Article
Immunology
Yanis Pelinski, Donia Hidaoui, Anne Stolz, Francois Hermetet, Rabie Chelbi, M'boyba Khadija Diop, Amir M. Chioukh, Francoise Porteu, Emilie Elvira-Matelot
Summary: Ionizing radiation leads to loss of HSC function, associated with loss of H3K9me3 at intronic LINE-1 of HSC genes. The TNF-alpha/NF-kappa B/H3K9me3/LINE-1 axis maintains HSC gene expression and function independently of DNA damage.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Review
Medicine, Research & Experimental
Jiaoyang Ning, Liu Chen, Gang Xiao, Yu Zeng, Wen Shi, Guilong Tanzhu, Rongrong Zhou
Summary: PRMTs are involved in the prognosis and metastasis of tumors, and their regulation of molecular mechanisms affects tumor metastasis. Inhibiting arginine methylation can reduce tumor metastasis, and this field holds promise for clinical application.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Laura Oksa, Artturi Makinen, Atte Nikkila, Noora Hyvarinen, Saara Laukkanen, Anne Rokka, Pekka Haapaniemi, Masafumi Seki, Junko Takita, Otto Kauko, Merja Heinaniemi, Olli Lohi
Summary: Approximately 15-25% of acute lymphoblastic leukemias (ALL) originate from T-lineage cells, with T-ALL having a less favorable prognosis compared to B-ALL. High expression of PRMT7 was identified in T-ALL cells, and genetic deletion of PRMT7 decreased colony formation and altered arginine monomethylation patterns in protein complexes associated with RNA and DNA processing. Disruption of arginine monomethylation patterns was observed in proteins linked to T-ALL pathogenesis, such as RUNX1, leading to deregulated target gene expression. These findings suggest that PRMT7 plays a crucial role in T-ALL pathogenesis.
Article
Cell Biology
Shasha Yin, Liu Liu, Lauren E. Ball, Yalong Wang, Mark T. Bedford, Stephen A. Duncan, Haizhen Wang, Wenjian Gan
Summary: This study identifies protein arginine methyltransferase 1 (PRMT1) as a critical regulator of the GATOR2 complex, which activates the mTORC1 pathway for tumor growth. Inhibition of the CDK5-PRMT1-WDR24 axis suppresses HCC cell proliferation and tumor growth. High PRMT1 protein expression is associated with elevated mTORC1 signaling in patients with HCC.
Article
Immunology
Shoubao Ma, Jiazhuo Yan, Tasha Barr, Jianying Zhang, Zhenhua Chen, Li-Shu Wang, Joseph C. Sun, Jianjun Chen, Michael A. Caligiuri, Jianhua Yu
Summary: The N-6-methyladenosine modification plays a crucial role in NK cell immunity, with YTHDF2 being a key reader; YTHDF2 maintains NK cell homeostasis and function, modulating NK cell survival and proliferation through a positive feedback loop.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Tiffany Tate, Tina Xiang, Sarah E. Wobker, Mi Zhou, Xiao Chen, Hyunwoo Kim, Ekatherina Batourina, Chyuan-Sheng Lin, William Y. Kim, Chao Lu, James M. Mckiernan, Cathy Lee Mendelsohn
Summary: The differential expression of PPARg in bladder cancer subtypes plays a crucial role in tumor formation and progression. The activation of Pparg in basal bladder cells can prevent tumor formation but injury-induced differentiation of these cells into luminal cells can lead to tumor development. Understanding the molecular mechanisms behind subtype transition provides important insights for the diagnosis and treatment of bladder cancer.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Sushil Kumar, Zexian Zeng, Archis Bagati, Rong En Tay, Lionel A. Sanz, Stella R. Hartono, Yoshinaga Ito, Fieda Abderazzaq, Elodie Hatchi, Peng Jiang, Adam N. R. Cartwright, Olamide Olawoyin, Nathan D. Mathewson, Jason W. Pyrdol, Mamie Z. Li, John G. Doench, Matthew A. Booker, Michael Y. Tolstorukov, Stephen J. Elledge, Frederic Chedin, X. Shirley Liu, Kai W. Wucherpfennig
Summary: Inhibition of CARM1 enhances T cell function, promotes tumor immunity, and sensitizes tumor cells to immune attack.
