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Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci (vol 50, pg 928, 2018)

NATURE GENETICS (2019)

Journal

NATURE GENETICS

Volume 51, Issue 2, Pages 363-363

Publisher

NATURE PUBLISHING GROUP

DOI: 10.1038/s41588-018-0330-6

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Genetics & Heredity

Funding

Cancer Research UK [10119, 10124, 14136] Funding Source: Medline
Medical Research Council [MR/N003284/1, G1000143, G0401527] Funding Source: Medline
NATIONAL HUMAN GENOME RESEARCH INSTITUTE [ZIAHG200325] Funding Source: NIH RePORTER
MRC [MR/N003284/1] Funding Source: UKRI

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Article Genetics & Heredity

Polymorphic variants involved in methylation regulation: a strategy to discover risk loci for pancreatic ductal adenocarcinoma

Chiara Corradi, Giulia Lencioni, Manuel Gentiluomo, Alessio Felici, Anna Latiano, Gediminas Kiudelis, Casper H. J. van Eijck, Katalin Marta, Rita T. Lawlor, Francesca Tavano, Ugo Boggi, Frederike Dijk, Giulia Martina Cavestro, Roel C. H. Vermeulen, Thilo Hackert, Maria Chiara Petrone, Faik Guentac Uzunoglu, Livia Archibugi, Jakob R. Izbicki, Luca Morelli, Alessandro Zerbi, Stefano Landi, Hannah Stocker, Renata Talar-Wojnarowska, Gregorio Di Franco, Peter Hegyi, Cosimo Sperti, Silvia Carrara, Gabriele Capurso, Maria Gazouli, Hermann Brenner, Stefania Bunduc, Olivier Busch, Francesco Perri, Martin Oliverius, Peter Jeno Hegyi, Mara Goetz, Pasquale Scognamiglio, Andrea Mambrini, Paolo Giorgio Arcidiacono, Edita Kreivenaite, Juozas Kupcinskas, Tamas Hussein, Stefano Ermini, Anna Caterina Milanetto, Pavel Vodicka, Vytautas Kiudelis, Viktor Hlavac, Pavel Soucek, George E. Theodoropoulos, Daniela Basso, John P. Neoptolemos, Mateus Nobrega Aoki, Raffaele Pezzilli, Claudio Pasquali, Roger Chammas, Sabrina Gloria Giulia Testoni, Beatrice Mohelnikova-Duchonova, Maurizio Lucchesi, Cosmeri Rizzato, Federico Canzian, Daniele Campa

Summary: This study identified a novel risk locus for PDAC which modulates cancer risk by controlling gene expression through DNA methylation.

JOURNAL OF MEDICAL GENETICS (2023)

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Article Oncology

PREDICT validity for prognosis of breast cancer patients with pathogenic BRCA1/2 variants

Taru Muranen, Anna Morra, Sofia R. Khan, Daniel K. Barnes, Manjeet Bolla, Joe Dennis, Renske Keeman, Goska T. Leslie, Michael Parsons, Qin U. Wang, Thomas Ahearn, Kristiina L. Aittomaeki, Irene K. Andrulis, Banu Arun, Sabine Behrens, Katarzyna E. Bialkowska, Stig J. Bojesen, Nicola Camp, Jenny Chang-Claude, Kamila Czene, Peter M. Devilee, Susan M. Domchek, Alison Dunning, Christoph Engel, D. Gareth Evans, Manuela Gago-Dominguez, Montserrat Garcia-Closas, Anne-Marie Gerdes, Gord Glendon, Pascal Guenel, Eric Hahnen, Ute Hamann, Helen J. Hanson, Maartje Hooning, Reiner Hoppe, Louise Izatt, Anna A. Jakubowska, Paul N. James, Vessela Kristensen, Fiona J. Lalloo, Geoffrey Lindeman, Arto Mannermaa, Sara L. Margolin, Susan G. Neuhausen, William Newman, Paolo Peterlongo, Kelly-Anne Phillips, Miquel Angel Pujana, Johanna Rantala, Karina Ronlund, Emmanouil K. Saloustros, Rita Schmutzler, Andreas F. Schneeweiss, Christian Singer, Maija Suvanto, Yen Yen R. Tan, Manuel Teixeira, Mads Thomassen, Marc Tischkowitz, Vishakha Tripathi, Barbara Wappenschmidt, Emily F. Zhao, Douglas C. Easton, Antonis Antoniou, Georgia Chenevix-Trench, Paul D. P. K. Pharoah, Marjanka Schmidt, Carl Blomqvist, Heli Nevanlinna

Summary: This study assessed the PREDICT v 2.2 for prognosis of breast cancer patients with pathogenic germline BRCA1 and BRCA2 variants. The results showed that PREDICT had modest discrimination for BRCA1 carrier patients with ER-negative breast cancer, but clearly distinguished the high-mortality group from lower risk categories. However, for ER-positive breast cancer, the discrimination was slightly lower in BRCA2 variant carriers, and the inclusion of tumor grade distorted the prognostic estimates.

NPJ BREAST CANCER (2023)

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Editorial Material Nutrition & Dietetics

The Role of Vitamin D for Human Health: The Challenge of the Right Study Designs and Interpretation

Hermann Brenner

NUTRIENTS (2023)

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Article Respiratory System

Interactions of platelets with obesity in relation to lung cancer risk in the UK Biobank cohort

Sofia Christakoudi, Konstantinos K. Tsilidis, Evangelos Evangelou, Elio Riboli

Summary: In men, platelet count is positively associated with lung cancer risk, while platelet size is inversely associated, with these associations being affected by obesity. In women, only platelet count is positively associated with lung cancer risk, with little evidence of interaction with obesity.

RESPIRATORY RESEARCH (2023)

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