Article
Pharmacology & Pharmacy
Marcus Fransson, Anders Hellden, Ase Ostholm Balkhed, Dzeneta Nezirevic Dernroth, Maria Ha, Mats Haglund, Peter Milos, Hakan Hanberger, Bertil Kagedal
Summary: This case report highlights a patient with multiple brain abscesses caused by Streptococcus intermedius, ultimately recovering but requiring enucleation of the left eye. Subtherapeutic antibiotic concentrations were initially an issue, only resolved by increasing the dosage. It serves as a reminder that augmented renal clearance can impact the treatment of serious bacterial infections.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pediatrics
Evelyn Dhont, Tatjana Van der Heggen, Evelien Snauwaert, Jef Willems, Siska Croubels, Joris Delanghe, Jan J. De Waele, Roos Colman, Johan Vande Walle, Peter De Paepe, Pieter A. De Cock
Summary: The study aimed to identify predictors of ARC and describe its time-course in critically ill children. Major surgery other than cardiac surgery and eGFR were found as independent predictors of ARC.
PEDIATRIC NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Mads Hornum, Morten Baltzer Houlind, Esben Iversen, Esteban Porrini, Sergio Luis-Lima, Peter Oturai, Martin Iversen, Pia Bredahl, Jorn Carlsen, Christian Holdflood Moller, Mads Jonsson Andersen, Bo Feldt-Rasmussen, Michael Perch
Summary: Patients undergoing lung transplantation (LTx) experience a rapid decline in glomerular filtration rate (GFR) in the acute postoperative period. This study compared different equations for estimating GFR in LTx patients and found that equations based on plasma creatinine underestimated GFR decline, while equations based on plasma cystatin C overestimated GFR decline after LTx. The 2021 CKD-EPI combination equation had the most accurate estimation of GFR in both pre-LTx and post-LTx periods. Therefore, caution should be exercised when interpreting renal function based on GFR estimation equations in the acute postoperative period following LTx.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Hyun-Ki Kim, Tae-Dong Jeong
Summary: With the updated 2020 vancomycin therapeutic drug monitoring guidelines, accurate estimation of AUC(24) has become more critical. This study aimed to compare the AUC(24) using Bayesian dosing software according to various eGFR equations and analyze the clinical impact of eGFR in vancomycin TDM. The results showed that the eGFR formula type had insignificant clinical impact on drug dosing recommendations.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Urology & Nephrology
Noppawit Aiumtrakul, Puvanant Wiputhanuphongs, Ouppatham Supasyndh, Bancha Satirapoj
Summary: A prospective cohort study in a Southeast Asian community-based population found an independent association of serum uric acid levels with impaired renal function, with higher incidence observed in males than females. Linear regression analysis showed a negative correlation between eGFR and serum uric acid levels.
Review
Biochemistry & Molecular Biology
Christophorus F. Adhipandito, Siu-Hung Cheung, Yu-Han Lin, Si-Han Wu
Summary: Recent studies found nanoparticles larger than the kidney filtration threshold remaining intact in the urine of laboratory mice, challenging the known size limit for renal clearance. This raises questions on what types of nanoparticles can bypass the filtration barrier, essential physical and chemical characteristics required, as well as the biomolecular and cellular mechanisms involved.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Chin-Chou Huang, Chia-Min Chung, Chih-Yu Yang, Hsin-Bang Leu, Po-Hsun Huang, Liang-Yu Lin, Tao-Cheng Wu, Shing-Jong Lin, Wen-Harn Pan, Jaw-Wen Chen
Summary: This study found an association between SLC12A3 gene polymorphisms and renal function in patients with hypertension.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Teh-Min Hu
Summary: The objective of this study is to propose a unified equation to quantify the changes of human basal metabolic rate, glomerular filtration rate, and drug clearance from infancy to adulthood. The proposed equation shows that these changes can be well described by a biphasic model with two distinct linear segments.
