Article
Biochemistry & Molecular Biology
Ilenia Martinelli, Mathieu Cinato, Sokhna Keita, Dimitri Marsal, Valentin Antoszewski, Junwu Tao, Oksana Kunduzova
Summary: The study found that short-term exposure to EMF did not have a significant effect on the myocardial antioxidant defense system and apoptotic cell death in cardiac cells and tissues.
Article
Oncology
Kuo Chen, Pengwei Lu, Narasimha M. Beeraka, Olga A. Sukocheva, SubbaRao Madhunapantula, Junqi Liu, Mikhail Y. Sinelnikov, Vladimir N. Nikolenko, Kirill Bulygin, Liudmila M. Mikhaleva, Igor Reshetov, Yuanting Gu, Jin Zhang, Yu Cao, Siva G. Somasundaram, Cecil E. Kirkland, Ruitai Fan, Gjumrakch Aliev
Summary: This article discusses the role of epigenetic regulation of mitochondrial DNA (mtDNA) in cancer cells and the potential use of mtDNA modifications as novel targets for breast cancer treatment.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Physiology
Paola Lunetti, Loredana Capobianco, Vincenzo Zara, Alessandra Ferramosca
Summary: Studies suggest that certain types of physical exercise can influence male reproductive potential, with mitochondria in gametes potentially playing a crucial role in coordinating molecular events related to the effects induced by exercise.
EXERCISE AND SPORT SCIENCES REVIEWS
(2021)
Review
Cell Biology
Matthew Batty, Martin R. Bennett, Emma Yu
Summary: Atherosclerosis is a leading cause of cardiovascular diseases globally, and excessive generation of reactive oxygen species (ROS) due to oxidative stress is a major risk factor for its development and progression. While ROS are important for maintaining vascular health, they can also activate pro-atherogenic processes. Enzymatic sources of vascular ROS include NADPH oxidases, xanthine oxidase, etc., and antioxidant systems play a role in balancing ROS production. Changes in ROS sources and antioxidants have been observed in human atherosclerosis, and animal models have provided mechanistic insight. However, clinical trials have not yet demonstrated atheroprotective effects of antioxidant molecules.
Article
Biochemistry & Molecular Biology
Hailun He, Lidan Xiong, Linge Jian, Liangman Li, Yan Wu, Shuai Qiao
Summary: This review discusses the role of mitochondria in UV-induced skin damage and summarizes the effects and molecular mechanisms of active chemical components in protecting the skin through mitochondrial protection, which have been described in the last five years.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Article
Immunology
Jun Ding, Jian Jin, Yan Na Lei, Sheng Cui, Hui Ying Li, Hai Lan Zheng, Shang Guo Piao, Yu Ji Jiang, Mei Ying Xuan, Ji Zhe Jin, Ying Shun Jin, Jung Pyo Lee, Byung Ha Chung, Bum Soon Choi, Chul Woo Yang, Can Li
Summary: The study demonstrated that PK treatment protects against chronic TAC-induced renal injury by inhibiting PI3K/AKT signaling. PK improved renal function and histopathology, while also downregulating proinflammatory and profibrotic cytokine expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Jose Yanez, Andrea Leiva
Summary: The placenta plays a crucial role in cholesterol biosynthesis, metabolism, and exchange between the maternal and fetal compartments. The mechanisms of cholesterol uptake and intracellular traffic in placental cells are not fully understood. Proteins such as LDLR, SR-BI, ABCA1, and ABCG1 are involved in the transport of cholesterol. The role of proteins related to intracellular cholesterol traffic in placental cells during normal and pathological pregnancies is still largely unknown. Oxidative stress induced by ROS has been implicated in lysosomal and mitochondrial dysfunction in hypercholesterolemic pregnancies.
Review
Biochemistry & Molecular Biology
Roberto Gualtieri, Guruprasad Kalthur, Vincenza Barbato, Maddalena Di Nardo, Satish Kumar Adiga, Riccardo Talevi
Summary: Mitochondria play a crucial role in cell metabolism and ATP synthesis, while also being responsible for generating ROS and maintaining calcium homeostasis. Dysfunction in mitochondria can lead to oxidative stress, affecting cell function. Assisted reproductive technologies and cryopreservation may compromise mitochondrial function, impacting reproductive outcomes by affecting sperm and oocyte quality and fertilization dynamics.
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yu Kitaoka
Summary: Nrf2 is believed to play a crucial role in protecting cells against oxidative stress and is also involved in energy metabolism. This review briefly discusses the role of Nrf2 in skeletal muscle metabolism from the perspective of exercise physiology.
