Article
Biochemistry & Molecular Biology
Ying Zhang, Gui-Yang Xia, Yu-Zhuo Wu, Xiao-Hong Wei, Huan Xia, Ling-Yan Wang, Peng-Cheng Lin, Ya-Nan Wang, Li-Xia Chen, Sheng Lin
Summary: Two new nor-seco isodhilarane meroterpenoids were isolated from the cultures of an endophytic fungus, exhibiting moderate inhibitory activity against the nitric oxide production in cells.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Plant Sciences
Ling-Yan Wang, Gui-Yang Xia, Min Wang, Yu-Zhuo Wu, Ya-Nan Wang, Li-Min Chai, Sheng Lin
Summary: A new polyketide derivative penicipurate A (1) containing a 3-hydroxydecanoic acid ester moiety was isolated from the solid cultures of the endophytic fungal strain Penicillium purpurogenum in the leaves of Edgeworthia chrysantha. The structure of 1 was determined using various spectroscopic methods and chemical degradation. Compound 1 exhibited moderate inhibitory activity against pancreatic lipase.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hai-Yan Cao, Jing-Yi Zhao, Cheng Yi, Sen-Feng Sun, Ke-liang Chen, Zhi-min Qin, Yun-Bao Liu
Summary: Six undescribed meleagrin analogues were isolated from a toxic medicinal plant, and their structures were elucidated through spectroscopic analysis. Among them, iso-meleagrin exhibited selective cytotoxicity against HGC27 cells.
Article
Chemistry, Organic
Fangfang Jia, Mingliang Zhang, Jiangping Fan, Yang Wang, Xiangyu Ge, Xinyu Mi, Xiao Liu, Juan Wang, Peng-Fei Tu, She-Po Shi
Summary: Two novel 3,5-dimethylorsellinic acid derived meroterpenoids (peniciterpenolides A and B), one new spongian-type diterpene (peniciterpenolide C), and one new drimane-type sesquiterpene (peniciterpenolide D), along with a known meroterpenoid (atlantinone B), were isolated from an endophytic fungus identified from Huperzia serrata. These compounds exhibited inhibitory activity against nitric oxide production in lipopolysaccharide-activated RAW 264.7 macrophage cells with IC50 values ranging from 20.6 to 46.9 μM.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Medicinal
Chen Chen, Geting Ye, Jing Tang, Jialin Li, Wenbin Liu, Li Wu, Yuhua Long
Summary: Four new polyketide compounds and two new citreoviridin derivatives were isolated from the mangrove endophytic fungus Penicillium sp. BJR-P2. Compound 2 exhibited stronger anti-inflammatory activity by inhibiting NO production induced by LPS.
Article
Chemistry, Medicinal
Mengyi Deng, Xia Chen, Zhengyi Shi, Shuangshuang Xie, Yuben Qiao, Gang Chen, Xiaosheng Tan, Yuanyuan Lu, Changxing Qi, Yonghui Zhang
Summary: Six new metabolites were isolated from an endophytic fungus Aspergillus sp., with compound 2 being the first example of a diphenolic derivative with an unusual structure, and compound 3 being the first example of a pseurotin type natural product with only one hydroxy group substituted on the side chain. Compounds 3, 7, and 8 exhibited inhibitory effects on murine T cell proliferation induced by anti-CD3/anti-CD28 monoclonal antibodies.
