Review
Chemistry, Multidisciplinary
Priyanka Muthukuru, P. Krishnaraj, Jayachandra Rayadurgam, Sabbasani Rajasekhara Reddy
Summary: The synthesis of sugar-based ionic liquids from natural sugars has been considered a promising strategy, given their natural abundance and the current need for sustainable and environmentally friendly resources. Researchers are looking for low-cost and sustainable resources to produce novel sugar-based ionic liquids for organic synthesis and catalysis in response to the current environmental crisis.
NEW JOURNAL OF CHEMISTRY
(2021)
Review
Microbiology
Fatma Seyma Gokdemir, Ozlem Darcansoy Iseri, Abhishek Sharma, Premila N. Achar, Fusun Eyidogan
Summary: Crop output is directly affected by infections, particularly those caused by fungi. Accurate diagnosis of these threats is crucial and the use of genomic analyses, such as metagenomic next-generation sequencing (mNGS) and metabarcoding, is becoming increasingly important. These technologies allow for genotyping identification, species level identification, illumination of metabolic pathways, and determination of microbiota. The data obtained so far indicate that mNGS is a promising approach for fungal disease detection. This review focuses on the application of mNGS technology, including metabarcoding, for detecting fungal pathogens and its future developments.
Article
Multidisciplinary Sciences
Yongmeng Liu, Yingjie Mei, Chuanzhi Sun, Pinghuan Xiao, Ruirui Li, Xiaoming Wang, Chengtian Li
Summary: This study establishes a multistage asymmetric rotor coaxial measurement stacking method and a propagation model based on geometric center stacking to effectively suppress the vibration of asymmetric rotor equipment. Experimental results confirm that the vibration amplitude under the minimum exciting force assembly phase is smaller than under the random assembly phase, validating the effectiveness of the method.
Article
Chemistry, Physical
Aipeng Li, Wang Ting, Ke Yang, Xuanshuo Zhang, Dongming Yin, Yong Qin, Lianbing Zhang
Summary: Mutants of carbonyl reductase BaSDR1 with improved catalytic performance towards alpha-tetralones were obtained by adjusting the steric hindrance and hydrophobicity of the residues affecting the approach of the substrate with the catalytic residues. The designed mutants showed enhanced catalytic activity towards halogenated alpha-tetralones, with significant improvements in activity and stereoselectivity. The study provides insights into enzyme engineering for bulky-bulky ketones.
Article
Chemistry, Multidisciplinary
Xiu-Ning Hu, Dong-Ping Wu, Ye-Peng Xu, Pei-Qiang Huang
Summary: The first organocatalytic asymmetric synthesis of an advanced intermediate of (+)-sarain A was achieved by combining organocatalytic asymmetric Michael addition reaction and a nitrogen-to-carbon chirality transfer. This method allows for the construction of three chiral centers and chemoselective reduction of a key lactam intermediate, providing a tricyclic intermediate with all necessary functionalities for further elaboration into (+)-sarain A.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Fabian Hammerle, Luis Quiros-Guerrero, Adriano Rutz, Jean-Luc Wolfender, Harald Schoebel, Ursula Peintner, Bianka Siewert
Summary: Fungi have developed defense strategies, including photoactivity. Some Cortinarius species exhibit photobiological activity due to the presence of anthraquinones.
Article
Economics
Chuanhai Zhang, Zhengjun Zhang, Mengyu Xu, Zhe Peng
Summary: Recent studies have found jumps in cryptocurrencies like Bitcoin, but little is known about self-exciting jump clustering. Using high frequency data, this study investigates the characteristics of self-exciting jumps in Bitcoin returns. The findings show strong asymmetry in self-excitation, with negative jumps triggering it more often than positive jumps. Additionally, negative asymmetry is found in bear markets, but no evidence of positive asymmetry in bull markets. The study also reveals asymmetric aftershock effects, where aftershocks triggered by negative self-excitation are more persistent. This research has important implications for risk management and asset pricing in Bitcoin.
