Article
Clinical Neurology
Chengyue Ji, Yuluo Rong, Hongyu Jia, Ning Yan, Tiesheng Hou, Yao Li, Weihua Cai, Shunzhi Yu
Summary: Surgical decompression should be considered in patients with cervical SCI in the chronic stage and persistent spinal cord compression and/or gross cervical instability. Lower initial AMS, longer duration, injury above C4 level, higher age, and female gender are the five major relevant factors for functional recovery.
EUROPEAN SPINE JOURNAL
(2021)
Article
Clinical Neurology
Timothy Chryssikos, Jesse A. Stokum, Abdul-Kareem Ahmed, Chixiang Chen, Aaron Wessell, Gregory Cannarsa, Nicholas Caffes, Jeffrey Oliver, Joshua Olexa, Phelan Shea, Mohamed Labib, Graeme Woodworth, Alexander Ksendzovsky, Uttam Bodanapally, Kenneth Crandall, Charles Sansur, Gary Schwartzbauer, Bizhan Aarabi
Summary: Real-time intraoperative ultrasound (IOUS) can be used as a supplement to postoperative MRI and CT myelography for the assessment of spinal cord decompression.
Article
Critical Care Medicine
Paula Valerie ter Wengel, Erin Elisabeth Anna de Gendt, Enrico Martin, Charlotte Yvette Adegeest, Janneke Marjan Stolwijk-Swuste, Michael G. Fehlings, F. Cumhur Oner, William Peter Vandertop
Summary: The timing of surgery has an impact on motor level recovery in patients with traumatic spinal cord injury, with early decompression surgery independently associated with enhanced neurological recovery.
JOURNAL OF NEUROTRAUMA
(2022)
Review
Medicine, General & Internal
Chaowei Yang, Xinming Yang
Summary: Acute traumatic cervical spinal cord injury is a catastrophic event with significant burdens to patients, families, and society. The optimal timing for spinal cord decompression in the treatment of acute SCI remains controversial. Therefore, this systematic review and meta-analysis aim to compare the efficacy of early and late surgical intervention for acute SCI.
Article
Medicine, General & Internal
Min Cheol Chang, Dae Yeong Kim, Jin-Woo Choi, Ho Yong Choi, Jin-Sung Park, Donghwi Park
Summary: In this study, we identified risk factors for dysphagia in patients with cervical spinal cord injury (C-SCI) by analyzing the correlation between clinical factors and the severity of dysphagia. The anterior surgical approach was found to be the only clinical factor significantly correlated with dysphagia severity in C-SCI patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Bizhan Aarabi, Chen Chixiang, J. Marc Simard, Timothy Chryssikos, Jesse A. Stokum, Charles A. Sansur, Kenneth M. Crandall, Joshua Olexa, Jeffrey Oliver, Melissa R. Meister, Gregory Cannarsa, Ashish Sharma, Cara Lomangino, Maureen Scarboro, Abdul-Kareem Ahmed, Nathan Han, Riccardo Serra, Phelan Shea, Carla Aresco, Gary T. Schwartzbauer
Summary: This study aimed to identify candidates for expansion duraplasty in patients with inadequate surgical decompression, based on the absence of cerebrospinal fluid (CSF) interface around the spinal cord on MRI. The results showed that 9.6% of patients failed bony decompression alone and either did or would benefit from expansion duraplasty.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Medicine, General & Internal
Bo-Ram Na, Hyoung-Yeon Seo
Summary: The study investigated the effect of surgical decompression for severe adult spinal cord injury without major bone injury, finding that intramedullary lesion length (IMLL) and compression rate have the most powerful effect on neurological outcome. Additionally, 5 out of 11 patients showed improved neurological grade one year postoperatively.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Chris J. Neal, Beatrice Ugiliweneza, Elizabeth G. Toups, Muhammad Abd-El-Barr, George Jimsheleishvili, Shekar N. Kurpad, Bizhan Aarabi, James S. Harrop, Christopher I. Shaffrey, Michael G. Fehlings, Charles H. Tator, Robert G. Grossman, James D. Guest
Summary: Data supports the benefits of early surgical intervention in acute spinal cord injury (SCI). This study analyzed the factors affecting the timing of surgery for acute cervical SCI within the North American Clinical Trials Network for SCI registry. The severity of neurological injury, the day of the week, and the treating center were found to be related to the variability in achieving early surgery.