Article
Biochemistry & Molecular Biology
Hongming Jiang, Runlin Cai, Zhenming Zang, Wencong Yang, Bo Wang, Ge Zhu, Jie Yuan, Zhigang She
Summary: In this study, nine undescribed azaphilone derivatives were obtained from a mangrove endophytic fungus and their structures were identified. Compound 3-5 exhibited inhibitory effects on nitric oxide production in macrophage cells.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Jialin Li, Zixuan Li, Tao Chen, Geting Ye, Liyu Qiu, Yuhua Long
Summary: Two new sclerotioramines and a new natural product of sclerotioramine analog, along with seven known compounds, were isolated from the mangrove endophytic fungus Penicillium sclerotiorin SCNU-F0040. The structures of these compounds were determined through spectroscopic analysis, and the absolute configurations were determined using specific rotation data and electronic circular dichroism spectra. The new compounds were tested for their anti-diabetes and anti-inflammatory activities, with compounds 1 and 2 showing potent α-glucosidase inhibition activity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Ben-Chao Li, Liu-Xia Lv, Li-Li Huang, Jia-Tong Zhou, Xi-Shan Huang, Jun Li, Rui-Yun Yang, Wei-Feng Xu
Summary: A new cyclopentapeptide and seven known compounds were isolated from the endophytic fungus Penicillium virgatum GDGJ-227. The structure and configuration of the new cyclopentapeptide were determined using NMR, MS, and single-crystal X-ray diffraction analysis. Two compounds showed antibacterial activities.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Applied
Yu-Yue Qin, Xi-Shan Huang, Xiao-Bo Liu, Tu-Xiang Mo, Zhao-Long Xu, Ben-Chao Li, Xiao-Ya Qin, Jun Li, Till F. Schaeberle, Rui-Yun Yang
Summary: Three new andrastin derivatives were isolated from an endophytic fungus, Penicillium vulpinum, along with four known analogues. Their structures were determined by NMR, and the absolute configurations were further confirmed using experimental and calculated ECD spectra. Compound 5 exhibited significant antibacterial activity against Bacillus paratyphosus B, while compounds 2 and 6 showed remarkable inhibitory activities against Bacillus megaterium.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Organic
Tu-Xiang Mo, Xi-Shan Huang, Wen-Xiu Zhang, Till F. Schaeberle, Jiang-Ke Qin, De-Xiong Zhou, Xiao-Ya Qin, Zhao-Long Xu, Jun Li, Rui-Yun Yang
Summary: Five new meroterpenoids were isolated from the fungus Penicillium sp. GDGJ-285 using MS/MS based molecular networking, including three novel skeleton meroterpenoids and two new isoaustinone analogues. The structures were determined by HRMS, NMR spectroscopy, and X-ray single-crystal diffraction analysis. Compound 3 showed inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophage cells with an IC50 value of 39.03 mu M.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Applied
Ke-tao Zhang, Bing Zhang, Zhi-pu Huang, Yu-xiao Xu, Xiao-rong Xu, Si-heng Li, Qing Zhao, Xiao-mei Zhang
Summary: A new sesquiterpene compound and six known compounds were isolated from an endophytic fungus obtained from Dracaena cochinchinensis in Xishuangbanna, Yunnan. Their structures were determined by spectroscopic data and X-ray diffraction analysis. Compound 6 showed certain antibacterial activities.
NATURAL PRODUCT RESEARCH
(2023)
Article
Green & Sustainable Science & Technology
Hongkun Li, Meijia Dou, Xinyu Wang, Na Guo, Ping Kou, Jiao Jiao, Yujie Fu
Summary: Endophytic fungi can degrade plant cellulose, and endophytic Penicillium has high cellulase activity. Endophytic fungi in special natural environments offer new directions for future industrial enzyme research.
Article
Chemistry, Medicinal
Ying Wang, Xiao-Ming Li, Sui-Qun Yang, Fan-Zhong Zhang, Bin-Gui Wang, Hong-Lei Li, Ling-Hong Meng
Summary: In this study, an endophytic fungus was isolated from a marine red alga and three novel compounds were identified from its culture extract. The structure of one compound was elucidated in detail, and the antimicrobial activities of all compounds were evaluated.
Article
Biochemistry & Molecular Biology
Jun-Fei Wang, Rong Huang, Zhi-Qiang Song, Qing-Rong Yang, Xin-Peng Li, Si-Si Liu, Shao-Hua Wu
Summary: The investigation of metabolites from the endophytic fungus Xylaria sp. YM 311647 led to the discovery of six undescribed compounds with strong antifungal activities. Among them, xylarioxide E exhibited excellent antifungal properties.
