Article
Urology & Nephrology
Kevin Louis, Paul Fadakar, Camila Macedo, Masaki Yamada, Michelle Lucas, Xinyan Gu, Adriana Zeevi, Parmjeet Randhawa, Carmen Lefaucheur, Diana Metes
Summary: This study used high dimensional flow cytometry to analyze the status of regulatory T cells and transitional B cells in kidney transplant recipients. It found that in patients with antibody-mediated rejection (ABMR), both cell types were significantly reduced in numbers, which correlated with inflammatory antibody responses, microvascular inflammation, and kidney allograft loss.
KIDNEY INTERNATIONAL
(2022)
Review
Immunology
Wang Long, Hedong Zhang, Wenjia Yuan, Gongbin Lan, Zhi Lin, Longkai Peng, Helong Dai
Summary: Recent studies have shown that regulatory B (Breg) cells may have protective effects against autoimmune diseases by secreting inhibitory cytokines, although no specific marker has been identified. Breg cells exhibit multiple phenotypes with varying functions, highlighting their potential therapeutic value in kidney diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Endeshaw Chekol Abebe, Tadesse Asmamaw Dejenie, Teklie Mengie Ayele, Nega Dagnew Baye, Assefa Agegnehu Teshome, Zelalem Tilahun Muche
Summary: Regulatory B cells (Bregs) are a novel subset of B cells that expand after activation upon specific stimuli, exerting negative immune regulatory roles and playing various roles in immune regulation, with potential pathological and protective effects in health and disease.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Urology & Nephrology
Christian Morath, Matthias Schaier, Eman Ibrahim, Lei Wang, Christian Kleist, Gerhard Opelz, Caner Suesal, Gerald Ponath, Mostafa Aly, Cristiam M. Alvarez, Florian Kaelble, Claudius Speer, Louise Benning, Christian Nusshag, Luiza Pego da Silva, Claudia Sommerer, Angela Hueckelhoven-Krauss, David Czock, Arianeb Mehrabi, Constantin Schwab, Ruediger Waldherr, Paul Schnitzler, Uta Merle, Thuong Hien Tran, Sabine Scherer, Georg A. Boehmig, Carsten Mueller-Tidow, Jochen Reiser, Martin Zeier, Michael Schmitt, Peter Terness, Anita Schmitt, Volker Daniel
Summary: This study shows that using donor-derived modified immune cells (MICs)-PBMCs for specific immunosuppression treatment before kidney transplantation can result in an increase in CD19(+)CD24(hi)CD38(hi) transitional B lymphocytes by up to 68-fold compared to transplanted controls.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Immunology
David Y. Oh, Lawrence Fong
Summary: Cytotoxic CD4(+) T cells play important roles in both cancer and non-cancer environments, where they can directly kill cancer cells. They are also found in situations like infection and autoimmunity. The cytolytic mechanisms of cytotoxic CD4(+) T cells vary across different disease states.
Review
Biochemistry & Molecular Biology
Natalia M. Krajewska, Remi Fiancette, Ye H. Oo
Summary: Immune-mediated cholangiopathies are characterized by the destruction of bile ducts, leading to liver inflammation and fibrosis. Regulatory T cells (Tregs) play a crucial role in these diseases, but their function can be impaired by the inflamed microenvironment. Mast cells (MCs) are also involved in the pathogenesis by releasing pro-inflammatory mediators. MCs can indirectly influence Treg function and there are also direct interactions between MCs and Tregs. Understanding the crosstalk between Tregs and MCs is important for the progression of autoimmune cholangiopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Fisheries
Jiafeng Cao, Haoyue Xu, Yongyao Yu, Zhen Xu
Summary: This article reviews the relationship between cytokines and T and B cells in fish, and the regulatory roles of cytokines in these two lymphocyte types. It provides important information for the development of adaptive immunity-based vaccines and immunostimulants in vertebrates.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yao Xu, Juan Fu, Mackenzie Henderson, Fei Lee, Noelle Jurcak, Anja Henn, Joachim Wahl, Yingkuan Shao, Jianxin Wang, Melissa Lyman, Vanessa Funes, Birginia Espinoza, Rui Zhang, India Washington, Sophia Y. Chen, Haley Zlomke, Junke Wang, Nan Niu, Pan Li, Fengxi Meng, William Burns, Matthias Friedrich, Sabine Stienen, Julie M. Bailis, Lei Zheng
Summary: AMG 910, a CLDN18.2-targeted BiTE molecule, demonstrated potent anti-tumor activity in preclinical models of gastric cancer and pancreatic ductal adenocarcinoma. Combination therapy with a PD-1 inhibitor enhanced the therapeutic effect of AMG 910. Moreover, infusion of Tregs enhanced the anti-tumor efficacy of AMG 910.