JOURNAL OF NEUROTRAUMA
(2023)
Review
Clinical Neurology
Ayesha Quddusi, Karlo M. M. Pedro, Mohammed Ali Alvi, Nader Hejrati, Michael G. G. Fehlings
Summary: Acute traumatic spinal cord injury (tSCI) is a severe event with global impact on morbidity and mortality. Early surgical intervention within 24 hours has been shown to improve prognosis and functional outcomes. This review explores the evidence, nuances, and challenges associated with timing of surgery, as well as the barriers to early surgical care for tSCI.
ACTA NEUROCHIRURGICA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Guoliang Chen, Fuxin Wei, Liangyu Shi, Jiachun Li, Xianxiang Wang, Meng Wang, Huachuan Wu, Zuofeng Xu, Xizhe Liu, Shaoyu Liu
Summary: French-door laminoplasty with intraoperative ultrasound (IOUS) can confirm sufficient decompression for the treatment of DCM, leading to higher likelihood of neurological recovery; inadequate spinal cord expansion after sufficient decompression may predict less satisfactory neurological recovery in DCM patients.
EUROPEAN RADIOLOGY
(2021)
Article
Clinical Neurology
Chenghua Yuan, Jian Guan, Yueqi Du, Zeyu Fang, Xinyu Wang, Qingyu Yao, Can Zhang, Shanhang Jia, Zhenlei Liu, Kai Wang, Wanru Duan, Xingwen Wang, Zuowei Wang, Hao Wu, Zan Chen, Fengzeng Jian
Summary: The study found that PTS tends to progress faster than CCJ-related syringomyelia. Except for the red blood cell count, peripheral blood inflammation markers (PBIMs) showed no value in distinguishing the two forms of syringomyelia. Spinal cord injury associated with PTS was more severe than that associated with CCJ.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Seyed Farzad Maroufi, Sina Azadnajafabad, Ahmad Pour-Rashidi, Seyed Behnam Jazayeri, Zahra Ghodsi, Heshmatollah Ghawami, Maryam Kheyri, Farzin Farahbakhsh, Amir Azarhomayoun, Maryam Bahreini, Jalil Arab Kheradmand, Morteza Faghih Jouibari, Mohammad Zareh, Michael G. Fehlings, Vafa Rahimi-Movaghar
Summary: The aim of this study is to adopt and adapt guidelines on the timing of decompressive surgery in acute spinal cord injury (SCI) in clinical settings in Iran, in order to improve the care and outcomes for trauma patients. After a systematic search and review of the literature, an expert panel was formed to evaluate and confirm the final recommendations.
ACTA NEUROCHIRURGICA
(2023)
Letter
Clinical Neurology
John Eraifej, Colin Nnadi, Mario Ganau
Summary: Recent evidence suggests that early decompressive spinal surgery can improve neurological outcomes in acute spinal cord injury patients, highlighting the need for hospital systems to swiftly restructure to meet the demand for early and possibly ultra-early spinal decompression in the future.
EUROPEAN SPINE JOURNAL
(2022)
Article
Critical Care Medicine
Zin Z. Khaing, Lindsay N. Cates, Dane M. Dewees, Jeffrey E. Hyde, Ashley Gaing, Zeinab Birjandian, Christoph P. Hofstetter
Summary: Surgical decompression through either durotomy alone or durotomy plus myelotomy effectively mitigates elevated intraspinal pressure following acute traumatic spinal cord injury. Durotomy plus myelotomy surgery promotes tissue sparing, gray matter preservation, motor neuron retention, and recovery of locomotor function. Biomarkers for selecting appropriate surgical strategies in spinal cord injuries need to be developed in the future.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Surgery
Chaohua Yang, Qing Wang, Shuang Xu, Can Guan, Guangzhou Li, Gaoju Wang
Summary: This study suggests that early extensive posterior decompression surgery may improve neurological outcomes after severe traumatic cervical spinal cord injury (tcSCI), especially in patients with cervical spinal stenosis (CSS).
