Review
Biochemistry & Molecular Biology
Malathi Bheri, Swati Mahiwal, Sibaji K. Sanyal, Girdhar K. Pandey
Summary: Protein phosphorylation and dephosphorylation are important reversible post-translational modifications, with protein phosphatases playing a key role in signaling networks. The classification and mechanism of phosphatases in plant systems still require further investigation.
Article
Multidisciplinary Sciences
Cecilia Akatukwasa, Monica Getahun, Alison M. El Ayadi, Judith Namanya, Irene Maeri, Harriet Itiakorit, Lawrence Owino, Naomi Sanyu, Jane Kabami, Emmanuel Ssemmondo, Norton Sang, Dalsone Kwarisiima, Maya L. Petersen, Edwin D. Charlebois, Gabriel Chamie, Tamara D. Clark, Craig R. Cohen, Moses R. Kamya, Elizabeth A. Bukusi, Diane V. Havlir, Carol S. Camlin
Summary: This qualitative study unveiled various forms of HIV-related stigma in eight communities in East Africa, including enacted, internalized, and anticipated stigma, with a greater impact on women in communities with lower HIV prevalence. Experiences of stigma led to anxiety, depression, and affected the seeking of care and treatment among PLHIV.
Article
Public, Environmental & Occupational Health
Xinxin Chen, Zhenjiang Liao, Shucai Huang, Qiuping Huang, Shuhong Lin, Yifan Li, Tianli Shao, Ying Tang, Jingyue Hao, Jing Qi, Yi Cai, Mingming Wang, Hongxian Shen
Summary: This study describes and assesses the COVID-19-related stigma among patients, their relatives, and healthy local residents in Zhangjiajie. The results show that stigmatizing attitudes and desire for social distance towards COVID-19 patients are common in all three groups. Therefore, public education, anti-stigma interventions, and policies are necessary to effectively control the spread of COVID-19 and aid in the recovery of a tourist city like Zhangjiajie.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Ping-Ping Gao, Xiao-Wei Qi, Na Sun, Yuan-Yuan Sun, Ye Zhang, Xuan-Ni Tan, Jun Ding, Fei Han, Yi Zhang
Summary: Protein reversible phosphorylation controlled by kinases and phosphatases is involved in various cellular processes. Dual-specificity phosphatases (DUSPs) have been identified as key players in human cancers, with potential differential expression serving as a potential biomarker for tumor prognosis. Further exploration is needed for unstudied members of the DUSPs family to understand their precise roles and mechanisms in cancers.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Multidisciplinary Sciences
Marlee Bower, Amarina Donohoe-Bales, Scarlett Smout, Andre Quan Ho Ngyuen, Julia Boyle, Emma Barrett, Maree Teesson
Summary: The COVID-19 pandemic has had significant and unprecedented mental health impacts in Australia. A lack of research directly asking Australian community members about their mental health experiences and priorities in relation to the pandemic has been identified. This study used qualitative data from a longitudinal mixed-methods study to explore the effects of COVID-19 on mental health in Australia. The findings revealed that participants described disruptions to their social world and financial stability as the primary impacts of COVID-19 on their mental health. Poor access to high quality mental health care and stigmatization were also identified as key concerns among participants with poor mental health.
Article
Multidisciplinary Sciences
Marlee Bower, Amarina Donohoe-Bales, Scarlett Smout, Andre Quan Ho Ngyuen, Julia Boyle, Emma Barrett, Maree Teesson
Summary: The COVID-19 pandemic has led to significant mental health impacts in Australia, with disruptions to social interactions and financial stability being key concerns. Participants in the study highlighted barriers to accessing quality mental health care and the strain on mental health services due to the pandemic, calling for targeted policy planning to address priority issues and improve the mental health system.