Article
Multidisciplinary Sciences
Scott A. Ochsner, Rudolf T. Pillich, Deepali Rawool, Jeffrey S. Grethe, Neil J. McKenna
Summary: This article describes how investigator-generated transcriptomic datasets can be repurposed to generate hypotheses about the signaling pathways of circulating immune cells in type 1 diabetes. By computing and validating sets of differentially expressed genes, as well as inferring and validating signaling node networks, the study demonstrated the value of these datasets in understanding the pathogenesis of T1D and generating actionable hypotheses. Additionally, a federated, cloud-based web resource was developed to provide unrestricted access and re-use of the data matrix by the research community.
Article
Immunology
Philipp Gauckler, Jana S. Kesenheimer, Duvuru Geetha, Balazs Odler, Kathrin Eller, Timothee Laboux, Federico Alberici, Mattia Zappa, Natasha Chebotareva, Sergey Moiseev, Marco Bonilla, Kenar D. Jhaveri, Julie Oniszczuk, Vincent Audard, Denise Costa, Gianna Mastroianni-Kirsztajn, Annette Bruchfeld, Masahiro Muto, Martin Windpessl, Gert Mayer, Andreas Kronbichler
Summary: Patients with immune-mediated glomerular diseases are at higher risk for severe COVID-19 outcomes. Risk factors for severe outcomes in this patient population include older age, male sex, ongoing intake of corticosteroids, and lower serum albumin levels at presentation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Nathaniel Oberholtzer, Carl Atkinson, Satish N. Nadig
Summary: Research is focused on cell-based therapies for inducing graft tolerance. Using regulatory cell types helps produce graft-specific tolerance. Significant progress has been made, but many questions remain to be answered.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Michael L. Dixon, Jonathan D. Leavenworth, Jianmei W. Leavenworth
Summary: Regulatory T-cells, particularly effector Tregs (eTregs), play a crucial role in maintaining self-tolerance and tissue homeostasis, with potential implications in tumor development. Understanding the mechanisms that modulate the stability and suppressive function of tumoral Tregs, such as eTregs and T-FR cells, can lead to the development of more effective cancer immunotherapies that target the tumor microenvironment while minimizing systemic side effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Feiling Xie, Hongmei Dong, Hao Zhang
Summary: PTPRO/PTPROt, as a member of the PTP family, plays a crucial role in immune cells by regulating their growth, differentiation, activation and immune responses. This review focuses on the regulatory roles and molecular mechanisms of PTPRO/PTPROt in B cells, T cells, and macrophages.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Jenny Lutshumba, Donna M. Wilcock, Nancy L. Monson, Ann M. Stowe
Summary: Neurological conditions such as Alzheimer's disease and related dementias present challenges due to heterogeneity and sex-based differences in disease progression. However, current research on these conditions often overlooks the importance of incorporating sex-based differences, hindering understanding and treatment of dementia. This review highlights the sex-based differences in pathological hallmarks, adaptive immune system, and the need for precision medicine in developing targeted treatments.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Immunology
Xin Ma, Yang Dai, Oliver Witzke, Shilei Xu, Monika Lindemann, Andreas Kribben, Sebastian Dolff, Benjamin Wilde
Summary: CQ has a suppressive effect on IL-10 regulatory B-cells and effector B-cells. These findings help explain the clinical efficacy of CQ in B-cell mediated autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Diego Catalan, Miguel Andres Mansilla, Ashley Ferrier, Lilian Soto, Kristine Oleinika, Juan Carlos Aguillon, Octavio Aravena
Summary: Regulatory B cells play a crucial role in maintaining immune tolerance and preventing exacerbated inflammatory responses. In addition to IL-10, other molecules such as IL-35, TGF-beta, and cell surface proteins like CD1d and PD-L1 are utilized by Bregs to regulate immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Letter
Infectious Diseases
Luca Borghesi, Valentina Viaggi, Marco Franzetti, Matteo Montoli, Carola Mauri, Giovanni Moioli, Mauro Roberto Benvenuti, Stefania Piconi, Francesco Luzzaro
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)
Review
Infectious Diseases
Carola Mauri, Alberto Enrico Maraolo, Stefano Di Bella, Francesco Luzzaro, Luigi Principe
Summary: The combination of aztreonam + avibactam shows promise in treating infections caused by MBL-producing bacteria, especially Enterobacterales. Clinical resolution within 30 days was reported in 80% of infected patients, with a lower success rate for patients with bloodstream infections caused by Pseudomonas. Further research is needed to fully understand the effectiveness of this combination therapy.
