Article
Pharmacology & Pharmacy
Naoto Ono, Tomoya Iibuchi, Hiroaki Todo, Shoko Itakura, Hirotoshi Adachi, Kenji Sugibayashi
Summary: Thermalporation is an effective method for improving skin permeation of middle and high molecular weight biopharmaceuticals. The study showed that using the PassPort(R) system can significantly enhance the skin permeation of FD-4 and insulin, with improved relative bioavailability of insulin. Additionally, the skin resistance value decreased immediately after the PS treatment but returned to the initial level within 12 hours.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Hui Shi, Jianhong Zhou, Yuan Wang, Yutuo Zhu, Deqing Lin, Lei Lei, Serhii Vakal, Jiaqing Wang, Xingyi Li
Summary: This study presents a minimally invasive delivery system for treating fungal keratitis using a dissolving microneedle patch based on Poly(D,L-lactide) and hyaluronic acid. The microneedle patch shows excellent properties and can penetrate the cornea with no ocular irritation. In a rabbit model, the microneedle patch medication exhibits superior therapeutic effects compared to eye drops and is comparable to intrastromal injection, offering a cost-effective treatment solution.
Review
Nanoscience & Nanotechnology
Piotr Gadzinski, Anna Froelich, Monika Wojtylko, Antoni Bialek, Julia Krysztofiak, Tomasz Osmalek
Summary: Eye diseases and injuries are a significant clinical problem worldwide. Traditional eye drops, gels, and ointments are often not well tolerated by patients. However, microneedle-based systems have made remarkable advances in recent years as an alternative, non-invasive form of drug administration.
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
(2022)
Review
Polymer Science
Dong-Jin Lim, Hong-Jun Kim
Summary: This review provides an overview of advanced fabrication techniques for microneedles and discusses various drug coating and drug elution strategies. It also explores the potential of microneedle technologies in improving the clinical efficacy of treating skin diseases.
Article
Engineering, Biomedical
Linyu Long, Dan Ji, Cheng Hu, Li Yang, Shibo Tang, Yunbing Wang
Summary: Tissue injury is a common problem that can greatly affect patients' lives. Microneedles, due to their unique composition and structure, have attracted attention in various tissues regeneration. They can penetrate barriers and improve drug availability, deliver bioactive molecules in situ, and provide mechanical support for tissue repair. This review summarizes the research progress, discusses shortcomings, future directions, and clinical application prospects of microneedles for in situ tissue regeneration over the past decade.
MATERIALS TODAY BIO
(2023)
Article
Pharmacology & Pharmacy
Suman Pahal, Kedar Badnikar, Vivek Ghate, Utkarsh Bhutani, Mangalore Manjunatha Nayak, Dinesh Narasimhaiah Subramanyam, Praveen Kumar Vemula
Summary: This review discusses the recent advances in microneedle-based devices for sustained release of vaccines, hormones, and antiretrovirals, emphasizing the importance of designing slow-degrading polymeric matrices or providing physiochemical triggers for on-demand drug release. These long-acting transdermal devices help prevent burst release of drugs, ensuring efficient drug delivery.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Seungyeon Lee, Jihye Lee, Kanghyun Choi, Hyoseon Kim, Youngkum Park, Juhee Yoon, June Hyun Kim, Seongwoo Ryu
Summary: Coated-type microneedles were developed for direct delivery of hispidin to the skin, enhancing skin permeability and showing various activities such as antioxidant, anti-inflammatory, and antimicrobial effects. The system demonstrated potential as a prototype platform for more effective subcutaneous delivery of vaccines, oligonucleotides, insulin, and cosmetic applications.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Multidisciplinary
Razina Z. Seeni, Mengjia Zheng, Daniel Chin Shiuan Lio, Christian Wiraja, Mohammad Firdaus Bin Mohd Yusoff, William Teck Yeow Koh, Yuchun Liu, Bee Tin Goh, Chenjie Xu
Summary: Microneedles have emerged as a minimally invasive alternative for local anesthesia delivery in dental procedures, reducing pain and anxiety associated with traditional needle injections. The development of a conductive microneedle array in combination with iontophoresis technique has shown to effectively penetrate oral mucosa and underlying bone tissue, providing a dual-role of creating micro-conduits and reducing tissue resistance for drug delivery.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Long Lin, Yuqiong Wang, Minkun Cai, Xinran Jiang, Yongyan Hu, Zaizai Dong, Dedong Yin, Yilin Liu, Shaohua Yang, Zhiguang Liu, Jian Zhuang, Ye Xu, Chuan Fei Guo, Lingqian Chang
Summary: The multimicrochannel microneedle microporation (4M) platform proposed in this work achieves high efficiency, safety, and uniformity for in vivo intracellular delivery. It utilizes internal microchannels implemented through the microneedle to provide a concentrated, safe electric field that accelerates cargo movement under electrophoresis and triggers cell electroporation for enhanced transport across cell membranes. This platform has shown significant improvements in anticancer effects and reduced systemic toxicity, making it a general-purpose delivery tool for emerging drugs in vivo.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Polymer Science
Bana Shriky, Maksims Babenko, Ben R. Whiteside
Summary: Hydrogel microneedles are a promising technology in the field of transdermal drug delivery. They offer tunable properties for use as delivery systems and extraction tools. However, there are challenges in manufacturing and regulatory aspects that need to be addressed for their successful implementation.
