Article
Biophysics
Huiling Liu, Peng Li, Ziniu Tang, Haoran Liu, Rui Zhang, Jun Ge, Huilin Yang, Xinye Ni, Xiao Lin, Lei Yang
Summary: This study investigated the potential of silver ions (Ag+) and silver nanoparticles (AgNPs) in modifying calcium phosphate bone cement for long-term antibacterial property. The results showed that both silver ions and silver nanoparticles had inhibitory effect on Staphylococcus aureus growth, but silver ions were more suitable for the fabrication of antibacterial bone cement and had sustainable antibacterial effects.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Materials Science, Ceramics
Polina A. Krokhicheva, Margarita A. Goldberg, Alexander S. Fomin, Dinara R. Khayrutdinova, Olga S. Antonova, Alexander S. Baikin, Anatoliy A. Konovalov, Aleksander V. Leonov, Ivan V. Mikheev, Ekaterina M. Merzlyak, Valentina A. Kirsanova, Irina K. Sviridova, Natalia S. Sergeeva, Sergey M. Barinov, Vladimir S. Komlev
Summary: This study aims to develop magnesium calcium phosphate bone cements (MCPCs) with antibacterial properties by incorporating silver ions. Increasing the silver ion concentration significantly improved the mechanical properties of the cements (compressive strength reached 41 +/- 2 MPa) and exhibited an 8 mm inhibition zone against Escherichia coli and Staphylococcus aureus in a disk diffusion test, without toxicity to MG-63 cells in vitro. Analysis of the MCPC samples soaked in Kokubo's simulated body fluid showed the formation of merrillite phase on the surface, transforming into bobierrite phase after 28 days of soaking. Histological examination and micro-CT analysis confirmed the osteoconductive and biodegradable nature of the newly developed MCPCs, making them suitable as bone substitutes.
CERAMICS INTERNATIONAL
(2023)
Article
Infectious Diseases
Varun Prasath Padmanabhan, Pugalmani Sivashanmugam, Ravichandran Kulandaivelu, Suresh Sagadevan, Balu Sridevi, Rajakumar Govindasamy, Muthu Thiruvengadam
Summary: This study evaluated the application of silver nanoparticles combined with biphasic calcium phosphate (BCP) composites in the field of orthopedics. The results showed that the composites had good osteoconductivity and biocompatibility, and exhibited antibacterial activity against various microorganisms.
Article
Nanoscience & Nanotechnology
Simon Chun Kiat Goh, Wenshuai Wu, Chun Fei Siah, Derek Keng Yang Phee, Aiqun Liu, Beng Kang Tay
Summary: This study investigates the use of low-cost graphite pencils to create antimicrobial surfaces, with high killing efficiency demonstrated through Ag photoreduction. Surface topography and defects play a key role in determining antimicrobial properties, with UV treatment showing promise over plasma O-2 treatment.
Article
Biophysics
Zhaonan Li, Dechao Jiao, Wenguang Zhang, Kewei Ren, Lingxiao Qiu, Chuan Tian, Yahua Li, Jing Li, Xueliang Zhou, Yanan Zhao, Xinwei Han
Summary: The study developed polylactic acid and silver nanoparticles nanofiber membranes with antibacterial and antihyperplasia properties, which showed promising results in treating rabbit tracheal stenosis by reducing inflammation and tissue hyperplasia.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Materials Science, Ceramics
Yessie W. Sari, Annisa Tsalsabila, Noviyan Darmawan, Yuliati Herbani
Summary: This study investigated the effects of surface-modified gold nanoparticles with different amino acids on the formation of hydroxyapatite. The results showed that aspartic acid modification of the gold nanoparticles promoted the crystallization of hydroxyapatite with a smaller crystallite size and a higher Ca/P ratio, which is beneficial for bone substitute applications.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Ceramics
Yessie W. Sari, Annisa Tsalsabila, Angga Saputra, Nur Aisyah Nuzulia, Yuliati Herbani
Summary: Surface modification of biomaterials affects the surface reactivity of implantable materials and induces the formation of apatite-like layers. This study investigates the bioactivity and surface reactivity of modified biomaterials (calcium-deficient hydroxyapatite [CDHA] on amino acid-capped AuNPs [AA-AuNPs]) by immersing them in simulated body fluid (SBF). The results show that AA-AuNPs, capped with charged and polar uncharged amino acids, are capable of inducing biomimetic hydroxyapatite formation. The presence of hydroxyapatite peaks in XRD patterns confirms the formation of hydroxyapatite after immersion in SBF. Furthermore, longer immersion time leads to nucleation and growth of hydroxyapatite, as indicated by changes in crystal structure. The surface modification of AA-AuNPs significantly affects the orientation of hydroxyapatite crystals and the presence of charged amino acids contributes to nucleation and growth, while polar uncharged amino acids only contribute to growth. The study highlights the bioactivity of CDHA-modulated AA-AuNPs in hydroxyapatite formation for bone tissue regeneration.
