Analysis of Motor Function in Amyloid Precursor-Like Protein 2 Knockout Mice: The Effects of Ageing and Sex

α-Motor neurons are spared from aging while their synaptic inputs degenerate in monkeys and mice

(2018) Nicholas Maxwell et al.   AGING CELL

Muscle strength and size are associated with motor unit connectivity in aged mice

(2018) Kajri A. Sheth et al.   NEUROBIOLOGY OF AGING

The exercise sex gap and the impact of the estrous cycle on exercise performance in mice

(2018) Aderbal S. Aguiar et al.   Scientific Reports

Evidence for dying-back axonal degeneration in age-associated skeletal muscle decline

(2017) Tae Chung et al.   MUSCLE & NERVE

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

Novel Insights into the Physiological Function of the APP (Gene) Family and Its Proteolytic Fragments in Synaptic Plasticity

(2017) Susann Ludewig et al.   Frontiers in Molecular Neuroscience

Amyloid Precursor Protein Protects Neuronal Network Function after Hypoxia via Control of Voltage-Gated Calcium Channels

(2016) D. Hefter et al.   JOURNAL OF NEUROSCIENCE

Performance of Male and Female C57BL/6J Mice on Motor and Cognitive Tasks Commonly Used in Pre-Clinical Traumatic Brain Injury Research

(2016) Laura B. Tucker et al.   JOURNAL OF NEUROTRAUMA

Age-related changes in behavior in C57BL/6J mice from young adulthood to middle age

(2016) Hirotaka Shoji et al.   Molecular Brain

Voluntary resistance wheel exercise from mid-life prevents sarcopenia and increases markers of mitochondrial function and autophagy in muscles of old male and female C57BL/6J mice

(2016) Zoe White et al.   Skeletal Muscle

Innervation and neuromuscular control in ageing skeletal muscle

(2015) Russell T. Hepple et al.   JOURNAL OF PHYSIOLOGY-LONDON

Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease

(2014) Edgar Dawkins et al.   JOURNAL OF NEUROCHEMISTRY

Differential role of APP and APLPs for neuromuscular synaptic morphology and function

(2014) Maja Klevanski et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1α

(2014) Anne-Sophie Arnold et al.   Nature Communications

Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression

(2014) Sascha W Weyer et al.   Acta Neuropathologica Communications

Environmental enrichment promotes robust functional and histological benefits in female rats after controlled cortical impact injury

(2013) Christina M. Monaco et al.   EXPERIMENTAL NEUROLOGY

The amyloid precursor protein: A biochemical enigma in brain development, function and disease

(2013) Natalia N. Nalivaeva et al.   FEBS LETTERS

Hippocampal Network Oscillations in APP/APLP2-Deficient Mice

(2013) Xiaomin Zhang et al.   PLoS One

Location- and sex-specific differences in weight and motor coordination in two commonly used mouse strains

(2013) Attila D. Kovács et al.   Scientific Reports

sAPPα rescues deficits in amyloid precursor protein knockout mice following focal traumatic brain injury

(2012) Frances Corrigan et al.   JOURNAL OF NEUROCHEMISTRY

Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function

(2012) Brea Midthune et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP

(2011) Sascha W Weyer et al.   EMBO JOURNAL

ALPHA, BETA AND GAMMA MOTONEURONS: FUNCTIONAL DIVERSITY IN THE MOTOR SYSTEM'S FINAL PATHWAY

(2011) MARIN MANUEL et al.   Journal of Integrative Neuroscience

Changes in Aging Mouse Neuromuscular Junctions Are Explained by Degeneration and Regeneration of Muscle Fiber Segments at the Synapse

(2011) Y. Li et al.   JOURNAL OF NEUROSCIENCE

Fiber Types in Mammalian Skeletal Muscles

(2011) Stefano Schiaffino et al.   PHYSIOLOGICAL REVIEWS

Striking Denervation of Neuromuscular Junctions without Lumbar Motoneuron Loss in Geriatric Mouse Muscle

(2011) Ruth Jinfen Chai et al.   PLoS One

The role of APP and APLP for synaptic transmission, plasticity, and network function: lessons from genetic mouse models

(2011) Martin Korte et al.   EXPERIMENTAL BRAIN RESEARCH

Cognitive dysfunction with aging and the role of inflammation

(2011) Arthur A. Simen et al.   Therapeutic Advances in Chronic Disease

Remodeling of the neuromuscular junction precedes sarcopenia related alterations in myofibers

(2010) Michael R. Deschenes et al.   EXPERIMENTAL GERONTOLOGY

Age-related Defects in Sensorimotor Activity, Spatial Learning, and Memory in C57BL/6 Mice

(2010) George Barreto et al.   JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY

Neural mechanisms of ageing and cognitive decline

(2010) Nicholas A. Bishop et al.   NATURE

Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise

(2010) G. Valdez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Behavioral changes in aging female C57BL/6 mice

(2009) Andreas Fahlström et al.   NEUROBIOLOGY OF AGING

Gamma and alpha motor neurons distinguished by expression of transcription factor Err3

(2009) A. Friese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth

(2008) BE Needham et al.   JOURNAL OF PATHOLOGY

Sex-related differences in recovery of cutaneous nociception after end-to-side nerve repair in the rat

(2008) Uroš Kovačič et al.   Journal of Plastic Reconstructive and Aesthetic Surgery

Sex-specific genetic architecture of human disease

(2008) Carole Ober et al.   NATURE REVIEWS GENETICS

Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

(2008) Chanel J. Taylor et al.   NEUROBIOLOGY OF DISEASE

Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning

(2007) Yann Senechal et al.   BEHAVIOURAL BRAIN RESEARCH