Journal
NATURE NEUROSCIENCE
Volume 21, Issue 11, Pages 1541-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41593-018-0256-4
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Funding
- 1000 Talents Program for Young Scholars
- National Natural Science Foundation of China [81671106, 81771175, 31700933]
- National Basic Research Program of China (973 Program) [2015CB759500]
- National Key Research and Development Program of China [2018YFA0109600]
- Science Fund for Creative Research Group of China [61721092]
- ULabor RD Program [2017ULab0001]
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Urination (also called micturition) is thought to be regulated by a neural network that is distributed in both subcortical and cortical regions. Previously, urination-related neurons have been identified in subcortical structures such as the pontine micturition center (also known as Barrington's nucleus). However, the origin of the descending cortical pathway and how it interfaces with this subcortical circuit to permit voluntary initiation of urination remain elusive. Here we identified a small cluster of layer 5 neurons in the primary motor cortex whose activities tightly correlate with the onset of urination in freely behaving mice and increase dramatically during territorial marking. Optogenetically activating these neurons elicits contraction of the bladder and initiates urination, through their projections to the pontine micturition center, while silencing or ablating them impairs urination and causes retention of urine. Together these results reveal a novel cortical component upstream of the pontine micturition center that is critically involved in urination.
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