FRONTIERS IN SURGERY
(2022)
Article
Clinical Neurology
Stefania Galimberti, Francesca Graziano, Andrew I. R. Maas, Giulia Isernia, Fiona Lecky, Sonia Jain, Xiaoying Sun, Raquel C. Gardner, Sabrina R. Taylor, Amy J. Markowitz, Geoffrey Manley, Maria Grazia Valsecchi, Giuseppe Bellelli, Giuseppe Citerio
Summary: Frailty is associated with outcomes in patients with traumatic brain injury, and a frailty index has been developed to predict 6-month outcomes.
Article
Critical Care Medicine
Yelena G. Bodien, Jason Barber, Sabrina R. Taylor, Kim Boase, John D. Corrigan, Sureyya Dikmen, Raquel C. Gardner, Joel H. Kramer, Harvey Levin, Joan Machamer, Thomas McAllister, Lindsay D. Nelson, Laura B. Ngwenya, Mark Sherer, Murray B. Stein, Mary Vassar, John Whyte, John K. Yue, Amy Markowitz, Michael A. McCrea, Geoffrey T. Manley, Nancy Temkin, Joseph T. Giacino
Summary: To assess the effects of traumatic brain injury (TBI), a multi-dimensional Flexible Outcome Assessment Battery (FAB) was designed, which assigns participants to different assessment groups based on a decision-making algorithm and guides test selection throughout recovery. The feasibility of FAB was demonstrated by a high proportion of participants completing the assessment and receiving valid scores. Furthermore, the level of function assessed by FAB at 2 weeks post-injury was associated with the GOSE scores at 6 and 12 months.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Clinical Neurology
Andrew I. R. Maas, David K. Menon, Geoffrey T. Manley, Mathew Abrams, Cecilia Akerlund, Nada Andelic, Marcel Aries, Tom Bashford, Michael J. Bell, Yelena G. Bodien, Benjamin L. Brett, Andras Buki, Randall M. Chesnut, Giuseppe Citerio, David Clark, Betony Clasby, D. Jamie Cooper, Endre Czeiter, Marek Czosnyka, Kristen Dams-O'Connor, Veronique De Keyser, Ramon Diaz-Arrastia, Ari Ercole, Thomas A. van Essen, Eanna Falvey, Adam R. Ferguson, Anthony Figaji, Melinda Fitzgerald, Brandon Foreman, Dashiell Gantner, Guoyi Gao, Joseph Giacino, Benjamin Gravesteijn, Fabian Guiza, Deepak Gupta, Mark Gurnell, Juanita A. Haagsma, Flora M. Hammond, Gregory Hawryluk, Peter Hutchinson, Mathieu van der Jagt, Sonia Jain, Swati Jain, Ji-Yao Jiang, Hope Kent, Angelos Kolias, Erwin J. O. Kompanje, Fiona Lecky, Hester F. Lingsma, Marc Maegele, Marek Majdan, Amy Markowitz, Michael McCrea, Geert Meyfroidt, Ana Mikoli, Stefania Mondello, Pratik Mukherjee, David Nelson, Lindsay D. Nelson, Virginia Newcombe, David Okonkwo, Matej Oresic, Wilco Peul, Dana Pisica, Suzanne Polinder, Jennie Ponsford, Louis Puybasset, Rahul Raj, Chiara Robba, Cecilie Roe, Jonathan Rosand, Peter Schueler, David J. Sharp, Peter Smielewski, Murray B. Stein, Nicole von Steinbuchel, William Stewart, Ewout W. Steyerberg, Nino Stocchetti, Nancy Temkin, Olli Tenovuo, Alice Theadom, Ilias Thomas, Abel Torres Espin, Alexis F. Turgeon, Andreas Unterberg, Dominique Van Praag, Ernest van Veen, Jan Verheyden, Thijs Vande Vyvere, Kevin K. W. Wang, Eveline J. A. Wiegers, W. Huw Williams, Lindsay Wilson, Stephen R. Wisniewski, Alexander Younsi, John K. Yue, Esther L. Yuh, Frederick A. Zeiler, Marina Zeldovich, Roger Zemek
Article
Clinical Neurology
John K. Yue, Nishanth Krishnan, Lawrence Chyall, Alexander F. Haddad, Paloma Vega, David J. Caldwell, Gray Umbach, Evelyne Tantry, Phiroz E. Tarapore, Michael C. Huang, Geoffrey T. Manley, Anthony M. DiGiorgio
Summary: This study examined the relationship between hospital length of stay in traumatic brain injury (TBI) patients and risk factors, finding that prolonged stay was associated with younger age, severe injuries, low socioeconomic status, and type of health insurance.