Article
Chemistry, Multidisciplinary
Lijun Cai, Zhiqiang Luo, Hanxu Chen, Yuanjin Zhao
Summary: Microneedle-motors (MNMs) for active drug delivery are developed using a flexible multimodal microfluidic lithographic approach. The MNMs, with sharp tips and spherical fuel-loading cavities, are continuously obtained from microfluidics with the assistance of flow lithography. The structural parameters of the MNMs can be precisely tailored by adjusting the flow speed or the shape of the photomask. These MNMs demonstrate efficient penetration of tissue-like substrates, indicating their potential in overcoming physiological barriers for cargo release. These findings highlight the value of multimodal microfluidic lithographic MNMs in biomedical and other relevant areas.
Review
Chemistry, Physical
Xiuli Hu, Huijuan Zhang, Zejun Wang, Chin Ying Angela Shiu, Zhen Gu
Summary: Microneedle-based techniques combined with nanoparticles have expanded applications, allowing on-demand drug release while reducing toxicity and enhancing therapeutic efficacy. This technology shows significant potential in various fields such as diabetes, cancer, vaccines, obesity, hair growth, and acne vulgaris.
Review
Instruments & Instrumentation
Qida Zong, Ranran Guo, Naijun Dong, Guixia Ling, Peng Zhang
Summary: Microneedle technology, as a promising alternative to subcutaneous insulin injection, has developed rapidly but still faces technical challenges, researchers are making efforts to overcome these limitations.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Jiahui He, Yuyue Zhang, Xinge Yu, Chenjie Xu
Summary: Transdermal drug delivery systems, particularly wearable patches, have advantages such as good drug bioavailability and patient compliance. The integration of stimulus-responsive materials and electronics in such systems allows for dosage, temporal, and spatial control of therapeutics delivery.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Pharmacology & Pharmacy
Xiaona Cao, Guojun Chen
Summary: This review provides an overview of recent advances in microneedle technology for non-transdermal applications, with a particular focus on its applications in ocular, vascular, oral, mucosal, and cancer tissues. The improved design of microneedles has expanded their potential for non-transdermal applications.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Review
Education, Scientific Disciplines
Yong Keun Song, Dong Hyun Jo
Summary: As surgical procedures become more complex, effective training in anatomy becomes increasingly important. Fresh frozen cadavers (FFCs) are known for their realistic tissue quality and have been successfully used in medical education and surgical training. This review summarizes the preparation procedures for FFCs and highlights their successful applications in various surgical training programs.
ANATOMICAL SCIENCES EDUCATION
(2022)
Article
Engineering, Biomedical
Hyewon Jang, Dong Hyun Jo, Chang Sik Cho, Jeong Hong Shin, Jung Hwa Seo, Goosang Yu, Ramu Gopalappa, Daesik Kim, Sung-Rae Cho, Jeong Hun Kim, Hyongbum Henry Kim
Summary: Prime editing has shown the potential to precisely correct disease-causing mutations and ameliorate disease phenotypes in mouse models of genetic diseases. By identifying optimal guide RNAs, it can precisely target genes without detectable off-target edits. However, further validation in more animal models is necessary.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Engineering, Biomedical
KangJu Lee, SeungHyun Park, Dong Hyun Jo, Chang Sik Cho, Ha Young Jang, Jiyeon Yi, Minkyung Kang, Jaeho Kim, Ho Yun Jung, Jeong Hun Kim, WonHyoung Ryu, Ali Khademhosseini
Summary: Intravitreal injection is a common technology used for treating ophthalmic diseases, but it may have side effects. Researchers have developed a self-plugging microneedle that can deliver drugs and seal the scleral puncture simultaneously, reducing the occurrence of side effects.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Mechanical
Dong-Yoon Kim, Yeon-Jun Woo, Keonwook Kang, Gil Ho Yoon
Summary: This paper presents a new nonlinear transformation-based augmentation method for processing vibration signals and predicting the classification of healthy or damaged systems. The research demonstrates that mapping laboratory model data to real healthy model data can effectively predict the data of complex real damaged models.
