Journal
PHYSICAL REVIEW LETTERS
Volume 121, Issue 25, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.121.257801
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Funding
- AFOSR Biomaterials Grant [FA9550-17-1-0249]
- NSF CAREER Grant [1255446]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1255446] Funding Source: National Science Foundation
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Composites of flexible and rigid polymers are ubiquitous in biology and industry alike, yet the physical principles determining their mechanical properties are far from understood. Here, we couple force spectroscopy with large-scale Brownian dynamics simulations to elucidate the unique viscoelastic properties of custom-engineered blends of entangled flexible DNA molecules and semiflexible actin filaments. We show that composites exhibit enhanced stress stiffening and prolonged mechanomemory compared to systems of actin or DNA alone, and that these nonlinear features display a surprising nonmonotonic dependence on the fraction of actin in the composite. Simulations reveal that these counterintuitive results arise from synergistic microscale interactions between the two biopolymers. Namely, DNA entropically drives actin filaments to form bundles that stiffen the network but reduce the entanglement density, while a uniform well-connected actin network is required to reinforce the DNA network against yielding and flow. The competition between bundling and connectivity triggers an unexpected stress response that leads equal mass DNA-actin composites to exhibit the most pronounced stress stiffening and the most long-lived entanglements.
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