Oxidosqualene cyclase and CYP716 enzymes contribute to triterpene structural diversity in the medicinal tree banaba

The triterpenoid corosolic acid blocks transformation and epigenetically reactivates Nrf2 in TRAMP-C1 prostate cells

(2018) Jie Yang et al.   MOLECULAR CARCINOGENESIS

Maslinic acid induces autophagy by down-regulating HSPA8 in pancreatic cancer cells

(2018) Ye Tian et al.   PHYTOTHERAPY RESEARCH

Combinatorial Transcriptional Control of Plant Specialized Metabolism

(2018) Maite Colinas et al.   TRENDS IN PLANT SCIENCE

An endoplasmic reticulum-engineered yeast platform for overproduction of triterpenoids

(2017) Philipp Arendt et al.   METABOLIC ENGINEERING

A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules

(2017) James Reed et al.   METABOLIC ENGINEERING

Triterpenoids

(2017) Robert A. Hill et al.   NATURAL PRODUCT REPORTS

Two CYP716A subfamily cytochrome P450 monooxygenases of sweet basil play similar but nonredundant roles in ursane- and oleanane-type pentacyclic triterpene biosynthesis

(2017) Rajesh Chandra Misra et al.   NEW PHYTOLOGIST

Transcriptomic Analysis of Kalopanax septemlobus and Characterization of KsBAS, CYP716A94 and CYP72A397 Genes Involved in Hederagenin Saponin Biosynthesis

(2017) Jung Yeon Han et al.   PLANT AND CELL PHYSIOLOGY

The ancient CYP716 family is a major contributor to the diversification of eudicot triterpenoid biosynthesis

(2017) Karel Miettinen et al.   Nature Communications

Triterpene Structural Diversification by Plant Cytochrome P450 Enzymes

(2017) Sumit Ghosh   Frontiers in Plant Science

Improvement of betulinic acid biosynthesis in yeast employing multiple strategies

(2016) Chen Zhou et al.   BMC BIOTECHNOLOGY

Corosolic acid protects hepatocytes against ethanol-induced damage by modulating mitogen-activated protein kinases and activating autophagy

(2016) Xiaolan Guo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Oleanolic, Ursolic, and Betulinic Acids as Food Supplements or Pharmaceutical Agents for Type 2 Diabetes: Promise or Illusion?

(2016) Filomena S. G. Silva et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Why do plants produce so many terpenoid compounds?

(2016) Eran Pichersky et al.   NEW PHYTOLOGIST

Multifunctional oxidosqualene cyclases and cytochrome P450 involved in the biosynthesis of apple fruit triterpenic acids

(2016) Christelle M. Andre et al.   NEW PHYTOLOGIST

A systematic review of pentacyclic triterpenes and their derivatives as chemotherapeutic agents against tropical parasitic diseases

(2016) MURTALA BINDAWA ISAH et al.   PARASITOLOGY

Corosolic acid inhibits the proliferation of osteosarcoma cells by inducing apoptosis

(2016) Yong Jia et al.   Oncology Letters

A thaumatin-like protein of Ocimum basilicum confers tolerance to fungal pathogen and abiotic stress in transgenic Arabidopsis

(2016) Rajesh Chandra Misra et al.   Scientific Reports

Andrographis paniculata transcriptome provides molecular insights into tissue-specific accumulation of medicinal diterpenes

(2015) Anchal Garg et al.   BMC GENOMICS

Unraveling the Triterpenoid Saponin Biosynthesis of the African Shrub Maesa lanceolata

(2015) Tessa Moses et al.   Molecular Plant

CYP72A67 Catalyzes a Key Oxidative Step in Medicago truncatula Hemolytic Saponin Biosynthesis

(2015) Elisa Biazzi et al.   Molecular Plant

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

P450s and UGTs: Key Players in the Structural Diversity of Triterpenoid Saponins

(2015) Hikaru Seki et al.   PLANT AND CELL PHYSIOLOGY

Identification and genome organization of saponin pathway genes from a wild crucifer, and their use for transient production of saponins inNicotiana benthamiana

