Disruption of sex-specific doublesex exons results in male- and female-specific defects in the black cutworm, Agrotis ipsilon

Identification of yellow gene family in Agrotis ipsilon and functional analysis of Aiyellow-y by CRISPR/Cas9

(2018) Xi'en Chen et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes

(2018) Kyros Kyrou et al.   NATURE BIOTECHNOLOGY

Sexually dimorphic traits in the silkworm, Bombyx mori , are regulated by doublesex

(2017) Jun Xu et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

upSET , the Drosophila homologue of SET3, Is Required for Viability and the Proper Balance of Active and Repressive Chromatin Marks

(2017) Kyle A. McElroy et al.   G3-Genes Genomes Genetics

Bombyx mori P-element Somatic Inhibitor (BmPSI) Is a Key Auxiliary Factor for Silkworm Male Sex Determination

(2017) Jun Xu et al.   PLoS Genetics

Functional analysis of the ABCs of eye color in Helicoverpa armigera with CRISPR/Cas9-induced mutations

(2017) Sher Afzal Khan et al.   Scientific Reports

CRISPR/Cas9 Mutagenesis Reveals Versatile Roles of Hox Genes in Crustacean Limb Specification and Evolution

(2016) Arnaud Martin et al.   CURRENT BIOLOGY

Functional characterization of SlitPBP3 in Spodoptera litura by CRISPR/Cas9 mediated genome editing

(2016) Guan-Heng Zhu et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Functional validation of cadherin as a receptor of Bt toxin Cry1Ac in Helicoverpa armigera utilizing the CRISPR/Cas9 system

(2016) Jing Wang et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

CRISPR/Cas9 mediated knockout of the abdominal-A homeotic gene in the global pest, diamondback moth (Plutella xylostella)

(2016) Yuping Huang et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

CRISPR/Cas9 in locusts: Successful establishment of an olfactory deficiency line by targeting the mutagenesis of an odorant receptor co-receptor (Orco)

(2016) Yan Li et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

CRISPR/Cas9-mediated targeted gene mutagenesis inSpodoptera litura

(2016) Hong-Lun Bi et al.   Insect Science

Can CRISPR-Cas9 gene drives curb malaria?

(2016) Luke Alphey   NATURE BIOTECHNOLOGY

microRNA-309 targets the Homeobox geneSIX4and controls ovarian development in the mosquitoAedes aegypti

(2016) Yang Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Internal guide RNA interactions interfere with Cas9-mediated cleavage

(2016) Summer B. Thyme et al.   Nature Communications

Molecular cloning and functional characterization of the sex-determination gene doublesex in the sexually dimorphic broad-horned beetle Gnatocerus cornutus (Coleoptera, Tenebrionidae)

(2016) Hiroki Gotoh et al.   Scientific Reports

Efficient CRISPR-mediated gene targeting and transgene replacement in the beetle Tribolium castaneum

(2015) A. F. Gilles et al.   DEVELOPMENT

Constraints on the evolution of adoublesextarget gene arising from doublesex’s pleiotropic deployment

(2015) Shengzhan D. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A male-determining factor in the mosquito Aedes aegypti

(2015) A. B. Hall et al.   SCIENCE

The ubiquity and ancestry of insect doublesex

(2015) Dana C. Price et al.   Scientific Reports

Genome Engineering with CRISPR-Cas9 in the Mosquito Aedes aegypti

(2015) Kathryn E. Kistler et al.   Cell Reports

Knockout crickets for the study of learning and memory: Dopamine receptor Dop1 mediates aversive but not appetitive reinforcement in crickets

(2015) Hiroko Awata et al.   Scientific Reports

Sex- and Tissue-Specific Functions of Drosophila Doublesex Transcription Factor Target Genes

(2014) Emily Clough et al.   DEVELOPMENTAL CELL

Expression patterns of sex-determination genes in single male and female embryos of twoBactrocerafruit fly species during early development

(2014) J. L. Morrow et al.   INSECT MOLECULAR BIOLOGY

Transcription activator-like effector nuclease (TALEN)-mediated female-specific sterility in the silkworm, Bombyx mori

(2014) J. Xu et al.   INSECT MOLECULAR BIOLOGY

A single female-specific piRNA is the primary determiner of sex in the silkworm

(2014) Takashi Kiuchi et al.   NATURE

CRISPR/Cas-Mediated Targeted Mutagenesis in Daphnia magna

(2014) Takashi Nakanishi et al.   PLoS One

Lepidopteran Sex Determination: A Cascade of Surprises

(2014) J. Nagaraju et al.   Sexual Development

The CRISPR/Cas System mediates efficient genome engineering in Bombyx mori

(2013) Yueqiang Wang et al.   CELL RESEARCH

The role of doublesex in the evolution of exaggerated horns in the Japanese rhinoceros beetle

(2013) Yuta Ito et al.   EMBO REPORTS

Sex pheromone recognition and immunolocalization of three pheromone binding proteins in the black cutworm moth Agrotis ipsilon

(2013) Shao-Hua Gu et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Conserved RNA cis-elements regulate alternative splicing of Lepidopteran doublesex

(2013) Xiu-Ye Wang et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

(2013) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

Transgene-based, female-specific lethality system for genetic sexing of the silkworm, Bombyx mori

(2013) A. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Engineered Female-Specific Lethality for Control of Pest Lepidoptera

(2013) Li Jin et al.   ACS Synthetic Biology

Highly Efficient Targeted Mutagenesis of Drosophila with the CRISPR/Cas9 System

(2013) Andrew R. Bassett et al.   Cell Reports

Diversification of doublesex function underlies morph-, sex-, and species-specific development of beetle horns

(2012) T. Kijimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Doublesex target genes in the red flour beetle, Tribolium castaneum

(2012) Jayendra Nath Shukla et al.   Scientific Reports

Genomic organization and splicing evolution of the doublesex gene, a Drosophila regulator of sexual differentiation, in the dengue and yellow fever mosquito Aedes aegypti

(2011) Marco Salvemini et al.   BMC EVOLUTIONARY BIOLOGY

Sex determination in insects: a binary decision based on alternative splicing

(2011) Helen K Salz   CURRENT OPINION IN GENETICS & DEVELOPMENT

The female-specific Doublesex isoform regulates pleiotropic transcription factors to pattern genital development in Drosophila

(2011) S. S. Chatterjee et al.   DEVELOPMENT

Evolution of Sex-Specific Traits through Changes in HOX-Dependent doublesex Expression

(2011) Kohtaro Tanaka et al.   PLOS BIOLOGY

Function and evolution of sex determination mechanisms, genes and pathways in insects

(2010) Tanja Gempe et al.   BIOESSAYS

Expression of a doublesex homologue is altered in sexual mosaics of Ostrinia scapulalis moths infected with Wolbachia

(2010) Takafumi N. Sugimoto et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Doublesex: a conserved downstream gene controlled by diverse upstream regulators

(2010) J. N. Shukla et al.   JOURNAL OF GENETICS

Genetic and molecular insights into the development and evolution of sexual dimorphism

(2009) Thomas M. Williams et al.   NATURE REVIEWS GENETICS

The Regulation and Evolution of a Genetic Switch Controlling Sexually Dimorphic Traits in Drosophila

(2008) Thomas M. Williams et al.   CELL

Masculinization of XX Drosophila transgenic flies expressing the Ceratitis capitata DoublesexM isoform

(2008) Giuseppe Saccone et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Sex-determining mechanisms in insects

(2008) Lucas Sanchez   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY