Article
Oncology
Heleen Bollen, Julie van der Veen, Annouschka Laenen, Sandra Nuyts
Summary: IMRT and VMAT have become standard of care in treating head and neck cancer. By analyzing treatment failure patterns, this study indirectly investigated the quality of target volume delineation and treatment delivery, which were performed accurately with few recurrences outside high-dose regions and no marginal failures observed.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Dirk Wagenaar, Roel G. J. Kierkels, Arjen van der Schaaf, Arturs Meijers, Daniel Scandurra, Nanna M. Sijtsema, Erik W. Korevaar, Roel J. H. M. Steenbakkers, Antje C. Knopf, Johannes A. Langendijk, Stefan Both
Summary: This study aimed to establish optimal robust optimization uncertainty settings for head and neck cancer patients undergoing proton therapy. Results showed that with a 2 mm/3% setup/range uncertainty setting, the primary and prophylactic CTV were adequately covered, and organ-at-risk dose and normal tissue complication probabilities were reduced. Additional studies with a larger cohort are needed to further substantiate the clinical introduction of margin reduction below 3 mm/3%.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Dana Keilty, Mohammad Khandwala, Zhihui Amy Liu, Vicky Papaioannou, Eric Bouffet, David Hodgson, Ryan Yee, Sharon Cushing, Normand Laperriere, Sameera Ahmed, Donald Mabbott, Vijay Ramaswamy, Uri Tabori, Annie Huang, Ute Bartels, Derek S. Tsang
Summary: This study evaluated the incidence and risk factors of hearing loss in patients with multiple ototoxic exposures, finding associations between hearing loss and factors such as mean cochlea dose, chemotherapy dose, and time since radiotherapy. A mean cochlea dose of <= 30 Gy is recommended to reduce the risk of hearing loss.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Noufal Manthala Padannayil, Dayananda Shamurailatpam Sharma, Sapna Nangia, Kartikeshwar C. Patro, Utpal Gaikwad, Nagarjuna Burela
Summary: In this study, dose surface histogram data from HNC patients treated with IMPT was used to predict the NTCP of skin. An unsupervised machine learning algorithm was used to cluster the grades of NTCP-skin. A new skin-sparing IMPT planning strategy was developed and implemented, resulting in a 34% lower NTCP-skin value compared to traditional IMPT.
RADIATION ONCOLOGY
(2023)
Article
Oncology
Michelle Oud, Sebastiaan Breedveld, Marta Gizynska, Michiel Kroesen, Stefan Hutschemaekers, Steven Habraken, Steven Petit, Zoltan Perko, Ben Heijmen, Mischa Hoogeman
Summary: This study proposes and evaluates a new approach in intensity modulated proton therapy, which involves the daily selection of plans from patient-specific pre-treatment established plan libraries for treatment. Compared to daily online re-planning, this approach is simpler and reduces the risk of xerostomia and dysphagia, while improving adherence to target coverage constraints.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xin Wu, Florian Amstutz, Damien C. Weber, Jan Unkelbach, Antony J. Lomax, Ye Zhang
Summary: This study presents and validates an energy-conservation-based dose accumulation validation workflow for lung cancer cases. The results showed that there were substantial errors in dose accumulation in regions with significant organ deformation. Therefore, caution should be taken when using dose accumulation results in radiotherapy.
Article
Oncology
Jesus Rojo-Santiago, Erik Korevaar, Zoltan Perko, Stefan Both, Steven J. M. Habraken, Mischa S. Hoogeman
Summary: In the Netherlands, head-and-neck cancer patients are referred for proton therapy through model-based selection. This study aims to derive probabilistic plan evaluation metrics on the CTV consistent with clinical metrics, evaluate plan consistency between photon and proton planning, and assess the robustness of the OAR doses and risk toxicities involved in the model-based selection.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Oncology
Sabah Falek, Rajesh Regmi, Joel Herault, Melanie Dore, Anthony Vela, Pauline Dutheil, Cyril Moignier, Pierre-Yves Marcy, Julien Drouet, Arnaud Beddok, Noah E. Letwin, Joel Epstein, Upendra Parvathaneni, Juliette Thariat
Summary: Metallic restorations may have a more severe impact on the quality of proton therapy compared to photon radiotherapy. Multidisciplinary assessment is required before proton therapy to evaluate metal-induced errors and make decisions regarding the conservation/removal of dental metals and the optimal radiotherapy approach.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Engineering, Biomedical
Mislav Bobic, Arthur Lalonde, Gregory C. Sharp, Clemens Grassberger, Joost M. Verburg, Brian A. Winey, Antony J. Lomax, Harald Paganetti
Summary: The study investigated the impact of weekly and daily online IMPT plan adaptation on treatment quality for head and neck patients, finding that while daily online adaptation was more effective at reducing random delivery errors on a fraction per fraction basis, both weekly and daily online adaptations achieved clinical goals for all patients.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hongying Feng, Jie Shan, Justin D. Anderson, William W. Wong, Steven E. Schild, Robert L. Foote, Christopher L. Patrick, Kathryn B. Tinnon, Mirek Fatyga, Martin Bues, Samir H. Patel, Wei Liu
Summary: The study proposed a new method utilizing per-voxel constraints to control dose/LET hot spots in IMPT, which proved to effectively reduce hot spot risks in the treatment. The LET-guided robust optimization outperformed conventional dose-only robust optimization in controlling xBD hot spots.
Article
Oncology
Shan Xu, Rezarta Frakulli, Yilan Lin
Summary: This study explored the effectiveness of various modern radiotherapy strategies in treating newly diagnosed glioblastoma patients. The findings highlighted the significant benefits of proton therapy in terms of survival outcomes.
Article
Oncology
Leslie Chang, Sherif G. Shaaban, Emile Gogineni, Brandi Page, Harry Quon, Heng Li, Rachel Ger
Summary: This retrospective study aimed to evaluate the absolute fractional deviation for dose and volume treatment metrics using 3 mm vs. 5 mm setup robustness in patients treated with head and neck proton therapy. The results showed that deviations from planning clinical target volumes were greater using 3 mm setup robustness, and the variation was greater for patients with primary and secondary clinical targets. However, the average fractional deviation was less than 1% in primary targets and up to 2% in secondary targets using 3 mm setup uncertainty. Robust optimization using 3 mm setup uncertainty with daily CBCT is recommended for patients being treated with proton head and neck therapy.
Article
Otorhinolaryngology
Arnaud Beddok, Caroline Saint-Martin, Samar Krhili, Catherine Ala Eddine, Laurence Champion, Anne Chilles, Farid Goudjil, Sofia Zefkili, Malika Amessis, Dominique Peurien, Olivier Choussy, Christophe le Tourneau, Remi Dendale, Irene Buvat, Gilles Crehange, Valentin Calugaru
Summary: This study analyzed the outcomes of curative reirradiation for recurrent head and neck squamous cell carcinoma, and found that the locoregional recurrence rate was high and there were risks of toxicity grade >= 2.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Florian Amstutz, Reinhardt Krcek, Barbara Bachtiary, Damien C. Weber, Antony J. Lomax, Jan Unkelbach, Ye Zhang
Summary: This study investigates whether combined proton-photon therapy (CPPT) improves treatment plan quality compared to single-modality intensity-modulated radiation therapy (IMRT) or intensity-modulated proton therapy (IMPT) for head and neck cancer (HNC) patients. The findings suggest that CPPT needs adaptive treatments and increasing proton beam flexibility can improve treatment plan quality.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Engineering, Biomedical
E. Borderias-Villarroel, A. Fredriksson, S. Cvilic, D. Di Perri, E. Longton, J. Pierrard, X. Geets, E. Sterpin
Summary: This study compared a not adapted planning strategy with three fully automated online adaptive proton therapy (OAPT) workflows based on the same optimization method. The OAPT methods aimed to compensate for anatomical changes in head and neck cancer patients by mimicking different dose distributions. The results showed that all OAPT strategies achieved higher target coverage compared to no adaptation, with OADEF and OAML performing the best.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Review
Oncology
Mario Terlizzi, Elaine Johanna Limkin, Yasmina Moukasse, Pierre Blanchard
Summary: The management of patients with biochemical recurrence after prostatectomy has changed significantly in recent years. Close monitoring of prostate-specific antigen (PSA) and early salvage radiotherapy (RT) have become the standard of care. However, uncertainties remain regarding the management of high-risk patients and the role of imaging.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mishka Gidwani, Ken Chang, Jay Biren Patel, Katharina Viktoria Hoebel, Syed Rakin Ahmed, Praveer Singh, Clifton David Fuller, Jayashree Kalpathy-Cramer
Summary: This study aims to uncover methodologic errors in radiomic machine learning studies, identifying inconsistent data partitioning and unproductive feature associations as common flaws. Simulations demonstrate the impact of these errors on accuracy and provide a review template to avoid them.
Article
Health Care Sciences & Services
Alex Koong, Ulysses Grant Gardner, Jason Burton, Caleb Stewart, Petria Thompson, Clifton David Fuller, Ethan Bernard Ludmir, Michael Kevin Rooney
Summary: In this observational cohort study, the authors aimed to characterize the landscape of open access (OA) publishing in oncology and identify characteristics of oncology journals predictive of article processing charges (APCs). The results showed that oncology journals with more citable articles, a hybrid OA model, higher impact factors, and based in North America or Europe tend to have higher APCs.
JMIR FORMATIVE RESEARCH
(2023)
Article
Otorhinolaryngology
Houda Bahig, Hanna Y. Y. Ehab, Adam S. S. Garden, Sweet Ping Ng, Steven J. J. Frank, Theresa Nguyen, Gary B. B. Gunn, David I. I. Rosenthal, Clifton D. D. Fuller, Renata Ferrarotto, Diana Bell, Shirley Su, Jack Phan
Summary: This study retrospectively analyzed the long-term outcomes of patients with sinonasal tumors treated with modern radiotherapy. The results showed favorable disease control rate and acceptable toxicity profile in patients treated with modern radiotherapy.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Otorhinolaryngology
Kevin J. Contrera, Nasim Shakibai, Shirley Y. Su, Maria K. Gule-Monroe, Dianna Roberts, Bledi Brahimaj, Michelle D. Williams, Renata Ferrarotto, Jack Phan, Brandon Gunn, Shaan Raza, Franco DeMonte, Ehab Y. Hanna
Summary: The objective of this study was to report outcomes of 19 consecutive patients with SMARCB1 (INI-1)-deficient sinonasal carcinoma. Patients were treated from 2014 to 2021 and followed for a median of 22.3 months. The median overall survival (OS) and disease-free survival (DFS) were 31.8 and 9.9 months, respectively. Patients with nasal cavity or maxillary sinus tumors had significantly better disease-specific survival (DSS) and DFS compared to patients with other sinonasal sites. Additionally, induction chemotherapy was associated with a lower risk of disease-related death.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Oncology
Miet Vandemaele, Marianne Aznar, Pierre Blanchard, Josep M. Borras, Michelle Leech, Ajay Aggarwal, Yolande Lievens
Summary: In order to address the evaluation issue of radiotherapy innovations, the HERO project of ESTRO has initiated the development of a radiotherapy-specific value-based framework. A systematic literature search revealed no widely accepted definition or classification system for radiotherapy innovations. However, the unique properties of radiotherapy interventions can be used to categorize innovations in radiation oncology, but clear terminology denoting radiotherapy-specific characteristics is still needed.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Amy Moreno, Abhishek A. Solanki, Tianlin Xu, Ruitao Lin, Jatinder Palta, Emily Daugherty, David Hong, Julian Hong, Sophia C. Kamran, Evangelia Katsoulakis, Kristy Brock, Mary Feng, Clifton Fuller, Charles Mayo
Summary: Prostate cancer is a common cancer and a major cause of cancer-related deaths in men in the United States. Accurate diagnosis, management, and surveillance are important for improving survival and quality of life. The study aimed to develop a consensus on key data elements for prostate cancer care. Through the Delphi method, experts identified a standardized list of treatment-related toxicities, ranked symptom questionnaires, and defined disease control metrics. These findings have facilitated the development of an operational ontology for prostate cancer care.
Article
Computer Science, Software Engineering
A. Wentzel, C. Floricel, G. Canahuate, M. A. Naser, A. S. Mohamed, C. D. Fuller, L. van Dijk, G. E. Marai
Summary: In this study, we developed a modeling system called DASS to support the development and validation of predictive models for estimating long-term toxicities related to radiotherapy doses in head and neck cancer patients. DASS incorporates human-in-the-loop visual steering, spatial data, and explainable AI to augment domain knowledge with automatic data mining. We demonstrated DASS by developing two practical clinical stratification models and received feedback from domain experts.
COMPUTER GRAPHICS FORUM
(2023)
Article
Otorhinolaryngology
Kevin J. Contrera, Jack Phan, Steven G. Waguespack, Mohammed Aldehaim, Xin Wang, Tze Yee Lim, Dianna B. Roberts, C. David Fuller, Michael T. Spiotto, Shaan M. Raza, Franco DeMonte, Ehab Y. Hanna, Shirley Y. Su
Summary: This study investigated the prevalence of pituitary dysfunction in adults who underwent anterior skull base radiation. The results showed that 46% of patients had abnormal pituitary hormone levels, with 12% requiring treatment for symptomatic abnormalities. The most common abnormalities were hyperprolactinemia, central hypothyroidism, and central hypogonadism. The study also found a dose-dependent association between hormonal dysfunction and radiation.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Guadalupe Canahuate, Andrew Wentzel, Abdallah S. R. Mohamed, Lisanne V. van Dijk, David M. Vock, Baher Elgohari, Hesham Elhalawani, Clifton D. Fuller, G. Elisabeta Marai
Summary: This study evaluated the effectiveness of machine learning tools that incorporate spatial information in predicting survival and toxicity outcomes for HPV+ oropharyngeal cancer patients. Patient stratifications based on radiometric data and lymph node metastasis patterns were identified and included in predictive models along with clinical features. The results showed that including these patient stratifications significantly improved the performance of the models in predicting survival and toxicity outcomes.
Review
Oncology
Michael K. Rooney, Lauren M. Andring, Kelsey L. Corrigan, Vincent Bernard, Tyler D. Williamson, Clifton D. Fuller, Adam S. Garden, Brandon Gunn, Anna Lee, Amy C. Moreno, William H. Morrison, Jack Phan, David I. Rosenthal, Michael Spiotto, Steven J. Frank, Francesca De Felice
Summary: This systematic review examines the incidence and risk factors of hypothyroidism induced by radiotherapy for head and neck cancer. The study finds large variations in estimates, with recent investigations suggesting a higher incidence than historical estimates. Additionally, the review highlights the lack of research on using advanced radiotherapy techniques to reduce thyroid toxicity.
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Computer Science, Interdisciplinary Applications
Temitayo Ajayi, Seyedmohammadhossein Hosseinian, Andrew J. Schaefer, Clifton D. Fuller
Summary: This paper presents a mixed-integer program for optimizing combination chemotherapy. The model incorporates various important operational constraints and controls treatment toxicity and white blood cell count for dose adjustments. Chance constraints are proposed to address the uncertainty of tumor heterogeneity and ensure reaching an operable tumor size with a high probability in a neoadjuvant setting.
INFORMS JOURNAL ON COMPUTING
(2023)
Article
Oncology
Vanita Noronha, Aditya Dhanawat, Vijay Maruti Patil, Nandini Menon, Ajay Kumar Singh, Pankaj Chaturvedi, Prathamesh Pai, Devendra Chaukar, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: Neo-adjuvant chemotherapy has shown long term survival benefits in patients with locally advanced oral cavity squamous cell carcinomas.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Gian Marco Pace, Bianca Maria Festa, Luca Cerri, Giorgio Gregory Giordano, Michael Dale, Giuseppe Spriano, Giorgio Peretti, Armando De Virgilio
Summary: This study aimed to predict the necessity of enteral nutrition at 28 days after surgery in patients with head and neck cancers. The results showed that the machine learning models had optimistic accuracy in predicting the need for enteral nutrition, but had moderate sensitivity.
Article
Oncology
Lirui Zhang, Qiaoshi Xu, Zhien Feng
Summary: This study presents a comprehensive clinical, genomic, and transcriptomic analysis of primary ghost cell odontogenic carcinoma (GCOC). The results provide the first comprehensive molecular atlas for primary GCOC, including previously identified CTNNB1 mutation and novel alterations in MAP3K, EP300, and the 22q11.21 region. The transcriptome analysis reveals significant involvement of cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. More GCOC cases should be compared to validate these findings for accurate clinical guidance.
Article
Oncology
Emily Capone, Vittoria Perrotti, Ilaria Cela, Rossano Lattanzio, Lucrezia Togni, Corrado Rubini, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio, Martina Colasante, Francesco Giansanti, Rodolfo Ippoliti, Stefano Iacobelli, Michael J. Wick, Nicole Spardy Burr, Gianluca Sala
Summary: This study explores the potential of galectin-3 binding protein (LGALS3BP) as a novel target for antibody-drug conjugate (ADC) therapy in adenoid cystic carcinoma (ACC). The results show that LGALS3BP is highly expressed in ACC tissues and treatment with anti-LGALS3BP ADC leads to durable tumor growth inhibition in animal models.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Summary: This study compares the outcomes of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). The results indicate that the da Vinci SP system has advantages in terms of reduced docking and console times, as well as improved rates of wide negative resection margins. However, there were no significant differences in complication rates or postoperative functional outcomes between the two systems.