Review
Food Science & Technology
Jing Yang, Huayi Suo, Jiajia Song
Summary: MitoQ reduces mitochondrial oxidative stress and promotes autophagy and mitochondrial biogenesis to alleviate MetS symptoms such as obesity, insulin resistance, hypertension, and cardiovascular disease. Its regulatory effect on mitochondrial homeostasis is mediated through AMPK and its downstream signaling pathways.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Cell Biology
S. Ankul Singh, Swathi Suresh, Chitra Vellapandian
Summary: This review discusses the rising global ozone in densely populated areas of Asia and Africa, and explores the possible neurotoxicity and biomarkers associated with ozone-induced oxidative stress. It also examines the impact of ozone on blood circulation, antibacterial action, immune response, and other aspects, and suggests the need for further research on biomarkers related to ozone and the brain.
AGEING RESEARCH REVIEWS
(2023)
Article
Medicine, Research & Experimental
Yaqian Qu, Ruonan Zhai, Dandan Wang, Zheng Wang, Guangjie Hou, Chenchen Wu, Meian Tang, Xiongbin Xiao, Jie Jiao, Yue Ba, Fang Zhou, Jian Qiu, Wu Yao
Summary: In this study, the upregulation of proteins involved in mitochondrial folate metabolism during myofibroblast differentiation and the negative regulation of myofibroblast differentiation by the proteins MTHFD2 and SLC25A32 were revealed. Furthermore, reduced plasma folate concentration in patients and mice with silicosis was observed. Folate supplementation elevated the expression of MTHFD2 and SLC25A32, alleviated oxidative stress, and effectively suppressed myofibroblast differentiation and silica-induced pulmonary fibrosis in mice.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Sylwia M. Kacprzak, Olivier Van Aken
Summary: Mitochondria play vital roles in plant metabolism and stress responses. Quality control systems, including mitophagy, are important for maintaining a healthy mitochondrial pool. The 'Friendly Mitochondria' protein (FMT) has been identified as a crucial player in mitophagy during dark-induced senescence in Arabidopsis.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Pauline Robert, Phuc Minh Chau Nguyen, Alexis Richard, Celine Grenier, Arnaud Chevrollier, Mathilde Munier, Linda Grimaud, Coralyne Proux, Tristan Champin, Eric Lelievre, Emmanuelle Sarzi, Emilie Vessieres, Samir Henni, Delphine Prunier, Pascal Reynier, Guys Lenaers, Celine Fassot, Daniel Henrion, Laurent Loufrani
Summary: The study found that mitochondrial fusion plays a protective role in hypertension by reducing oxidative stress. Defects in mitochondrial fusion worsen hypertension. Additionally, increased mitochondrial ROS production leads to apoptosis in vascular cells and decreased proliferation of VSMCs.
Review
Gastroenterology & Hepatology
Clara Balsano, Anna Alisi, Maurizia R. Brunetto, Pietro Invernizzi, Patrizia Burra, Fabio Piscaglia
Summary: The integration of human and artificial intelligence in medicine shows great potential for improving the management of liver diseases. However, ethical considerations and addressing challenges are crucial in the data collection and application process.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Medicine, General & Internal
Gaia Sinatti, Silvano Junior Santini, Giovanni Tarantino, Giovanna Picchi, Benedetta Cosimini, Francesca Ranfone, Nicolo Casano, Maria Antonella Zingaropoli, Nerio Iapadre, Simone Bianconi, Antonietta Armiento, Paolo Carducci, Maria Rosa Ciardi, Claudio Maria Mastroianni, Alessandro Grimaldi, Clara Balsano
Summary: The study demonstrated that a PaO2/FiO2 ratio < 274 mmHg is a good predictive index for forecasting severe respiratory failure in COVID-19-infected patients. Compared to inflammatory scores, the PaO2/FiO2 ratio was found to be the most reliable parameter in identifying patients requiring closer respiratory monitoring and more aggressive supportive therapies.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Health Care Sciences & Services
Silvia Rossi, Silvano Junior Santini, Daniela Di Genova, Gianpaolo Maggi, Alberto Verrotti, Giovanni Farello, Roberta Romualdi, Anna Alisi, Alberto Eugenio Tozzi, Clara Balsano
Summary: This study assessed the impact of social robots (SRs) on managing stress in children waiting for emergency room consultations. The results showed that salivary cortisol levels significantly decreased more in the group exposed to robot interaction compared to the other two groups. This suggests that SRs are an effective tool for reducing stress in the emergency room.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Genetics & Heredity
Giovanna Di Emidio, Carla Tatone, Vincenza Barbato, Vincenzo Genovese, Martina Placidi, Riccardo Talevi, Roberto Gualtieri
Summary: This study evaluated the potential fertoprotective effects of the specific inhibitor of SIRT1, EX-527, on the loss of primordial follicles (PFs) caused by the treatment side effects in female cancer patients. The results showed that EX-527 reduced PF activation and growth induced by the treatment while PM promoted PF activation. Therefore, SIRT1 could be a candidate molecule for protecting ovarian follicles from alkylating agents and EX-527 could be a potential fertoprotective agent for cancer patients.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Stefania Vitale, Sara Colanero, Martina Placidi, Giovanna Di Emidio, Carla Tatone, Fernanda Amicarelli, Anna Maria D'Alessandro
Summary: This study summarizes recent research on herbal preparations for wound management, finding that several herbal medicaments have activity at different stages, with components such as flavonoids, alkaloids, saponins, and phenolic compounds contributing to this activity. The application of natural compounds using nanotechnology systems may significantly improve the efficacy of wound treatments.
