Mechanistic insights revealed by a UBE2A mutation linked to intellectual disability

Regulation of E2s: A Role for Additional Ubiquitin Binding Sites?

(2017) Adam J. Middleton et al.   JOURNAL OF MOLECULAR BIOLOGY

Rad6 upregulation promotes stem cell-like characteristics and platinum resistance in ovarian cancer

(2016) Ranganatha R. Somasagara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

E2 enzymes: more than just middle men

(2016) Mikaela D Stewart et al.   CELL RESEARCH

Perturbed proteostasis in autism spectrum disorders

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Next-generation sequencing in X-linked intellectual disability

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KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and Lysosome-Mediated Degradation

(2015) Jenny H. Hong et al.   MOLECULAR & CELLULAR PROTEOMICS

Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains

(2015) Emma Branigan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of a non-canonical surface of Rad6 in ubiquitin conjugating activity

(2015) Pankaj Kumar et al.   NUCLEIC ACIDS RESEARCH

Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains

(2015) Emma Branigan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The molecular basis of lysine 48 ubiquitin chain synthesis by Ube2K

(2015) Adam J. Middleton et al.   Scientific Reports

Affected Kindred Analysis of Human X Chromosome Exomes to Identify Novel X-Linked Intellectual Disability Genes

(2015) Tejasvi S. Niranjan et al.   PLoS One

UBE2A deficiency syndrome: A report of two unrelated cases with large Xq24 deletions encompassingUBE2Agene

(2014) Sofia Thunstrom et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Etiological yield of SNP microarrays in idiopathic intellectual disability

(2014) G. Eda Utine et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Ubiquitination in disease pathogenesis and treatment

(2014) Doris Popovic et al.   NATURE MEDICINE

Exploring the RING-Catalyzed Ubiquitin Transfer Mechanism by MD and QM/MM Calculations

(2014) Yunmei Zhen et al.   PLoS One

Rad6 is a Potential Early Marker of Melanoma Development

(2014) Karli Rosner et al.   Translational Oncology

Single exon-resolution targeted chromosomal microarray analysis of known and candidate intellectual disability genes

(2013) Tracy Tucker et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Novel Inhibitors of Rad6 Ubiquitin Conjugating Enzyme: Design, Synthesis, Identification, and Functional Characterization

(2013) M. A. Sanders et al.   MOLECULAR CANCER THERAPEUTICS

Mutations in the Intellectual Disability Gene Ube2a Cause Neuronal Dysfunction and Impair Parkin-Dependent Mitophagy

(2013) Dominik M. Haddad et al.   MOLECULAR CELL

X-linked intellectual disability type Nascimento is a clinically distinct, probably underdiagnosed entity

(2013) Johanna Czeschik et al.   Orphanet Journal of Rare Diseases

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Structural Insights into the Conformation and Oligomerization of E2∼Ubiquitin Conjugates

(2012) Richard C. Page et al.   BIOCHEMISTRY

Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases

(2012) Jonathan N. Pruneda et al.   MOLECULAR CELL

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

(2012) Anna Plechanovová et al.   NATURE

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Ubiquitin in Motion: Structural Studies of the Ubiquitin-Conjugating Enzyme∼Ubiquitin Conjugate

(2011) Jonathan N. Pruneda et al.   BIOCHEMISTRY

The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2

(2011) Katherine E. Wickliffe et al.   CELL

Essential Role for Ubiquitin-Ubiquitin-Conjugating Enzyme Interaction in Ubiquitin Discharge from Cdc34 to Substrate

(2011) Anjanabha Saha et al.   MOLECULAR CELL

A framework for variation discovery and genotyping using next-generation DNA sequencing data

(2011) Mark A DePristo et al.   NATURE GENETICS

E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6

(2011) R. G. Hibbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

UBE2A deficiency syndrome: Mild to severe intellectual disability accompanied by seizures, absent speech, urogenital, and skin anomalies in male patients

(2010) Nicole de Leeuw et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Novel missense mutations in the ubiquitination-related geneUBE2Acause a recognizable X-linked mental retardation syndrome

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Novel deletion at Xq24 including the UBE2A gene in a patient with X-linked mental retardation

(2010) Shozo Honda et al.   JOURNAL OF HUMAN GENETICS

Crystal Structure of UbcH5b∼Ubiquitin Intermediate: Insight into the Formation of the Self-Assembled E2∼Ub Conjugates

(2010) Eri Sakata et al.   STRUCTURE

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins

(2009) Sjoerd J. L. van Wijk et al.   FASEB JOURNAL

Solution structure and dynamics of human ubiquitin conjugating enzyme Ube2g2

(2009) Tingting Ju et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Novel Variants in UBE2B Gene and Idiopathic Male Infertility

(2008) V. Suryavathi et al.   JOURNAL OF ANDROLOGY