Article
Pharmacology & Pharmacy
Yifei Zhang, Catherine M. Sherwin, Daniel Gonzalez, Qunshu Zhang, Mona Khurana, Jeffrey Fisher, Gilbert J. Burckart, Yanin Wang, Lynne P. Yao, Charles J. Ganley, Jian Wang
Summary: The study evaluated the performance of eGFR equations in estimating drug clearance in pediatric patients, finding that Schwartz equations led to an overestimation of drug clearance. The bedside Schwartz equation showed a higher eGFR/CL ratio in subjects with lower SCR or CL.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Max Taubert, Elke Schaeffner, Peter Martus, Markus van der Giet, Uwe Fuhr, Amina Loesment, Natalie Ebert
Summary: In this study, the impact of a Bayesian estimation procedure on iohexol clearance estimates was evaluated, and an optimal sampling strategy was identified based on data in individuals aged 70+. A simplified three-compartment model was found to be optimal for estimating iohexol clearance in elderly patients with reduced GFR.
SCIENTIFIC REPORTS
(2021)
Article
Urology & Nephrology
Nori J. L. Smeets, Joanna IntHout, Maurice J. P. van der Burgh, George J. Schwartz, Michiel F. Schreuder, Saskia N. de Wildt
Summary: This study establishes reference values for GFR in healthy, term-born neonates through an analysis of individual participant data (IPD). The study also optimizes the estimation of GFR using creatinine levels. The findings reveal a biphasic increase in GFR in neonates, with the largest increase occurring between days 1 and 5 after birth.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Clinical Neurology
Mayumi Fukuda-Doi, Haruko Yamamoto, Masatoshi Koga, Yohei Doi, Adnan I. Qureshi, Sohei Yoshimura, Kaori Miwa, Akiko Ishigami, Masayuki Shiozawa, Katsuhiro Omae, Masafumi Ihara, Kazunori Toyoda
Summary: Renal impairment is associated with unfavorable outcomes following intracerebral hemorrhage, and there may be safety concerns for intensive blood pressure control in patients with renal impairment.
Article
Medicine, General & Internal
Ampornpan Theeranut, Nonglak Methakanjanasak, Pattama Surit, Junto Srina, Dhavee Sirivongs, Doangjai Adisuksodsai, Sunee Lertsinudom, Kittisak Sawanyawisuth
Summary: The study aimed to evaluate the benefits of multidisciplinary CKD care on CKD progression in patients with up to stage 3b CKD, showing slower renal progression in patients treated by a multidisciplinary approach.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Fatma Hefny, Anna Stuart, Janice Y. Kung, Sherif Hanafy Mahmoud
Summary: This study conducted a systematic review and meta-analysis to investigate the prevalence and risk factors of augmented renal clearance (ARC) in critically ill patients. The results showed a high prevalence of ARC in critically ill patients, especially in the neurocritical care and trauma ICU population. Young age, male sex, and trauma were identified as risk factors for ARC. This study is important for further research on optimal drug dosing in the setting of ARC.
Article
Peripheral Vascular Disease
Lingyan Fei, Minze Xu, Honghong Wang, Cheng Zhong, Shan Jiang, Falk-Bach Lichtenberger, Cem Erdogan, Han Wang, Julia S. Bonk, En Yin Lai, Pontus B. Persson, Richard Kovacs, Zhihua Zheng, Andreas Patzak, Pratik H. Khedkar
Summary: Acute hyperglycemia is a risk factor for acute kidney injury, and our study suggests that hyperglycemia-induced hyperosmolarity facilitates vasodilation through Piezo1-mediated eNOS activation. Our findings indicate that inhibiting Piezo1 and CaMKII can prevent the vasodilation induced by hyperglycemia and hyperosmotic mannitol solution.