(2015) Bekzod Khakimov et al.   PLANT JOURNAL

The Effect of Ursolic Acid on Leishmania (Leishmania) amazonensis Is Related to Programed Cell Death and Presents Therapeutic Potential in Experimental Cutaneous Leishmaniasis

(2015) Eduardo S. Yamamoto et al.   PLoS One

Triterpene Biosynthesis in Plants

(2014) Ramesha Thimmappa et al.   Annual Review of Plant Biology

MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0

(2013) Koichiro Tamura et al.   MOLECULAR BIOLOGY AND EVOLUTION

Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biologyin vivoandin vitro

(2013) Tessa Moses et al.   NEW PHYTOLOGIST

The Involvement of  -Amyrin 28-Oxidase (CYP716A52v2) in Oleanane-Type Ginsenoside Biosynthesis in Panax ginseng

(2013) J.-Y. Han et al.   PLANT AND CELL PHYSIOLOGY

Methyl Jasmonate-Elicited Transcriptional Responses and Pentacyclic Triterpene Biosynthesis in Sweet Basil

(2013) R. C. Misra et al.   PLANT PHYSIOLOGY

Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants

(2013) K. Geisler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extraction of High-Quality RNA from Rubber Tree Leaves

(2012) Liu-Hong DENG et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosaL.) and Corosolic Acid

(2012) Toshihiro Miura et al.   Evidence-based Complementary and Alternative Medicine

Total anthocyanin content determination in intact açaí (Euterpe oleracea Mart.) and palmitero-juçara (Euterpe edulis Mart.) fruit using near infrared spectroscopy (NIR) and multivariate calibration

(2012) Maria Raquel Cavalcanti Inácio et al.   FOOD CHEMISTRY

A simple GC–MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients

(2012) Augusta Caligiani et al.   FOOD CHEMISTRY

Catalytic Mechanism and Product Specificity of Oxidosqualene-Lanosterol Cyclase: A QM/MM Study

(2012) Bo-Xue Tian et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Ursane-type pentacyclic triterpenoids as useful platforms to discover anticancer drugs

(2012) Jorge A. R. Salvador et al.   NATURAL PRODUCT REPORTS

Oleanolic acid

(2012) Jacob Pollier et al.   PHYTOCHEMISTRY

A novel procedure for absolute real-time quantification of gene expression patterns

(2012) Yingqing Lu et al.   Plant Methods

Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus

(2012) Lili Huang et al.   PLANTA

Mining the Biodiversity of Plants: A Revolution in the Making

(2012) V. De Luca et al.   SCIENCE

Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases

(2011) Huaming Sheng et al.   NATURAL PRODUCT REPORTS

Full-length transcriptome assembly from RNA-Seq data without a reference genome

(2011) Manfred G Grabherr et al.   NATURE BIOTECHNOLOGY

CYP716A Subfamily Members are Multifunctional Oxidases in Triterpenoid Biosynthesis

(2011) Ery O. Fukushima et al.   PLANT AND CELL PHYSIOLOGY

Medicago truncatulaCYP716A12 Is a Multifunctional Oxidase Involved in the Biosynthesis of Hemolytic Saponins

(2011) Maria Carelli et al.   PLANT CELL

Recruitment of a duplicated primary metabolism gene into the nicotine biosynthesis regulon in tobacco

(2011) Tsubasa Shoji et al.   PLANT JOURNAL

A P450-centric view of plant evolution

(2011) David Nelson et al.   PLANT JOURNAL

Triterpenoid Biosynthesis and Engineering in Plants

(2011) Satoru Sawai et al.   Frontiers in Plant Science

Triterpene acids isolated fromLagerstroemia speciosaleaves asα-glucosidase inhibitors

(2008) Wenli Hou et al.   PHYTOTHERAPY RESEARCH