Article
Cell & Tissue Engineering
Kun Wang, Yiyang Wang, Yuanjian Wang, Shujie Liu, Chunyan Wang, Shuo Zhang, Tianli Zhang, Xingsheng Yang
Summary: The study reveals that EIF5A2 positively regulates stemness in ovarian cancer cells through the E2F1/KLF4 pathway, indicating its potential as a target for CSCs-targeted therapy in ovarian cancer.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Medicine, Research & Experimental
Shruthi Sriramkumar, Riddhi Sood, Thomas D. Huntington, Ahmed H. Ghobashi, Truc T. Vuong, Tara X. Metcalfe, Weini Wang, Kenneth P. Nephew, Heather M. O'Hagan
Summary: This study reveals the impact of platinum-based chemotherapy on metabolic pathways and identifies key targets that can be therapeutically exploited to inhibit platinum-induced enrichment of OCSCs, ultimately improving the survival of OC patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Chun-Wen Cheng, Wen-Ling Liao, Po-Ming Chen, Jyh-Cherng Yu, Hui-Ping Shiau, Yi-Hsien Hsieh, Huei-Jane Lee, Yu-Chun Cheng, Pei-Ei Wu, Chen-Yang Shen
Summary: The study demonstrates that miR-139 can suppress invasion and migration of breast cancer stem cells by down-regulating CXCR4/p-Akt signaling, and its reduced expression is associated with worse clinicopathological features in breast cancer patients, suggesting it as a potential therapeutic target for invasive breast cancer.
Article
Cell Biology
Lu Chen, Wujiang Gao, Chunli Sha, Meiling Yang, Li Lin, Taoqiong Li, Hong Wei, Qi Chen, Jie Xing, Mengxue Zhang, Shijie Zhao, Wenlin Xu, Yuefeng Li, Xiaolan Zhu
Summary: The E3 ligase SIAH1 is decreased in epithelial ovarian cancer (EOC) and negatively correlated with RPS3 levels. Overexpression of SIAH1 can suppress tumor cell growth, invasion, and cisplatin resistance by promoting RPS3 degradation and subsequent NF-kappa B inactivation.
Article
Biochemistry & Molecular Biology
Tongtong Kan, Shupeng Zhang, Shengtao Zhou, Ya Zhang, Yun Zhao, Yinghua Gao, Tao Zhang, Feng Gao, Xin Wang, Linjie Zhao, Mengsu Yang
Summary: This study utilizes single-cell RNA sequencing to investigate the development and origin of relapse cells in epithelial ovarian cancers (EOCs). The researchers identified seven distinct subpopulations in primary tumors, with the CYR61(+) stress subpopulation being identified as the relapse-initiators. They also discovered a subpopulation of RGS5(+) cancer-associated fibroblasts (CAFs) that strongly support tumor metastasis. Furthermore, the combined expression scores of CYR61/RGS5 were found to be significantly correlated with the relapse-free-survival of EOC patients and can be used as predictors of EOC recurrence.
