Article
Neurosciences
Vanessa A. Mitchell, Juliette Harley, Sherelle L. Casey, Arabella C. Vaughan, Bryony L. Winters, Christopher W. Vaughan
Summary: The study found that oral THC and CBD, either alone or in combination, have analgesic effects in an animal neuropathic pain model. However, unlike injection studies, the combination of THC:CBD lacks analgesic synergy when delivered orally. Furthermore, both oral THC and THC:CBD combination display a relatively poor therapeutic window, suggesting that CBD may provide a safer but less effective oral treatment for nerve injury-induced neuropathic pain than THC.
Review
Medicine, General & Internal
Francesco Bartoli, Ilaria Riboldi, Bianca Bachi, Angela Calabrese, Federico Moretti, Cristina Crocamo, Giuseppe Carra
Summary: CBD may attenuate psychotic-like symptoms induced by THC in healthy volunteers and positive symptoms in individuals with schizophrenia. Preliminary data on the efficacy of CBD for cannabis use disorders show mixed findings. Evidence from ongoing clinical studies will provide insight into the possible role of CBD for treating psychotic and cannabis use disorders.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Luca F. Kaiser, Theo O. J. Gruendler, Oliver Speck, Lennart Luettgau, Gerhard Jocham
Summary: The balance between excitation and inhibition in the dorsal anterior cingulate cortex plays a role in patch-leaving decisions, while the same balance in the ventromedial prefrontal cortex is related to value-guided decision-making. This differential relationship highlights the importance of weighing immediate rewards against long-term gains in different cortical areas.
NATURE COMMUNICATIONS
(2021)
Letter
Pediatrics
Erica M. Wymore, Claire Palmer, George S. Wang, Torri D. Metz, David W. A. Bourne, Cristina Sempio, Maya Bunik
Summary: This cohort study examines Delta-9-tetrahydrocannabinol levels in breast milk and serum samples from women who recently stopped using marijuana and had just given birth.
Article
Geriatrics & Gerontology
Prakash Nidadavolu, Andras Bilkei-Gorzo, Michael Kraemer, Britta Schuermann, Michela Palmisano, Eva C. Beins, Burkhard Madea, Andreas Zimmer
Summary: The use of Δ9-THC was found to improve cognitive function in aged mice, while the combination of Δ9-THC and CBD in a 1:1 ratio did not have the same effect. The presence of CBD altered the metabolism of Δ9-THC, causing a more rapid decline in its beneficial effects.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Alberto Sainz-Cort, Daniel Jimenez-Garrido, Elena Munoz-Marron, Raquel Viejo-Sobera, Joost Heeroma, Jose Cralos Bouso
Summary: The study indicates that CBD can reduce psychotomimetic effects when coadministered with THC, while CBD alone and placebo do not have psychotomimetic effects. This research provides important evidence for the clinical practice of medical cannabis and enhances understanding of the link between the endocannabinoid system and psychotic-like symptoms. Furthermore, it demonstrates the application of reliable methodologies in real-life scenarios to gather valid ecological evidence beyond traditional laboratory settings.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Christopher H. Domen, Stefan Sillau, Ying Liu, Michelle Adkins, Sarah Rajkovic, Jacquelyn Bainbridge, Cristina Sempio, Jost Klawitter, Maureen A. Leehey
Summary: This study presents cognitive safety data from a study on an orally administered high-dose cannabidiol (CBD; 100 mg) and low-dose Delta 9-tetrahydrocannabinol (THC; 3.3 mg) drug in patients with Parkinson's disease. The results indicate that the CBD/THC drug has a small detrimental effect on cognition following acute/short-term use, as evidenced by worse performance on the Animal Verbal Fluency test and higher incidence of adverse cognitive events compared to the placebo group.
MOVEMENT DISORDERS
(2023)
Article
Andrology
Samuel Kelechi Mobisson, Daniel Ewa Ikpi, Iheanyichukwu Wopara, Agona Odey Obembe, Olaposi Omotuyi
Summary: This study investigates the binding affinity of THC and CBD to the human androgen receptor (AR) using computational molecular dynamic simulation. The results show that both THC and CBD have high binding activity to AR, which indicates a potential inhibition of reproductive function and prostate cancer progression.
Article
Pharmacology & Pharmacy
Patricia Alves, Cristina Amaral, Natercia Teixeira, Georgina Correia-da-Silva
Summary: In recent years, there has been an increase in cannabis use among pregnant women. The cannabinoids CBD and THC can cross the placenta and may interfere with crucial processes for placental development, compromising pregnancy success.
Article
Neurosciences
Nadia R. P. W. Hutten, T. R. Arkell, F. Vinckenbosch, J. Schepers, R. C. Kevin, E. L. Theunissen, K. P. C. Kuypers, I. S. McGregor, J. G. Ramaekers
Summary: This study suggests that cannabis products containing both THC and CBD may produce less anxiety than THC-only products.
PSYCHOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Hanna J. Szkudlarek, Mar Rodriguez-Ruiz, Roger Hudson, Marta De Felice, Tony Jung, Walter J. Rushlow, Steven R. Laviolette
Summary: Clinical and pre-clinical evidence show distinct psychotropic effects of THC and CBD, with THC inducing anxiety and CBD displaying antipsychotic properties. In the study, intra-PFC THC caused panic-like responses while CBD counteracted them. CBD impaired sensory functions and cognitive processes through 5-HT1A receptor activation, while THC promoted anxiety-related behavior through ERK1/2 phosphorylation in the PFC.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Sherelle L. Casey, Vanessa A. Mitchell, Eddy E. Sokolaj, Bryony L. Winters, Christopher W. Vaughan
Summary: Intrathecal administration of THC and CBD, either alone or in combination, effectively reduces neuropathic pain without significant side effects. The anti-allodynic effects of THC are partially mediated by CB1 and CB2 receptors, while the effects of CBD are partially mediated by CB2 receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Yeong Eun Sim, Ji Woo Kim, Beom Jun Ko, Jin Young Kim, Jae Chul Cheong, Jaesung Pyo
Summary: In this study, an automated online micro-solid-phase extraction (mu SPE)-liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the detection of metabolites of cannabidiol (CBD), A8-tetrahydrocannabinol (A8-THC), and A9-tetrahydrocannabinol (A9-THC) in urine. The developed method showed good sensitivity and accuracy for the detection of the target analytes. The method was successfully applied to the analysis of urine samples, and the target metabolites were detected at various concentrations.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yanhong Wang, Yuzhu Hong, Jiyu Yan, Breanna Brown, Xiaoyang Lin, Xiaolin Zhang, Ning Shen, Minghua Li, Jianfeng Cai, Marcia Gordon, David Morgan, Qingyu Zhou, Chuanhai Cao
Summary: This study aimed to investigate the therapeutic effect of low-dose delta-9-tetrahydrocannabinol (THC) in Alzheimer's disease (AD). The results showed that low-dose THC can reduce amyloid-beta aggregation and improve spatial learning in aged AD mouse models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Lu Zhang, Chunqiao Lin, Jiushuang Zhu, Yan He, Meng Zhan, Xiuwen Xia, Ni Yang, Kun Yang, Baojia Wang, Zhanqion Zhong, Yili Wang, Weijun Ding, Youjun Yang
Summary: Maternal immune activation during pregnancy from viral infections is associated with an increased risk of neurodevelopmental disorders in offspring. In this study, we used a mouse model to demonstrate that CBD can alleviate behavioral abnormalities caused by MIA by modulating synaptic transmission. Additionally, we identified the LPI-GPR55 signaling pathway as being involved in CBD's therapeutic effects.
Article
Pharmacology & Pharmacy
Manuela Cerina, Hanna J. Szkudlarek, Philippe Coulon, Patrick Meuth, Tatyana Kanyshkova, Xuan Vinh Nguyen, Kerstin Goebel, Thomas Seidenbecher, Sven G. Meuth, Hans-Christian Pape, Thomas Budde
BRITISH JOURNAL OF PHARMACOLOGY
(2015)
Article
Neurosciences
Kay Juengling, Maren D. Lange, Hanna J. Szkudlarek, Joerg Lesting, Frank S. Erdmann, Michael Doengi, Sebastian Kuegler, Hans-Christian Pape
NEUROPSYCHOPHARMACOLOGY
(2015)
Article
Neurosciences
Jing Jing Li, Hanna Szkudlarek, Justine Renard, Roger Hudson, Walter Rushlow, Steven R. Laviolette
JOURNAL OF NEUROSCIENCE
(2018)
Article
Neurosciences
Hanna J. Szkudlarek, Olga Herdzina, Marian H. Lewandowski
EUROPEAN JOURNAL OF NEUROSCIENCE
(2008)
Article
Biochemical Research Methods
Damodharan Palani, Dobromila Pekala, Armantas Baginskas, Hanna Szkudlarek, Morten Raastad
JOURNAL OF NEUROSCIENCE METHODS
(2012)
Article
Neurosciences
Dobromila Pekala, Armantas Baginskas, Hanna J. Szkudlarek, Morten Raastad
JOURNAL OF PHYSIOLOGY-LONDON
(2014)
Article
Multidisciplinary Sciences
Hanna J. Szkudlarek, Patrycja Orlowska, Marian H. Lewandowski
Article
Neurosciences
Patrycja Orlowska-Feuer, Annette Elisabeth Allen, Timothy Matthew Brown, Hanna Jowita Szkudlarek, Robert James Lucas, Riccardo Storchi
Summary: Neurophysiological activity in the subcortical visual system shows fluctuations in infra-slow and fast oscillatory ranges, with the phase of infra-slow modulating fast beta/gamma oscillations. Genetic ablations reveal that infra-slow and fast oscillations interact uniquely, potentially guiding visual processing. This interaction may play a significant role in vision function and disruptions in these oscillatory behaviors could contribute to vision dysfunction in retinal dystrophy.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Clinical Neurology
Hanna J. Szkudlarek, Mar Rodriguez-Ruiz, Roger Hudson, Marta De Felice, Tony Jung, Walter J. Rushlow, Steven R. Laviolette
Summary: Clinical and pre-clinical evidence show distinct psychotropic effects of THC and CBD, with THC inducing anxiety and CBD displaying antipsychotic properties. In the study, intra-PFC THC caused panic-like responses while CBD counteracted them. CBD impaired sensory functions and cognitive processes through 5-HT1A receptor activation, while THC promoted anxiety-related behavior through ERK1/2 phosphorylation in the PFC.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Taygun C. Uzuneser, Hanna J. Szkudlarek, Matthew J. Jones, Mina G. Nashed, Timothy Clement, Hehe Wang, Iwao Ojima, Walter J. Rushlow, Steven R. Laviolette
Summary: This study identifies FABP-5 inhibition as a potential target for treating anxiety disorders. It also uncovers a novel CB2R-dependent FABP-5 signaling pathway in the prefrontal cortex (PFC) that strongly modulates anxiety-related behaviors and neuronal transmission patterns.
Article
Neurosciences
H. J. Szkudlarek, M. Raastad