CERAMICS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Ramon Perez-Tanoira, Monica Fernandez-Arias, Carmen Potel, Raquel Carballo-Fernandez, Sonia Perez-Castro, Mohamed Boutinguiza, Miguel Gorgolas, Fernando Lusquinos, Juan Pou
Summary: Silver nanoparticles have antimicrobial effects against various biofilms and may help prevent the development of peri-implantitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Nishal M. Egodawaththa, Amy L. Knight, Jingxuan Ma, D. Andrew Knight, Eric Guisbert, Nasri Nesnas
Summary: Silver nanoparticles conjugated with organic ligands have been successfully synthesized and demonstrated significant antimicrobial activity and antibacterial capabilities against E. coli. The synthesis of functionalized silver nanoparticles is critical for the further development of silver-nanoconjugated antibacterial agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Ali Seraj, Alireza Allafchian, Fathallah Karimzadeh, Arian Valikhani, Seyed Amir Hossein Jalali
Summary: In this study, an enhanced antibacterial agent was developed by inlaying silver nanoparticles (AgNPs) on a kappa-carrageenan (KC) base and coating them on Fe3O4 magnetic cores (Fe3O4@KC@Ag). The resulting Fe3O4@KC@Ag nanocomposites showed improved antibacterial activity due to the decreased agglomeration of AgNPs. These findings suggest that Fe3O4@KC@Ag nanocomposites could be promising agents for combating bacterial infections in aqueous environments.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Gitishree Das, Han-Seung Shin, Jayanta Kumar Patra
Summary: This study investigates the fabrication of Ag nanoparticles using extracts from curly kale and evaluates their biological potentials. The results show that the synthesized BroL-Ag nanoparticles have antidiabetic, antioxidant, antibacterial, and cytotoxic effects. The study provides a promising approach for eco-friendly green synthesis of Ag nanoparticles and suggests their potential applications in pharmacological and related industries.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Engineering, Biomedical
Gabriela Graziani, Katia Barbaro, Inna Fadeeva, Daniele Ghezzi, Marco Fosca, Enrico Sassoni, Gianluca Vadala, Martina Cappelletti, Francesco Valle, Nicola Baldini, Julietta Rau
Summary: This study demonstrates that nanostructured antibacterial and bioactive thin films obtained by Ionized Jet Deposition show promising potential for orthopedic implant applications, with significant antimicrobial efficacy against various bacterial strains and fungus while maintaining good biocompatibility. The deposition process allows for fine control over film composition and morphology, and the coatings exhibit suitable mechanical properties for implant integration.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Fatma Abdelghaffar, Manal G. Mahmoud, Mohsen S. Asker, Sahar S. Mohamed
Summary: This study successfully deposited antibacterial silver nanoparticles on linen fabrics using a green synthesis method; optimization of AgNPs synthesis conditions led to smaller particle sizes; the results demonstrated that BSEPS/AgNPs played a dual role in reducing bacterial activity and increasing dyeability.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Biophysics
Ying Luo, Jiaqian Zhao, Xinran Zhang, Chengcheng Wang, Tongyu Wang, Min Jiang, Qin Zhu, Tian Xie, Dajing Chen
Summary: Researchers have successfully developed enzyme-loaded amorphous calcium phosphate nanoparticles with adjustable diameters using co-precipitation and nano-channel extrusion methods. These nano-sized particles exhibit high stability, biocompatibility, and can be utilized as intracellular enzyme probes for monitoring glucose levels in living cells to study metabolism rates of cancer cells and normal cells. The nano-channel extrusion method can also serve as a template for encapsulating different enzymes for expanding catalysis and biosensing applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Polymer Science
Nafise Amiri, Sahand Ghaffari, Ida Hassanpour, Taesik Chae, Reza Jalili, Ruhangiz Taghi Kilani, Frank Ko, Aziz Ghahary, Dirk Lange
Summary: A silver nanoparticle-based hydrogel composite has been created to prevent infection, promote tissue repair, and fill cavities in wounds that are difficult to reach with other dressings.
