Article
Pharmacology & Pharmacy
Yunlu Jiang, Maocai Yan, Chunmei Wang, Qinqin Wang, Xiaoyu Chen, Rumin Zhang, Lei Wan, Bingyuan Ji, Bo Dong, Huiyun Wang, Jing Chen
Summary: Research showed that different Apelin and Elabela ligands activated APJ resulted in distinct G protein-dependent and beta-arrestin-dependent signaling pathways. Elabela-32 exhibited a >1000-fold bias towards the beta-arrestin-dependent pathway, while Apelin-17 was biased towards the beta-arrestin-dependent signaling. Eabela-21 and pGlu(1)-Apelin-13 showed very different activities on the G protein-dependent pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Jing Chen, Zhengwen Wang, Rumin Zhang, Haiyan Yin, Peixiang Wang, Chunmei Wang, Yunlu Jiang
Summary: The study reveals the formation of a heterodimer between APJ and ORL1, which play roles in signaling and physiological effects. The APJ-ORL1 dimer exhibits a biased signaling pathway that is G protein-dependent. The structural interface of the dimer switches from TM1/TM2 to TM5 upon activation.
Article
Biochemistry & Molecular Biology
Carline Chaves-Almagro, Johanna Auriau, Alizee Dortignac, Pascal Clerc, Hubert Lulka, Simon Deleruyelle, Fabrice Projetti, Jessica Nakhle, Audrey Frances, Judit Berta, Veronique Gigoux, Daniel Fourmy, Marlene Dufresne, Anne Gomez-Brouchet, Julie Guillermet-Guibert, Pierre Cordelier, Bernard Knibiehler, Ralf Jockers, Philippe Valet, Yves Audigier, Bernard Masri
Summary: This study investigated the expression and protumoral function of apelin and its receptor APJ in human pancreatic adenocarcinoma. It was found that apelin and APJ were co-expressed by tumor cells in the invasive stage, and apelin promoted cancer cell proliferation, migration, and glucose uptake. Blocking the apelin receptor reduced cancer cell proliferation and pancreatic tumor burden.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Abul K. Azad, Kieran R. Campbell, Pavel Zhabyeyev, Gavin Y. Oudit, Ronald B. Moore, Allan G. Murray
Summary: This study investigates the role of apelin as a pro-angiogenic ligand in tumor growth and angiogenesis. The findings suggest that loss of apelin delays tumor growth and reduces tumor vessel density when combined with the VEGF receptor tyrosine kinase inhibitor, sunitinib. Targeting apelin may be an effective adjuvant therapy in combination with VEGF signaling inhibition to inhibit the growth of advanced tumors.
Article
Multidisciplinary Sciences
Wenji Piao, Lushen Li, Vikas Saxena, Jegan Iyyathurai, Ram Lakhan, Yigang Zhang, Isadora Tadeval Lape, Christina Paluskievicz, Keli L. Hippen, Young Lee, Emma Silverman, Marina W. Shirkey, Leonardo Riella, Bruce R. Blazar, Jonathan S. Bromberg
Summary: This study reveals the regulatory role of PD-L1 signaling in the transendothelial migration of T cells and highlights the importance of PD-L1 in cell migration and immune regulation.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Thomas L. L. Williams, Robyn G. C. Macrae, Rhoda E. E. Kuc, Alastair J. H. Brown, Janet J. J. Maguire, Anthony P. P. Davenport
Summary: This article describes the design and validation of four novel fluorescent ligands that can bind to the apelin receptor and trigger receptor internalization. These ligands have potential applications in regulating the human cardiovascular system and drug discovery.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Deguan Lv, Xuling Luo, Zhe Chen, Jiaqi Liu, Meiqing Liu, Yao Li, Shifang Huang, Mingzhu Tang, Li Yang, Liqun Lu, Jinyong Jiang, Qionglin Zhou, Feng Xie, Cuiqing Zhong, Lanfang Li, Linxi Chen
Summary: This study reveals that apelin induces autophagy activation in lung adenocarcinoma cells, promoting cell migration through regulating BECN1 transcription via HIF1A. The findings suggest a potential therapeutic target for lung adenocarcinoma through targeting apelin-induced autophagy.