Article
Pediatrics
Lesley Rees, Vanessa Shaw, Leila Qizalbash, Caroline Anderson, An Desloovere, Laurence Greenbaum, Dieter Haffner, Christina Nelms, Michiel Oosterveld, Fabio Paglialonga, Nonnie Polderman, Jose Renken-Terhaerdt, Jetta Tuokkola, Bradley Warady, Johan Van de Walle, Rukshana Shroff
Summary: This article discusses the variations in methods of enteral tube feeding for children in different countries, as well as the clinical practice recommendations developed by an international team for children with chronic kidney disease. The recommendations cover types of enteral feeding tubes, placement techniques, recommendations, contraindications, and evidence for their effects on growth parameters.
PEDIATRIC NEPHROLOGY
(2021)
Article
Pediatrics
Winnie Sohn, Isidro B. Salusky, Claus Peter Schmitt, Christina Taylan, Johan Vande Walle, Jude Ngang, Lucy Yan, Mark Kroenke, Bradley A. Warady
Summary: The study demonstrated that single-dose etelcalcetide (0.035 mg/kg) was well tolerated in pediatric hemodialysis patients and exhibited expected pharmacokinetic and safety profiles. The overall pattern of changes in serum intact parathyroid hormone and serum calcium was similar between cohorts and consistent with the expected responses to etelcalcetide.
PEDIATRIC NEPHROLOGY
(2021)
Article
Pharmacology & Pharmacy
L. B. S. Aulin, P. De Paepe, E. Dhont, A. de Jaeger, J. Vande Walle, W. Vandenberghe, B. C. McWhinney, J. P. J. Ungerer, J. G. C. van Hasselt, P. A. J. G. De Cock
Summary: This study successfully characterized the pharmacokinetics of unbound and total teicoplanin in critically ill pediatric patients. The highly variable unbound fraction of teicoplanin could not be predicted using albumin levels, supporting the use of therapeutic drug monitoring of unbound concentrations. Poor target attainment was shown for the most commonly used dosing regimen, regardless of the pharmacokinetic-pharmacodynamic target evaluated.
CLINICAL PHARMACOKINETICS
(2021)
Article
Pediatrics
Amina El Amouri, Evelien Snauwaert, Aurelie Foulon, Charlotte Vande Moortel, Maria Van Dyck, Koen Van Hoeck, Nathalie Godefroid, Griet Glorieux, Wim Van Biesen, Johan Vande Walle, Ann Raes, Sunny Eloot
Summary: The study found that dietary fiber intake in pediatric CKD patients is generally low, especially in advanced CKD stages. Lower levels of pCG were observed in groups with higher fiber intake, independent of kidney function. Current dietary fiber recommendations for healthy children are not being met.
PEDIATRIC NEPHROLOGY
(2021)
Article
Pediatrics
An Desloovere, Jose Renken-Terhaerdt, Jetta Tuokkola, Vanessa Shaw, Larry A. Greenbaum, Dieter Haffner, Caroline Anderson, Christina L. Nelms, Michiel J. S. Oosterveld, Fabio Paglialonga, Nonnie Polderman, Leila Qizalbash, Bradley A. Warady, Rukshana Shroff, Johan Vande Walle
Summary: Dyskalemias are common in children with chronic kidney disease, with both hyperkalemia and hypokalemia being possible. Adjusting dietary potassium intake is crucial, but can be challenging due to potential impacts on nutrient intake and palatability. Following recommendations from the Pediatric Renal Nutrition Taskforce is important for effective management.
PEDIATRIC NEPHROLOGY
(2021)
Article
Food Science & Technology
Amina El Amouri, Evelien Snauwaert, Aurelie Foulon, Charlotte Vande Moortel, Maria Van Dyck, Koen Van Hoeck, Nathalie Godefroid, Griet Glorieux, Wim Van Biesen, Johan Vande Walle, Ann Raes, Sunny Eloot
Summary: Increased dietary fiber intake in pediatric CKD patients is inversely related to the serum concentrations of certain PBUTs, suggesting potential benefits of dietary fiber for this population. These findings should inform dietary recommendations for children with CKD.
