Journal
NEUROREPORT
Volume 29, Issue 16, Pages 1413-1417Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0000000000001127
Keywords
aggression; default mode network; functional connectivity; mild traumatic brain injury; postconcussive symptoms; resting state functional magnetic resonance imaging
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Funding
- Office of the Assistant Secretary of Defense for Health Affairs
- Defense Health Agency J9, Research and Development Directorate, through the US Army Medical Research and Materiel Command (USAMRMC) [W81XWH-12-0386]
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Mild traumatic brain injury (mTBI) can alter the structure of the brain and result in a range of symptoms, including elevated aggression. Neurological damage associated with mTBI is traditionally viewed as transient, yet a growing number of studies suggest long-lasting psychological and neurological changes following mTBI. However, research examining the neural basis of emotion processing in the chronic stage of mTBI recovery remains sparse. In the current study, we utilized resting state functional MRI to explore the association between default mode network connectivity and aggression in 17 healthy controls and 17 adults at least 6 months post-mTBI. The association between within-network connectivity and aggression was examined using general linear models, controlling for the effects of depression. Increased connectivity between the right hippocampus and midcingulate cortex was associated with elevated aggression in adults with mTBI, but not in healthy controls. The results provide evidence for a link between intrinsic functional network disruptions and the manifestation of postconcussive symptoms within chronic stages of recovery following mTBI. These findings expand upon the current research, providing evidence for the use of resting state functional connectivity as a potential biomarker of postconcussive aggression in chronic mTBI.
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