Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea Morotti, Giorgio Busto, Gregoire Boulouis, Elisa Scola, Alessandro Padovani, Ilaria Casetta, Enrico Fainardi
Summary: The combined analysis of non-contrast CT and CT perfusion markers improves the prediction of hematoma expansion and outcome in intracerebral hemorrhage.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Andrea Morotti, Qi Li, Valentina Mazzoleni, Jawed Nawabi, Frieder Schlunk, Federico Mazzacane, Giorgio Busto, Elisa Scola, Laura Brancaleoni, Sebastiano Giacomozzi, Luigi Simonetti, Michele Laudisi, Anna Cavallini, Andrea Zini, Ilaria Casetta, Enrico Fainardi, Dar Dowlatshahi, Alessandro Padovani, Francesco Arba
Summary: This study found that non-contrast computed tomography (NCCT) features are related to hematoma expansion (HE) in intracerebral hemorrhage (ICH), but the diagnostic accuracy is influenced by the time of examination. Early examination can better identify hypodensities and heterogeneous density in patients with HE, while late examination is more accurate in identifying irregular shape. These findings may improve the utilization of NCCT in future studies and clinical trials targeting HE.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Medicine, General & Internal
Muhammad Junaid Akram, Xinni Lv, Lan Deng, Zuoqiao Li, Tiannan Yang, Hao Yin, Xiaofang Wu, Mingjun Pu, Chu Chen, Libo Zhao, Qi Li
Summary: This study examined how off-hour admissions affect the outcomes of intracerebral hemorrhage (ICH) patients. A retrospective analysis was conducted on a cohort of ICH patients admitted to the First Affiliated Hospital of Chongqing Medical University between January 2017 and December 2019. Off-hour admission was found to be significantly associated with a poor functional outcome at 3 months, even after adjusting for other factors. Patients admitted during off-hours had a higher risk of poor functional outcomes compared to those admitted during working hours.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Linda Loczi, Rita Orban-Kalmandi, Tamas Arokszallasi, Istvan Fekete, Klara Fekete, Mate Heja, Judit Toth, Laszlo Csiba, Zsuzsa Bagoly
Summary: In patients with ICH, thrombin generation is increased compared to healthy controls, and peak thrombin measurement might be a useful tool to predict outcomes in ICH patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Martina B. Goeldlin, Achim Mueller, Bernhard M. Siepen, Madlaine Mueller, Davide Strambo, Patrik Michel, Michael Schaerer, Carlo W. Cereda, Giovanni Bianco, Florian Lindheimer, Christian Berger, Friedrich Medlin, Roland Backhaus, Nils Peters, Susanne Renaud, Loraine Fisch, Julien Niederhaeuser, Emmanuel Carrera, Elisabeth Dirren, Christophe Bonvin, Rolf Sturzenegger, Timo Kahles, Krassen Nedeltchev, Georg Kaegi, Jochen Vehoff, Biljana Rodic, Manuel Bolognese, Ludwig Schelosky, Stephan Salmen, Marie-Luise Mono, Alexandros A. Polymeris, Stefan T. Engelter, Philippe Lyrer, Susanne Wegener, Andreas R. Luft, Werner Z'Graggen, David Bervini, Bastian Volbers, Tomas Dobrocky, Johannes Kaesmacher, Pasquale Mordasini, Thomas R. Meinel, Marcel Arnold, Javier Fandino, Leo H. Bonati, Urs Fischer, David J. Seiffge
Summary: Knowledge about different etiologies of non-traumatic intracerebral hemorrhage (ICH) and their outcomes is scarce. Hypertension is the leading etiology of ICH, but other etiologies are also common. Around one-third of patients achieve functional independence at 3 months, but the mortality rate is high. The risk of ischemic stroke within 3 months of ICH is higher than the risk of recurrent hemorrhage, except for patients with cerebral amyloid angiopathy (CAA).
Article
Neurosciences
Jing Chen-Roetling, Yang Li, Yang Cao, Zhe Yan, Xiangping Lu, Raymond F. Regan
Summary: The study showed that systemic administration of exogenous hemopexin can reduce early injury after ICH, but the effect is not sustained potentially due to an imbalance between striatal tissue heme and hemopexin content at later time points. Further research is needed to explore the efficacy of hemopexin treatment when more efficiently targeting CNS delivery.
Article
Clinical Neurology
Nefeli Valyraki, Adrien Goujon, Marjorie Mateos, Adrien Lecoeuvre, Augustin Lecler, Igor Raynouard, Candice Sabben, Michael Obadia, Julien Savatovsky, Pierre Seners
Summary: The presence of MRI spot sign in patients with acute intracerebral hemorrhage is independently associated with hematoma expansion and poor functional outcome. The number of spot signs shows a dose-dependent effect on hematoma expansion and poor functional outcome.
JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ekaterina Vasilevskaya, Aleksandr Makarenko, Galina Tolmacheva, Irina Chernukha, Anastasiya Kibitkina, Liliya Fedulova
Summary: The study conducted a comprehensive short-term study on the development of cerebrovascular disorders in rats with an intracerebral hematoma model. The overall lethality of the model was 43.7% and it reflects the main diagnostic criteria for acute disorders of cerebral circulation.
Article
Clinical Neurology
Ashkan Mowla, Banafsheh Shakibajahromi, Shima Shahjouei, Humain Baharvahdat, Ali Amini Harandi, Farzad Rahmani, Stefania Mondello, Nasrin Rahimian, Achille Cernigliaro, Elyar Sadeghi Hokmabadij, Seyed Amir Ebrahimzadeh, Mahtab Ramezani, Kaveh Mehrvar, Mehdi Farhoudi, Soheil Naderi, Shahab Mahmoudnejad Fenderi, Masoud Pishjoo, Orkhan Alizada, Francisco Purroy, Manuel Requena, Georgios Tsivgoulis, Ramin Zand
Summary: Infection with SARS-CoV-2 may be associated with increased odds of in-hospital mortality in patients with intracerebral hemorrhage (ICH). SARS-CoV-2 infected ICH patients are younger, have higher ICH scores, more frequent history of diabetes, and lower platelet counts.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Medical Laboratory Technology
Junichiro Takahashi, Kenichiro Sakai, Takeo Sato, Hiroki Takatsu, Teppei Komatsu, Hidetaka Mitsumura, Hidetomo Murakami, Yasuyuki Iguchi
Summary: Lower serum AA levels were associated with poor functional outcomes in patients with intracerebral hemorrhage (ICH). AA may serve as an important biomarker for severity among ICH patients.
CLINICAL BIOCHEMISTRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stefan Pszczolkowski, Jose P. Manzano-Patron, Zhe K. Law, Kailash Krishnan, Azlinawati Ali, Philip M. Bath, Nikola Sprigg, Rob A. Dineen
Summary: The study aimed to predict hematoma expansion and poor functional outcome in spontaneous intracerebral hemorrhage patients using radiomics-based features, comparing them with radiological signs and clinical factors. Radiomics-based features outperformed radiological signs and were similar to clinical factors in predictive performance. Combining radiomics-based features with clinical factors improved performance.