Article
Chemistry, Multidisciplinary
Ichie Okamoto, Hirofumi Miyaji, Saori Miyata, Kanako Shitomi, Tsutomu Sugaya, Natsumi Ushijima, Tsukasa Akasaka, Satoshi Enya, Satoshi Saita, Hideya Kawasaki
Summary: The novel photosensitizer Lys-Au NCs/RB has low cytotoxicity, effectively inhibiting bacterial activity and reducing biofilm formation, potentially improving dental treatments.
Article
Dentistry, Oral Surgery & Medicine
Yukimi Kanemoto, Hirofumi Miyaji, Erika Nishida, Saori Miyata, Kayoko Mayumi, Yuto Yoshino, Akihito Kato, Tsutomu Sugaya, Tsukasa Akasaka, Arputharaj Joseph Nathanael, Syama Santhakumar, Ayako Oyane
Summary: The Ap-CS fabricated by the plasma- and precursor-assisted biomimetic process demonstrated superior promotion of osteogenic differentiation and bone regeneration compared to CS, as shown in rat and canine experiments.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hisanori Kosuge, Maki Nakamura, Ayako Oyane, Kazuko Tajiri, Nobuyuki Murakoshi, Satoshi Sakai, Akira Sato, Atsushi Taninaka, Taishiro Chikamori, Hidemi Shigekawa, Kazutaka Aonuma
Summary: This study evaluated the viability of macrophages with GNPs after NIR laser exposure and assessed the utility of intravenously injected GNPs for in vivo imaging of vascular inflammation in mice. The results showed that GNPs reduced macrophage viability upon NIR laser exposure and accumulated at sites of vascular inflammation, enabling detection of carotid atherosclerosis and AAAs in CT imaging. Therefore, GNPs have potential as multifunctional biologically compatible particles for the detection and therapy of vascular inflammation.
MOLECULAR IMAGING AND BIOLOGY
(2022)
Article
Chemistry, Physical
Tsukasa Akasaka, Miho Tamai, Yoshitaka Yoshimura, Natsumi Ushijima, Shinichiro Numamoto, Atsuro Yokoyama, Hirofumi Miyaji, Ryo Takata, Shuichi Yamagata, Yoshiaki Sato, Ko Nakanishi, Yasuhiro Yoshida
Summary: The surface topography of a material can influence osteoclast activity. Pillar-shaped patterns are the most effective in inducing osteoclastogenesis. The generation of osteoclasts can be controlled by designing surfaces with specific morphologies.
Correction
Chemistry, Physical
Tsukasa Akasaka, Miho Tamai, Yoshitaka Yoshimura, Natsumi Ushijima, Shinichiro Numamoto, Atsuro Yokoyama, Hirofumi Miyaji, Ryo Takata, Shuichi Yamagata, Yoshiaki Sato, Ko Nakanishi, Yasuhiro Yoshida
Summary: The article examines how different micro/nano-scale patterns of surface materials influence osteoclastogenesis and actin structure.
Article
Dentistry, Oral Surgery & Medicine
Hirofumi Miyaji, Kayoko Mayumi, Yukimi Kanemoto, Ichie Okamoto, Asako Hamamoto, Akihito Kato, Tsutomu Sugaya, Tsukasa Akasaka, Saori Tanaka
Summary: This study investigated the adhesion and antibacterial activity of S-PRG nanofiller dispersion on cementum substrates, as well as its effects on periodontal healing. The results showed that ultrasonic irrigation with S-PRG nanofiller dispersion enabled the delivery of the nanofiller to the root surface, resulting in improved periodontal parameters and modification of the subgingival periodontal microflora composition.
