Article
Geriatrics & Gerontology
Rikke S. Kamper, Julian Alcazar, Lars L. Andersen, Bryan Haddock, Niklas Rye Jorgensen, Peter Hovind, Charlotte Suetta
Summary: The study investigated the relationship between chronic low-grade inflammation and age-related muscle decline and physical performance. Results showed that with age, levels of certain inflammatory biomarkers in the blood increased significantly, correlating with decreased muscle strength and physical function.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Geriatrics & Gerontology
Mengyu Cao, Junsong Lian, Xisheng Lin, Jinwei Liu, Chao Chen, Shuaixuan Xu, Shuang Ma, Fang Wang, Nihui Zhang, Xiaolei Qi, Guogang Xu, Nan Peng
Summary: This study investigates the consistency between the latest diagnostic criteria for sarcopenia, AWGS 2019, and other common criteria in China. The study also analyzes the changes in muscle mass, muscle strength, and physical function with age and their impact on sarcopenia diagnosis. The results show that AWGS 2019 is highly consistent with other criteria and that the effects of age on muscle strength and function are more significant than on muscle mass.
Article
Geriatrics & Gerontology
Kira Scheerman, Carel G. M. Meskers, Sjors Verlaan, Andrea B. Maier
Summary: This study found that older patients hospitalized with sarcopenia or probable sarcopenia at admission had a higher risk of long-term mortality. Low handgrip strength, skeletal muscle mass index, and appendicular lean mass were also associated with an increased risk of mortality. The associations of handgrip strength and muscle mass with mortality were influenced by sex.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Valentina Muollo, Toni Tatangelo, Laura Ghiotto, Valentina Cavedon, Chiara Milanese, Mauro Zamboni, Federico Schena, Andrea P. Rossi
Summary: This study investigated the association between handgrip strength and muscle function of the lower limbs, as well as predictors of appendicular lean mass index in older adults with obesity. Results showed that handgrip strength was weakly associated with lower limbs muscle function and physical performance, while BMI was a significant predictor for ALMI in both genders. In the group of men, markers related to strength and power of the lower limbs were found to better explain variations in ALMI compared to handgrip strength.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Geriatrics & Gerontology
Zhi-Hui Lu, Freddy M. H. Lam, Jason C. S. Leung, Timothy C. Y. Kwok
Summary: This study aimed to evaluate the difference in resilience across frailty status, and found that frail older people experienced more significant changes in lean mass, physical performance, and quality of life after unplanned hospitalization, as well as a higher risk of subsequent hospitalization.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Geriatrics & Gerontology
Marc Sim, Jack Dalla Via, David Scott, Wai H. Lim, Jonathan M. Hodgson, Kun Zhu, Robin M. Daly, Gustavo Duque, Richard L. Prince, Joshua R. Lewis
Summary: The study found that women with low Cr:Cyc had weaker grip strength, worse performance in the timed-up-and-go test, and lower appendicular lean mass adjusted for height or body mass index. They also had a higher risk of falls and fall-related hospitalizations compared to women with high Cr:Cyc.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Marc Sim, Kun Zhu, Joshua R. Lewis, Jonathan M. Hodgson, Richard L. Prince
Summary: In a cohort of community-dwelling older Australian women aged >= 70 years, higher plasma 25-hydroxyvitamin D levels were associated with a decreased risk of falls-related hospitalizations, indicating that maintaining plasma 25OHD at 75 nmol/L or above may confer benefits to muscle function and long-term prevention of injurious falls requiring hospitalization. This relationship seems to be independent of better physical function observed in women with higher 25OHD levels.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Urology & Nephrology
Hugo de Luca Correa, Andre Bonadias Gadelha, Baruch Vainshelboim, Maurilio Tiradentes Dutra, Joao B. Ferreira-Junior, Lysleine Alves Deus, Rodrigo Vanerson Passos Neves, Andrea Lucena Reis, Thais Branquinho de Araujo, Carmen Tzanno-Martins, Fernanda Silveira Tavares, Rosangela Vieira Andrade, Thiago dos Santos Rosa
Summary: This study investigated the association between sarcopenia and all-cause mortality, hospitalizations, and cardiovascular diseases in patients with end-stage renal disease (ESRD). The results showed that sarcopenia was associated with significantly higher risk of mortality, hospitalizations, and cardiovascular diseases in ESRD patients. This suggests that sarcopenia may be a risk factor for negative outcomes in ESRD patients.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Physiology
Sara A. Harper, Brennan J. Thompson
Summary: Assessing neuromuscular capacity in older adults is crucial for determining age-related functional decline risks; Minimal dose eccentric resistance training can improve muscle quality and functional performance in older adults; Improved exercise tolerance may enhance exercise participation and overall health in older adult populations.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Maria Amasene, Maria Medrano, Inaki Echeverria, Miriam Urquiza, Ana Rodriguez-Larrad, Amaia Diez, Idoia Labayen, Besga-Basterra Ariadna
Summary: This study found that better nutritional status and physical function were significantly associated with lower CCI scores among hospitalized older adults. Patients with malnutrition or risk of malnutrition, as well as frailty, had significantly increased the risk for severe comorbidity. Patients at risk of malnutrition or that are malnourished had higher CCI scores regardless of handgrip strength, and frail patients had higher CCI despite their nutritional status.