Article
Hospitality, Leisure, Sport & Tourism
Chiara Mauri, Consuelo R. Nava
Summary: The study found that during winter mountain holidays, 21% of tourists perceive boredom, with a portion of them experiencing both excitement and boredom at the same time. Most of these bored tourists are mothers accompanying their relatives, staying in hotels, participating in many activities, and spending more than other tourists.
ANNALS OF TOURISM RESEARCH
(2021)
Editorial Material
Immunology
Christopher J. M. Piper, Claudia Mauri
Summary: This study reveals a novel mechanism showing how 25-hydroxycholesterol inhibits the differentiation of IgA plasma cells in the Peyer's patches by regulating SREBP2, independent of EBI2-mediated migration.
Article
Infectious Diseases
Aurora Piazza, Matteo Perini, Carola Mauri, Francesco Comandatore, Elisa Meroni, Francesco Luzzaro, Luigi Principe
Summary: This study reports a hypermucoviscous K. pneumoniae strain causing recurrent meningitis and investigates its genomic features using whole-genome sequencing analysis. The strain is susceptible to most antibiotics despite the presence of some resistance genes and exhibits several virulence factors related to pathogenicity. Phylogenetic analysis shows high similarity between this strain and a Chinese isolate, suggesting a hidden circulation of this lineage.
Article
Infectious Diseases
Gianluca Morroni, Raffaela Bressan, Simona Fioriti, Gloria D'Achille, Marina Mingoia, Oscar Cirioni, Stefano Di Bella, Aurora Piazza, Francesco Comandatore, Carola Mauri, Roberta Migliavacca, Francesco Luzzaro, Luigi Principe, Cristina Lagatolla
Summary: MBLs are challenging bacterial enzymes, with ATM being the only beta-lactam not hydrolyzed by MBLs but often inactivated by ESBLs. In this study, the combination of ATM with various BLIs showed promising activity against MBL and ESBL co-producing Gram-negative clinical isolates, providing multiple treatment options. However, some non-fermentative bacilli were not inhibited by any ATM-BLI combination, indicating the presence of additional resistance mechanisms complicating therapy choices.
Article
Microbiology
Stefano Di Bella, Roberta Maria Antonello, Gianfranco Sanson, Alberto Enrico Maraolo, Daniele Roberto Giacobbe, Chiara Sepulcri, Simone Ambretti, Richard Aschbacher, Laura Bartolini, Mariano Bernardo, Alessandra Bielli, Marina Busetti, Davide Carcione, Giulio Camarlinghi, Edoardo Carretto, Tiziana Cassetti, Chiara Chilleri, Francesco Giuseppe De Rosa, Saveria Dodaro, Raffaele Gargiulo, Francesca Greco, Anna Knezevich, Jari Intra, Tommaso Lupia, Erika Concialdi, Gabriele Bianco, Francesco Luzzaro, Carola Mauri, Gianluca Morroni, Adriana Mosca, Elisabetta Pagani, Eva Maria Parisio, Claudio Ucciferri, Chiara Vismara, Roberto Luzzati, Luigi Principe
Summary: This study provides updated data on the burden and profile of anaerobic bloodstream infections (ABIs) in Italy. The findings show that the average age of ABIs patients is relatively high, with a majority being males. The susceptibility testing of antibiotics reveals a low resistance rate to metronidazole and a high resistance rate to penicillin among anaerobes. The resistance of Bacteroides spp. to clindamycin has increased over the study period. These results offer a comprehensive overview of the epidemiology of ABIs.