Review
Engineering, Biomedical
Eric N. Horst, Michael E. Bregenzer, Pooja Mehta, Catherine S. Snyder, Taylor Repetto, Yang Yang-Hartwich, Geeta Mehta
Summary: Traditional cancer treatments are often non-specific, limiting efficacy, especially in heterogeneous patient populations. Personalized tumor-specific models offer potential breakthroughs in precision medicine, allowing for tailored therapies based on individual patient characteristics. By analyzing patient biopsies and generating precise 3D models, these personalized cancer models can have significant clinical applications and inform the development of new targeted therapies.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
Lubna Therachiyil, Roopesh Krishnankutty, Fareed Ahmad, Jericha M. Mateo, Shahab Uddin, Hesham M. Korashy
Summary: This study reveals that activation of aryl hydrocarbon receptor (AhR) affects the progression and metastasis of ovarian cancer, potentially mediated by the activation of the PI3K/Akt, Wnt/β-catenin, and EMT pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Taoqiong Li, Li Lin, Qin Liu, Wujiang Gao, Lu Chen, Chunli Sha, Qi Chen, Wenlin Xu, Yuefeng Li, Xiaolan Zhu
Summary: The study revealed that exosomal transfer of miR-429 enhances chemoresistance and proliferation of epithelial ovarian cancer cells. NF-κB promotes miR-429 expression, affecting the calcium-sensing receptor pathway and leading to drug resistance in cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Oncology
Chalaithorn Nantasupha, Chanisa Thonusin, Kittipat Charoenkwan, Siriporn Chattipakorn, Nipon Chattipakorn
Summary: Cancer cells show adaptations to their metabolism to facilitate growth, invasiveness, and metastasis. While aerobic glycolysis has been thought to be the dominant energy metabolism in cancer, recent data suggest that oxidative phosphorylation may be more likely in some cancer cells, particularly in epithelial ovarian cancer.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Yiping Wen, Yaya Hou, Xiaoqing Yi, Si Sun, Jing Guo, Xiaoqi He, Tao Li, Jing Cai, Zehua Wang
Summary: The study revealed that EZH2 plays a critical role in ovarian cancer stemness and chemo-resistance, with CHK1 being a target involved in CSC stemness regulated by EZH2. Clinical samples showed that high levels of EZH2 and CHK1 were associated with poorer prognosis and increased resistance to platinum drugs in ovarian cancer patients.
Article
Multidisciplinary Sciences
I-M Launonen, N. Lyytikainen, J. Casado, E. A. Anttila, A. Szabo, U-M Haltia, C. A. Jacobson, J. R. Lin, Z. Maliga, B. E. Howitt, K. C. Strickland, S. Santagata, K. Elias, A. D. D'Andrea, P. A. Konstantinopoulos, P. K. Sorger, A. Farkkila
Summary: In this study, the authors used highly multiplexed imaging to analyze the immune microenvironment of high-grade serous ovarian cancers (HGSOC) and identified phenotypic characteristics and spatial interactions associated with BRCA1/2 gene mutations. These findings have important implications for improving immunotherapeutic strategies and patient stratification.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Ajit C. Dhadve, Pritha Ray
Summary: Progression, relapse, and therapy resistance in cancer therapy are challenging features that are driven by cancer stem cell population. This study reveals that RUNX1 maintains the undifferentiated state of cancer stem cells through upregulation of ID1 and ID3, and promotes chemoresistance through upregulation of BCL2.
Article
Biochemistry & Molecular Biology
Abhilash Nitin Deo, Rahul Thorat, Ajit Chandrakant Dhadve, Abhijit De, Bharat Rekhi, Pritha Ray
Summary: Recurrent metastatic epithelial ovarian cancer (EOC) poses challenges due to treatment limitations, with chemoresistance exacerbating organ-specific metastasis through the IGF1R-alpha 6 integrin-S100A4 molecular network. S100A4 may serve as a potential target for treating recurrent metastatic EOC.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Oncology
Hongying Zhao, Rongke Jiang, Chunmei Zhang, Zhijing Feng, Xue Wang
Summary: This study aims to unravel the molecular mechanism of the cancer stem cells (CSCs) marker gene CXCR4 in the growth and metastasis of gastric cancer (GC) using single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing (bulk RNA-seq). The research identified CXCR4 as a key gene promoting malignant phenotypes of CSCs, resulting in tumor growth and liver metastasis of GC. Knockdown of CXCR4 inhibited CSCs' malignant phenotypes, tumorigenesis, and liver metastasis.
NPJ PRECISION ONCOLOGY
(2023)
Article
Oncology
Yuan Li, Chunliang Shang, Huamao Liang, Kun Zhang, Yu Wu, Hongyan Guo
Summary: The relationship between novel serum lipid index and chemoresistance as well as prognosis of epithelial ovarian cancer (EOC) was evaluated. The study included 249 EOC patients and their serum lipid profiles were collected and calculated. The results revealed a significant correlation between HDL-C/TC ratio and chemoresistance, and HDL-C/LDL-C ratio was closely related to the clinicopathological characteristics and prognosis of EOC patients, serving as an independent protective factor indicating better outcome.
FRONTIERS IN ONCOLOGY
(2023)