FRONTIERS IN NUTRITION
(2022)
Article
Geriatrics & Gerontology
D. Nogueira Paranhos Amorim, D. C. Nascimento, W. Stone, V. P. Alves, C. F. Moraes, K. H. Coelho Vilaca E. Silva
Summary: The study found that with increasing muscle quality (MQ), the likelihood of having more than four falls in history decreases. Non-fallers were younger and took more medications compared to recurrent fallers. Recurrent fallers had lower MQ compared to fallers and non-fallers, and they also had a lower score on the Geriatric Depression Scale (GDS) compared to fallers. Additionally, fallers had lower scores in balance compared to non-fallers.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Geriatrics & Gerontology
Ryan Mcgrath, Grant R. Tomkinson, Jeremy M. Hamm, Kirsten Juhl, Kelly Knoll, Kelly Parker, Ashleigh E. Smith, Yeong Rhee
Summary: The study found that each weakness cut-point has different predictive value for future cognitive impairment, and aggregating weakness cut-points may improve their predictive utility.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Review
Geriatrics & Gerontology
Stuart M. Phillips, Kyle J. Lau, Alysha C. D'Souza, Everson A. Nunes
Summary: This study reviewed systematic reviews on the effects of HMB supplementation on muscle growth and muscle loss in ageing and clinical populations. The majority of reviews concluded that HMB supplementation did not affect muscle strength or physical function, and there was controversy regarding its impact on increasing muscle mass.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Physiology
Sarah A. Purcell, Michelle Mackenzie, Thiago G. Barbosa-Silva, Isabelle J. Dionne, Sunita Ghosh, Mario Siervo, Ming Ye, Carla M. Prado
Summary: Sarcopenic obesity prevalence varies greatly depending on definitions, often associated with low handgrip strength in older Canadian adults.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Geriatrics & Gerontology
Jesse J. Aarden, Esmee M. Reijnierse, Marike van der Schaaf, Martin van der Esch, Lucienne A. Reichardt, Rosanne van Seben, Jos A. Bosch, Jos W. R. Twisk, Andrea B. Maier, Raoul H. H. Engelbert, Bianca M. Buurman
Summary: This study found that muscle mass decreases in acutely hospitalized older adults, but physical performance significantly improves in the 3 months post-discharge. Muscle strength did not change significantly. Approximately 80% of older adults scored below the cutoff point for muscle mass at 3 months post-discharge.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Geriatrics & Gerontology
Jesse Zanker, Marc Sim, Kate Anderson, Saliu Balogun, Sharon L. Brennan-Olsen, Elsa Dent, Gustavo Duque, Christian M. Girgis, Mathis Grossmann, Alan Hayes, Tim Henwood, Vasant Hirani, Charles Inderjeeth, Sandra Iuliano, Justin Keogh, Joshua R. Lewis, Gordon S. Lynch, Julie A. Pasco, Steven Phu, Esmee M. Reijnierse, Nicholas Russell, Lara Vlietstra, Renuka Visvanathan, Troy Walker, Debra L. Waters, Solomon Yu, Andrea B. Maier, Robin M. Daly, David Scott
Summary: This study aims to develop guidelines for sarcopenia prevention, assessment, and management based on consumer values and preferences, to be used by clinicians and researchers in Australia and New Zealand. A three-phase Consumer Expert Delphi process was conducted to gather consumer opinions on sarcopenia outcomes, consultation preferences, and interventions. The consumer preferences identified in this study can guide the implementation of sarcopenia guidelines at various levels of clinical practice in Australia and New Zealand.