JOURNAL OF ORAL BIOSCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Tsukasa Akasaka, Hiroshi Hayashi, Miho Tamai, Yoshitaka Yoshimura, Yoh-ichi Tagawa, Hirofumi Miyaji, Ko Nakanishi, Yasuhiro Yoshida
Summary: This study found that different shapes, sizes, heights, and wettability of micro/nanoscale patterns have an impact on osteoclastogenesis from bone marrow cells. Osteoclast formation was promoted on pillars, especially on hydrophobic ones. The designed patterns are useful for designing the surface of dental implants or bone replacement materials with a controllable balance between osteoblast and osteoclast activities.
JOURNAL OF ORAL BIOSCIENCES
(2022)
Review
Dentistry, Oral Surgery & Medicine
Hirofumi Miyaji, Ayako Oyane, Aiko Narazaki
Summary: This article introduces two novel techniques that use laser light for coating the tooth surface with apatite to treat periodontal disease. The experimental results demonstrate the potential of these techniques as new tools in the treatment of periodontal disease.
JOURNAL OF ORAL BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maki Nakamura, Wakako Bunryo, Aiko Narazaki, Ayako Oyane
Summary: This study demonstrates that heparin-immobilized CaP nanoparticles have a higher co-immobilizing capacity for basic proteins compared to acidic proteins. Heparin acts as both a particle-dispersing agent and a immobilizing agent for basic proteins, leading to improved immobilization efficiency within the nanoparticles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Hirofumi Miyaji, Yukimi Kanemoto, Asako Hamamoto, Kanako Shitomi, Erika Nishida, Akihito Kato, Tsutomu Sugaya, Saori Tanaka, Natsuha Aikawa, Hideya Kawasaki, Syun Gohda, Hironobu Ono
Summary: A new coating method using graphene oxide (GO) has been developed to retain antimicrobial surfactants on the tooth surface, providing sustained antibacterial activity.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Ayako Oyane, Ikuko Sakamaki, Maki Nakamura, Kenji Koga, Kanako Shitomi, Saori Tanaka, Hirofumi Miyaji
Summary: The study developed a technique for forming fluoridated apatite coating on teeth, showing antibacterial activity and vertically oriented pillar-like nanocrystal structure. The technology holds promise as a tool for tooth surface functionalization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yukimi Kanemoto, Hirofumi Miyaji, Erika Nishida, Asako Hamamoto, Tsutomu Sugaya, Syun Gohda, Hironobu Ono
Summary: Graphene oxide (GO) was attached to the surface of medical gauze fibers, forming a complex with a cationic surface active agent (CSAA). The treated gauze exhibited antibacterial activity even after rinsing with water.
JOURNAL OF ORAL BIOSCIENCES
(2023)
Article
Materials Science, Biomaterials
Maki Nakamura, Katsuya Ueda, Yumiko Yamamoto, Kaoru Aoki, Minfang Zhang, Naoto Saito, Masako Yudasaka
Summary: This study developed a new nanocomposite for the treatment of bone metastasis by inhibiting the destruction of bones. The nanocomposite, composed of BPs loaded onto OxCNHs using CaPs as mediators, showed promising potential for localized treatment of bone destruction caused by metastasis.
BIOMATERIALS SCIENCE
(2022)
Article
Multidisciplinary Sciences
Kayoko Mayumi, Hirofumi Miyaji, Saori Miyata, Erika Nishida, Tomokazu Furihata, Yukimi Kanemoto, Tsutomu Sugaya, Kanako Shitomi, Tsukasa Akasaka
Summary: The study demonstrated that the coating of S-PRG nanofillers provides antibacterial effects on tooth surfaces and improves clinical parameters of periodontitis. Experimental results showed that the S-PRG nanofiller coating significantly reduced clinical inflammatory parameters of periodontitis and enhanced bone healing.