Editorial Material
Infectious Diseases
Edgar I. Campos-Madueno, Carola Mauri, Elisa Meroni, Pablo Porragas Paseiro, Alessandra Consonni, Francesco Luzzaro, Andrea Endimiani
Summary: This study reports two bla(KPC-3)-positive isolates identified as Klebsiella oxytoca and Escherichia coli in the same rectal swab. Whole-genome sequencing revealed that the K. oxytoca isolate was actually Klebsiella grimontii, while the E. coli isolate belonged to a different strain. The study also identified additional bla(KPC)-positive K. grimontii strains misidentified as K. oxytoca in public databases.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Correction
Infectious Diseases
Gianluca Morroni, Raffaela Bressan, Simona Fioriti, Gloria D'Achille, Marina Mingoia, Oscar Cirioni, Stefano Di Bella, Aurora Piazza, Francesco Comandatore, Carola Mauri, Roberta Migliavacca, Francesco Luzzaro, Luigi Principe, Cristina Lagatolla
Review
Immunology
Kristine Oleinika, Baiba Slisere, Diego Catalan, Elizabeth C. Rosser
Summary: Obesity, a major risk factor for various diseases, has tripled worldwide in less than 50 years. Chronic inflammatory response is associated with obesity and B cells play a crucial role in driving obesity-related meta-inflammation. Obesity also affects the ability to respond to and clear infections, leading to more severe complications and poor vaccine responses.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jeremiah Bernier-Latmani, Cristina Mauri, Rachel Marcone, Francois Renevey, Stephan Durot, Liqun He, Michael Vanlandewijck, Catherine Maclachlan, Suzel Davanture, Nicola Zamboni, Graham W. Knott, Sanjiv A. Luther, Christer Betsholtz, Mauro Delorenzi, Cathrin Brisken, Tatiana Petrova
Summary: The specialized structure of small intestinal villus tip blood vessels is maintained by ADAMTS18(+) telocytes, which regulate the level and location of VEGFA signaling to ensure the presence of endothelial fenestrae for nutrient absorption, while avoiding excessive leakiness and destabilization of villus tip epithelial structures.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Hannah F. Bradford, Liis Haljasmagi, Madhvi Menon, Thomas C. R. McDonnell, Karita Sarekannu, Martti Vanker, Part Peterson, Chris Wincup, Rym Abida, Raquel Fernandez Gonzalez, Vincent Bondet, Darragh Duffy, David A. Isenberg, Kai Kisand, Claudia Mauri
Summary: Systemic lupus erythematosus (SLE) patients often exhibit increased expression of type I interferon (IFN)-regulated genes. In our study of 501 SLE patients, we found that 73 (14%) had autoantibodies against IFN-alpha (anti-IFN-Abs). The presence of neutralizing anti-IFN-Abs in 4.2% of patients correlated with low IFN-alpha protein levels, inhibition of IFN-I downstream gene signatures, and inactive disease score. These neutralizing anti-IFN-Abs were found to play a role in controlling SLE pathogenesis, specifically in regulating B cell populations.
CELL REPORTS MEDICINE
(2023)
Article
Endocrinology & Metabolism
B. Slisere, M. Arisova, O. Aizbalte, M. M. Salmina, M. Zolovs, M. Levensteins, M. Mukans, I. Troickis, L. Meija, A. Lejnieks, G. Bilande, E. C. Rosser, K. Oleinika
Summary: Bariatric surgery leads to changes in the composition of B cells and partially restores the balance of naive and memory B cells. However, post-operative patients still exhibit an increase in B cell subsets associated with chronic inflammation. The specific immunometabolic state created by bariatric surgery may have implications for health outcomes.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Linguistics
Caterina Mauri, Andrea Sanso
Summary: This paper provides a diachronic typology of heterogeneous plurals, including associative plurals and similative plurals. Based on a 110-language sample, the most recurrent sources of these two types of plurals are identified. Associative plurals develop from elements that work as set constructors, while similative plurals comprise elements with vague reference. There are also some sources that may develop into both associative and similative plurals. These differences can be explained in terms of the referential properties of the nominal bases and the discourse contexts in which the plurals are used.
LINGUISTIC TYPOLOGY
(2023)