An Expandable Mechanopharmaceutical Device (1): Measuring the Cargo Capacity of Macrophages in a Living Organism

Development and validation of probe drug cocktails for the characterization of CYP450-mediated metabolism by human heart microsomes

(2018) Jade Huguet et al.   XENOBIOTICA

Reverse Engineering the Intracellular Self-Assembly of a Functional Mechanopharmaceutical Device

(2018) Tehetina Woldemichael et al.   Scientific Reports

Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation

(2018) Katerina Cermakova et al.   MOLECULES

Macrophage-Mediated Clofazimine Sequestration Is Accompanied by a Shift in Host Energy Metabolism

(2017) Julie Trexel et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Detecting ordered small molecule drug aggregates in live macrophages: a multi-parameter microscope image data acquisition and analysis strategy

(2017) Phillip Rzeczycki et al.   Biomedical Optics Express

Clofazimine Biocrystal Accumulation in Macrophages Upregulates Interleukin 1 Receptor Antagonist Production To Induce a Systemic Anti-Inflammatory State

(2016) Gi S. Yoon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Repositioning Clofazimine as a Macrophage-Targeting Photoacoustic Contrast Agent

(2016) Rahul K. Keswani et al.   Scientific Reports

A far-red fluorescent probe for flow cytometry and image-based functional studies of xenobiotic sequestering macrophages

(2015) Rahul K. Keswani et al.   CYTOMETRY PART A

Volume of Distribution in Drug Design

(2015) Dennis A. Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemical Analysis of Drug Biocrystals: A Role for Counterion Transport Pathways in Intracellular Drug Disposition

(2015) Rahul K. Keswani et al.   MOLECULAR PHARMACEUTICS

Phagocytosed Clofazimine Biocrystals Can Modulate Innate Immune Signaling by Inhibiting TNFα and Boosting IL-1RA Secretion

(2015) Gi S. Yoon et al.   MOLECULAR PHARMACEUTICS

Origin and Functions of Tissue Macrophages

(2014) Slava Epelman et al.   IMMUNITY

Amine-Containing Molecules and the Induction of an Expanded Lysosomal Volume Phenotype: A Structure–Activity Relationship Study

(2014) Randall Logan et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Computational approaches to analyse and predict small molecule transport and distribution at cellular and subcellular levels

(2013) Kyoung Ah Min et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

Polarized light imaging of birefringence and diattenuation at high resolution and high sensitivity

(2013) Shalin B Mehta et al.   Journal of Optics

Multiscale Distribution and Bioaccumulation Analysis of Clofazimine Reveals a Massive Immune System-Mediated Xenobiotic Sequestration Response

(2012) Jason Baik et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cationic Amphiphilic Drugs Cause a Marked Expansion of Apparent Lysosomal Volume: Implications for an Intracellular Distribution-Based Drug Interaction

(2012) Ryan S. Funk et al.   MOLECULAR PHARMACEUTICS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Macrophages Sequester Clofazimine in an Intracellular Liquid Crystal-Like Supramolecular Organization

(2012) Jason Baik et al.   PLoS One

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

Cellular Pharmacokinetics of the Novel Biaryloxazolidinone Radezolid in Phagocytic Cells: Studies with Macrophages and Polymorphonuclear Neutrophils

(2010) S. Lemaire et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of Macrophage Phagocytotic Activity by a Receptor-targeted Polymer Vesicle-based Drug Delivery Formulation of Pravastatin

(2009) Pavel Broz et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Quantitative modeling of selective lysosomal targeting for drug design

(2008) Stefan Trapp et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS