Article
Cell Biology
Trishna Pani, Kajal Rajput, Animesh Kar, Harsh Sharma, Rituparna Basak, Nihal Medatwal, Sandhini Saha, Gagan Dev, Sharwan Kumar, Siddhi Gupta, Arnab Mukhopadhyay, Dipankar Malakar, Tushar Kanti Maiti, Aneeshkumar G. Arimbasseri, S. V. S. Deo, Ravi Datta Sharma, Avinash Bajaj, Ujjaini Dasgupta
Summary: The study identified specific alternative splicing events of sphingolipid genes in different subtypes of breast cancer, with an event in CERS2 being a poor prognostic factor for Luminal B subtype, leading to a decrease in very-long-chain ceramides and enhanced cancer cell proliferation and migration. These findings suggest subtype-specific alternative splicing of sphingolipid genes as a potential therapeutic target in breast tumors.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Salih Kucuk, Jennifer Niven, Jorge Caamano, Simon W. Jones, Dolores Camacho-Munoz, Anna Nicolaou, Claudio Mauro
Summary: Obesity is a global epidemic associated with various diseases, with ceramides elevated in obesity and related conditions, while n-3 PUFA demonstrate anti-inflammatory effects. Inhibition of ceramide synthesis can lead to an anti-inflammatory environment.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dolores Camacho-Munoz, Magdalena Kiezel-Tsugunova, Orsolya Kiss, Mohib Uddin, Mattias Sunden, Maria Ryaboshapkina, Lars Lind, Jan Oscarsson, Anna Nicolaou
Summary: In this study, the effects of Fibrates and omega-3 polyunsaturated acids on plasma levels of bioactive lipid mediators in patients with obese non-alcoholic fatty liver and hypertriglyceridemia were investigated. The results showed that these two drugs have different effects on the plasma mediator lipidome, with omega-3 promoting lipid mediators potentially affecting chronic inflammation, while Fibrates mainly reducing ceramides. These findings suggest that both treatments could alleviate chronic inflammation and possibly impact disease outcomes, independent of triglyceride reduction.
Article
Physiology
Maria Eugenia Vazquez-Mosquera, Mercedes Fernandez-Moreno, Estefania Cortes-Pereira, Sara Relano, Andrea Dalmao-Fernandez, Paula Ramos-Louro, Alejandro Duran Sotuela, Ignacio Rego-Perez, Francisco J. Blanco
Summary: The study reveals that palmitate can cause mitochondrial dysfunction, contributing to the understanding of the relationship between obesity and osteoarthritis, while oleate leads to increased accumulation of lipid droplets.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Domenico Sergi, Enrico Zauli, Veronica Tisato, Paola Secchiero, Giorgio Zauli, Carlo Cervellati
Summary: Cerebrovascular diseases and brain hypoperfusion form the basis of vascular dementia. Dyslipidemia, characterized by an increase in triglycerides and LDL-cholesterol levels and a decrease in HDL-cholesterol, promotes atherosclerosis in cardiovascular and cerebrovascular diseases. The quality and functionality of HDL-cholesterol play a significant role in cardiovascular health and cognitive function, and ceramides embedded in lipoproteins are proposed as a novel risk factor for atherosclerosis. This review discusses the role of HDL lipoprotein and ceramides in cerebrovascular diseases and their impact on vascular dementia, as well as the influence of saturated and omega-3 fatty acids on HDL levels and ceramide metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Agata Zwara, Katarzyna Wertheim-Tysarowska, Adriana Mika
Summary: The skin is a flexible and dynamic organ that plays a crucial role in maintaining homeostasis and immune response, with lipids being key to this function. The epidermis, with its main lipids including cholesterol, fatty acids, and ceramides, possesses the best characteristics in this regard. Very long-chain fatty acids and ultra long-chain fatty acids are important components of ceramides, responsible for the rigidity and impermeability of cell membranes in the skin.
FRONTIERS IN MEDICINE
(2021)
Review
Physiology
Matteo Vietri Rudan, Fiona M. Watt
Summary: Mammalian epidermal lipids play a significant role in tissue biology by forming an impermeable barrier, protecting against external insults, shaping the commensal microbiota, and modulating immune responses and epidermal differentiation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Jihyun Lee, Minjoo Noh, Jihui Jang, Jun Bae Lee, Yoon-Ho Hwang, Hyomin Lee
Summary: In this study, we used skin penetration enhancers (SPEs) in lipid nanovesicles to enhance the transdermal delivery of active ingredients. The results showed that the SPE-incorporated lipid nanovesicles (SPE-LNV) had better penetration depth and faster permeation rate compared to conventional lipid nanovesicles (LNV) and LNV with only ceramide. In vivo clinical trials confirmed that the SPE-LNV formulation effectively delivered niacinamide and adenosine, resulting in reduced melanin index and skin wrinkles. The strategy of incorporating both ceramide and fatty acids in lipid nanovesicles offers a simple and convenient route for delivering water-soluble active ingredients across the skin barrier layer.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Plant Sciences
Fengzhong Lu, Wanchen Li, Yalin Peng, Yang Cao, Jingtao Qu, Fuai Sun, Qingqing Yang, Yanli Lu, Xuehai Zhang, Lanjie Zheng, Fengling Fu, Haoqiang Yu
Summary: This study characterized a maize PP2C family member, ZmPP2C26, which negatively regulated drought tolerance in maize by dephosphorylating ZmMAPK3 and ZmMAPK7. Alternative splicing generated ZmPP2C26L and ZmPP2C26S isoforms, with ZmPP2C26S showing higher phosphatase activity. The expression of ZmPP2C26L and ZmPP2C26 was inhibited by drought stress, and the zmpp2c26 mutant exhibited enhanced drought tolerance. However, overexpression of ZmPP2C26L and ZmPP2C26S decreased drought tolerance in Arabidopsis and rice. Phosphoproteomic analysis revealed that ZmPP2C26 also altered phosphorylation levels of proteins involved in photosynthesis. This study provides insights into the mechanism of PP2C in response to abiotic stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
C. J. Urso, Heping Zhou
Summary: The study revealed that CD36 plays a crucial role in fatty acid uptake and palmitic acid (PA) lipotoxicity in N2a neuroblastoma cells, suggesting that CD36 may represent a regulatory target against pathologies caused by excess fatty acids.
Article
Biochemistry & Molecular Biology
Isy F. de Sousa, Vincenzo Migliaccio, Marilena Lepretti, Gaetana Paolella, Ilaria Di Gregorio, Ivana Caputo, Eliane Beraldi Ribeiro, Lilla Lionetti
Summary: This study evaluated the dose- and time-dependent effects of oleate and palmitate on mitochondrial fusion/fission proteins, finding that oleate had minimal impact on protein content and maintained cell viability, while palmitate reduced protein content and cell viability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Qing Wei Calvin Ho, Xiaofeng Zheng, Yusuf Ali
Summary: Ceramides, a class of sphingolipids, play a role in various skin disorders and metabolic diseases. Recent research has focused on identifying specific ceramide species and their effects on different diseases, and has found ceramides linked to metabolic dysfunction and cardiac decline.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Changsheng Shao, Fangfang Cai, Yanping Zhang, Zhiru Bao, Gehui Shi, Manzhu Bao, Jiaqi Zhang
Summary: This study provides insights into the regulatory mechanisms of alternative splicing (AS) in plants, showing that AS signals are distributed within the introns where the splice sites are present and may also be present in exons or other introns.
Article
Biochemistry & Molecular Biology
Jinxi Yang, Manjiangcuo Wang, Qi Qiu, Yan Huang, Yiqin Wang, Qianlun Pu, Na Jiang, Rui Wang, Li Wen, Xiaoying Zhang, Chenxia Han, Dan Du
Summary: The relationship between the type and intensities of lipids in blood and pancreas during severe acute pancreatitis (SAP) is still unclear. Through a rat model of SAP induced by ornithine injections, this study found changes in lipid profiles in both blood and pancreas. The levels of glycerophospholipids decreased while cholesterol esters increased in the pancreas. In the blood, specific carbon atom TAGs decreased while CERs increased in the pancreas. Moreover, TAGs with specific carbon atom numbers showed a significant increase during the repair phase in both blood and pancreas.
Article
Pharmacology & Pharmacy
Yumi Kim, Wona Jee, Eun-Jin An, Hyun Min Ko, Ji Hoon Jung, Yun-Cheol Na, Hyeung-Jin Jang
Summary: Timosaponin A3 (TA3) was found to inhibit pancreatic cancer growth through the regulation of sterol regulatory element-binding protein-1 (SREBP-1), providing a potential novel approach for the prevention and treatment of pancreatic cancer.