AUSTRALASIAN JOURNAL ON AGEING
(2023)
Article
Biochemistry & Molecular Biology
Maryam Asadi Farsani, Ebrahim Banitalebi, Mohammad Faramarzi, Nuredin Bakhtiari, Mostafa Rahimi, Gustavo Duque
Summary: This study explored the effects of ursolic acid and different types of exercise on glycemic control and aging/diabetes-associated complications. The results showed that eight weeks of resistance training could affect miR-133a expression in muscles and the biomarker RUNX2 in aged type 2 diabetes model rats.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Endocrinology & Metabolism
Jocelyn Tan, Carrie-Anne Ng, Nicolas H. Hart, Timo Rantalainen, Marc Sim, David Scott, Kun Zhu, Beth Hands, Paola Chivers
Summary: Bone health is compromised in children and adolescents with low motor competence (LMC). This study found that LMC is associated with decreased bone mineral density (BMD) at load-bearing bone sites, particularly in males. Engaging in osteogenic physical activity can increase BMD, but factors like diversity and movement quality may also contribute to BMD differences based on LMC status.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Pratik Pokharel, Jamie W. Bellinge, Frederik Dalgaard, Kevin Murray, Marc Sim, Bu B. Yeap, Emma Connolly, Lauren C. Blekkenhorst, Catherine P. Bondonno, Joshua R. Lewis, Gunnar Gislason, Anne Tjonneland, Kim Overvad, Jonathan M. Hodgson, Carl Schultz, Nicola P. Bondonno
Summary: Observational studies have shown a lower risk of type 2 diabetes with higher vitamin K-1 intake. This study found that higher intake of foods rich in vitamin K-1 was associated with a lower risk of diabetes. This association was present in all subgroups at higher risk, indicating that more cases of diabetes could be prevented.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Guillaume Duval, Anne-Marie Schott, Yves Rolland, Jennifer Gautier, Hubert Blain, Gustavo Duque, Cedric Annweiler
Summary: This study found that a decrease in systolic blood pressure while standing was associated with baseline cognitive impairment in older women, but orthostatic hypotension itself and a decrease in diastolic blood pressure while standing were not. Furthermore, none of these factors could predict incident cognitive decline after 7 years. This suggests that the relationship between orthostatic hypotension and cognitive impairment is more complex than previously thought.
Article
Nutrition & Dietetics
Chia-Ling Kuo, Ben Kirk, Meiruo Xiang, Luke C. C. Pilling, George A. A. Kuchel, Richard Kremer, Gustavo Duque
Summary: This study examined the relationship between vitamin D levels and leukocyte telomere length (LTL) in older participants. It found that low or extremely low vitamin D levels were associated with shorter LTL, as well as high vitamin D levels. However, these associations may be influenced by unmeasured confounders.
Article
Oncology
Huah Shin Ng, Richard Woodman, Bogda Koczwara
Summary: This study compared the health status and mental distress between individuals with and without cancer according to comorbidity type. The results showed that individuals with cancer were more likely to report poor health for specific comorbidities, particularly those with a comorbid mental illness. The study highlights the importance of addressing comorbidities in cancer care and research.
Article
Peripheral Vascular Disease
Jin Nuo Joan Tsang, Stephen Bacchi, Joshua G. Kovoor, Aashray K. Gupta, Brandon Stretton, Samuel Gluck, Toby Gilbert, Yogesh Sharma, Richard Woodman, Arduino A. Mangoni
Summary: The study investigated the prevalence of elevated blood pressure and its association with in-hospital mortality in Australian medical inpatients. The results showed that elevated systolic blood pressure levels were common in this group, and a negative association was observed between systolic blood pressure values ≥ 140 mmHg and in-hospital mortality. Further research is needed to determine the clinical significance and optimal management of blood pressure elevations in this population.