WORLD NEUROSURGERY
(2022)
Review
Mathematical & Computational Biology
J. Russell Huie, Rohit Vashisht, Anoop Galivanche, Constance Hadjadj, Saam Morshed, Atul J. Butte, Adam R. Ferguson, Conor O'Neill
Summary: Chronic low back pain is a common problem that affects adults in the United States and is often associated with neuropsychiatric disorders and opioid addiction. Developing effective treatments requires identifying the causal relationships, which can be achieved through rigorous causal inference methods using big data and artificial intelligence.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Kira D. A. Rienecker, Katherine Grue, Maria Serena Paladini, Elma S. Frias, Valentina Frattini, Mia C. Borlongan, Austin Chou, Abel Torres-Espin, Karen Krukowski, Adam R. Ferguson, Susanna Rosi
Summary: To protect the health and performance of astronauts during interplanetary space travel, it is important to understand the effects of deep space hazards. Our study is the first to investigate the cumulative and synergistic impacts of ionizing radiation, confinement, and altered gravity on behavior and cognition. We found that these factors have independent effects on behavioral and cognitive performance, with different resilience observed between male and female mice.
SCIENTIFIC REPORTS
(2023)
Article
Psychiatry
Murray J. Stein, Sonia S. Jain, Livia A. Parodi, Karmel Choi, Adam J. Maihofer, Lindsay Nelson, Pratik Mukherjee, Xiaoying T. Sun, Feng He, David Okonkwo, Joseph Giacino, Frederick R. Korley, Mary Vassar, Claudia Robertson, Michael McCrea, Nancy Temkin, Amy Markowitz, Ramon R. Diaz-Arrastia, Jonathan K. Rosand, Geoffrey Manley, TRACK TBI Investigators
Summary: This study found that the polygenic risk for PTSD, as well as for related mental health disorders, is associated with an increased likelihood of PTSD following mTBI. However, the polygenic risk for major depressive disorder and neuroticism did not show significant associations with PTSD. These findings suggest that the risk for PTSD after mTBI is partly influenced by genetics.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Benjamin Pierce, Thomas Kirsh, Adam R. Ferguson, Thomas C. Neylan, Sisi Ma, Erich Kummerfeld, Beth E. Cohen, Jessica L. Nielson
Summary: The study found that individuals with PTSD are more likely to have other psychiatric disorders and experience diminished health and psychosocial functioning. Longitudinal analysis revealed a direct association between PTSD symptoms and depressive symptoms, as well as indirect effects on social functioning through depression.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Biotechnology & Applied Microbiology
J. Russell Huie, Jessica L. L. Nielson, Jorden Wolfsbane, Clark R. R. Andersen, Heidi M. M. Spratt, Douglas S. S. DeWitt, Adam R. R. Ferguson, Bridget E. E. Hawkins
Summary: This study used modern data science tools to understand the complexity of recovery from chronic traumatic brain injury (cTBI) by integrating large-scale data and exploring the relationships between gene expression and behavioral outcomes. The findings demonstrate that the integration of genomics and behavioral domains can reveal the underlying mechanisms of TBI recovery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Clinical Neurology
Nitin Agarwal, Jacob Blitstein, Austin Lui, Abel Torres-Espin, Chalisar Vasnarungruengkul, John Burke, Praveen V. Mummaneni, Sanjay S. Dhall, Philip R. Weinstein, Xuan Duong-Fernandez, Austin Chou, Jonathan Pan, Vineeta Singh, Adam R. Ferguson, Debra D. Hemmerle, Nikos Kyritsis, Jason F. Talbott, William D. Whetstone, Jacqueline C. Bresnahan, Michael S. Beattie, Geoffrey T. Manley, Anthony DiGiorgio
Summary: This study analyzed complications and outcomes in elderly patients with spinal cord injury (SCI) and found that cardiovascular and pulmonary complications were common. It is suggested that caution should be taken in the clinical treatment of elderly SCI patients, and blood pressure control and cardiology consultation are recommended.