MECHANICAL SYSTEMS AND SIGNAL PROCESSING
(2022)
Article
Chemistry, Multidisciplinary
Kyung Soo Park, Jae Hyeon Kwon, Ji Su Yu, So Yun Jeong, Dong Hyun Jo, Chan-Hwa Chung, Jong Wook Bae
Summary: This study verifies the enhanced thermal and catalytic stability of monodispersed Ni-Co bimetal nanoparticles encapsulated by SiO2 shell in harsh dry reforming of methane with CO2. The study also identifies the positive contributions of oxophilic Co species and spatial confinement effects that suppress coke formations and aggregations of Ni-Co nanoparticles.
JOURNAL OF CO2 UTILIZATION
(2022)
Article
Materials Science, Multidisciplinary
Haryeong Choi, Taehee Kim, Taeho Kim, Sunil Moon, SangHyuk Yoo, Vinayak G. Parale, Rushikesh P. Dhavale, Keonwook Kang, Hyunchul Sohn, Hyung-Ho Park
Summary: This study proposes the use of highly porous cross-linked silica aerogel thin films as ultralow-kappa dielectric materials in nanodevice interconnect technology. These films have a low dielectric constant and can withstand chemical mechanical polishing and plasma dry etching processes.
APPLIED MATERIALS TODAY
(2022)
Article
Materials Science, Multidisciplinary
Yunjeong Kim, JiYong Lee, Hyeonaug Hong, SeungHyun Park, WonHyoung Ryu
Summary: This study designs and constructs micropyramid-assisted piezoelectric film (MPF) sensors and investigates their performance through experiments and simulations. The results reveal that MPF sensors with polydimethylsiloxane micropyramids covered with highly compliant Ecoflex exhibit the highest sensitivity. The MPF sensors can be attached to the wrist and neck to measure blood pressure signals and compared with values measured by a commercial cuff device through linear regression.
ADVANCED ENGINEERING MATERIALS
(2023)
Review
Ophthalmology
Dong Hyun Jo, Sangsu Bae, Hyongbum Henry Kim, Jin-Soo Kim, Jeong Hun Kim
Summary: Inherited retinal diseases (IRDs) are vision-threatening retinal disorders caused by gene variants related to vision. Current treatment options are limited, but genome editing using CRISPR-Cas9 technologies shows promise for correcting pathogenic variants and providing new treatment opportunities.
PROGRESS IN RETINAL AND EYE RESEARCH
(2023)
Article
Pediatrics
Yoon Sunwoo, Jung Yoon Choi, Hyun Jin Park, Bo Kyung Kim, Kyung Taek Hong, Sang In Khwarg, Jaemoon Koh, Sung-Hye Park, Dong Hyun Jo, Jeong Hun Kim, Jung-Eun Cheon, Hyoung Jin Kang
Summary: This study presents the treatment outcomes of patients with unilateral retinoblastoma who received primary enucleation and adjuvant chemotherapy. The overall survival rate was 100% and the event-free survival rate was 95%. Treatment with chemotherapy was well tolerated with minimal toxicity. However, further research is needed on risk stratification and treatment intensity.
Article
Medicine, Research & Experimental
Dong Hyun Jo, Hyeon-Ki Jang, Chang Sik Cho, Jun Hee Han, Gahee Ryu, Youngri Jung, Sangsu Bae, Jeong Hun Kim
Summary: Leber congenital amaurosis (LCA) is a genetic retinal degeneration disease that causes severe visual dysfunction. This study focused on using dual adeno-associated virus (AAV) vectors containing split adenine base editors (ABEs) for base editing in an animal model of LCA. The results showed successful correction of the pathogenic variant and recovery of normal retinal function. ABEs were found to be a strong and reliable method for treating LCA compared to other editing strategies.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Zoology
Ha Young Jang, Jina Kwak, Seok Jae Lee, Jun Wu, Hui Jiang, Eun-Saem Choi, Chan-Wook Park, Byeong-Cheol Kang, Jeong Hun Kim
Summary: The common marmoset is an ideal species for developing genetically modified nonhuman primate models of human eye disease. Prenatal ultrasonography is an accurate tool for monitoring fetal eye development. This study established criteria for studying congenital eye anomalies in marmosets by measuring orbital structures and found that biorbital distance has the highest correlation with gestational age, making it a reliable indicator for monitoring eye growth in normal marmosets.
AMERICAN JOURNAL OF PRIMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chang Sik Cho, Dong Hyun Jo, Jin Hyoung Kim, Jeong Hun Kim
Summary: The study established carboplatin-resistant retinoblastoma cell lines, which can be used to investigate chemoresistance in retinoblastoma and develop potential therapeutics.
MOLECULES AND CELLS
(2022)
Article
Biochemistry & Molecular Biology
Chang Sik Cho, Dong Hyun Jo, Jin Hyoung Kim, Jeong Hun Kim
Summary: This study established carboplatin-resistant retinoblastoma cell lines, providing a tool for research on the treatment of chemoresistant retinoblastoma.
MOLECULES AND CELLS
(2022)