EUROPEAN RADIOLOGY
(2021)
Article
Geriatrics & Gerontology
Moxin Wu, Kai Chen, Min Jiang, Fusheng Xie, Xianming Cao, Liang Chen, Zhiying Chen, Xiaoping Yin
Summary: This study found that plasma complement C4 levels are significantly elevated in patients with intracerebral hemorrhage (ICH) and positively correlated with the severity of the disease. This indicates that complement C4 plays an important role in brain injury after ICH and can serve as a novel predictor of clinical outcome for this disease.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Edith H. Svensson, Martin Soderholm
Summary: Higher baseline FGF23 levels were significantly associated with incident intracerebral hemorrhage (ICH), particularly in lobar and non-lobar ICH. FGF23 was also significantly associated with fatal ICH, ICH with large volume, and ICH with poor functional outcome. Further studies are needed to determine if this association is causal.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Immunology
Jielian Luo, Yang Chen, Guanghai Tang, Zhuo Li, Xiaobo Yang, Xiaoxiao Shang, Tao Huang, Gan Huang, Lixin Wang, Yun Han, Yuexiang Zhou, Chuyang Wang, Bin Wu, Qihua Guo, Baoying Gong, Mengzhen Li, Ruihua Wang, Jiecong Yang, Wanzhen Cui, Jianbin Zhong, Linda Ld Zhong, Jianwen Guo
Summary: This study explores the alterations in gut microbiota composition and cytokine responses in patients with hypertensive intracerebral hemorrhage (ICH). The results suggest that changes in gut microbiota, including enriched Enterococcus and depleted Prevotella, increase the risk of ICH and subsequent stroke-associated pneumonia (SAP). The altered gut microbiota composition and serum cytokine profiles may serve as potential biomarkers for predicting disease progression and outcomes in patients with ICH.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Genetics & Heredity
Aleksandra Ekkert, Aleksandra Sliachtenko, Algirdas Utkus, Dalius Jatuzis
Summary: Intracerebral hemorrhage (ICH) is a devastating type of stroke with unfavorable functional outcomes. Timely prevention and optimized treatment strategies are crucial given the burden of ICH. Genetic factors play a significant role in the pathogenesis of ICH, with various gene-related types identified. Although current data is mostly theoretical and scientific, emerging evidence holds promise for future clinical applications.
Article
Clinical Neurology
Andrea Morotti, Gregoire Boulouis, Andreas Charidimou, Qi Li, Loris Poli, Paolo Costa, Valeria De Giuli, Eleonora Leuci, Federico Mazzacane, Giorgio Busto, Francesco Arba, Laura Brancaleoni, Sebastiano Giacomozzi, Luigi Simonetti, Michele Laudisi, Giuseppe Micieli, Anna Cavallini, Elisa Candeloro, Massimo Gamba, Mauro Magoni, Andrew D. Warren, Christopher D. Anderson, M. Edip Gurol, Alessandro Biffi, Anand Viswanathan, Ilaria Casetta, Enrico Fainardi, Andrea Zini, Alessandro Pezzini, Alessandro Padovani, Steven M. Greenberg, Jonathan Rosand, Joshua N. Goldstein
Summary: In patients with primary spontaneous intracerebral hemorrhage and unclear symptom onset, hematoma expansion is common and independently associated with worse outcome, suggesting that these patients may benefit from medical treatments targeting hematoma expansion.
Review
Clinical Neurology
Jingfei Yang, Jie Jing, Shiling Chen, Xia Liu, Yingxin Tang, Chao Pan, Zhouping Tang
Summary: This article reviews the changes in cerebral blood flow and DWI lesions after ICH, and discusses the risk factors and possible mechanisms associated with the occurrence of DWI lesions, providing potential therapeutic interventions for improving long-term recovery in patients with ICH.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Neurosciences
Zi-Jie Wang, Rui Zhao, Xiao Hu, Wen-Song Yang, Lan Deng, Xin-Ni Lv, Zuo-Qiao Li, Jing Cheng, Ming-Jun Pu, Zhou-Ping Tang, Guo-Feng Wu, Li-Bo Zhao, Peng Xie, Qi Li
Summary: The global SVD score is associated with small ICH and is inversely correlated with hematoma volume, especially in non-lobar ICH.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Xiao Hu, Mingjun Pu, Zijie Wang, Jialun Yu, Xiaofang Wu, Jing Cheng, Chu Chen, Hao Yin, Tiannan Yang, Zhehao Zhang, Libo Zhao, Peng Xie, Qi Li
Summary: Objective dysphagia is a common complication of acute ischemic stroke, and predicting dysphagia is important for post-stroke treatment. This study aimed to identify predictors of dysphagia and swallowing function recovery after stroke and to investigate the location of dysphagia-associated lesions. The findings showed that initial risk of aspiration, aphasia, and larger white matter hyperintensity were significant predictors of swallowing function recovery. The right corona radiata was identified as an important brain area for dysphagia.