Article
Biochemistry & Molecular Biology
Chun-Yu Li, Hao-Nan Wang, Rong-Jing He, Jian Huang, Li-Lin Song, Yun-Qing Song, Peng-Chao Huo, Jie Hou, Guang Ji, Guang-Bo Ge
Summary: This study discovered a natural compound called AMF that can inhibit lsBSH produced by gut microbes, thus modulating bile acid metabolism. AMF reversibly inhibits the catalytic activity of lsBSH in a mixed-inhibition manner and binds to lsBSH through hydrophobic interactions and hydrogen bonding.
Article
Chemistry, Multidisciplinary
Guiyang Xia, Lingyan Wang, Huan Xia, Yuzhuo Wu, Yanan Wang, Haiyu Hu, Sheng Lin
Summary: A new family of circularly polarized luminescence-active small organic molecules (CPL-SOMs) with high fluorescence efficiency and fascinating CPL properties was discovered and characterized. The usefulness of CPL-calculation as a unique method for stereochemical assignment was demonstrated. This study may open up a new perspective for the future development of stereochemical studies and CPL materials.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Medicinal
Rongfei Qin, Pengxu Wang, Bin Wang, Lei Fu, Sarah M. Batt, Gurdyal S. Besra, Chengwei Wu, Yanan Wang, Haihong Huang, Yu Lu, Gang Li
Summary: A series of thiophene-benzenesulfonamide derivatives were designed and synthesized to explore their structure-activity relationship as antituberculosis agents. Compound 17b showed improved activity compared to the lead compounds, displaying good intracellular antimycobacterial activity and favorable drug properties.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Zhiguo Liu, Li Liu, Anqi Wang, Li Li, Sinan Zhao, Yanan Wang, Yi Sun
Summary: Five novel tyrosine-decahydrofluorene analogues were isolated from the endophytic fungus Xenoacremonium sinensis. These compounds displayed anti-inflammatory and antiproliferative activities.
Article
Biochemical Research Methods
Mengyin Tian, Yanan Wang, Anqi Lu, Qianru Zhang, Xin Li, Ning Zhang, Jianjun Zhang, Sujuan Wang
Summary: The study aims to reveal the chemical differences between Ramulus Mori (RM) and Cortex Mori (CM) and evaluate their quality. It concludes that CM exhibits chemical diversity, while RM has good homogeniety. In addition, content limits for four quality markers with anti-inflammatory or analgesic activities were proposed for RM, and a possible biosynthetic relationship between kuwanon C, kuwanon G, and morusin was hypothesized.
PHYTOCHEMICAL ANALYSIS
(2022)
Article
Plant Sciences
Ling-Yan Wang, Gui-Yang Xia, Min Wang, Yu-Zhuo Wu, Ya-Nan Wang, Li-Min Chai, Sheng Lin
Summary: A new polyketide derivative penicipurate A (1) containing a 3-hydroxydecanoic acid ester moiety was isolated from the solid cultures of the endophytic fungal strain Penicillium purpurogenum in the leaves of Edgeworthia chrysantha. The structure of 1 was determined using various spectroscopic methods and chemical degradation. Compound 1 exhibited moderate inhibitory activity against pancreatic lipase.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2022)
Article
Chemistry, Analytical
Yan Wu, Jia-Qi Wang, Ya-Nan Wang, Xiao-Xia Pang, Jie Bao, Xiao-Bing Guan, Su-Juan Wang
Summary: This study analyzed the serum metabolites in hamsters with ZSP-induced liver damage using metabolomics methods and identified 12 metabolites associated with ZSP-induced hepatotoxicity. Amino acid metabolism and the urea cycle were significantly altered, and the role of three amino acid metabolic enzymes was validated. The major hepatotoxic constituents in ZSP were identified as furanoids from two herbs, and a preparation method with low hepatotoxicity was proposed.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Letter
Medicine, General & Internal
Xiaodong Li, Xiaomeng Zheng, Yanxia Cao, Yanan Wang, Xiangyu Fan, Wengui Xu