Review
Cell Biology
Dirk Schmidt-Arras, Stefan Rose-John
Summary: Interleukin-6 plays a key role in inflammatory processes and cancer, as well as metabolic regulation and neural activities. Its receptor complexes can signal from both the plasma membrane and endomembranes, with pathogenic GP130 variants interfering with spatial activation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Juping Wang, Haoming Hua, Fanlu Wang, Shuling Yang, Qinghong Zhou, Xiangsheng Wu, Ding Feng, Hui Peng
Summary: This study identified the critical role of PRMT2 and protein arginine methylation in enhancing IFN-beta production via the TLR4/IRF3 signaling pathway, offering a potential therapeutic strategy for controlling endotoxemia.
MOLECULAR IMMUNOLOGY
(2021)
Article
Agronomy
Hanzhi Liang, Hongmei Lai, Jing Zeng, Jian Sun, Xiangjin Kong, Yueming Jiang, Xuewu Dua
Summary: This study identified and cloned nine PRMTs from the banana genome and investigated their molecular characteristics, functions, and roles in banana fruit ripening. The results suggested that PRMT-mediated protein arginine methylation plays an important role in banana fruit ripening.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2022)
Review
Immunology
Matthew Bell, Stephen Gottschalk
Summary: CAR T cell therapy is effective for hematological malignancies, but there is a need to improve its efficacy for solid tumors and brain tumors. Several approaches are being pursued to enhance the antitumor activity of CAR T cells, including augmenting signal 3 of T cell activation and improving the function of CAR T cells in the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Tommy Regen, Sandrine Isaac, Ana Amorim, Nicolas Gonzalo Nunez, Judith Hauptmann, Arthi Shanmugavadivu, Matthias Klein, Roman Sankowski, Ilgiz A. Mufazalov, Nir Yogev, Jula Huppert, Florian Wanke, Michael Witting, Alexandra Grill, Eric J. C. Galvez, Alexei Nikolaev, Michaela Blanfeld, Immo Prinz, Philippe Schmitt-Kopplin, Till Strowig, Christoph Reinhardt, Marco Prinz, Tobias Bopp, Burkhard Becher, Carles Ubeda, Ari Waisman
Summary: Research has shown that IL-17A and IL-17F are not encephalitogenic mediators, but rather modulators of intestinal homeostasis that indirectly alter CNS-directed autoimmunity.
SCIENCE IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Noriko Sato, Richard N. Bamford, Bonita R. Bryant, Yutaka Tagaya, Thomas A. Waldmann
Summary: When purified, naive T cells and regulatory T cells could not proliferate to the γC-cytokines IL-2, IL-7, or IL-15, despite expressing the cognate cytokine receptors. However, dendritic cells enabled their proliferation through cell-to-cell contact, independent of T cell receptor stimulation. This preconditioning effect activated specific cellular pathways and facilitated cytokine-mediated proliferation of T cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Qiang Li, Weicong Ren, Jinfeng Yuan, Haiping Guo, Yuanyuan Shang, Wei Wang, Junhua Pan, Mengqiu Gao, Yu Pang
Summary: This study compared the host immunological response to TB-specific antigens between active TB patients with positive and negative IGRA results. It found that the combination of IFN-γ and IL-4 performed well in identifying TB infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Raquel Castillo-Gonzalez, Danay Cibrian, Nieves Fernandez-Gallego, Marta Ramirez-Huesca, Maria Laura Saiz, Maria N. Navarro, Manuel Fresno, Hortensia de la Fuente, Francisco Sanchez-Madrid
Summary: Allergic contact dermatitis is a common T-cell-mediated inflammatory skin disease characterized by red, itchy, swollen, and cracked skin. The absence of endogenous Gal-1 in CD8+ T cells plays a protective role in controlling the development of allergic contact dermatitis, as Gal-1-deficient mice display more sustained and severe skin inflammation after treatment.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)