NEUROLOGICAL SCIENCES
(2023)
Article
Immunology
Sai Luo, Wen-Song Yang, Yi-Qing Shen, Ping Chen, Shu-Qiang Zhang, Zhen Jia, Qi Li, Jian-Ting Zhao, Peng Xie
Summary: This study aimed to investigate the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and D-dimer-to-fibrinogen ratio (DFR) as predictors of pneumonia and poor outcomes in patients with acute intracerebral hemorrhage (ICH). The results showed that NLR and PLR were independent predictors of pneumonia, while NLR and DFR were independent predictors of poor 90-day outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Qianqian Si, Yuming Teng, Caiyan Liu, Weizhuang Yuan, Xiaoyuan Fan, Xiaoqian Zhang, Zongmuyu Zhang, Mingli Li, Qing Liu, Peng Wang, Zhongrui Yan, Bo Wu, Qiang Liu, Hangjuan Li, Yan Ji, Yuncai Ran, Bo Song, Shiguang Zhu, Hongyan Li, Jingxia Guan, Manli Zhao, Yonggang Hao, Pengfei Wang, Hong Bian, Ningfen Wang, Yulin Wang, Yuning Pan, Hongwei An, Rong Guo, Cong Han, Junshi Zhang, Hebo Wang, Yong You, Hongquan Jiang, Zifan Liu, Jingli Liu, Dingbo Tao, Xiangyu Piao, Jiangtao Zhang, Pei Wang, Shen Yang, Zhou Liu, Xiue Wei, Kai Han, Zhimin Shi, Aihua Liu, Zuowen Zhang, Chunye Ma, Baichen Wang, Gejuan Zhang, Chengguang Song, Guilian Zhang, Xiao Yang, Bing Chen, Baoquan Lu, Beilei Chen, Meng Zuo, Kun Han, Xiaodan Zhang, Wenfeng Cao, Lingfeng Wu, Qi Li, Xiaokun Geng, Junshan Zhou, Mengfei Zhong, Minghua Wang, Yangmei Chen, Jiachun Liu, Tingrui Wang, Youqing Deng, Weihai Xu
Summary: The SICO-ICAS study aims to elucidate the pathophysiology of stroke and cognitive impairment in the ICAS population, comprehensively evaluating the complex interactions among life-course exposure, genomic variation, vascular risk factors, cerebrovascular burden, and coexisting neurodegeneration.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Emergency Medicine
Andrew D. Warren, Qi Li, Kristin Schwab, Brenna McKaig, Alexa N. Goldstein, Steven M. Greenberg, Anand Viswanathan, Christopher Anderson, M. Edip Gurol, Aman Patel, Joshua N. Goldstein
Summary: Intraventricular hemorrhage (IVH) is common after intracerebral hemorrhage (ICH) and is associated with higher mortality and worse clinical outcome. The use of external ventricular drains (EVDs) is associated with lower mortality but not clearly with better neurologic outcome in ICH patients. Moreover, more rapid EVD placement is associated with higher mortality, potentially indicating early development of herniation or obstructive hydrocephalus.
INTERNATIONAL JOURNAL OF EMERGENCY MEDICINE
(2022)
Review
Neurosciences
Yunjie Li, Xia Liu, Shiling Chen, Jingyi Wang, Chao Pan, Gaigai Li, Zhouping Tang
Summary: Antiplatelet medications are increasingly used for the prevention of ischemic stroke, but they may also increase the risk of intracerebral hemorrhage (ICH). Restarting antiplatelet therapy after ICH is a complex decision that depends on the individual patient's risks of both thrombotic events and bleeding. More research is needed to determine the optimal timing for restarting antiplatelet therapy and to provide evidence-based guidelines for clinical decision-making.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Qi Li, Andrea Morotti, Andrew Warren, Adnan Qureshi, Dar Dowlatshahi, Guido Falcone, Kevin N. Sheth, Ashkan Shoamanesh, Santosh B. Murthy, Anand Viswanathan, Joshua N. Goldstein
Summary: Objective: This study aimed to determine whether intensive blood pressure reduction could benefit patients with fast bleeding intracerebral hemorrhage (ICH). The results suggest that early use of intensive blood pressure reduction may reduce hematoma growth and improve outcomes in fast bleeding patients.