Article
Pharmacology & Pharmacy
Anouk van der Veen, Annemie Somers, Sophie Vanhaesebrouck, Rob ter Heine, Roger Bruggemann, Karel Allegaert, Pieter De Cock
Summary: Significant inter-centre variability in dosing and TDM practices was found in Belgian and Dutch NICUs. Development of international consensus guidelines is required to optimize therapy, while dosing calculators to guide dosing are not yet considered as part of standard-of-care.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2022)
Article
Infectious Diseases
Astrid Heus, David W. Uster, Veerle Grootaert, Nele Vermeulen, Annemie Somers, Diana Huis in't Veld, Sebastian G. Wicha, Pieter A. De Cock
Summary: This study identified two suitable popPK models for predicting individual exposure profiles after continuous vancomycin infusion. Model averaging and model selection approaches performed equally as well as individual popPK models and could be used in clinical practice to guide dosing decisions.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Review
Pharmacology & Pharmacy
Jeroen Vervalcke, Arnaud De Clercq, Peter De Paepe, Mirko Petrovic, Tania Desmet, Pieter A. A. De Cock
Summary: This systematic review examines the pharmacokinetics and target attainment of ss-lactam antibiotics in older people, highlighting the need for dose optimization in this patient population. The study reveals decreased clearance and prolonged elimination half-life in aged subjects compared to young subjects, with renal function being a critical factor. It emphasizes the importance of model-based PK studies that consider both physiological and disease-related changes.
CLINICAL PHARMACOKINETICS
(2023)
Article
Medicine, General & Internal
Wim Vandenberghe, Jorien De Loor, Katrien Francois, Kristof Vandekerckhove, Ingrid Herck, Johan Vande Walle, Harlinde Peperstraete, Thierry Bove, Daniel De Wolf, Lieve Nuytinck, Jan J. De Waele, Evelyne Meyer, Eric A. J. Hoste
Summary: This study evaluated serum CHI3L1, NGAL, TIMP-2, IGFBP7, and NephroCheck(R) as predictors of acute kidney injury (AKI) after pediatric cardiac surgery. The results showed that these markers could reliably predict the occurrence of AKI within 48 hours and 12 hours, respectively, after adjusting for urine dilution.
Article
Infectious Diseases
Eline Hermans, Mathias Devreese, Markus Zeitlinger, Evelyn Dhont, Nick Verougstraete, Roos Colman, Johan Vande Walle, Peter De Paepe, Pieter A. De Cock
Summary: This study explored the feasibility and performance of microdialysis experiments in septic piglets and children, and found that microdialysis is a safe and applicable method for measuring tissue drug concentrations.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Pediatrics
Evelyn Dhont, Tatjana Van der Heggen, Evelien Snauwaert, Jef Willems, Siska Croubels, Joris Delanghe, Jan J. De Waele, Roos Colman, Johan Vande Walle, Peter De Paepe, Pieter A. De Cock
Summary: The study aimed to identify predictors of ARC and describe its time-course in critically ill children. Major surgery other than cardiac surgery and eGFR were found as independent predictors of ARC.
PEDIATRIC NEPHROLOGY
(2023)
Letter
Pediatrics
Evelyn Dhont, Tatjana Van der Heggen, Pieter A. De Cock
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Evelyn Dhont, Charlotte Windels, Evelien Snauwaert, Tatjana Van der Heggen, Annick de Jaeger, Laura Dhondt, Joris Delanghe, Siska Croubels, Johan Vande Walle, Peter De Paepe, Pieter A. De Cock
Summary: The reliability of common estimated glomerular filtration rate (eGFR) formulas was assessed in a pediatric intensive care unit (PICU) population. The study found that most eGFR formulas overestimated the measured GFR (mGFR) in critically ill children, with poor precision. Therefore, clinicians should use these formulas with caution when guiding intensive care decision-making and drug dosing.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)