Article
Plant Sciences
R. Alipanah-Moghadam, A. Mehri, F. Manafi, V. Malekzadeh, A. Nemati, V. Aghamohammadi, M. Mazani, C. T. Clark Cain, M. Mohammadzadeh-Vardin
Summary: Andrographis paniculata has various pharmacological effects, including antibacterial, antiviral, and hypoglycemic effects, and can increase hepatic apelin gene expression. Experimental results indicate that andrographolide can significantly influence apelin gene expression and blood glucose levels in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Polymer Science
Huanhuan Zhang, Senhao Zhang, Shuaishuai Zhou, Zhao-xia Huang, Jin-Ping Qu
Summary: In this study, two-dimensional organically modified montmorillonite (OMMT) was incorporated into poly(vinylidene fluoride)/carbon tubes (PVDF/CNTs) nanocomposites, effectively blocking the conductive pathway formation of carbon nanotubes. This led to the achievement of high dielectric constant and low loss at high dispersion concentration.
Article
Multidisciplinary Sciences
Liuying Hu, Yumiko Hayashi, Hiroyasu Kidoya, Nobuyuki Takakura
Summary: The Apelin/APJ signaling pathway plays a role in regulating tumor growth by inducing vascular maturation and enhancing anti-tumor immunity. Lack of Apelin leads to increased tumor growth, while treatment with [Pyr(1)]Apelin-13 inhibits tumor growth.EC-derived Apelin may regulate tumor formation in an autocrine manner by expressing APJ, and Apelin induces chemokine CCL8 expression in ECs. These findings suggest that Apelin acts as a tumor suppressor by enhancing the infiltration of CD8(+) T cells into tumors and inhibiting tumor growth.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Mehran Ilaghi, Adel Soltanizadeh, Shiva Amiri, Kristi A. Kohlmeier, Mohammad Shabani
Summary: Apelin is a regulatory peptide that interacts with the APJ receptor to exert cytoprotective effects. It is involved in cardiovascular and central nervous system functions and can modulate signaling through interactions with other receptors. The interaction between APJ and KOR has been shown to be important in cellular processes such as cell proliferation. Understanding the cellular protective actions of apelin and its receptor interactions has implications for the treatment of various diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Jian Song, Zhigang He, Muqing Yang, Tianyu Yu, Xiaodong Wang, Bin Liu, Jiyu Li
Summary: In hepatic ischemia reperfusion injury, tryptase is accumulated in the circulation and positively correlated with liver injury. Tryptase inhibition can down-regulate adhesion molecules expression and reduce neutrophil infiltration in the liver. The activation of tryptase/PAR-2 axis participates in liver injury through the regulation of neutrophil adhesion and inflammatory factor secretion.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Liang Ding, Yong Fu, Nisha Zhu, Mengxiang Zhao, Zhuang Ding, Xiaoxin Zhang, Yuxian Song, Yue Jing, Qian Zhang, Sheng Chen, Xiaofeng Huang, Lorraine A. O'Reilly, John Silke, Qingang Hu, Yanhong Ni
Summary: The authors identified a subset of fibroblasts expressing oxytocin receptor enriched in highly invasive WPOI 4-5 OSCC tumors, which can be targeted to reduce desmoplastic stroma and tumor metastasis. Targeting ERK5 signaling in OXTRHigh CAFs is suggested as a potential therapeutic strategy for OSCC patients with WPOI 4-5, as these fibroblasts contribute to local-regional metastasis.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Cai Read, Duuamene Nyimanu, Peiran Yang, Rhoda E. Kuc, Thomas L. Williams, Christopher M. Fitzpatrick, Richard Foster, Robert C. Glen, Janet J. Maguire, Anthony P. Davenport
Summary: CMF-019, a small molecule apelin agonist, demonstrates strong vasodilatory effects in vivo and protects human pulmonary artery endothelial cells from apoptosis. It exhibits remarkable bias at the apelin receptor and could serve as the basis for designing novel therapeutic agents for chronic diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Borhan Shokrollahi, Hai-Ying Zheng, Ling-Yu Li, Li-Ping Tang, Xiao-Ya Ma, Xing-Rong Lu, An-Qin Duan, Yu Zhang, Xiao-Hui Tan, Chen-Xi Huang, Yuan-Yuan Xu, Jiang-Hua Shang
Summary: This study investigated the expression levels of APLN/APJ in buffalo ovarian granulose cells (GCs) and the effects of IGF1 and FSH on APLN/APJ expression. The results showed that APLN expression was highest in large-sized GCs, while APJ expression increased with follicle enlargement. IGF1 and FSH increased the expression of APLN and FSH, and IGF1 also increased the expression of APJ. Both isoforms of APLN increased the secretion of E2 and P4, potentially through upregulation of CYP19A1 and StAR expression. In conclusion, APLN may play a crucial role in steroidogenesis and follicular development in buffalo ovarian GCs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
