy of Sciences [2015-XBQN-B-14]
  4. Central Asian Drug Discovery & Development Centre of Chinese Academy of Sciences

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Eight previously undescribed norditerpenoid alkaloids, pseudophnines A-D, pseudorenines A-B, and pseudonidines A-B, together with ten known norditerpenoid alkaloids, tianshanisine E, sharwuphinine B, potanisine A, lycoctonine, delbruline, isondelpheline, delavaines A-B, and shawurenines A-B were isolated from the whole plant of Delphinium pseudoaemulans C. Y. Yang et B. Wang. Their structures were established on the basis of spectroscopic analyses, including HR-ESI-MS, 1D and 2D NMR analysis. Additionally, no cytotoxicity was observed against A549 and HeLa cancer cells of these diterpenoid alkaloids when evaluated in vitro using the MTT method.

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