JOURNAL OF CLINICAL HYPERTENSION
(2023)
Article
Cell & Tissue Engineering
Jack Feehan, Macsue Jacques, Dmitry Kondrikov, Nir Eynon, Tissa Wijeratne, Vasso Apostolopoulos, Jeffrey M. Gimble, William D. Hill, Gustavo Duque
Summary: Circulating osteoprogenitors (COP) are a unique population of cells in the peripheral circulation that share similar functional characteristics with bone marrow-derived MSCs and adipose-derived MSCs. This study compared COP cells to BM-MSCs and ASCs through transcriptomic and proteomic analyses, and found distinct gene and protein expression patterns in COP cells, but similar proliferation and differentiation capacity.
Article
Nutrition & Dietetics
Jocelyn M. Choo, Karen J. Murphy, Alexandra T. Wade, Yanan Wang, Ella L. Bracci, Courtney R. Davis, Kathryn A. Dyer, Richard J. Woodman, Jonathan M. Hodgson, Geraint B. Rogers
Summary: The impact of a Mediterranean diet supplemented with dairy foods on the gut microbiome in Australians at risk of cardiovascular disease was evaluated. The Mediterranean diet with 3-4 daily serves of dairy foods resulted in changes in the abundance of specific gut bacteria. Increases in Butyricicoccus relative abundance were inversely correlated with lower systolic blood pressure and positively correlated with changes in fasting glucose levels. These findings suggest that the MedDairy diet may have a positive effect on clinical outcomes in adults at risk of CVD.
Article
Geriatrics & Gerontology
M. B. Formica, J. Gianoudis, C. A. Nowson, S. L. O'Connell, C. Milte, K. A. Ellis, Robin M. Daly
Summary: This study found that consuming lean red meat on three exercise training days per week did not promote greater improvements in health-related quality of life compared to exercise alone in community-dwelling older adults.
JOURNAL OF NUTRITION HEALTH & AGING
(2023)
Article
Geriatrics & Gerontology
Ben Kirk, Chloe French, Maria Gebauer, Sara Vogrin, Jesse Zanker, Myrla Sales, Gustavo Duque
Summary: The aim of this study was to compare the diagnostic value of relative sit-to-stand muscle power with grip strength or gait speed for identifying a history of recurrent falls and fractures in older adults. The results showed that, although slightly better, relative sit-to-stand muscle power had low diagnostic power compared to grip strength or gait speed. Further research is needed to evaluate the diagnostic power of relative sit-to-stand muscle power for incident falls and fractures, and to determine its clinical value.
EUROPEAN GERIATRIC MEDICINE
(2023)
Article
Geriatrics & Gerontology
Miguel German Borda, Gustavo Duque, Mario Ulises Perez-Zepeda, Jonathan Patricio Baldera, Eric Westman, Anna Zettergren, Jessica Samuelsson, Silke Kern, Lina Ryden, Ingmar Skoog, Dag Aarsland
Summary: This study aimed to provide a more accessible way to detect sarcopenia by comparing the traditional method of DXA lean mass estimation versus the tongue and masseter muscle mass assessed in a standard brain MRI. The results showed a significant correlation between tongue and masseter muscle mass with DXA lean mass, and the prevalence of sarcopenia calculated using head muscles did not differ from sarcopenia calculated using DXA. Almost all participants were correctly classified using both methods.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Review
Endocrinology & Metabolism
Cassandra Smith, Marc Sim, Jack Dalla Via, Itamar Levinger, Gustavo Duque
Summary: Loss of muscle and bone mass, strength, and quality, which commonly occur with aging, can lead to reduced physical function and increased risk of falls and fractures. The interaction between bone and muscle, driven by bone-muscle crosstalk, plays a crucial role in this process. Exercise is the primary strategy for improving both muscle and bone health. However, holistic treatment plans that incorporate exercise and other allied health services are underutilized in preventing or treating musculoskeletal diseases.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Nutrition & Dietetics
Horacio Sanchez-Trigo, Wolfgang Kemmler, Gustavo Duque, Borja Sanudo
Summary: This randomized controlled trial investigates the effect of bone turnover markers on physical activity intervention, finding that it can improve bone mineral density in premenopausal women and the markers may be useful for early assessment. Further research is needed.
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
(2023)