JOURNAL OF NEUROSURGERY-SPINE
(2023)
Article
Critical Care Medicine
Andrea L. C. Schneider, J. Russell Huie, Sonia Jain, Xiaoying R. Sun, Adam Ferguson, Cillian K. Lynch, John T. Yue, Geoffrey Manley, Kevin K. W. K. Wang, Danielle Sandsmark, Christopher Campbell, Ramon Diaz-Arrastia
Summary: Traumatic brain injury (TBI) is a complex condition, and the use of biomarker panels is necessary to capture its heterogeneity. This study found that biomarkers of microvascular injury are associated with TBI severity.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Multidisciplinary Sciences
Catherine R. Jutzeler, Lucie Bourguignon, Bobo Tong, Elias Ronca, Eric Bailey, Noam Y. Harel, Fred Geisler, Adam R. Ferguson, Brian K. Kwon, Jacquelyn J. Cragg, Lukas Grassner, John L. K. Kramer
Summary: The study systematically examined the administration of multiple types and classes of medications in the acute management of traumatic spinal cord injury. It found a high degree of polypharmacy in the acute stages of spinal cord injury, which could potentially affect neurological recovery.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
John K. Yue, Nishanth Krishnan, John H. Kanter, Hansen Deng, David O. Okonkwo, Ava M. Puccio, Debbie Y. Madhok, Patrick J. Belton, Britta E. Lindquist, Gabriela G. Satris, Young M. Lee, Gray Umbach, Ann-Christine Duhaime, Pratik Mukherjee, Esther L. Yuh, Alex B. Valadka, Anthony M. DiGiorgio, Phiroz E. Tarapore, Michael C. Huang, Geoffrey T. Manley
Summary: Neuroworsening is an early indicator of traumatic brain injury severity and a predictor of neurosurgical intervention and unfavorable outcome. Clinicians should be vigilant in detecting neuroworsening to provide immediate therapeutic interventions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
John H. Yue, Firas Kobeissy, Sonia Jain, Xiaoying Sun, Ryan R. L. K. Phelps, Frederick C. Korley, Raquel R. Gardner, Adam Ferguson, J. Russell Huie, Andrea L. C. Schneider, Zhihui Yang, Haiyan E. Xu, Cillian Lynch, Hansen Deng, Miri J. Rabinowitz, Mary R. Vassar, Sabrina Taylor, Pratik L. Mukherjee, Esther J. Yuh, Amy M. Markowitz, Ava O. Puccio, David Okonkwo, Ramon T. Diaz-Arrastia, Geoffrey Manley, Kevin K. W. Wang
Summary: The study investigated the relationship between systemic inflammation and secondary injury in TBI. Inflammatory markers were found to be associated with TBI diagnosis and prognosis. IL-15 and serum amyloid A were identified as priority markers with acceptable discriminatory ability.
NEUROTRAUMA REPORTS
(2023)