Article
Chemistry, Analytical
Huizi Man, Lin Zhou, Guanghao Zhu, Ying Zheng, Zhiwei Ye, Zhenlong Huang, Xinru Teng, Chunzhi Ai, Guangbo Ge, Yi Xiao
Summary: Autophagy is a crucial cellular recycling process associated with tumorigenesis and various diseases. Conventional microscopy has limited resolution, leading to a lack of detailed understanding of autophagy. Researchers have developed a practical labeling system that provides robust fluorescence for studying the autophagy microenvironment. With the help of this system, they have successfully monitored live-cell ferritinophagy for the first time.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Qiang Jin, Zan Li, Meng-Jie Zhang, Wen-Cai Liu, Li-Wei Zou, Hua Sui, Dan-Dan Wang, Qing-Feng Tang, Guang-Bo Ge
Summary: This study investigated the species differences in CES1A-mediated hydrolytic metabolism using a bioluminescence sensor and liver microsomes from six mammalian species. The results showed significant variation in hydrolytic rate among different species. The findings suggest the importance of selecting appropriate animal models for evaluating the in vivo effects of CES1A inhibitors.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Analytical
Lilin Song, Mengru Sun, Jinhui Shi, Zhenhao Tian, Yuqing Song, Huixin Liu, Shanshan Zhao, Heng Yin, Guangbo Ge
Summary: By using computer-aided molecular design and experimental verification, octanoyl luciferin (OL) was selected as a reliable bioluminescent substrate for detecting Notum activity in complex biological systems. OL showed excellent specificity, high detection sensitivity, and high signal-to-noise ratio for human Notum. This study provides a reliable and easy-to-use tool for sensing Notum activities in biological systems, which will strongly facilitate fundamental studies, disease diagnosis, and drug discovery related to Notum.
ANALYTICAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Rongjing He, Ziru Dai, Moshe Finel, Feng Zhang, Dongzhu Tu, Ling Yang, Guangbo Ge
Summary: This review provides an overview of recent advances in the development of highly specific optical substrates for human CYP enzymes and their applications in screening CYP inhibitors and studying DDIs/HDIs. The review summarizes optical-based biochemical assays for efficient detection of CYP activities, which have greatly facilitated the discovery of CYP inhibitors and the investigation of CYP-mediated DDIs.
DRUG METABOLISM AND DISPOSITION
(2023)
Article
Chemistry, Multidisciplinary
Tian Tian, Bei Zhao, Huizhen Wei, Mengru Sun, Zhaoshuai Gao, Min Lv, Haozhi Lei, Zhilei Ge, Guangbo Ge
Summary: In this study, a multifunctional tetrahedral DNA framework (TDF) was developed as a drug carrier to recruit chemotherapeutants and trigger immunogenic cell death (ICD) effects, which could turn tumors from cold to hot to boost the efficacy of antitumor immunotherapy.
Article
Chemistry, Analytical
Yufan Fan, Tiantian Zhang, Yunqing Song, Zhipei Sang, Hairong Zeng, Peiqi Liu, Ping Wang, Guangbo Ge
Summary: This study developed a highly specific near-infrared substrate for human carboxylesterase 2A (hCES2A) and established a high-throughput biochemical assay for screening potent inhibitors. Furthermore, the substrate showed high imaging resolution for imaging hCES2A in living systems.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Wenxuan Wu, Jiayu Qian, Changjie Liang, Jingya Yang, Guangbo Ge, Qingping Zhou, Xiaoqing Guan
Summary: GeoDILI is an interpretable graph neural network that uses molecular geometric representation for predicting hepatotoxic compounds. Compared to other models, GeoDILI demonstrates superior predictive performance and provides precise and mechanistically elucidated structural alerts.
CHEMICAL RESEARCH IN TOXICOLOGY
(2023)