ECONOMIC MODELLING
(2023)
Article
Chemistry, Multidisciplinary
Antia Pintor, Ashley P. Mattey, Ivan Lavandera, Vicente Gotor-Fernandez, Alexey Volkov
Summary: The use of multienzymatic systems has become popular for complex (asymmetric) syntheses. Incompatible substrates, reagents, and enzymes can limit the applicability of a cascade reaction in batch conditions, so flow systems are preferred. Immobilized enzymes in continuous flow reactors enable the segregation and isolation of enzymes, allowing for otherwise challenging reaction cascades.
Article
Chemistry, Physical
William Finnigan, Lorna J. Hepworth, Sabine L. Flitsch, Nicholas J. Turner
Summary: With the expanding enzyme toolbox for biocatalysis, there is potential for constructing powerful enzymatic cascades for efficient and selective synthesis of target molecules. RetroBioCat is an intuitive tool for computer-aided design of biocatalytic cascades, utilizing expertly encoded reaction rules and literature precedent to identify promising biocatalytic pathways.
Article
Chemistry, Applied
Masatoshi Yamada, Sayuri Hirano, Ryoji Tsuruoka, Masahiro Takasuga, Kenichi Uno, Kotaro Yamaguchi, Mitsuhisa Yamano
Summary: In this study, a more cost-effective synthesis process for Alogliptin was reported, involving ruthenium-catalyzed asymmetric hydrogenation and Hofmann rearrangement to introduce a chiral amino moiety. The use of inexpensive and readily available compounds led to excellent total yield and comparable quality to the original process.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2021)
Article
Chemistry, Multidisciplinary
Marco Bottin, Graziano Di Carmine, Olga Bortolini, Carmela De Risi, Monica Bertoldo, Tommaso R. I. Cataldi, Cosima D. Calvano, Alessandro Massi, Daniele Ragno
Summary: This article presents an alternative synthetic route to macrocyclic oligoesters (MCOs) using N-heterocyclic carbene (NHC) catalysis under highly diluted oxidative conditions. The method allows for the straightforward access to MCOs using commercial dialdehydes, without the use of toxic diacyl chlorides commonly employed in traditional processes. The method is metal-free, takes place in a green solvent, and uses a recyclable quinone oxidant.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Organic
Pep Rojo, Antoni Riera, Xavier Verdaguer
Summary: The efficient electrophilic P-stereogenic transfer reagent BOM-tert-butylmethylphosphinite borane was used for the synthesis of bulky tertiary phosphines with high stereospecificity in a one-pot deprotection/substitution reaction. A wide range of tertiary phosphines in excellent enantiomeric excess was synthesized using this method, including a bulky P-stereogenic BisP* ligand analogue.
Article
Chemistry, Multidisciplinary
Cheng-Juan Wu, Xin-Yu Li, Ting-Rui Li, Ming-Zhen Shao, Li-Jing Niu, Xiao-Fan Lu, Jing-Lan Kan, Yan Geng, Yu-Bin Dong
Summary: This study reports the first-ever synthesis of COF using natural sunlight and demonstrates its application as a reusable photocatalyst for promoting light-driven oxidation reactions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Ken-Loon Choo, Bijan Mirabi, Karl Z. Demmans, Mark Lautens
Summary: Enantioenriched spiro-oxiranes with three contiguous stereocenters were synthesized using a rhodium-catalyzed cascade reaction, enabling the formation of a spirocyclic framework in a single step. Both sp(2)- and sp-hybridized carbon nucleophiles were found to be efficient initiators, yielding products with different functional groups. Derivatization studies demonstrated the synthetic versatility of the products' epoxide and alkyne moieties. DFT calculations were employed to explain spectroscopic discrepancies between solution- and solid-state structures of the products.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Applied
Feng Cheng, Jia-Min Zhang, Zhen-Tao Jiang, Xiao-Hu Wu, Ya-Ping Xue, Yu-Guo Zheng
Summary: Chiral amino acids have extensive applications in various industries. It has been shown that by gene mining and protein engineering, an NADH-dependent biocatalyst with high catalytic activity can be obtained, which allows the construction of an efficient and low-cost NAD(H)-driven biocatalytic system for the synthesis of chiral amino acids.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
