Direct observation of topoisomerase IA gate dynamics

Investigating mycobacterial topoisomerase I mechanism from the analysis of metal and DNA substrate interactions at the active site

(2018) Nan Cao et al.   NUCLEIC ACIDS RESEARCH

An orthogonal single-molecule experiment reveals multiple-attempt dynamics of type IA topoisomerases

(2017) Kathryn H Gunn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RecQ helicase triggers a binding mode change in the SSB–DNA complex to efficiently initiate DNA unwinding

(2017) Maria Mills et al.   NUCLEIC ACIDS RESEARCH

An orthogonal single-molecule experiment reveals multiple-attempt dynamics of type IA topoisomerases

(2017) Kathryn H Gunn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Small-Molecule Inhibitors Targeting Topoisomerase I as Novel Antituberculosis Agents

(2016) Shayna Sandhaus et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Single molecule measurements of DNA helicase activity with magnetic tweezers and t- test based step-finding analysis

(2016) Yeonee Seol et al.   METHODS

Targeting bacterial topoisomerase I to meet the challenge of finding new antibiotics

(2015) Yuk-Ching Tse-Dinh   Future Medicinal Chemistry

Genetic and chemical validation identifies Mycobacterium tuberculosis topoisomerase I as an attractive anti-tubercular target

(2015) Sudha Ravishankar et al.   TUBERCULOSIS

Conditional silencing of topoisomerase I gene ofMycobacterium tuberculosisvalidates its essentiality for cell survival

(2014) Wareed Ahmed et al.   FEMS MICROBIOLOGY LETTERS

Structural and mechanistic insight into Holliday-junction dissolution by Topoisomerase IIIα and RMI1

(2014) Nicolas Bocquet et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Single-molecule analysis uncovers the difference between the kinetics of DNA decatenation by bacterial topoisomerases I and III

(2014) Ksenia Terekhova et al.   NUCLEIC ACIDS RESEARCH

Type IA topoisomerase inhibition by clamp closure

(2013) Majety Naga Leelaram et al.   FASEB JOURNAL

CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data

(2013) Jing Huang et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation

(2013) Dongyi Xu et al.   NATURE NEUROSCIENCE

Comparison of DNA decatenation by Escherichia coli topoisomerase IV and topoisomerase III: implications for non-equilibrium topology simplification

(2013) Yeonee Seol et al.   NUCLEIC ACIDS RESEARCH

Isolation and Quantitation of Topoisomerase Complexes Accumulated on Escherichia coli Chromosomal DNA

(2012) Sandra Aedo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Decatenation of DNA by the S. cerevisiae Sgs1-Top3-Rmi1 and RPA Complex: A Mechanism for Disentangling Chromosomes

(2012) Petr Cejka et al.   MOLECULAR CELL

A role for topoisomerase III inEscherichia colichromosome segregation

(2012) Brenda A. Perez-Cheeks et al.   MOLECULAR MICROBIOLOGY

Bacterial topoisomerase I and topoisomerase III relax supercoiled DNA via distinct pathways

(2012) Ksenia Terekhova et al.   NUCLEIC ACIDS RESEARCH

Interfacial inhibitors: targeting macromolecular complexes

(2011) Yves Pommier et al.   NATURE REVIEWS DRUG DISCOVERY

Learning Rates and States from Biophysical Time Series: A Bayesian Approach to Model Selection and Single-Molecule FRET Data

(2009) Jonathan E. Bronson et al.   BIOPHYSICAL JOURNAL

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Deciphering the Distinct Role for the Metal Coordination Motif in the Catalytic Activity of Mycobacterium smegmatis Topoisomerase I

(2009) Anuradha Gopal Bhat et al.   JOURNAL OF MOLECULAR BIOLOGY

Resolution of Converging Replication Forks by RecQ and Topoisomerase III

(2008) Catherine Suski et al.   MOLECULAR CELL

Structural studies of type I topoisomerases

(2008) N. M. Baker et al.   NUCLEIC ACIDS RESEARCH

Inhibition of Mg 2+ binding and DNA religation by bacterial topoisomerase I via introduction of an additional positive charge into the active site region

(2008) Elena P. Sorokin et al.   NUCLEIC ACIDS RESEARCH