Review
Biochemistry & Molecular Biology
Martina Placidi, Giovanna Di Emidio, Ashraf Virmani, Angela D'Alfonso, Paolo Giovanni Artini, Anna Maria D'Alessandro, Carla Tatone
Summary: The importance of bioenergetics in the reproductive process has highlighted the role of carnitines as mitochondrial modulators. Carnitine supplementation may help counteract energetic and redox imbalances during in vitro culture and cryopreservation. Carnitines activate pathways involved in antiapoptotic, antiglycative, antioxidant, and antiinflammatory signaling, potentially improving oocyte and embryo competence.
Editorial Material
Biochemistry & Molecular Biology
Carla Tatone, Giovanna Di Emidio
Review
Cell Biology
Marco Ponzetti, Nadia Rucci, Stefano Falone
Summary: Disruption of redox homeostasis and RNA methylome-dependent control of gene expression play critical roles in cancer resistance to treatment. However, little research has focused on the involvement of redox-dependent or -responsive signaling pathways in the epitranscriptome-directed adaptations underlying acquired and/or innate resistance traits in cancer. This review summarizes the current understanding of this topic and provides new perspectives for delaying or preventing refractory cancer and tumor recurrence.
Editorial Material
Oncology
Antonio Giordano, Nadia Rucci, Stefano Falone
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Grazia Palmerini, Guido Macchiarelli, Domenica Cocciolone, Ilaria Antenisca Mascitti, Martina Placidi, Teresa Vergara, Giovanna Di Emidio, Carla Tatone
Summary: This study aimed to investigate the morphological and molecular changes in the PCOS uterus and the regulatory effects of different carnitine formulations. The results showed that the PCOS uterus had tissue and oxidative damage, and carnitine administration alleviated these damages and maintained mitochondrial content.
Article
Biochemistry & Molecular Biology
Martina Placidi, Teresa Vergara, Giovanni Casoli, Irene Flati, Daria Capece, Paolo Giovanni Artini, Ashraf Virmani, Samuele Zanatta, Anna Maria D'Alessandro, Carla Tatone, Giovanna Di Emidio
Summary: Carnitines play a crucial role in treating polycystic ovarian syndrome by improving metabolism and reproductive function through modulating mitochondrial activity and redox homeostasis.
Review
Nutrition & Dietetics
Valerio Caputo, Giovanni Tarantino, Silvano Junior Santini, Giovanna Fracassi, Clara Balsano
Summary: Metabolic dysfunction-associated steatotic fatty liver disease (MASLD), a novel definition for NAFLD, is one of the most common liver diseases with increasing incidence worldwide. Its complex etiopathogenesis involves mitochondrial dysfunction, altered lipid metabolism, inflammation, and oxidative stress. Changes in diet and lifestyle, as well as the influence of natural compounds, can modulate these mechanisms and improve the understanding and treatment of MASLD.
Article
Oncology
Marco Ponzetti, Argia Ucci, Chiara Puri, Luca Giacchi, Irene Flati, Daria Capece, Francesca Zazzeroni, Alfredo Cappariello, Nadia Rucci, Stefano Falone
Summary: This study investigated the effects of osteoblast-derived extracellular vesicles (OB-EVs) on the phenotype, energy metabolism, and oxidative status of osteosarcoma cells. The results showed that OB-EVs reduced the aggressiveness and viability of osteosarcoma cells through redox-dependent signaling pathways.
FRONTIERS IN ONCOLOGY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Anna Guiotto, Valeria Cordone, Andrea Vallese, Mascia Benedusi, Franco Cervellati, Joussef Hayek, Carlo Cervellati, Giuseppe Valacchi, Alessandra Pecorelli
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Alessandra Pecorelli, Valeria Cordone, Anna Guiotto, Joussef Hayek, Carlo Cervellati, Giuseppe Valacchi
FREE RADICAL BIOLOGY AND MEDICINE
(2022)