ANNALS OF NEUROLOGY
(2023)
Article
Neurosciences
Xiao Hu, Zhong-Song Xiao, Yi-Qing Shen, Wen-Song Yang, Peng Wang, Pei-Zheng Li, Zi-Jie Wang, Ming-Jun Pu, Li-Bo Zhao, Peng Xie, Qi Li
Summary: This study investigated the relationship between several inflammatory biomarkers and cerebral small vessel disease (CSVD) features. The results showed that the SERPINA3 level was associated with WMH severity, revealing a novel biomarker for CSVD and validating its relationship with inflammation and endothelial dysfunction.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Zhongsong Xiao, Peizheng Li, Yiqing Shen, Anatol Manaenko, Wensong Yang, Peng Wang, Xinhui Li, Fangyu Liu, Peng Xie, Qi Li
Summary: Despite limited treatment options for intracerebral hemorrhage (ICH), recent evidence suggests that the ultra-early stage of ICH may have significant importance. This study investigated the metabolic changes induced by ICH in the ultra-early stage using a mouse model and identified key pathological mechanisms associated with this stage.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Critical Care Medicine
Xiao-Fang Wu, Lan Deng, Xin-Ni Lv, Zuo-Qiao Li, Zi-Jie Wang, Xiao Hu, Ming-Jun Pu, Chu Chen, Li-Bo Zhao, Qi Li
Summary: This study investigated the clinical, imaging, and outcome characteristics of intracerebral hemorrhage (ICH) caused by structural vascular lesions. Compared to primary ICH, ICH caused by structural vascular lesions was found to occur in younger patients with a lower incidence of hypertension and diabetes. These patients predominantly had lobar hemorrhages and smaller baseline hematoma volumes. Additionally, they had lower mortality rates at 30 days and 3 months and better functional outcomes at 3 months.
NEUROCRITICAL CARE
(2023)
Review
Medicine, General & Internal
Xin-Ni Lv, Zuo-Qiao Li, Qi Li
Summary: Intracerebral hemorrhage is a dangerous subtype of stroke with high rates of morbidity and mortality. Targeting prevention of hematoma growth and perihematomal edema expansion shows promise as a therapeutic approach. Blood-based biomarkers are being studied as potential diagnostic, predictive, and prognostic markers due to their accessibility and acceptance in clinical practice. Validation studies are needed to determine the usefulness of these biomarkers in the future.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
Luwei Nie, Dabao Yao, Shiling Chen, Jingyi Wang, Chao Pan, Dongcheng Wu, Na Liu, Zhouping Tang
Summary: Due to the limited capacity of the adult mammalian brain to self-repair and regenerate, neurological diseases, such as neurodegenerative disorders and stroke, are often considered as refractory diseases. Neural stem cells (NSCs) have the potential to differentiate into specific neural cell types and offer new approaches for the treatment of neurological diseases. This review outlines the advances in generating different neuronal lineage subtypes from NSCs and summarizes their therapeutic effects in neurological disease models, focusing on Parkinson's disease and ischemic stroke. The strengths and weaknesses of different sources of NSCs and methods of directed differentiation are compared, and future research directions for NSCs in regenerative medicine are proposed.
CELL DEATH DISCOVERY
(2023)
Article
Cell Biology
Hong Deng, Ye Zhang, Gai-Gai Li, Hai-Han Yu, Shuang Bai, Guang-Yu Guo, Wen-Liang Guo, Yang Ma, Jia-Hui Wang, Na Liu, Chao Pan, Zhou-Ping Tang
Summary: P2X7 receptor plays a crucial role in oxidative stress regulation in the central nervous system following intracerebral hemorrhage. Inhibition of P2X7R can reduce oxidative stress and alleviate neurological damage, brain edema, and apoptosis after intracerebral hemorrhage. The activation of P2X7R aggravates NOX2-induced oxidative stress through the ERK1/2 and NF-kappa B pathways in mice.
NEURAL REGENERATION RESEARCH
(2021)