Journal
ORGANIC LETTERS
Volume 20, Issue 24, Pages 7921-7925Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b03483
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Funding
- Auburn University
- NSF Award [1427720]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1427720] Funding Source: National Science Foundation
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The syntheses of unsymmetrical 1,4-bifunctional allylboron reagents via Cu-catalyzed highly regio- and stereoselective 1,4-protoboration of dienylboronates were developed. The resulting allylboronates underwent chemoselective allylboration with aldehydes followed by oxidative workup to give diol products with high diastereoselectivity. Transition state analysis revealed that the disfavored transition states suffer from either a severe A(1,3) allylic strain or 1,3-syn-pentane interactions. Minimization of such nonbonding 1,3-syn-pentane interactions is proposed to be the origin of observed chemoselectivity of the reaction.
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