Article
Biotechnology & Applied Microbiology
Yuli Wang, Wenyue Hu, Zixin Deng, Xinyi He
Summary: In this study, a chromogenic reaction between MAP and ferric chloride was reported, leading to the discovery of a new colored compound. This compound was used to screen phosphatases, and PhoN and YcdX phosphatases were identified in the bacterial cell lysate. The activity of these phosphatases was validated through in vitro assays.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Kali A. Smolen, Arminja N. Kettenbach
Summary: Most cellular processes are regulated by dynamic protein phosphorylation, with phosphoprotein phosphatases (PPPs) coordinating the dephosphorylation process. This plays an important regulatory role in the pathophysiology of various diseases. However, the mechanisms controlling PPPs and those controlled by PPPs are poorly understood. This article introduces a novel proteomic method, called phosphatase inhibitor beads and mass spectrometry (PIB-MS), which can quickly identify and quantify PPPs and their associated proteins. This method does not require the use of specific antibodies, and expands our understanding of dephosphorylation signaling.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Immunology
Poonum Korpe, Zhanmo Ni, Mamun Kabir, Masud Alam, Tahsin Ferdous, Rifat Ara, Rebecca M. Munday, Rashidul Haque, Priya Duggal
Summary: A longitudinal study in Bangladesh found that prolonged shedding of Cryptosporidium was common among infants and adults, and high rates of cryptosporidiosis were observed in infants and children. Transmission within the household was identified as an important route of exposure for young infants.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Silvia Moreira, Ricardo Silva, David F. Carrageta, Marco G. Alves, Vicente Seco-Rovira, Pedro F. Oliveira, Maria de Lourdes Pereira
Summary: Carbamates, widely used as pesticides, have both medical applications and adverse effects on the male reproductive system. Their inhibitory effect on acetylcholine hydrolyzation can lead to male fertility problems and disrupt the male endocrine system. The molecular mechanisms behind these effects are not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Madeline Smith-Johnson
Summary: This study reveals that transgender adults have a higher probability of reporting disabilities compared to their cisgender peers in the US. The adjusted probabilities show that transgender adults have a 27% chance of having at least one disability at age twenty and a 39% chance at age fifty-five, nearly twice the rate of their cisgender counterparts at both ages. The findings underscore the importance of considering disability from a life-course perspective, the impact of intersectional identities on disability risk, and the urgency of targeted health interventions for transgender individuals in the US.
Article
Chemistry, Applied
Qian-Qian Zhao, Wen-Jun Wei, Ya Li, Kun Gao
Summary: Three new highly modified lanostane triterpenoids, along with six known compounds, were isolated from the stems and leaves of Schisandra chinensis. Their structures were established through extensive spectroscopic analyses. Compounds 7 and 8 showed significant inhibition of Cdc25A phosphatase in vitro.
NATURAL PRODUCT RESEARCH
(2022)
Article
Plant Sciences
Yaming Yang, Lijuan Chen, Gen Su, Fangfang Liu, Qiang Zeng, Rui Li, Guili Cha, Cuihua Liu, Libo Xing, Xiaolin Ren, Yuduan Ding
Summary: This study identified the LPP family genes in kiwifruit and revealed their characteristics in subcellular localization, genomic distribution, evolutionary relationships, and functions. GO functional annotation and transcript level analysis showed that the LPP family in kiwifruit plays an important role in growth, development, and stress response. These findings are significant for studying the agricultural characteristics of kiwifruit and improving its stress resistance.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Dermatology
Hirofumi Kamada, Shinji Yasuhira, Masahiko Shibazaki, Hiroo Amano, Chihaya Maesawa
Summary: This study identified the role of DUSP4 in melanoma genesis. The findings suggest that DUSP4 maintains high ERK1/2 activity by negatively regulating DUSP6, contributing to the survival and growth of melanoma cells.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Public, Environmental & Occupational Health
Deqiang Liu, Yiming Zhang, Hui Fang, Jinxiang Yuan, Lizhen Ji
Summary: Pseudophosphatases are a class of enzymes that mutate at the catalytically active site and play important roles in life processes and diseases. This review discusses the structures, action types, and signaling mechanisms of pseudophosphatases in various families.
FRONTIERS IN PUBLIC HEALTH
(2022)
